Cited by 956Ion channel regulation and functionCardiac electrophysiology and arrhythmiasNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Calcium-activated potassium channels

Open access

Vergara, Cecilia, Latorre, Ramon, Marrion, Neil V, Adelman, John P·1998·Current Opinion in Neurobiology

DOI 10.1016/s0959-4388(98)80056-1

Open this paper in CoChat — free account

Abstract

Calcium-activated potassium channels are fundamental regulators of neuronal excitability, participating in interspike interval and spike-frequency adaptation. For large-conductance calcium-activated potassium (BK) channels, recent experiments have illuminated the fundamental biophysical mechanisms of gating, demonstrating that BK channels are voltage gated and calcium modulated. Structurally, BK channels have been shown to possess an extracellular amino-terminal domain, different from other potassium channels. Domains and residues involved in calcium-gating, and perhaps calcium binding itself, have been identified. For small- and intermediate-conductance calcium-activated potassium channels, SK and IK channels, clones have only recently become available, and they show that SK channels are a distinct subfamily of potassium channels. The biophysical properties of SK channels demonstrate that kinetic differences between apamin-sensitive and apamin-insensitive slow afterhyperpolarizations are not attributable to intrinsic gating differences between the two subtypes. Interestingly, SK and IK channels may prove effective drug targets for diseases such as myotonic muscular dystrophy and sickle cell anemia.

Integrity signals

Registry

Crossref · 10.1016/s0959-4388(98)80056-1

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Stability constants of metal-ion complexes
Sillén, L. G., Martell, A. E., Bjerrum, J., & Schwarzenbach, G. (1964) · Medical Entomology and Zoology · Cited by 3,983
Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation
Hoshi, T., Zagotta, W. N., & Aldrich, R. W. (1990) · Science · doi:10.1126/science.2122519 · Cited by 1,527
Relaxation of Arterial Smooth Muscle by Calcium Sparks
Nelson, M. T., Cheng, H., Rubart, M., Santana, L. F., Bonev, A. D., Knot, H. J., & Lederer, W. J. (1995) · Science · doi:10.1126/science.270.5236.633 · Cited by 1,399
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence
Noda, M., Shimizu, S., Tanabe, T., Takai, T., Kayano, T., Ikeda, T., Takahashi, H., Nakayama, H., Kanaoka, Y., Minamino, N., et al. (1984) · Nature · doi:10.1038/312121a0 · Cited by 1,349
Small-Conductance, Calcium-Activated Potassium Channels from Mammalian Brain
Kohler, M.-L., Hirschberg, B., Bond, C. T., Kinzie, J. M., Marrion, N. V., Maylie, J., & Adelman, J. P. (1996) · Science · doi:10.1126/science.273.5282.1709 · Cited by 946
Self-citation
Ca2+-activated K+ currents in neurones: types, physiological roles and modulation
Sah, P. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80026-9 · Cited by 892
Mutations in the K+ channel signature sequence
Heginbotham, L., Lü, Z., Abramson, T., & MacKinnon, R. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80887-2 · Cited by 853
Varieties of Calcium-Activated Potassium Channels
Latorre, R., Oberhauser, A. F., Labarca, P. P., & Alvarez, O. A. (1989) · Annual Review of Physiology · doi:10.1146/annurev.ph.51.030189.002125 · Cited by 735
Self-citation
The Coupling of Neurotransmitter Receptors to Ion Channels in the Brain
Nicoll, R. A. (1988) · Science · doi:10.1126/science.2456612 · Cited by 729
Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy
Harley, H. G., Brook, J. D., Rundle, S. A., Crow, S., Reardon, W., Buckler, A., Harper, P. S., Housman, D. E., & Shaw, D. J. (1992) · Nature · doi:10.1038/355545a0 · Cited by 725

