Cited by 956Ion channel regulation and functionCardiac electrophysiology and arrhythmiasNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Calcium-activated potassium channels

Open access

Vergara, Cecilia, Latorre, Ramon, Marrion, Neil V, Adelman, John P·1998·Current Opinion in Neurobiology

DOI 10.1016/s0959-4388(98)80056-1

Open this paper in CoChat — free account

Abstract

Calcium-activated potassium channels are fundamental regulators of neuronal excitability, participating in interspike interval and spike-frequency adaptation. For large-conductance calcium-activated potassium (BK) channels, recent experiments have illuminated the fundamental biophysical mechanisms of gating, demonstrating that BK channels are voltage gated and calcium modulated. Structurally, BK channels have been shown to possess an extracellular amino-terminal domain, different from other potassium channels. Domains and residues involved in calcium-gating, and perhaps calcium binding itself, have been identified. For small- and intermediate-conductance calcium-activated potassium channels, SK and IK channels, clones have only recently become available, and they show that SK channels are a distinct subfamily of potassium channels. The biophysical properties of SK channels demonstrate that kinetic differences between apamin-sensitive and apamin-insensitive slow afterhyperpolarizations are not attributable to intrinsic gating differences between the two subtypes. Interestingly, SK and IK channels may prove effective drug targets for diseases such as myotonic muscular dystrophy and sickle cell anemia.

Integrity signals

Registry

Crossref · 10.1016/s0959-4388(98)80056-1

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Stability constants of metal-ion complexes
Sillén, L. G., Martell, A. E., Bjerrum, J., & Schwarzenbach, G. (1964) · Medical Entomology and Zoology · Cited by 3,983
Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation
Hoshi, T., Zagotta, W. N., & Aldrich, R. W. (1990) · Science · doi:10.1126/science.2122519 · Cited by 1,527
Relaxation of Arterial Smooth Muscle by Calcium Sparks
Nelson, M. T., Cheng, H., Rubart, M., Santana, L. F., Bonev, A. D., Knot, H. J., & Lederer, W. J. (1995) · Science · doi:10.1126/science.270.5236.633 · Cited by 1,399
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence
Noda, M., Shimizu, S., Tanabe, T., Takai, T., Kayano, T., Ikeda, T., Takahashi, H., Nakayama, H., Kanaoka, Y., Minamino, N., et al. (1984) · Nature · doi:10.1038/312121a0 · Cited by 1,349
Small-Conductance, Calcium-Activated Potassium Channels from Mammalian Brain
Kohler, M.-L., Hirschberg, B., Bond, C. T., Kinzie, J. M., Marrion, N. V., Maylie, J., & Adelman, J. P. (1996) · Science · doi:10.1126/science.273.5282.1709 · Cited by 946
Self-citation
Ca2+-activated K+ currents in neurones: types, physiological roles and modulation
Sah, P. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80026-9 · Cited by 892
Mutations in the K+ channel signature sequence
Heginbotham, L., Lü, Z., Abramson, T., & MacKinnon, R. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80887-2 · Cited by 853
Varieties of Calcium-Activated Potassium Channels
Latorre, R., Oberhauser, A. F., Labarca, P. P., & Alvarez, O. A. (1989) · Annual Review of Physiology · doi:10.1146/annurev.ph.51.030189.002125 · Cited by 735
Self-citation
The Coupling of Neurotransmitter Receptors to Ion Channels in the Brain
Nicoll, R. A. (1988) · Science · doi:10.1126/science.2456612 · Cited by 729
Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy
Harley, H. G., Brook, J. D., Rundle, S. A., Crow, S., Reardon, W., Buckler, A., Harper, P. S., Housman, D. E., & Shaw, D. J. (1992) · Nature · doi:10.1038/355545a0 · Cited by 725

