The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Genetic instability and darwinian selection in tumours
Open accessAbstract
Genetic instability has long been hypothesized to be a cardinal feature of cancer. Recent work has strengthened the proposal that mutational alterations conferring instability occur early during tumour formation. The ensuing genetic instability drives tumour progression by generating mutations in oncogenes and tumour-suppressor genes. These mutant genes provide cancer cells with a selective growth advantage, thereby leading to the clonal outgrowth of a tumour. Here, we discuss the role of genetic instability in tumour formation and outline future work necessary to substantiate the genetic instability hypothesis.
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Cites
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Self-citationGenetic instabilities in human cancers
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Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
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Self-citation
Cited by
Greaves, M., & Maley, C. C. (2012) · Nature · doi:10.1038/nature10762 · Cited by 3,162
Genomic instability — an evolving hallmark of cancer
Negrini, S., Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2858 · Cited by 2,397
The causes and consequences of genetic heterogeneity in cancer evolution
Burrell, R. A., McGranahan, N., Bartek, J., & Swanton, C. (2013) · Nature · doi:10.1038/nature12625 · Cited by 2,262
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966
Rules for Making Human Tumor Cells
Hahn, W. C., & Weinberg, R. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmra021902 · Cited by 951
Metadata
- Authors
- Cahill, D. P., Kinzler, K. W., Vogelstein, B., & Lengauer, C.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 9
- Issue
- 12
- Pages
- M57-M60
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W1990085600
- Cited by
- 748
- References
- 4
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cahill, D. P., Kinzler, K. W., Vogelstein, B., & Lengauer, C. (1999). Genetic instability and darwinian selection in tumours. Trends in Cell Biology. https://doi.org/10.1016/s0962-8924(99)01661-x
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