Show all 85 references

Sorted by citations

Items 301–400 of 956

Input-Driven Components of Spike-Frequency Adaptation Can Be UnmaskedIn Vivo
Gollisch, T., & Herz, A. V. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0398-04.2004 · Cited by 55
Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress
Hong, M.-P., Vu, K., Bautos, J., & Gelli, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.056218 · Cited by 54
Palmitoylation and Membrane Association of the Stress Axis Regulated Insert (STREX) Controls BK Channel Regulation by Protein Kinase C
Zhou, X., Wulfsen, I., Korth, M., McClafferty, H., Łukowski, R., Shipston, M. J., Ruth, P., Dobrev, D., & Wieland, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.386359 · Cited by 54
Calcium‐activated potassium currents differentially modulate respiratory rhythm generation
Zavala‐Tecuapetla, C., Aguileta, M. A., López-Guerrero, J. J., González‐Marín, M. C., & Peña‐Ortega, F. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06214.x · Cited by 54
Gain modulation of respiratory neurons
Zuperku, E. J., & McCrimmon, D. R. (2002) · Respiratory Physiology & Neurobiology · doi:10.1016/s1569-9048(02)00042-3 · Cited by 54
Expression and Modulation of the Intermediate- Conductance Ca2+-Activated K+ Channel in Glioblastoma GL-15 Cells
Fioretti, B., Castigli, E., Micheli, M. R., Bova, R., Sciaccaluga, M., Harper, A. A., Franciolini, F., & Catacuzzeno, L. (2006) · Cellular Physiology and Biochemistry · doi:10.1159/000095135 · Cited by 54
Detecting acute changes in oxygen: will the real sensor please stand up?
Kemp, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.034587 · Cited by 52
KCNE4 and KCNE5: K+ channel regulation and cardiac arrhythmogenesis
Abbott, G. W. (2016) · Gene · doi:10.1016/j.gene.2016.07.069 · Cited by 54
Bis-Quinolinium Cyclophanes: 8,14-Diaza-1,7(1,4)-diquinolinacyclotetradecaphane (UCL 1848), a Highly Potent and Selective, Nonpeptidic Blocker of the Apamin-Sensitive Ca2+-Activated K+ Channel
Chen, J., Galanakis, D., Ganellin, C. R., Dunn, P. M., & Jenkinson, D. H. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000904v · Cited by 54
Ligand-Dependent Activation of Slo Family Channels Is Defined by Interchangeable Cytosolic Domains
Xia, X., Zhang, X., & Lingle, C. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1296-04.2004 · Cited by 54
Cell Membrane Stretch Modulates the High-Conductance Ca 2+ -Activated K + Channel in Bovine Trabecular Meshwork Cells
Gasull, X., Ferrer, E., Llobet, A., Castellano, A., Nicola´s, J. M., Palés, J., & Gual, A. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0384 · Cited by 54
Single‐channel properties of BK‐type calcium‐activated potassium channels at a cholinergic presynaptic nerve terminal
Sun, X., Schlichter, L. C., & Stanley, E. F. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0639p.x · Cited by 53
Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain
Merlos, M., Burgueño, J., Portillo-Salido, E. F., Plata‐Saláman, C. R., & Vela, J. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-50174-1_8 · Cited by 53
The calcium binding proteins calbindin, parvalbumin, and calretinin have specific patterns of expression in the gray matter of cat spinal cord
Anelli, R., & Heckman, C. J. (2005) · Journal of Neurocytology · doi:10.1007/s11068-006-8724-2 · Cited by 53
Effect of Phosphatidylserine on Unitary Conductance and Ba2+ Block of the BK Ca2+–activated K+ Channel
Park, J. B., Kim, H. J., Ryu, P. D., & Moczydlowski, E. G. (2003) · The Journal of General Physiology · doi:10.1085/jgp.200208746 · Cited by 53
Ca2+-Activated, Large Conductance K+Channel in the Ovary: Identification, Characterization, and Functional Involvement in Steroidogenesis
Kunz, L., Thalhammer, A., Berg, F. D., Berg, U., Duffy, D. M., Stouffer, R. L., Dissen, G. A., Ojeda, S. R., & Mayerhofer, A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020841 · Cited by 53
Developmental Regulation of Neuronal KCaChannels by TGFβ1: An Essential Role for PI3 Kinase Signaling and Membrane Insertion
Lhuillier, L., & Dryer, S. E. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.2.954 · Cited by 53
A Role for the S0 Transmembrane Segment in Voltage-dependent Gating of BK Channels
Koval, O. M., Fan, Y., & Rothberg, B. S. (2007) · The Journal of General Physiology · doi:10.1085/jgp.200609662 · Cited by 52
Role of NKCC in BK channel-mediated net K+secretion in the CCD
Liu, W., Schreck, C., Coleman, R. A., Wade, J. B., Hernandez, Y., Zavilowitz, B. J., Warth, R., Kleyman, T. R., & Satlin, L. M. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00347.2011 · Cited by 52
Bursting in Substantia Nigra Pars Reticulata Neurons In Vitro: Possible Relevance for Parkinson Disease