Show all 85 references

Sorted by citations

Items 101–200 of 956

Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel
Herrera, G. M., Pozo, M. J., Zvara, P., Petkov, G. V., Bond, C. T., Adelman, J. P., & Nelson, M. T. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00893.x · Cited by 137
Self-citation
BK channels: multiple sensors, one activation gate
Yang, H.-H., Zhang, G.-H., & Cui, J.-M. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00029 · Cited by 130
Fluensulfone is a nematicide with a mode of action distinct from anticholinesterases and macrocyclic lactones
Kearn, J., Ludlow, E., Dillon, J., O'Connor, V. M., & Holden-Dye, L. M. (2014) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2014.01.004 · Cited by 133
The slowpoke Gene Is Necessary for Rapid Ethanol Tolerance in Drosophila
Cowmeadow, R. B., Krishnan, H. R., & Atkinson, N. S. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000183232.56788.62 · Cited by 132
Role of KCNMA1gene in breast cancer invasion and metastasis to brain
Khaitan, D., Sankpal, U. T., Weksler, B. B., Meister, E. A., Romero, I. A., Couraud, P., & Ningaraj, N. S. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-258 · Cited by 133
Allosteric Regulation of Bk Channel Gating by Ca2+ and Mg2+ through a Nonselective, Low Affinity Divalent Cation Site
Zhang, X., Solaro, C. R., & Lingle, C. J. (2001) · The Journal of General Physiology · doi:10.1085/jgp.118.5.607 · Cited by 130
Quantifying the Neural Elements Activated and Inhibited by Globus Pallidus Deep Brain Stimulation
Johnson, M. D., & McIntyre, C. C. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90372.2008 · Cited by 129
The β Subunit Increases the Ca2+ Sensitivity of Large Conductance Ca2+-activated Potassium Channels by Retaining the Gating in the Bursting States
Nimigean, C. M., & Magleby, K. L. (1999) · The Journal of General Physiology · doi:10.1085/jgp.113.3.425 · Cited by 127
Oxidative Regulation of Large Conductance Calcium-Activated Potassium Channels
Tang, X. D., Daggett, H. T., Hanner, M., García, M. L., McManus, O. B., Brot, N., Weissbach, H., Heinemann, S. H., & Hoshi, T. (2001) · The Journal of General Physiology · doi:10.1085/jgp.117.3.253 · Cited by 127
Consequences of the Stoichiometry ofSlo1α and Auxiliary β Subunits on Functional Properties of Large-Conductance Ca2+-Activated K+Channels
Wang, Y., Ding, J. P., Xia, X., & Lingle, C. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01550.2002 · Cited by 126
SKCaChannels Mediate the Medium But Not the Slow Calcium-Activated Afterhyperpolarization in Cortical Neurons
Villalobos, C. A., Shakkottai, V. G., Chandy, K. G., Michelhaugh, S. K., & Andrade, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0380-04.2004 · Cited by 126
Afterhyperpolarization Regulates Firing Rate in Neurons of the Suprachiasmatic Nucleus
Cloues, R. K., & Sather, W. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01593.2003 · Cited by 126
SK channels and the varieties of slow after‐hyperpolarizations in neurons
Vogalis, F., Storm, J. F., & Lancaster, B. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03040.x · Cited by 122
Cloning of a New Mouse Two-P Domain Channel Subunit and a Human Homologue with a Unique Pore Structure
Salinas, M., Reyes, R. V., Lesage, F., Fosset, M., Heurteaux, C., Romey, G., & Lazdunski, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11751 · Cited by 125
Gating Kinetics of Single Large-Conductance Ca2+-Activated K+ Channels in High Ca2+ Suggest a Two-Tiered Allosteric Gating Mechanism✪
Rothberg, B. S., & Magleby, K. L. (1999) · The Journal of General Physiology · doi:10.1085/jgp.114.1.93 · Cited by 124
Elimination of the BKCa Channel's High-Affinity Ca2+ Sensitivity
Bao, L., Rapin, A. M., Holmstrand, E. C., & Cox, D. H. (2002) · The Journal of General Physiology · doi:10.1085/jgp.20028627 · Cited by 124
Modulation of recombinant and native neuronal SK channels by the neuroprotective drug riluzole
Cao, Y., Dreixler, J. C., Couey, J. J., & Houamed, K. M. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01987-8 · Cited by 122
FUNCTIONS OF SK CHANNELS IN CENTRAL NEURONS
Faber, E. S. L., & Sah, P. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04725.x · Cited by 120
Intracellular Mg2+ Enhances the Function of Bk-Type Ca2+-Activated K+ Channels
Shi, J., & Cui, J. (2001) · The Journal of General Physiology · doi:10.1085/jgp.118.5.589 · Cited by 120
Characterization of large conductance Ca2+‐activated K+ channels in cerebellar Purkinje neurons
Womack, M. D., & Khodakhah, K. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02171.x · Cited by 120
Distribution of rSlo Ca2+-activated K+ channels in rat astrocyte perivascular endfeet
