Activation of p53 by Oxidative Stress Involves Platelet-derived Growth Factor-β Receptor-mediated Ataxia Telangiectasia Mutated (ATM) Kinase Activation

p53, the cellular gatekeeper for growth and division

Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works

Oxidants, antioxidants, and the degenerative diseases of aging.

Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958 · see citing works

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785 · see citing works

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

Sundaresan, M., Yu, Z.-X., Ferrans, V. J., Irani, K., & Finkel, T. (1995) · Science · doi:10.1126/science.270.5234.296 · Cited by 2,520 · see citing works

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

Shieh, S.-Y., Ikeda, M., Taya, Y., & Prives, C. (1997) · Cell · doi:10.1016/s0092-8674(00)80416-x · Cited by 2,100 · see citing works

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042 · see citing works

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Honda, R., Tanaka, H., & Yasuda, H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01480-4 · Cited by 1,951 · see citing works

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797 · see citing works

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712 · see citing works

Cell transformation by the superoxide-generating oxidase Mox1

Suh, Y.-A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., & Lambeth, J. D. (1999) · Nature · doi:10.1038/43459 · Cited by 1,480 · see citing works

A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046 · see citing works

Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

Meng, T.-C., Fukada, T., & Tonks, N. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00445-8 · Cited by 1,040 · see citing works

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

Rosette, C., & Karin, M. (1996) · Science · doi:10.1126/science.274.5290.1194 · Cited by 1,034 · see citing works

Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

Lee, S.-R., Kwon, K.-S., Kim, S.-R., & Rhee, S. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15366 · Cited by 969 · see citing works

Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation

Denu, J. M., & Tanner, K. G. (1998) · Biochemistry · doi:10.1021/bi973035t · Cited by 945 · see citing works

Regulation and function of the p53 tumor suppressor protein

Ryan, K. M., Phillips, A. C., & Vousden, K. H. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00216-7 · Cited by 721 · see citing works

Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.

Lin, W.-C., Lin, F., & Nevins, J. R. (2001) · PubMed Central · Cited by 440 · see citing works

Natural Antioxidants in Human Health and Disease

(1994) · Elsevier eBooks · doi:10.1016/c2009-0-03361-3 · Cited by 427 · see citing works

A p53 Amino-Terminal Nuclear Export Signal Inhibited by DNA Damage-Induced Phosphorylation

Zhang, Y., & Xiong, Y. (2001) · Science · doi:10.1126/science.1058637 · Cited by 378 · see citing works

ATM: from gene to function

Rotman, G. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.10.1555 · Cited by 322 · see citing works

Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells

Linseman, D. A., Benjamin, C. W., & Jones, D. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12563 · Cited by 290 · see citing works

ATR/ATM Targets Are Phosphorylated by ATR in Response to Hypoxia and ATM in Response to Reoxygenation

Hammond, E. M., Dorie, M. J., & Giaccia, A. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212360200 · Cited by 282 · see citing works

Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases

Lambeth, J. D. (2002) · Current Opinion in Hematology · doi:10.1097/00062752-200201000-00003 · Cited by 282 · see citing works

Src and Cas Mediate JNK Activation but Not ERK1/2 and p38 Kinases by Reactive Oxygen Species

Yoshizumi, M., Abe, J., Haendeler, J., Huang, Q., & Berk, B. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11706 · Cited by 263 · see citing works

Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs

Barlow, C., Dennery, P. A., Shigenaga, M. K., Smith, M. A., Morrow, J. D., Roberts, L. J., Wynshaw-Boris, A. J., & Levine, R. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9915 · Cited by 246 · see citing works

The Inactivation Mechanism of Low Molecular Weight Phosphotyrosine-protein Phosphatase by H2O2

Caselli, A., Marzocchini, R., Camici, G., Manao, G., Moneti, G., Pieraccini, G., & Ramponi, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32554 · Cited by 213 · see citing works

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK

Hall-Jackson, C. A., Cross, D. A. E., MORRICE, N. A., & Smythe, C. (1999) · Oncogene · doi:10.1038/sj.onc.1203077 · Cited by 213 · see citing works

c-Jun N-terminal Kinase Activation by Hydrogen Peroxide in Endothelial Cells Involves Src-dependent Epidermal Growth Factor Receptor Transactivation