Ibáñez-Sandoval, O., Carrillo‐Reid, L., Galarraga, E., Tapia, D., Mendoza, E., Gómora, J. C., Aceves, J., & Bargas, J. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00620.2007 · Cited by 52
Dequalinium, a selective blocker of the slow afterhyperpolarization in rat sympathetic neurones in culture
Dunn, P. M. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90596-7 · Cited by 52
Ca2+ entry through l-type Ca2+ channels helps terminate epileptiform activity by activation of a Ca2+ dependent afterhyperpolarisation in hippocampal CA3.
Empson, R. M., & Jefferys, J. G. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00494-2 · Cited by 52
Ca2+‐independent activation of BKCa channels at negative potentials in mammalian inner hair cells
Thurm, H., Fakler, B., & Oliver, D. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.094680 · Cited by 52
Ionic Basis of on and off Persistent Activity in Layer III Lateral Entorhinal Cortical Principal Neurons
Tahvildari, B., Alonso, A. A., & Bourque, C. W. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00911.2007 · Cited by 52
Conditional and Unconditional Inhibition of Calcium-activated Potassium Channels by Reversible Protein Phosphorylation
Hall, S., & Armstrong, D. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.3749 · Cited by 51
Opposing effects of spinal nerve ligation on calcium-activated potassium currents in axotomized and adjacent mammalian primary afferent neurons
Sarantopoulos, C. D., McCallum, J. B., Rigaud, M., Fuchs, A., Kwok, W.-M., & Hogan, Q. H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.055 · Cited by 50
Inwardly Rectifying Current-Voltage Relationship of Small-Conductance Ca2+-Activated K+ Channels Rendered by Intracellular Divalent Cation Blockade
Soh, H., & Park, C. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76193-0 · Cited by 50
Structural Determinants of the Closed KCa3.1 Channel Pore in Relation to Channel Gating: Results from a Substituted Cysteine Accessibility Analysis
Klein, H., Garneau, L., Banderali, U., Simoes, M., Parent, L., & Sauvé, R. (2007) · The Journal of General Physiology · doi:10.1085/jgp.200609726 · Cited by 50
Accelerated Ca2+entry by membrane hyperpolarization due to Ca2+-activated K+channel activation in response to histamine in chondrocytes
Funabashi, K., Ohya, S., Yamamura, H., Hatano, N., Muraki, K., Giles, W. R., & Imaizumi, Y. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00469.2009 · Cited by 50
The Action of Blocking Agents Applied to the Inner Face of Ca 2+ -activated K + Channels from Human Erythrocytes
Dunn, P. M. (1998) · The Journal of Membrane Biology · doi:10.1007/s002329900427 · Cited by 50
Modulation of Calcium-dependent Chloride Secretion by Basolateral SK4-like Channels in a Human Bronchial Cell Line
Bernard, K. F., Bogliolo, S., Soriani, O., & Ehrenfeld, J. (2003) · The Journal of Membrane Biology · doi:10.1007/s00232-003-0621-3 · Cited by 50
Extracellular Nucleotides Activate non‐Selective Cation and Ca2+‐Dependent K+ Channels in Rat Osteoclasts
Weidema, A. F., Barbera, J., Dixon, S. J., & Sims, S. M. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.303bh.x · Cited by 50
Voltage-Sensitive Oxonol Dyes Are Novel Large-Conductance Ca2+-Activated K+ Channel Activators Selective for β1 and β4 but Not for β2 Subunits
Morimoto, T., Sakamoto, K., Sade, H., Ohya, S., Muraki, K., & Imaizumi, Y. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.031146 · Cited by 49
Oxidation of K+ Channels in Aging and Neurodegeneration
Sesti, F. (2016) · Aging and Disease · doi:10.14336/ad.2015.0901 · Cited by 49
NPPB block of the intermediate-conductance Ca2+-activated K+ channel
Fioretti, B., Castigli, E., Calzuola, I., Harper, A. A., Franciolini, F., & Catacuzzeno, L. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.06.034 · Cited by 49
The Fibroblast Intermediate Conductance K Ca Channel, FIK, as a Prototype for the Cell Growth Regulatory Function of the IK Channel Family
Peña, T. L., & Rane, S. G. (1999) · The Journal of Membrane Biology · doi:10.1007/s002329900601 · Cited by 49
Characterization of a Functionally Expressed Stretch-activated BKca Channel Cloned from Chick Ventricular Myocytes
Tang, Q., Qi, Z., Naruse, K., & Sokabe, M. (2003) · The Journal of Membrane Biology · doi:10.1007/s00232-003-0637-8 · Cited by 49
Ion channel–transporter interactions
Neverisky, D. L., & Abbott, G. W. (2016) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2016.1172553 · Cited by 51
Leucine Zipper Domain Targets cAMP-dependent Protein Kinase to Mammalian BK Channels
Tian, L., Coghill, L. S., Macdonald, S. H.-F., Armstrong, D. L., & Shipston, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211661200 · Cited by 48
Rapidly inactivating and non‐inactivating calcium‐activated potassium currents in frog saccular hair cells