Price, D. L., Ludwig, J., Mi, H., Schwarz, T. L., & Ellisman, M. H. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03266-3 · Cited by 118
Gating and Ionic Currents Reveal How the BKCa Channel's Ca2+ Sensitivity Is Enhanced by its β1 Subunit
Bao, L., & Cox, D. H. (2005) · The Journal of General Physiology · doi:10.1085/jgp.200509346 · Cited by 117
The pharmacology of hSK1 Ca 2+ ‐activated K + channels expressed in mammalian cell lines
Shah, M. M., & Haylett, D. G. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703111 · Cited by 115
Alternative Pre-mRNA Splicing and Neuronal Function
Black, D. L., & Grabowski, P. J. (2003) · Progress in molecular and subcellular biology · doi:10.1007/978-3-662-09728-1_7 · Cited by 117
Kinase-dependent Regulation of the Intermediate Conductance, Calcium-dependent Potassium Channel, hIK1
Gerlach, A. C., Gangopadhyay, N. N., & Devor, D. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.585 · Cited by 114
Differential regulation of SK and BK channels by Ca2+ signals from Ca2+ channels and ryanodine receptors in guinea‐pig urinary bladder myocytes
Herrera, G. M., & Nelson, M. T. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.017707 · Cited by 114
Osmotic Forces and Gap Junctions in Spreading Depression: A Computational Model
Shapiro, B. E. (2001) · Journal of Computational Neuroscience · doi:10.1023/a:1008924227961 · Cited by 107
Spike Frequency Adaptation in Neurons of the Central Nervous System
Ha, G. E., & Cheong, E. (2017) · Experimental Neurobiology · doi:10.5607/en.2017.26.4.179 · Cited by 113
Mapping the BKCa Channel's “Ca2+ Bowl”
Bao, L., Kaldany, C., Holmstrand, E. C., & Cox, D. H. (2004) · The Journal of General Physiology · doi:10.1085/jgp.200409052 · Cited by 113
Non-synaptic ion channels in insects — basic properties of currents and their modulation in neurons and skeletal muscles
Wicher, D., Walther, C., & Wicher, C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00066-6 · Cited by 116
Functional Roles of a Ca 2+ -Activated K + Channel in Atrioventricular Nodes
Zhang, Q., Timofeyev, V., Lü, L., Li, N., Singapuri, A., Long, M., Bond, C. T., Adelman, J. P., & Chiamvimonvat, N. (2007) · Circulation Research · doi:10.1161/circresaha.107.161778 · Cited by 112
Self-citation
Small- and intermediate-conductance Ca2+-activated K+channels directly control agonist-evoked nitric oxide synthesis in human vascular endothelial cells
Sheng, J., & Braun, A. P. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00036.2007 · Cited by 111
Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons
Seutin, V., Johnson, S. W., & North, R. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90675-d · Cited by 111
Relationships Between Intracellular Calcium and Afterhyperpolarizations in Neocortical Pyramidal Neurons
Abel, H. J., Lee, J. C. F., Callaway, J. C., & Foehring, R. C. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00583.2003 · Cited by 110
New advancement in anthelmintic drugs in veterinary medicine
Epe, C., & Kaminsky, R. (2013) · Trends in Parasitology · doi:10.1016/j.pt.2013.01.001 · Cited by 120
Paradoxical Role of Large-Conductance Calcium-Activated K+(BK) Channels in Controlling Action Potential-Driven Ca2+Entry in Anterior Pituitary Cells
Van Goor, F., Li, Y.-X., & Stojilkovic, S. S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-05902.2001 · Cited by 109
Genetic algorithm optimization in drug design QSAR: Bayesian-regularized genetic neural networks (BRGNN) and genetic algorithm-optimized support vectors machines (GA-SVM)
Fernández, M., Caballero, J., Fernández, L., & Sarai, A. (2010) · Molecular Diversity · doi:10.1007/s11030-010-9234-9 · Cited by 108
Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability
Dell’Orco, J., Wasserman, A. H., Chopra, R., Ingram, M. A. C., Hu, Y., Singh, V., Wulff, H., Opal, P., Orr, H. T., & Shakkottai, V. G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-15.2015 · Cited by 109
Calcium‐Activated Potassium Currents In Mammalian Neurons
Sah, P., & Davies, P. (2000) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2000.03317.x · Cited by 109
The soma and neurites of primary afferent neurons in the guinea‐pig intestine respond differentially to deformation
Kunze, W. A. A., Clerc, N., Furness, J. B., & Gola, M. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00375.x · Cited by 109
Cardioprotective effects of estradiol include the activation of large-conductance Ca2+-activated K+ channels in cardiac mitochondria
Ohya, S., Kuwata, Y., Sakamoto, K., Muraki, K., & Imaizumi, Y. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00016.2005 · Cited by 108
Calcium-Activated Potassium Conductances Contribute to Action Potential Repolarization at the Soma But Not the Dendrites of Hippocampal CA1 Pyramidal Neurons