Chen, K., Vita, J. A., Berk, B. C., & Keaney, J. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011766200 · Cited by 200 · see citing works

Involvement of Tyrosine Phosphorylation and Protein Kinase C in the Activation of Phospholipase D by H2O2 in Swiss 3T3 Fibroblasts

Min, D. S., Kim, E., & Exton, J. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29986 · Cited by 174 · see citing works

Angiotensin II Induces Transactivation of Two Different Populations of the Platelet-derived Growth Factor β Receptor

Heeneman, S., Haendeler, J., Saito, Y., Ishida, M., & Berk, B. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909616199 · Cited by 162 · see citing works

Reactive Oxygen Species Activate p90 Ribosomal S6 Kinase via Fyn and Ras

Abe, J., Okuda, M., Huang, Q., Yoshizumi, M., & Berk, B. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1739 · Cited by 141 · see citing works

Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53

Turenne, G. A., Paul, P., Laflair, L., & Price, B. D. (2001) · Oncogene · doi:10.1038/sj.onc.1204665 · Cited by 120 · see citing works

Oxidative stress induces tyrosine phosphorylation of PDGF α-and β-receptors and pp60c−src in mesangial cells

González-Rubio, M., Voit, S., Rodrı́guez-Puyol, D., Weber, M. F. A., & Marx, M. (1996) · Kidney International · doi:10.1038/ki.1996.299 · Cited by 87 · see citing works

Requirement of ATM in UVA-induced Signaling and Apoptosis

Zhang, Y., Ma, W., Kaji, A., Bode, A. M., & Dong, Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110245200 · Cited by 87 · see citing works

Expression of Inducible Nitric Oxide Synthase mRNA in Rat Digestive Tissues after Endotoxin and Its Role in Intestinal Mucosal Injury

Chen, K., Inoue, M., & Okada, A. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1087 · Cited by 86 · see citing works

Mechanism of thiamine uptake by human jejunal brush-border membrane vesicles

Dudeja, P. K., Tyagi, S., Kavilaveettil, R. J., Gill, R. K., & Said, H. M. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.3.c786 · Cited by 79 · see citing works

DNA-dependent Protein Kinase-independent Activation of p53 in Response to DNA Damage

Burma, S., Kurimasa, A., Xie, G., Taya, Y., Araki, R., Abe, M., Crissman, H. A., Ouyang, H., Li, G. C., & Chen, D. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17139 · Cited by 73 · see citing works

Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function.

Marston, N., Crook, T., & Vousden, K. H. (1994) · PubMed · Cited by 70 · see citing works

Response of fibroblast cultures from ataxia‐telangiectasia patients to reactive oxygen species generated during inflammatory reactions

Ward, A. J., Olive, P. L., Burr, A., & Rosin, M. P. (1994) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850240205 · Cited by 60 · see citing works

Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation.

Mayr, G. A., Reed, M. J., Wang, P., Wang, Y., Schweds, J. F., & Tegtmeyer, P. (1995) · PubMed · Cited by 53 · see citing works

Active oxygen species mediate the solar ultraviolet radiation‐dependent increase in the tumour suppressor protein p53 in human skin fibroblasts

Vile, G. F. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00748-5 · Cited by 49 · see citing works

Induction of Single-Strand DNA Breaks in Human Cells by H 2 O 2 Formed in Near-uv (Black Light)-Irradiated Medium

Wang, R. J., Ananthaswamy, H. N., Nixon, B. T., Hartman, P. S., & Eisenstark, A. (1980) · Radiation Research · doi:10.2307/3575378 · Cited by 34 · see citing works

Hypersensitivity of ataxia-telangiectasia fibroblasts to a nitric oxide donor

Green, M. H. L., Marcovitch, A. J., Harcourt, S. A., Lowe, J. E., Green, I. C., & Arlett, C. F. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00336-x · Cited by 26 · see citing works

Stimulated production of ATP by H2O2 disproportionation in extracts from normal and xeroderma pigmentosum skins, and from normal, xeroderma pigmentosum, ataxia telangiectasia and simian virus 40 transformed cell lines

Vuillaume, M., Best‐Belpomme, M., Lafont, R., Hubert, M., Decroix, Y., & Sarasin, A. R. (1989) · Carcinogenesis · doi:10.1093/carcin/10.8.1375 · Cited by 10 · see citing works

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019 · see citing works

Redox regulation of cell survival

Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781 · see citing works

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling.