Armstrong, C. E., & Roberts, W. M. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00049.x · Cited by 47
Acute Alcohol Tolerance Is Intrinsic to the BKCa Protein, but Is Modulated by the Lipid Environment
Yuan, C., O'Connell, R. J., Wilson, A., Pietrzykowski, A. Z., & Treistman, S. N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708214200 · Cited by 47
The BK channel: a vital link between cellular calcium and electrical signaling
Rothberg, B. S. (2012) · Protein & Cell · doi:10.1007/s13238-012-2076-8 · Cited by 47
Arthropod venoms: A vast arsenal of insecticidal neuropeptides
Schwartz, E. F., Mourão, C. B. F., Moreira, K. G., Camargos, T. S., & Mortari, M. R. (2012) · Biopolymers · doi:10.1002/bip.22100 · Cited by 47
Enhancement of Hippocampal Pyramidal Cell Excitability by the Novel Selective Slow-Afterhyperpolarization Channel Blocker 3-(Triphenylmethylaminomethyl)pyridine (UCL2077)
Shah, M. M., Javadzadeh‐Tabatabaie, M., Benton, D. C. H., Ganellin, C. R., & Haylett, D. G. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.026625 · Cited by 46
Molecular Separation of Two Behavioral Phenotypes by a Mutation Affecting the Promoters of a Ca-Activated K Channel
Atkinson, N. S., Brenner, R., Chang, W.-M., Wilbur, J. L., Larimer, J. L., & Yu, J. Y. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02988.2000 · Cited by 47
The Janus‐faced atracotoxins are specific blockers of invertebrate KCa channels
Gunning, S. J., Maggio, F., Windley, M. J., Valenzuela, S. M., King, G. F., & Nicholson, G. M. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06545.x · Cited by 47
PKA-mediated inhibition of a novel K+ channel underlies the slow after-hyperpolarization in enteric AH neurons
Vogalis, F., Harvey, J. R., & Furness, J. B. (2003) · The Journal of Physiology · doi:10.1111/j..2003.t01-1-00801.x · Cited by 47
Prostaglandin E2 Induces Interaction Between hSlo Potassium Channel and Syk Tyrosine Kinase in Osteosarcoma Cells
Rezzonico, R., Schmid‐Alliana, A., Romey, G., Bourget, I., Breuil, V., Breittmayer, V. A., Tartare‐Deckert, S., Rossi, B., & Schmid‐Antomarchi, H. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.5.869 · Cited by 47
Mg2+ Enhances Voltage Sensor/Gate Coupling in BK Channels
Horrigan, F. T., & Ma, Z. (2007) · The Journal of General Physiology · doi:10.1085/jgp.200709877 · Cited by 46
Interaction between the Cytoplasmic and Transmembrane Domains of the Mechanosensitive Channel MscS
Nomura, T., Sokabe, M., & Yoshimura, K. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.114785 · Cited by 46
Measuring the Influence of the BKCa β1 Subunit on Ca2+ Binding to the BKCa Channel
Sweet, T.-B., & Cox, D. H. (2009) · The Journal of General Physiology · doi:10.1085/jgp.200810129 · Cited by 46
Selective Toxicity of the Anthelmintic Emodepside Revealed by Heterologous Expression of Human KCNMA1 in Caenorhabditis elegans
Crisford, A., Murray, C., O'Connor, V. M., Edwards, R. J., Krüger, N., Welz, C., von Samson‐Himmelstjerna, G., Harder, A., Walker, R. J., & Holden-Dye, L. M. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.071043 · Cited by 46
Nitrergic–purinergic interactions in rat distal colon motility
Crombruggen, K. V., & Lefebvre, R. A. (2004) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00454.x · Cited by 46
Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds
Dreixler, J. C., Bian, J., Cao, Y., Roberts, M. T., Roizen, J. D., & Houamed, K. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00401-5 · Cited by 46
An S6 Mutation in BK Channels Reveals β1 Subunit Effects on Intrinsic and Voltage-dependent Gating
Wang, B., & Brenner, R. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200609596 · Cited by 46
Role of Apamin-Sensitive KCa Channels for Reticulospinal Synaptic Transmission to Motoneuron and for the Afterhyperpolarization
Cangiano, L., Wallén, P., & Grillner, S. E. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.1.289 · Cited by 46
Mechanisms of cellular synchronization in the vascular wall. Mechanisms of vasomotion.
Matchkov, V. V. (2010) · PubMed · Cited by 45
Regulation of K+ Flow by a Ring of Negative Charges in the Outer Pore of BKCa Channels. Part I
Haug, T. M., Sigg, D. M., Ciani, S., Toro, L., Stefani, E., & Olcese, R. (2004) · The Journal of General Physiology · doi:10.1085/jgp.200308949 · Cited by 45
Homogeneous distribution of large‐conductance calcium‐dependent potassium channels on soma and apical dendrite of rat neocortical layer 5 pyramidal neurons
Benhassine, N., & Berger, T. K. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03934.x · Cited by 45
cSloencodes calcium–activated potassium channels in the chick's cochlea
Jiang, G., Zidanic, M., Michaels, R., Do, M. T. H., Griguer, C. E., & Fuchs, P. A. (1997) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1997.0104 · Cited by 45
BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice
Kreifeldt, M., Le, D., Treistman, S. N., Koob, G. F., & Contet, C. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00105 · Cited by 42
The LRRC26 Protein Selectively Alters the Efficacy of BK Channel Activators
Almássy, J., & Begenisich, T. B. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.075234 · Cited by 44
Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels
Weisbrod, D., Haron‐Khun, S., Bueno, H., Peretz, A. S., & Attali, B. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.135 · Cited by 44
Activation of TRPV4 stimulates transepithelial ion flux in a porcine choroid plexus cell line
Preston, D., Simpson, S., Halm, D. R., Hochstetler, A., Schwerk, C., Schroten, H., & Blazer‐Yost, B. L. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00312.2017 · Cited by 47
Cardiac ion channels and mechanisms for protection against atrial fibrillation.
Grunnet, M., Bentzen, B., Sørensen, U., & Diness, J. G. (2012) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/112_2011_3 · Cited by 42
Localization of Divalent Cation-Binding Site in the Pore of a Small Conductance Ca2+-Activated K+ Channel and Its Role in Determining Current-Voltage Relationship
Soh, H., & Park, C. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75264-8 · Cited by 44
Regulation of K+ channels underlying the slow afterhyperpolarization in enteric afterhyperpolarization‐generating myenteric neurons: Role of calcium and phosphorylation
Vogalis, F., Harvey, J. R., Neylon, C. B., & Furness, J. B. (2002) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2002.03755.x · Cited by 44
Firing Properties of GABAergic Versus Non-GABAergic Vestibular Nucleus Neurons Conferred by a Differential Balance of Potassium Currents
Gittis, A. H., & du Lac, S. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00141.2007 · Cited by 45
Metabotropic Receptor-Mediated Ca2+Signaling Elevates Mitochondrial Ca2+and Stimulates Oxidative Metabolism in Hippocampal Slice Cultures
Kann, O., Kovács, R., & Heinemann, U. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00042.2003 · Cited by 44
Inhibitory NANC neurotransmission in choledocho–duodenal junction of rabbits—a possible role of PACAP
Imoto, A., Inoue, R., Tanaka, M., & Ito, Y. (1998) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(98)00051-4 · Cited by 44
K+ channels and colonic function
Warth, R., & Bleich, M. (2006) · Springer eBooks · doi:10.1007/bfb0035550 · Cited by 44
Stretch-induced activation of Ca2+-activated K+channels in mouse skeletal muscle fibers
Mallouk, N., & Allard, B. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.3.c473 · Cited by 44
Treatment of experimental asthma using a single small molecule with anti‐inflammatory and BK channel‐activating properties
Goldklang, M. P., Perez‐Zoghbi, J. F., Trischler, J., Nkyimbeng, T., Zakharov, S. I., Shiomi, T., Zelonina, T., Marks, A. R., D'Armiento, J. M., & Marx, S. O. (2013) · The FASEB Journal · doi:10.1096/fj.13-235176 · Cited by 43
Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior
Cannady, R., Rinker, J. A., Nimitvilai, S., Woodward, J. J., & Mulholland, P. J. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2017_90 · Cited by 40
Clotrimazole analogues: effective blockers of the slow afterhyperpolarization in cultured rat hippocampal pyramidal neurones
Shah, M. M., Miscony, Z., Javadzadeh‐Tabatabaie, M., Ganellin, C. R., & Haylett, D. G. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703895 · Cited by 43
Voltage‐gated ionic currents in an identified modulatory cell type controlling molluscan feeding
Staras, K., Győri, J., & Kemenes, G. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01845.x · Cited by 43
The Role of P2Y1 Purinergic Receptors and Cytosolic Ca2+ in Hypotonically Activated Osmolyte Efflux from a Rat Hepatoma Cell Line
Junankar, P. R., Karjalainen, A., & Kirk, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204712200 · Cited by 43
Potassium fluxes across the endoplasmic reticulum and their role in endoplasmic reticulum calcium homeostasis
Kuum, M., Veksler, V., & Kaasik, A. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.11.004 · Cited by 41
Selectivity filter gating in large-conductance Ca2+-activated K+ channels
Thompson, J. L., & Begenisich, T. B. (2012) · The Journal of General Physiology · doi:10.1085/jgp.201110748 · Cited by 42
Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy
Diness, J. G., Bentzen, B. H., Sørensen, U. S., & Grunnet, M. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000249 · Cited by 42
SK Channel Regulation of Dendritic Excitability and Dendrodendritic Inhibition in the Olfactory Bulb