Poolos, N. P., & Johnston, D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05205.1999 · Cited by 108
Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line
Fernández‐Fernández, J. M., Nobles, M., Currid, A., Vázquez, E., & Valverde, M. A. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00245.2002 · Cited by 108
Hydrogen sulfide increases calcium-activated potassium (BK) channel activity of rat pituitary tumor cells
Ситдикова, Г. Ф., Weiger, T. M., & Hermann, A. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0737-0 · Cited by 107
State-independent Block of BK Channels by an Intracellular Quaternary Ammonium
Wilkens, C. M., & Aldrich, R. W. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200609579 · Cited by 105
TheDrosophila ergK+Channel Polypeptide Is Encoded by the Seizure Locus
Titus, S. A., Warmke, J. W., & Ganetzky, B. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-03-00875.1997 · Cited by 106
Ca 2+ dependence of flow-stimulated K secretion in the mammalian cortical collecting duct
Liu, W., Morimoto, T., Woda, C. B., Kleyman, T. R., & Satlin, L. M. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00057.2007 · Cited by 102
Ethanol Increases the Activity of Ca++-Dependent K+ (mslo) Channels: Functional Interaction with Cytosolic Ca++
Dopico, A. M., Anantharam, V., & Treistman, S. N. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37207-6 · Cited by 105
Distinct stoichiometry of BK Ca channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase
Tian, L., Coghill, L. S., McClafferty, H., Macdonald, S. H.-F., Antoni, F. A., Ruth, P., Knaus, H., & Shipston, M. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402590101 · Cited by 105
The Role of BKCa Channels in Electrical Signal Encoding in the Mammalian Auditory Periphery
Oliver, D., Taberner, A. M., Thurm, H., Sausbier, M., Arntz, C., Ruth, P., Fakler, B., & Liberman, M. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1047-06.2006 · Cited by 104
Calcium‐activated potassium channel SK1‐ and IK1‐like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors
Boettger, M. K., Till, S., Chen, M. X., Anand, U., Otto, W. R., Plumpton, C., Trezise, D. J., Tate, S., Bountra, C., Coward, K., et al. (2002) · Brain · doi:10.1093/brain/awf026 · Cited by 104
Somatic Colocalization of Rat SK1 and D class (Cav 1.2) L-type Calcium Channels in Rat CA1 Hippocampal Pyramidal Neurons
Bowden, S. E. H., Fletcher, S., Loane, D. J., & Marrion, N. V. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-j0006.2001 · Cited by 103
Self-citation
Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects
Woda, C. B., Miyawaki, N., Ramalakshmi, S., Ramkumar, M., Rojas, R., Zavilowitz, B. J., Kleyman, T. R., & Satlin, L. M. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00191.2003 · Cited by 103
Intracellular calcium store depletion and acrosome reaction in human spermatozoa: role of calcium and plasma membrane potential
Rossato, M. (2001) · Molecular Human Reproduction · doi:10.1093/molehr/7.2.119 · Cited by 102
Expression pattern and functional characteristics of two novel splice variants of the two‐pore‐domain potassium channel TREK‐2
Gu, W., Schlichthörl, G., Hirsch, J. R., Engels, H., Karschin, C., Karschin, A., Derst, C., Steinlein, O. K., & Daut, J. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013432 · Cited by 101
Opposite Regulation of Slick and Slack K+Channels by Neuromodulators
Santi, C. M., Ferreira, G., Yang, B., Gazula, V., Butler, A., Wei, A. D., Kaczmarek, L. K., & Salkoff, L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3372-05.2006 · Cited by 100
Effects of intracellular stores and extracellular Ca2+ on Ca2+‐activated K+ currents in mature mouse inner hair cells
Marcotti, W., Johnson, S. L., & Kros, C. J. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.060137 · Cited by 98
Mice with Deficient BK Channel Function Show Impaired Prepulse Inhibition and Spatial Learning, but Normal Working and Spatial Reference Memory
Typlt, M., Mirkowski, M., Azzopardi, E., Ruettiger, L., Ruth, P., & Schmid, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081270 · Cited by 105
The calcium-sensitive large-conductance potassium channel (BK/MAXI K) is present in the inner mitochondrial membrane of rat brain
Douglas, R. M., Lai, J. C. K., Bian, S., Gunther-Cummins, L., Moczydlowski, E. G., & Haddad, G. G. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.061 · Cited by 97
Heme Regulates Allosteric Activation of the Slo1 BK Channel
Horrigan, F. T., Heinemann, S. H., & Hoshi, T. (2005) · The Journal of General Physiology · doi:10.1085/jgp.200509262 · Cited by 97