Lee, J., Giordano, S., & Zhang, J. (2012) · Biochemical Journal · doi:10.1042/bj20111451 · Cited by 1,438 · see citing works

ATM Activation by Oxidative Stress

Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079 · see citing works

Hydrogen peroxide sensing, signaling and regulation of transcription factors

Marinho, H. S., Real, C., Cyrne, L., Soares, H., & Antunes, F. (2014) · Redox Biology · doi:10.1016/j.redox.2014.02.006 · Cited by 851 · see citing works

DNA damage responses to oxidative stress

Barzilai, A., & Yamamoto, K.-I. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.002 · Cited by 796 · see citing works

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Suzuki, S., Tanaka, T., Poyurovsky, M. V., Nagano, H., Mayama, T., Ohkubo, S., Lokshin, M., Hosokawa, H., Nakayama, T., Suzuki, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002459107 · Cited by 705 · see citing works

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

Kurz, E. U., & Lees‐Miller, S. P. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.029 · Cited by 478 · see citing works

Regulation of ROS signal transduction by NADPH oxidase 4 localization

Chen, K., Kirber, M. T., Xiao, H. Q., Yang, Y., & Keaney, J. F. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709049 · Cited by 468 · see citing works

Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells

Chen, J., & Russo, J. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.06.004 · Cited by 330 · see citing works

Radiation-induced cell signaling: inside-out and outside-in

Valerie, K. C., Yacoub, A., Hagan, M. P., Curiel, D. T., Fisher, P. B., Grant, S., & Dent, P. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0596 · Cited by 329 · see citing works

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

Yang, Y., Ludwig, R. L., Jensen, J. P., Pierre, S. A., Medaglia, M. V., Davydov, I. V., Safiran, Y. J., Oberoi, P., Kenten, J. H., Phillips, A. C., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.029 · Cited by 321 · see citing works

Tumor suppressor genes and ROS: complex networks of interactions

Vurusaner, B., Poli, G., & Başağa, H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.035 · Cited by 292 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works

Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage

Suraweera, A., Bécherel, O. J., Chen, P., Rundle, N. T., Woods, R. G., Nakamura, J., Gatei, M. H., Criscuolo, C., Filla, A., Chessa, L., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200701042 · Cited by 196 · see citing works

BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery

Hagenbuchner, J., Kuznetsov, A. V., Obexer, P., & Ausserlechner, M. J. (2012) · Oncogene · doi:10.1038/onc.2012.500 · Cited by 175 · see citing works

Metabolic changes in cancer: beyond the Warburg effect

Wu, W., & Zhao, S. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gms104 · Cited by 173 · see citing works

Reactive Oxygen Species Induced p53 Activation: DNA Damage, Redox Signaling, or Both?

Shi, T., & Dansen, T. B. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8074 · Cited by 164 · see citing works

The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle

Biton, S., Barzilai, A., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.006 · Cited by 133 · see citing works

Regulation of the protein disulfide proteome by mitochondria in mammalian cells

Yang, Y., Song, Y., & Loscalzo, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702027104 · Cited by 129 · see citing works

Iron Deprivation in Cancer––Potential Therapeutic Implications

Heath, J. L., Weiss, J. M., Lavau, C., & Wechsler, D. S. (2013) · Nutrients · doi:10.3390/nu5082836 · Cited by 121 · see citing works

Mitochondrial Function Is Required for Hydrogen Peroxide-induced Growth Factor Receptor Transactivation and Downstream Signaling

Chen, K., Thomas, S. R., Albano, A., Murphy, M. P., & Keaney, J. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404859200 · Cited by 116 · see citing works

Deletion of the PDGFR-β Gene Affects Key Fibroblast Functions Important for Wound Healing

Gao, Z., Sasaoka, T., Fujimori, T., Oya, T., Ishii, Y., Sabit, H., Kawaguchi, M., Kurotaki, Y., Naito, M., Wada, T., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413081200 · Cited by 111 · see citing works

Caveolin-1, cellular senescence and age-related diseases

Zou, H., Stoppani, E., Volonte, D., & Galbiati, F. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.11.001 · Cited by 112 · see citing works

