Cited by 956Ion channel regulation and functionCardiac electrophysiology and arrhythmiasNeuroscience and Neuropharmacology Research

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Calcium-activated potassium channels

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Vergara, Cecilia, Latorre, Ramon, Marrion, Neil V, Adelman, John P·1998·Current Opinion in Neurobiology

DOI 10.1016/s0959-4388(98)80056-1

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Abstract

Calcium-activated potassium channels are fundamental regulators of neuronal excitability, participating in interspike interval and spike-frequency adaptation. For large-conductance calcium-activated potassium (BK) channels, recent experiments have illuminated the fundamental biophysical mechanisms of gating, demonstrating that BK channels are voltage gated and calcium modulated. Structurally, BK channels have been shown to possess an extracellular amino-terminal domain, different from other potassium channels. Domains and residues involved in calcium-gating, and perhaps calcium binding itself, have been identified. For small- and intermediate-conductance calcium-activated potassium channels, SK and IK channels, clones have only recently become available, and they show that SK channels are a distinct subfamily of potassium channels. The biophysical properties of SK channels demonstrate that kinetic differences between apamin-sensitive and apamin-insensitive slow afterhyperpolarizations are not attributable to intrinsic gating differences between the two subtypes. Interestingly, SK and IK channels may prove effective drug targets for diseases such as myotonic muscular dystrophy and sickle cell anemia.

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Authors: Vergara, C., Latorre, R., Marrion, N. V., & Adelman, J. P.
Affiliations: University of Chile (CL)
Oregon Health & Science University (US)
ORCID: Vergara, Cecilia
Marrion, Neil V
Adelman, John P
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 1998-06
Volume: 8
Issue: 3
Pages: 321-329
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/s0959-4388(98)80056-1
OpenAlex: W1993938009
Cited by: 954
References: 85
Citations by year: 2026: 10 · 2025: 17 · 2024: 10 · 2023: 14 · 2022: 14 · 2021: 14 · 2020: 20 · 2019: 17 · 2018: 16 · 2017: 15 · 2016: 25 · 2015: 28 · 2014: 40 · 2013: 45 · 2012: 28
FWCI: 3.38
Type: journal article
Language: en
Open access: green
repositorio.uchile.cl
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Universidad de Chile (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: calcium-activated potassium channels, BK channels, small conductance calcium-activated potassium channels, intermediate-conductance calcium-activated potassium channel, IK channels, neuronal excitability, spike frequency adaptation, interspike intervals, voltage-dependent gating, calcium regulation, calcium binding, N-terminal domain, slow afterhyperpolarization, apamin, therapeutic target, myotonic dystrophy, sickle cell disease
MeSH terms: Amino Acid Sequence, Calcium, Molecular Sequence Data, Potassium Channels, Signal Transduction, Ion Channel Gating, Protein Structure, Tertiary, Potassium Channels, Calcium-Activated, Large-Conductance Calcium-Activated Potassium Channels

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