Functional Analysis of Native and Recombinant Ion Channels Using a High-Capacity Nonradioactive Rubidium Efflux Assay
Terstappen, G. C. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4179 · Cited by 95
A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neurons
Shruti, S., Clem, R. L., & Barth, A. L. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.02.002 · Cited by 100
Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic pain
Chen, S., Cai, Y.-Q., & Pan, H. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06138.x · Cited by 94
Potassium Channels: Newly Found Players in Synaptic Plasticity
Kim, J., & Hoffman, D. A. (2007) · The Neuroscientist · doi:10.1177/1073858408315041 · Cited by 89
Photolytic Manipulation of [Ca2+]iReveals Slow Kinetics of Potassium Channels Underlying the Afterhyperpolarization in Hipppocampal Pyramidal Neurons
Sah, P., & Clements, J. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-03657.1999 · Cited by 91
Ca2+Channels Involved in the Generation of the Slow Afterhyperpolarization in Cultured Rat Hippocampal Pyramidal Neurons
Shah, M. M., & Haylett, D. G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.2554 · Cited by 89
Cell-cycle-dependent expression of the large Ca2+-activated K+ channels in breast cancer cells
Ouadid‐Ahidouch, H., Roudbaraki, M. M., Ahidouch, A., Delcourt, P., & Prevarskaya, N. B. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.041 · Cited by 88
Molecular Basis of Pimarane Compounds as Novel Activators of Large-Conductance Ca2+-Activated K+ Channel α-Subunit
Imaizumi, Y., Sakamoto, K., Yamada, A., Hotta, A., Ohya, S., Muraki, K., Uchiyama, M., & Ohwada, T. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.4.836 · Cited by 88
Emerging role of the KCNT1 Slack channel in intellectual disability
Kim, G. E., & Kaczmarek, L. K. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00209 · Cited by 85
Proteomic Analysis of a Membrane Preparation from Rat Olfactory Sensory Cilia
Mayer, U., Ungerer, N., Klimmeck, D., Warnken, U. H., Schnölzer, M., Frings, S., & Möhrlen, F. (2007) · Chemical Senses · doi:10.1093/chemse/bjm073 · Cited by 85
Localization and developmental expression of BK channels in mammalian cochlear hair cells
Hafidi, A., Beurg, M., & Dulon, D. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.038 · Cited by 87
IK channels are involved in the regulatory volume decrease in human epithelial cells
Wang, J., Morishima, S., & Okada, Y. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00132.2002 · Cited by 87
The beneficial health effects of flavonoids on the cardiovascular system: Focus on K+ channels
Fusi, F., Trezza, A., Tramaglino, M., Sgaragli, G., Saponara, S., & Spiga, O. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104625 · Cited by 86
Hair Cells – Beyond the Transducer
Housley, G. D., Marcotti, W., Navaratnam, D. S., & Yamoah, E. N. (2006) · The Journal of Membrane Biology · doi:10.1007/s00232-005-0835-7 · Cited by 86
Unique Inner Pore Properties of BK Channels Revealed by Quaternary Ammonium Block
Li, W., & Aldrich, R. W. (2004) · The Journal of General Physiology · doi:10.1085/jgp.200409067 · Cited by 85
Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol
Martin, G. E., Hendrickson, L. M., Penta, K. L., Friesen, R. M., Pietrzykowski, A. Z., Tapper, A. R., & Treistman, S. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801068105 · Cited by 86
Critical roles of a small conductance Ca2+-activated K+ channel (SK3) in the repolarization process of atrial myocytes
Zhang, X.-D., Timofeyev, V., Li, N., Myers, R. E., Zhang, D., Singapuri, A., Lau, V. C., Bond, C. T., Adelman, J. P., Lieu, D. K., et al. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt262 · Cited by 86
Self-citation
Dihydroxyeicosatrienoic acids are potent activators of Ca2+‐activated K+ channels in isolated rat coronary arterial myocytes
Lü, T., Katakam, P. V. G., VanRollins, M., Weintraub, N. L., Spector, A. A., & Lee, H. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00651.x · Cited by 86
Calcium-Activated Potassium Channels BK and IK1 Are Functionally Expressed in Human Gliomas but Do Not Regulate Cell Proliferation
Abdullaev, I. F., Rudkouskaya, A., Mongin, A. A., & Kuo, Y.-H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012304 · Cited by 85
Small conductance calcium-activated potassium channels: From structure to function
Weatherall, K. L., Goodchild, S. J., Jane, D. E., & Marrion, N. V. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.03.002 · Cited by 84
Self-citation
The regulation of BK channel activity by pre- and post-translational modifications
Kyle, B. D., & Braun, A. P. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00316 · Cited by 84