Activation of Ataxia Telangiectasia Mutated by DNA Strand Break-inducing Agents Correlates Closely with the Number of DNA Double Strand Breaks

Ismail, I. H., Nyström, S., Nygren, J., & Hammarsten, O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411588200 · Cited by 103 · see citing works

Mammalian Antioxidant Defenses Are Not Inducible by H2O2

Desaint, S., Luriau, S., Aude, J.-C., Rousselet, G., & Tolédano, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401888200 · Cited by 96 · see citing works

Acute acidic exposure induces p53-mediated oxidative stress and DNA damage in tilapia (Oreochromis niloticus) blood cells

Mai, W., Yan, J.-L., Wang, L., Zheng, Y., Xin, Y., & Wang, W.-N. (2010) · Aquatic Toxicology · doi:10.1016/j.aquatox.2010.07.025 · Cited by 95 · see citing works

Reactive Oxygen Species–Mediated Signal Transduction in the Endothelium

Chen, K., & Keaney, J. F. (2004) · Endothelium · doi:10.1080/10623320490482655 · Cited by 91 · see citing works

Early Single Cell Bifurcation of Pro- and Antiapoptotic States during Oxidative Stress

Nair, V. D., Yuen, T., Olanow, C. W., & Sealfon, S. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312135200 · Cited by 90 · see citing works

The Cellular Ataxia Telangiectasia-Mutated Kinase Promotes Epstein-Barr Virus Lytic Reactivation in Response to Multiple Different Types of Lytic Reactivation-Inducing Stimuli

Hagemeier, S. R., Barlow, E. A., Meng, Q., & Kenney, S. C. (2012) · Journal of Virology · doi:10.1128/jvi.01850-12 · Cited by 82 · see citing works

Mouse brains deficient in neuronal PDGF receptor‐β develop normally but are vulnerable to injury

Ishii, Y., Oya, T., Zheng, L., Gao, Z., Kawaguchi, M., Sabit, H., Matsushima, T., Tokunaga, A., Ishizawa, S., Hori, E., et al. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03922.x · Cited by 82 · see citing works

Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson’s disease

Nair, V. D. (2006) · APOPTOSIS · doi:10.1007/s10495-006-6316-3 · Cited by 80 · see citing works

Cytokine-Stimulated GTP Cyclohydrolase I Expression in Endothelial Cells Requires Coordinated Activation of Nuclear Factor-κB and Stat1/Stat3

Huang, A., Zhang, Y., Chen, K., Hatakeyama, K., & Keaney, J. F. (2004) · Circulation Research · doi:10.1161/01.res.0000153669.24827.df · Cited by 79 · see citing works

p38 Mitogen-Activated Protein Kinase Activates eNOS in Endothelial Cells by an Estrogen Receptor α-Dependent Pathway in Response to Black Tea Polyphenols

Anter, E., Chen, K., Shapira, O. M., Karas, R. H., & Keaney, J. F. (2005) · Circulation Research · doi:10.1161/01.res.0000168807.63013.56 · Cited by 78 · see citing works

Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A‐type lamins as intrinsic modulators of ageing in adult stem cells and their niches

Pekovic, V., & Hutchison, C. J. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00928.x · Cited by 75 · see citing works

Nuclear Ataxia-Telangiectasia Mutated (ATM) Mediates the Cellular Response to DNA Double Strand Breaks in Human Neuron-like Cells

Biton, S., Dar, I., Mittelman, L. A., Pereg, Y., Barzilai, A., & Shiloh, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601895200 · Cited by 74 · see citing works

Differential effects of cholesterol and phytosterols on cell proliferation, apoptosis and expression of a prostate specific gene in prostate cancer cell lines

Ifere, G. O., Barr, E., Equan, A., Gordon, K., Singh, U. P., Chaudhary, J., Igietseme, J. U., & Ananaba, G. A. (2009) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2008.12.002 · Cited by 72 · see citing works

The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress

Kim, T.-S., Kawaguchi, M., Suzuki, M., Jung, C., Asai, K., Shibamoto, Y., Lavin, M. F., Khanna, K. K., & Miura, Y. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004689 · Cited by 69 · see citing works

Caveolin-1 Expression Is Required for the Development of Pulmonary Emphysema through Activation of the ATM-p53-p21 Pathway

Volonté, D., Kahkonen, B., Shapiro, S. D., Di, Y. P., & Galbiati, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800225200 · Cited by 66 · see citing works

Regulation of caspase-3 and -9 activation in oxidant stress to RTE by forkhead transcription factors, Bcl-2 proteins, and MAP kinases

Kaushal, G. P., Liu, L., Kaushal, V., Hong, X., Melnyk, O. V., Seth, R., Safirstein, R. L., & Shah, S. V. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00391.2003 · Cited by 63 · see citing works

Hydrogen peroxide is a mediator of indole‐3‐acetic acid/horseradish peroxidase‐induced apoptosis

Kim, D.-S., Jeon, S., Jeong, Y., Kim, S.-Y., Kwon, S., & Park, K.-C. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.01.073 · Cited by 62 · see citing works

Ets-1 regulates energy metabolism in cancer cells

Verschoor, M. L., Wilson, L. A., Verschoor, C. P., & Singh, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013565 · Cited by 59 · see citing works

The regulation of energy generating metabolic pathways by p53

Corcoran, C. A., Huang, Y., & Sheikh, M. S. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.12.3617 · Cited by 57 · see citing works

Mechanisms associated with mitochondrial-generated reactive oxygen species in cancerThis article is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

Verschoor, M. L., Wilson, A., & Singh, G. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-135 · Cited by 57 · see citing works

Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells

Gugliesi, F., Mondini, M., Ravera, R., Robotti, A., Andrea, M. D., Gribaudo, G., Gariglio, M., & Landolfo, S. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0904507 · Cited by 56 · see citing works

Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-β receptor-mediated ERK and p38 pathways

Zhang, F., Ni, C., Kong, D., Zhang, X., Zhu, X., Chen, L., Lu, Y., & Zheng, S. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.09.016 · Cited by 53 · see citing works

EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis

Nuntharatanapong, N., Chen, K., Sinhaseni, P., & Keaney, J. F. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00901.2004 · Cited by 49 · see citing works

Feedback Control of p53 Translation by REDD1 and mTORC1 Limits the p53-Dependent DNA Damage Response

Vadysirisack, D. D., Baenke, F., Ory, B., Lei, K., & Ellisen, L. W. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05541-11 · Cited by 48 · see citing works

Age‐dependent response of primary human dermal fibroblasts to oxidative stress: cell survival, pro‐survival kinases, and entrance into cellular senescence

Gurjala, A. N., Liu, W. R., Mogford, J. E., Procaccini, P. S. A., & Mustoe, T. A. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2005.00079.x · Cited by 42 · see citing works

P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo

Gu, C., Zhang, Y., Hu, Q., Wu, J., Ren, H., Liu, C., & Wang, G. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.250 · Cited by 39 · see citing works

Uncoupling Protein 2 Impacts Endothelial Phenotype via p53-Mediated Control of Mitochondrial Dynamics

Shimasaki, Y., Pan, N., Messina, L. M., Li, C., Chen, K., Liu, L., Cooper, M. P., Vita, J. A., & Keaney, J. F. (2013) · Circulation Research · doi:10.1161/circresaha.113.301319 · Cited by 38 · see citing works

Gene Expression in the Lung of p53 Mutant Mice Exposed to Cigarette Smoke

Izzotti, A., Cartiglia, C., Longobardi, M., Bagnasco, M., Merello, A., You, M., Lubet, R. A., & Flora, S. D. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1420 · Cited by 37 · see citing works

Unfolded protein response is activated in aged retinas

Lenox, A. R., Bhootada, Y., Gorbatyuk, O. S., Fullard, R. J., & Gorbatyuk, M. S. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.10.019 · Cited by 34 · see citing works

Nonresponsiveness of cerebral p53-MDM2 functional circuit in newborn rat pups rendered IUGR via uteroplacental insufficiency

Ke, X., McKnight, R. A., Wang, Z.-M., Yu, X., Wang, L., Callaway, C. W., Albertine, K. H., & Lane, R. H. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00701.2004 · Cited by 34 · see citing works

High glucose induces mitochondrial p53 phosphorylation by p38 MAPK in pancreatic RINm5F cells

Flores-López, L. A., Díaz-Flores, M., García-Macedo, R., Ávalos‐Rodríguez, A., Vergara-Onofre, M., Cruz, M., Contreras‐Ramos, A., Königsberg, M., & Ortega‐Camarillo, C. (2013) · Molecular Biology Reports · doi:10.1007/s11033-013-2595-2 · Cited by 33 · see citing works

CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop

Wei, Z., Guo, H., Liu, Z., Zhang, X., Liu, Q., Qian, Y., Gong, Y., & Shao, C. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.010 · Cited by 30 · see citing works

PDGF: the nuts and bolts of signalling toolbox

Farooqı, A. A., Waseem, S., Riaz, A. M., Dilawar, B. A., Mukhtar, S., Minhaj, S., Waseem, M. S., Daniel, S., Malik, B. A., Nawaz, A., et al. (2011) · Tumor Biology · doi:10.1007/s13277-011-0212-3 · Cited by 31 · see citing works

Crude aqueous extracts of Pluchea indica (L.) Less. inhibit proliferation and migration of cancer cells through induction of p53-dependent cell death

Cho, J. J., Cho, C.-L., Kao, C., Chen, C., Tseng, C., Lee, Y., Liao, L., & Hong, Y. (2012) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-12-265 · Cited by 30 · see citing works

Dracorhodin Perchlorate Induces A375-S2 Cell Apoptosis via Accumulation of p53 and Activation of Caspases

Xia, M., Wang, M., Tashiro, S., Onodera, S., Minami, M., & Ikejima, T. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.226 · Cited by 29 · see citing works

BCR/ABL Recruits p53 Tumor Suppressor Protein to Induce Drug Resistance

Stokłosa, T., Słupianek, A., Datta, M., Nieborowska-Skorska, M., Nowicki, M. O., Koptyra, M., & Skórski, T. (2004) · Cell Cycle · doi:10.4161/cc.3.11.1229 · Cited by 29 · see citing works

Hypoxamirs and Mitochondrial Metabolism

Cottrill, K. A., Chan, S. Y., & Loscalzo, J. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5641 · Cited by 26 · see citing works

Ascochlorin activates p53 in a manner distinct from DNA damaging agents

Jeong, J.-H., Nakajima, H., Magae, J., Furukawa, C., Taki, K., Otsuka, K., Tomita, M., Lee, I., Kim, C., Chang, H., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24259 · Cited by 25 · see citing works

Oxidation of methionine residue at hydrophobic core destabilizes p53 tetrameric structure

Nomura, T., Kamada, R., Ito, I., Chuman, Y., Shimohigashi, Y., & Sakaguchi, K. (2008) · Biopolymers · doi:10.1002/bip.21084 · Cited by 24 · see citing works

Evaluation of the p53 and Thioredoxin reductase in sperm from asthenozoospermic males in comparison to normozoospermic males

Moradi, M.-N., Karimi, J., Khodadadi, I., Amiri, I., Karami, M., Saidijam, M., Vatannejad, A., & Tavilani, H. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.038 · Cited by 24 · see citing works

Oxidative stress enhances phosphorylation of p53 in neonatal rat cardiomyocytes

Long, X., Goldenthal, M. J., & Marı́n-Garcı́a, J. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9470-1 · Cited by 24 · see citing works

Deep senescent human fibroblasts show diminished DNA damage foci but retain checkpoint capacity to oxidative stress

Chen, J., & Ozanne, S. E. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.11.023 · Cited by 24 · see citing works

Recombinant Plasminogen Activator Inhibitor-1 Inhibits Intimal Hyperplasia

Wu, J., Peng, L., McMahon, G. A., Lawrence, D. A., & Fay, W. P. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.189514 · Cited by 23 · see citing works

Redox control of enzymatic functions: The electronics of life's circuitry

Bonini, M. G., Consolaro, M. E. L., Hart, P. C., Mao, M., de Abreu, A. L. P., & Master, А. M. (2014) · IUBMB Life · doi:10.1002/iub.1258 · Cited by 21 · see citing works

Excess Manganese-Induced Apoptosis in Chicken Cerebrums and Embryonic Neurocytes

Zhang, K., Zhu, Y., Wang, X., Zhao, X., Li, S., & Teng, X. (2017) · Biological Trace Element Research · doi:10.1007/s12011-017-0992-4 · Cited by 21 · see citing works