Maher, B. J., & Westbrook, G. L. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00797.2005 · Cited by 42
The synergistic activity between Cry1Aa and Cry1c from Bacillus thuringiensis against Spodoptera exigua and Helicoverpa armigera
Xue, J.-L., Cai, Q.-X., Zheng, D.-S., & Yuan, Z. (2005) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2005.01712.x · Cited by 42
The Effects of Putative K+ Channel Blockers on Volume Regulation of Murine Spermatozoa1
Barfield, J. P., Yeung, C., & Cooper, T. G. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.104.038448 · Cited by 42
Potassium channels in brain mitochondria.
Bednarczyk, P. (2009) · Acta Biochimica Polonica · doi:10.18388/abp.2009_2471 · Cited by 41
Functional insights into modulation of BKCa channel activity to alter myometrial contractility
Lorca, R. A., Wakle‐Prabagaran, M., & England, S. K. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00289 · Cited by 41
IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Neuronal Firing in the Suprachiasmatic Nucleus and Circadian Rhythms in Locomotor Activity
Granados‐Fuentes, D., Norris, A. J., Carrasquillo, Y., Nerbonne, J. M., & Herzog, E. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0174-12.2012 · Cited by 43
Vasorelaxation induced by the new nitric oxide donor cis-[Ru(Cl)(bpy)2(NO)](PF6) is due to activation of KCa by a cGMP-dependent pathway
Lunardi, C. N., Vercesi, J. A., da Silva, R. S., & Bendhack, L. M. (2007) · Vascular Pharmacology · doi:10.1016/j.vph.2007.05.003 · Cited by 41
Ion currents and spiking properties of identified subtypes of locust octopaminergic dorsal unpaired median neurons
Heidel, E., & Pflüger, H. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04655.x · Cited by 41
Slo1 Tail Domains, but Not the Ca2+ Bowl, Are Required for the β1 Subunit to Increase the Apparent Ca2+ Sensitivity of BK Channels
Qian, X., Nimigean, C. M., Niu, X., Moss, B. L., & Magleby, K. L. (2002) · The Journal of General Physiology · doi:10.1085/jgp.20028692 · Cited by 41
Voltage-dependent Gating of Single Wild-Type and S4 Mutant KAT1 Inward Rectifier Potassium Channels
Zei, P. C., & Aldrich, R. W. (1998) · The Journal of General Physiology · doi:10.1085/jgp.112.6.679 · Cited by 41
BmBKTx1, a Novel Ca2+-activated K+ Channel Blocker Purified from the Asian Scorpion Buthus martensi Karsch
Xu, C., Brône, B., Wicher, D., Bozkurt, Ö., Lu, W., Huys, I., Han, Y., Tytgat, J., Kerkhove, E. V., & Chi, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312798200 · Cited by 40
Involvement of BKCa channels in the relaxation of detrusor muscle via β-adrenoceptors
Kobayashi, H., Adachi‐Akahane, S., & Nagao, T. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00606-3 · Cited by 40
Is there a role for potassium channel openers in neuronal ion channel disorders?
Lawson, K. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.10.2269 · Cited by 40
Co-treatment with riluzole, a neuroprotective drug, ameliorates the 3-acetylpyridine-induced neurotoxicity in cerebellar Purkinje neurones of rats: Behavioural and electrophysiological evidence
Janahmadi, M., Goudarzi, I., Kaffashian, M. R., Behzadi, G., Fathollahi, Y., & Hajizadeh, S. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.02.014 · Cited by 40
Cholinergic Modulation of Large-Conductance Calcium-Activated Potassium Channels Regulates Synaptic Strength and Spine Calcium in Cartwheel Cells of the Dorsal Cochlear Nucleus
He, S., Wang, Y., Petralia, R. S., & Brenowitz, S. D. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3728-13.2014 · Cited by 39
BK channels play a counter-adaptive role in drug tolerance and dependence
Ghezzi, A., Pohl, J. B., Wang, Y., & Atkinson, N. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005439107 · Cited by 38
Molecular assembly and dynamics of fluorescent protein-tagged single KCa1.1 channel in expression system and vascular smooth muscle cells
Yamamura, H., Ikeda, C., Suzuki, Y., Ohya, S., & Imaizumi, Y. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00191.2011 · Cited by 39
SK4/IK1-like channels mediate TEA-insensitive, Ca2+-activated K+ currents in bovine parotid acinar cells
Takahata, T., Hayashi, M., & Ishikawa, T. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00250.2002 · Cited by 39
Genomic organization and promoter analysis of human KCNN3 gene
Sun, G., Tomita, H., Shakkottai, V. G., & Gargus, J. J. (2001) · Journal of Human Genetics · doi:10.1007/s100380170046 · Cited by 39
Brownian Dynamics Simulations of the Recognition of the Scorpion Toxin P05 with the Small-conductance Calcium-activated Potassium Channels
Cui, M., Shen, J., Briggs, J. M., Fu, W., Wu, J., Zhang, Y., Luo, X., Chi, Z., Ji, R., Jiang, H., et al. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00095-5 · Cited by 39