Somatic Localization of a Specific Large-Conductance Calcium-Activated Potassium Channel Subtype Controls Compartmentalized Ethanol Sensitivity in the Nucleus Accumbens
Martin, G. E., Puig, S. I., Pietrzykowski, A. Z., Zadek, P., Emery, P., & Treistman, S. N. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0684-04.2004 · Cited by 84
Regulation of Uterine Smooth Muscle Function during Gestation
Riemer, R. K., & Heymann, M. A. (1998) · Pediatric Research · doi:10.1203/00006450-199811000-00001 · Cited by 83
β2 and β4 Subunits of BK Channels Confer Differential Sensitivity to Acute Modulation by Steroid Hormones
King, J. T., Lovell, P. V., Rishniw, M., Kotlikoff, M. I., Zeeman, M. L., & McCobb, D. P. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01352.2005 · Cited by 83
Calcium-Activated Potassium Current Modulates Ventricular Repolarization in Chronic Heart Failure
Bonilla, I. M., Long, V. P., Vargas-Pinto, P. A., Wright, P., Belevych, A. E., Lou, Q., Mowrey, K. A., Yoo, J. C., Binkley, P. F., Fedorov, V. V., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108824 · Cited by 83
BK channel activity determines the extent of cell degeneration after oxygen and glucose deprivation: a study in organotypical hippocampal slice cultures
Rundén‐Pran, E., Haug, F. Š., Storm, J. F., & Ottersen, O. P. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00092-1 · Cited by 83
Single Transmembrane Domain Insulin-Like Growth Factor-II/Mannose-6-Phosphate Receptor Regulates Central Cholinergic Function by Activating a G-Protein-Sensitive, Protein Kinase C-Dependent Pathway
Hawkes, C. A., Jhamandas, J. H., Harris, K. H., Fu, W., MacDonald, R. G., & Kar, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2730-05.2006 · Cited by 83
Ion sensing in the RCK1 domain of BK channels
Zhang, G., Huang, S.-Y., Yang, J., Shi, J., Yang, X. Y., Moller, A., Zou, X., & Cui, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010124107 · Cited by 81
Regulation of cation transport in the distal nephron by mechanical forces
Satlin, L. M., Carattino, M. D., Liu, W., & Kleyman, T. R. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00192.2006 · Cited by 80
Measurements of the BKCa Channel's High-Affinity Ca2+ Binding Constants: Effects of Membrane Voltage
Sweet, T.-B., & Cox, D. H. (2008) · The Journal of General Physiology · doi:10.1085/jgp.200810094 · Cited by 81
Ion Channel Associated Diseases: Overview of Molecular Mechanisms
Zaydman, M. A., Silva, J. R., & Cui, J. (2012) · Chemical Reviews · doi:10.1021/cr300360k · Cited by 80
Inositol 1,4,5-Triphosphate-Evoked Responses in Midbrain Dopamine Neurons
Morikawa, H., Imani, F., Khodakhah, K., & Williams, J. T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-20-j0003.2000 · Cited by 80
Contribution of BK Ca2+-Activated K+Channels to Auditory Neurotransmission in the Guinea Pig Cochlea
Skinner, L. J., Enée, V., Beurg, M., Jung, H. H., Ryan, A. F., Hafidi, A., Aran, J., & Dulon, D. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01155.2002 · Cited by 80
Ion channels and transporters in microglial function in physiology and brain diseases
Luo, L., Song, S., Ezenwukwa, C. C., Jalali, S., Sun, B., & Sun, D. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104925 · Cited by 82
Matching molecules to function: neuronal Ca2+-activated K+ channels and afterhyperpolarizations
Stocker, M., Hirzel, K., D’hoedt, D., & Pedarzani, P. (2004) · Toxicon · doi:10.1016/j.toxicon.2003.12.009 · Cited by 79
Co-assembly of N-type Ca2+ and BK channels underlies functional coupling in rat brain
Loane, D. J., Lima, P. A., & Marrion, N. V. (2007) · Journal of Cell Science · doi:10.1242/jcs.03399 · Cited by 78
Self-citation
Small-Conductance Calcium-Activated K+ Channels Are Expressed in Pancreatic Islets and Regulate Glucose Responses
Tamarina, N. A., Wang, Y., Mariotto, L., Kuznetsov, A., Bond, C. T., Adelman, J. P., & Philipson, L. H. (2003) · Diabetes · doi:10.2337/diabetes.52.8.2000 · Cited by 77
Self-citation
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling
Balistrieri, A., Makino, A., & Yuan, J. X. ‐. (2022) · Physiological Reviews · doi:10.1152/physrev.00030.2021 · Cited by 77
Hypoxia inhibits human recombinant large conductance, Ca2+-activated K+ (maxi-K) channels by a mechanism which is membrane delimited and Ca2+ sensitive
Lewis, A., Peers, C., Ashford, M. L. J., & Kemp, P. J. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013888 · Cited by 77
AHP's, HAP's and DAP's: How Potassium Currents Regulate the Excitability of Rat Supraoptic Neurones
Roper, P., Callaway, J. C., Shevchenko, T., Teruyama, R., & Armstrong, W. E. (2003) · Journal of Computational Neuroscience · doi:10.1023/a:1027424128972 · Cited by 76