Multiparametric cerebellar imaging and clinical phenotype in childhood ataxia telangiectasia

Dineen, R. A., Raschke, F., McGlashan, H. L., Pszczółkowski, S., Hack, L., Cooper, A. D., Prasad, M., Chow, G., Whitehouse, W. P., & Auer, D. P. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102110 · Cited by 20 · see citing works

A278C mutation of dihydropteridine reductase decreases autophagy via mTOR signaling

Si, Q., Sun, S., & Gu, Y. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx061 · Cited by 15 · see citing works

Cholesterol and phytosterols differentially regulate the expression of caveolin 1 and a downstream prostate cell growth-suppressor gene

Ifere, G. O., Equan, A., Gordon, K., Nagappan, P., Igietseme, J. U., & Ananaba, G. A. (2010) · Cancer Epidemiology · doi:10.1016/j.canep.2010.04.009 · Cited by 14 · see citing works

Study of dual angiogenic/neurogenic growth factors among Saudi autistic children and their correlation with the severity of this disorder

Zakareia, F. A., AL-Ayadhi, L. Y., & Al-Drees, A. A. (2012) · Neurosciences · doi:10.17712/1658-3183.1949 · Cited by 12 · see citing works

Coenzyme Q2 induced p53-dependent apoptosis

Esaka, Y. H., Nagahara, Y., Hasome, Y., Nishio, R., & Ikekita, M. (2005) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.04.013 · Cited by 11 · see citing works

Genetic depletion of p53 attenuates cocaine-induced hepatotoxicity in mice

Nhu, H., Sharma, G., Sharma, N., Shin, E., Kim, D.-J., Pham, D. T., Trinh, Q. D., Jang, C., Nah, S. Y., Jeong, J. H., et al. (2018) · Biochimie · doi:10.1016/j.biochi.2018.12.009 · Cited by 10 · see citing works

FAF1 mediates necrosis through JNK1-mediated mitochondrial dysfunction leading to retinal degeneration in the ganglion cell layer upon ischemic insult

Yu, C., Kim, B., Park, M., Do, Y., Kong, Y., & Kim, E. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0265-7 · Cited by 8 · see citing works

Pancreatic β‑cell apoptosis in type 2 diabetes is related to post‑translational modifications of p53 (Review)

Flores-López, L. A., Enríquez‐Flores, S., Mora, I. D. L. M. L., García‐Torres, I., López‐Velázquez, G., Viedma‐Rodríguez, R., Ávalos‐Rodríguez, A., Contreras‐Ramos, A., & Ortega‐Camarillo, C. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13317 · Cited by 7 · see citing works

Glutamine and leukemia research: progress and clinical prospects

Wang, Z., Liu, M., & Yang, Q. (2024) · Discover Oncology · doi:10.1007/s12672-024-01245-0 · Cited by 6 · see citing works

A reverse-engineering approach to dissect post-translational modulators of transcription factor’s activity from transcriptional data

Gambardella, G., Peluso, I., Montefusco, S., Bansal, M., Medina, D. L., Lawrence, N. D., & di Bernardo, D. (2015) · BMC Bioinformatics · doi:10.1186/s12859-015-0700-3 · Cited by 6 · see citing works

Probing phenylalanine environments in oligomeric structures with pentafluorophenylalanine and cyclohexylalanine

Nomura, T., Kamada, R., Ito, I., Sakamoto, K., Chuman, Y., Ishimori, K., Shimohigashi, Y., & Sakaguchi, K. (2011) · Biopolymers · doi:10.1002/bip.21594 · Cited by 4 · see citing works

Agaricus subrufescens fermented rye affects the development of intestinal microbiota, local intestinal and innate immunity in suckling-to-nursery pigs

Wen, C., Geervliet, M., de Vries, H., Fabà, L., den Hil, P. J. R.-V., Skovgaard, K., Savelkoul, H. F. J., Schols, H. A., Wells, J. M., Tijhaar, E. J., et al. (2023) · Animal Microbiome · doi:10.1186/s42523-023-00244-w · Cited by 3 · see citing works

Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment

Deacon, S., Dalleywater, W. J., Peat, C., Paine, S., & Dineen, R. A. (2023) · The Cerebellum · doi:10.1007/s12311-023-01560-2 · Cited by 2 · see citing works

Antioxidative action of N-a-tosyl-L-lysine chloromethyl ketone prevents death of glutathione-depleted cardiomyocytes induced by hydrogen peroxide

Takahashi, K., Oyama, K., Motoshige, H., & Sakurai, K. (2010) · Journal of Biophysical Chemistry · doi:10.4236/jbpc.2010.13019 · Cited by 1 · see citing works

Signaling Cascades in Heart Failure: From Cardiomyocytes Growth and Survival to Mitochondrial Signaling Pathways

Marı́n-Garcı́a, J. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-147-9_7 · Cited by 1 · see citing works

P53 AND REACTIVE OXYGEN SPECIES: A CONVOLUTED STORY

Liu, B. (2007) · UKnowledge (University of Kentucky) · Cited by 1 · see citing works

APOPTOSIS

Choi, A. M. K., & Wang, X. (2006) · Elsevier eBooks · doi:10.1016/b0-12-370879-6/00030-2 · Cited by 1 · see citing works

DNA Damage and Oxidative Stress Induced-p53 Activity In Astrocytes causes Growth Arrest

Humphrey, S. A. (2012) · Scholarship@Western (Western University)

From cell penetrating peptides to peptoids and polyamines as novel artificial molecular transporters

Schmitz, K. (2005)

Mecanismes de toxicitat de la dopamina en cèl·lules de neuroblastoma humà SH-SY5Y

Xavier, P. G. (2008) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)

Regulation of Caspase-3 and -9 Activation in Oxidant Stress to Renal Tubular Epithelial Cells by Forkhead Transcription Factors, Bcl-2 Proteins and Mitogen- Activated Protein Kinases

Kaushal, G. P., Liu, L., Kaushal, V., Hong, X., Melnyk, O. V., Seth, R., Safirstein, R. L., & Shah, S. V. (2004)

Modificaciones postraduccionales en p53 inducidas por hiperglucemia durante la apoptosis de las células RINm5F

López, L. A. F. (2013) · doi:10.24275/uami.5138jf11m

Mitochondrial localisation of hTERT protects against nuclear DNA damage and mitochondrial ROS production after endogenous and exogenous stress

Singhapol, C. (2013)

Additional file 1 of Agaricus subrufescens fermented rye affects the development of intestinal microbiota, local intestinal and innate immunity in suckling-to-nursery pigs

Wen, C., Geervliet, M., de Vries, H., Fabà, L., den Hil, P. J. R.-V., Skovgaard, K., Savelkoul, H. F. J., Schols, H. A., Wells, J. M., Tijhaar, E. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26581682

Rôle de la plasticité cellulaire et du métabolisme dans la radiorésistance des cellules de glioblastomes : mise en évidence de nouvelles cibles thérapeutiques potentielles

Dahan, P. (2015) · theses.fr (ABES) · doi:10.70675/515e2aa9z1921z4297zaf7az36c49ac09385

Reactive Oxygen Species-induced Phosphorylation of p53 on Serine 20 Is Mediated in Part by Polo-like Kinase-3

Xie, S., Wang, Q., Wu, H., Cogswell, J. P., Luo, L., Jhanwar‐Uniyal, M., & Dai, W. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104157200 · Cited by 137 · see citing works

the ATR-Chk1 pathway and phosphorylates p53 at multiple sites. Am

Das, K. C., Dashnamoorthy, R., Kumuda, C., Activates, R. D. H., Physiol, J., Cell, L., L–l, M. P., & Published, F. (2003)

Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites

Das, K. C., & Ravi, D. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00203.2002 · Cited by 55 · see citing works

DNA damage and oxidant stress activate p53 through differential upstream signaling pathways.

Shi, T., van Soest, D. M. K., Polderman, P. E., Burgering, B., & Dansen, T. (2021) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2021.06.013 · Cited by 155 · see citing works

Tyr740and Tyr751residues of platelet-derived growth factor beta receptor are responsible for the redox regulation of phosphatase and tensin homolog in the cells stimulated with platelet-derived growth factor

Kim, I., Han, S.-J., Kim, Y., Ahn, Y., Chay, K.-O., & Lee, S.-R. (2011) · Redox Report · doi:10.1179/1351000211y.0000000005 · Cited by 10 · see citing works