Authors: Vergara, C., Latorre, R., Marrion, N. V., & Adelman, J. P.
Affiliations: University of Chile (CL)
Oregon Health & Science University (US)
ORCID: Vergara, Cecilia
Marrion, Neil V
Adelman, John P
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 1998-06
Volume: 8
Issue: 3
Pages: 321-329
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/s0959-4388(98)80056-1
OpenAlex: W1993938009
Cited by: 954
References: 85
Citations by year: 2026: 10 · 2025: 17 · 2024: 10 · 2023: 14 · 2022: 14 · 2021: 14 · 2020: 20 · 2019: 17 · 2018: 16 · 2017: 15 · 2016: 25 · 2015: 28 · 2014: 40 · 2013: 45 · 2012: 28
FWCI: 3.38
Type: journal article
Language: en
Open access: green
repositorio.uchile.cl
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Universidad de Chile (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: calcium-activated potassium channels, BK channels, small conductance calcium-activated potassium channels, intermediate-conductance calcium-activated potassium channel, IK channels, neuronal excitability, spike frequency adaptation, interspike intervals, voltage-dependent gating, calcium regulation, calcium binding, N-terminal domain, slow afterhyperpolarization, apamin, therapeutic target, myotonic dystrophy, sickle cell disease
MeSH terms: Amino Acid Sequence, Calcium, Molecular Sequence Data, Potassium Channels, Signal Transduction, Ion Channel Gating, Protein Structure, Tertiary, Potassium Channels, Calcium-Activated, Large-Conductance Calcium-Activated Potassium Channels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Calcium-activated potassium channels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks