The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism
Abstract
Recent autopsy and/or quantitative magnetic resonance imaging studies of autistic patients have identified agenesis of the superior olive, dysgenesis of the facial nucleus, reduced numbers of Purkinje neurons, hypoplasia of the brainstem and posterior cerebellum, and increased neuron-packing density of the medial, cortical and central nuclei of the amygdala and the medial septum. As neurogenesis occurs for these different neuron types during approximately the fifth week of gestation, the possibility is raised that this may be a 'window of vulnerability' for autism; the likely etiologic heterogeneity of autism suggests that other windows of vulnerability are also possible.
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“Post-mortem anatomical studies of brains from autistic individuals thus far revealed loss of Purkinje cells in the posterior vermis and intermediate cerebellar cortex as the most consistent neuropathology, suggesting a key role of the cerebellum in autism [213].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [213]
Citations
Cites
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360
Zola-Morgan, S., Squire, L., & Amaral, D. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02950.1986 · Cited by 1,997
Schmahmann, J. D. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2018.07.005 · Cited by 1,625
Practice-related Changes in Human Brain Functional Anatomy during Nonmotor Learning
Raichle, M. E., Fiez, J. A., Videen, T. O., MacLeod, A.-M. K., Pardo, J. V., Fox, P. T., & Petersen, S. E. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.1.8 · Cited by 1,593
Hypoplasia of cerebellar vermal lobules VI and VII in autism
Courchesne, E., Yeung-Courchesne, R., Hesselink, J. R., & Jernigan, T. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805263182102 · Cited by 1,058
Self-citationHistoanatomic observations of the brain in early infantile autism
Bauman, M., & Kemper, T. L. (1985) · Neurology · doi:10.1212/wnl.35.6.866 · Cited by 964
Bayer, S. A., Altman, J., Russo, R. J., & Zhang, X. (1993) · PubMed · Cited by 912
Attentional Activation of the Cerebellum Independent of Motor Involvement
Allen, G., Buxton, R. B., Wong, E. C., & Courchesne, E. (1997) · Science · doi:10.1126/science.275.5308.1940 · Cited by 785
Self-citationCerebellum Implicated in Sensory Acquisition and Discrimination Rather Than Motor Control
Gao, J., Parsons, L. M., Bower, J. M., Xiong, J., Li, J., & Fox, P. T. (1996) · Science · doi:10.1126/science.272.5261.545 · Cited by 674
Research works printed but not linked: 3
- Fehlow, 1993, Autismus infantum und exzessive aerophagie mit symptomatischem megakolon und ileus bei einem fall von ehlers-danlos-syndrom, Pediatr Grenzgeb, 31, 259
- Courchesne, 1995, Infantile autism. Part 2: A new neurodevelopmental model, Int Pediatr, 10, 155
- Courchesne, 1995, Infantile autism. Part 1: MR imaging abnormalities and their neurobehavioral correlates, Int Pediatr, 10, 141
Cited by
Sorted by citations
Empathy: its ultimate and proximate bases
Preston, S. D., & de Waal, F. B. M. (2002) · Behavioral and Brain Sciences · doi:10.1017/s0140525x02000018 · Cited by 4,126
Basal ganglia and cerebellar loops: motor and cognitive circuits
Middleton, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00040-5 · Cited by 1,940
The emulation theory of representation: Motor control, imagery, and perception
Grush, R. (2004) · Behavioral and Brain Sciences · doi:10.1017/s0140525x04000093 · Cited by 1,387
Autism and Abnormal Development of Brain Connectivity: Figure 1.
Belmonte, M. K., Allen, G., Beckel-Mitchener, A., Boulanger, L. M., Carper, R. A., & Webb, S. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3340-04.2004 · Cited by 1,217
Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder
Dawson, G. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000370 · Cited by 1,138
Metadata
- Authors
- Courchesne, E.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Courchesne, Eric
- ORCID
- Courchesne, Eric
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 1997-04
- Volume
- 7
- Issue
- 2
- Pages
- 269-278
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2165792108
- Cited by
- 401
- References
- 63
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 10 · 2018: 4 · 2017: 10 · 2016: 11 · 2015: 17 · 2014: 11 · 2013: 20 · 2012: 20
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH036840, 1-RO1-MH36840)
- National Institute of Neurological Disorders and Stroke (R01NS019855, 2-RO1-NS-19855)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- autism spectrum disorder, brainstem, cerebellum, limbic system, Purkinje cells, brainstem hypoplasia, amygdala, medial septum, neurogenesis, developmental vulnerability, autism etiology
- MeSH terms
- Autistic Disorder, Brain Stem, Cerebellum, Humans, Limbic System
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