Authors: Vergara, C., Latorre, R., Marrion, N. V., & Adelman, J. P.
Affiliations: University of Chile (CL)
Oregon Health & Science University (US)
ORCID: Vergara, Cecilia
Marrion, Neil V
Adelman, John P
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 1998-06
Volume: 8
Issue: 3
Pages: 321-329
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/s0959-4388(98)80056-1
OpenAlex: W1993938009
Cited by: 954
References: 85
Citations by year: 2026: 10 · 2025: 17 · 2024: 10 · 2023: 14 · 2022: 14 · 2021: 14 · 2020: 20 · 2019: 17 · 2018: 16 · 2017: 15 · 2016: 25 · 2015: 28 · 2014: 40 · 2013: 45 · 2012: 28
FWCI: 3.38
Type: journal article
Language: en
Open access: green
repositorio.uchile.cl
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Universidad de Chile (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: calcium-activated potassium channels, BK channels, small conductance calcium-activated potassium channels, intermediate-conductance calcium-activated potassium channel, IK channels, neuronal excitability, spike frequency adaptation, interspike intervals, voltage-dependent gating, calcium regulation, calcium binding, N-terminal domain, slow afterhyperpolarization, apamin, therapeutic target, myotonic dystrophy, sickle cell disease
MeSH terms: Amino Acid Sequence, Calcium, Molecular Sequence Data, Potassium Channels, Signal Transduction, Ion Channel Gating, Protein Structure, Tertiary, Potassium Channels, Calcium-Activated, Large-Conductance Calcium-Activated Potassium Channels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Calcium-activated potassium channels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks