Do infectious agents play a role in dementia?

Initial interaction of herpes simplex virus with cells is binding to heparan sulfate

WuDunn, D., & Spear, P. G. (1989) · Journal of Virology · doi:10.1128/jvi.63.1.52-58.1989 · Cited by 920 · see citing works

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

Miyata, M., & Smith, J. D. (1996) · Nature Genetics · doi:10.1038/ng0996-55 · Cited by 889 · see citing works

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

McGeer, P. L., Itagaki, S., Tago, H., & McGeer, E. G. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90696-3 · Cited by 836 · see citing works

Herpes simplex virus type 1 in brain and risk of Alzheimer's disease

Itzhaki, R. F., Lin, W., Shang, D., Wilcock, G. K., Faragher, B. E., & Jamieson, G. A. (1997) · The Lancet · doi:10.1016/s0140-6736(96)10149-5 · Cited by 671 · see citing works

Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain

Balin, B. J., Gérard, H. C., Arking, E. J., Appelt, D. M., Branigan, P. J., Abrams, J. T., Whittum-Hudson, J. A., & Hudson, A. P. (1998) · Medical Microbiology and Immunology · doi:10.1007/s004300050071 · Cited by 506 · see citing works

βA4 amyloid protein deposition in brain after head trauma

Roberts, G., Gentleman, S., Lynch, A., & Graham, D. I. (1991) · The Lancet · doi:10.1016/0140-6736(91)92724-g · Cited by 440 · see citing works

Pathology of fatal human infection associated with avian influenza A H5N1 virus

To, K., Chan, P. K. S., Chan, K.-F., Lee, W.-K., Lam, W.-Y., Wong, K.-F., Tang, N. L. S., Tsang, D. N. C., Sung, R. Y. T., Buckley, T. A., et al. (2001) · Journal of Medical Virology · doi:10.1002/1096-9071(200103)63:3 · Cited by 422 · see citing works

Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease

Riviere, G. R., Riviere, K. H., & Smith, K. S. (2002) · Oral Microbiology and Immunology · doi:10.1046/j.0902-0055.2001.00100.x · Cited by 362 · see citing works

Latent herpes simplex virus type 1 in normal and Alzheimer's disease brains

Jamieson, G. A., Maitland, N. J., Wilcock, G. K., Craske, J., & Itzhaki, R. F. (1991) · Journal of Medical Virology · doi:10.1002/jmv.1890330403 · Cited by 333 · see citing works

Effects of total pathogen burden on coronary artery disease risk and C-reactive protein levels

Zhu, J., Quyyumi, A. A., Norman, J. E., Csákó, G., Waclawiw, M. A., Shearer, G. M., & Epstein, S. E. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00653-0 · Cited by 298 · see citing works

Viral Infections of the Nervous System.

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HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy

Corder, E. H., Robertson, K., Lannfelt, L., Bogdanović, N., Eggertsen, G., Wilkins, J. W., & Hall, C. D. (1998) · Nature Medicine · doi:10.1038/2677 · Cited by 249 · see citing works

“Limbic Predilection in Alzheimer Dementia: Is Reactivated Herpesvirus Involved?”

Ball, M. J. (1982) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100044115 · Cited by 243 · see citing works

Herpes simplex virus genomes in human nervous system tissue analyzed by polymerase chain reaction

Baringer, J. R., & Pisani, P. (1994) · Annals of Neurology · doi:10.1002/ana.410360605 · Cited by 242 · see citing works

Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells

Ji, Z. S., Brecht, W. J., Miranda, R. D., Hussain, M. M., Innerarity, T. L., & Mahley, R. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82186-x · Cited by 240 · see citing works

Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease

Schmidt, M., Zhukareva, V., Newell, K., Lee, V., & Trojanowski, J. (2001) · Acta Neuropathologica · doi:10.1007/s004010000330 · Cited by 230 · see citing works

Prevalence of Alzheimer plaques in AIDS

Esiri, M. M., Biddolph, S. C., & Morris, C. S. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.1.29 · Cited by 224 · see citing works

Cytokine Gene Expression as a Function of the Clinical Progression of Alzheimer Disease Dementia

Luterman, J. D., Haroutunian, V., Yemul, S., Ho, L., Purohit, D., Aisen, P. S., Mohs, R., & Pasinetti, G. M. (2000) · Archives of Neurology · doi:10.1001/archneur.57.8.1153 · Cited by 192 · see citing works

Herpesviruses in brain and Alzheimer's disease

Lin, W., Wozniak, M. A., Cooper, R. J., Wilcock, G. K., & Itzhaki, R. F. (2002) · The Journal of Pathology · doi:10.1002/path.1127 · Cited by 187 · see citing works

Apolipoprotein E-ε4 protects against severe liver disease caused by hepatitis C virus

Wozniak, M. A., Itzhaki, R. F., Faragher, B. E., James, M. W., Ryder, S. D., & Irving, W. L. (2002) · Hepatology · doi:10.1053/jhep.2002.34745 · Cited by 180 · see citing works

Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type

Jamieson, G. A., Maitland, N. J., Wilcock, G. K., Yates, C. M., & Itzhaki, R. F. (1992) · The Journal of Pathology · doi:10.1002/path.1711670403 · Cited by 172 · see citing works

Atypical herpes simplex virus encephalitis diagnosed by PCR amplification of viral DNA from CSF

Fodor, P. A., Levin, M. J., Weinberg, A., Sandberg, E., Sylman, J., & Tyler, K. L. (1998) · Neurology · doi:10.1212/wnl.51.2.554 · Cited by 159 · see citing works

Aβ as a bioflocculant: implications for the amyloid hypothesis of Alzheimer’s disease

Robinson, S. R., & Bishop, G. M. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00342-6 · Cited by 153 · see citing works

Herpes Simplex Virus Types 1 and 2 Differ in Their Interaction with Heparan Sulfate

Trybala, E., Liljeqvist, J., Svennerholm, B., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.19.9106-9114.2000 · Cited by 140 · see citing works

Alzheimerʼs disease—a spirochetosis?

Miklossy, J. (1993) · Neuroreport · doi:10.1097/00001756-199307000-00002 · Cited by 137 · see citing works

Alzheimer Disease -- A Spirochetosis?

Judith Miklossy, A. (1994) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4615-8149-9_7 · Cited by 130 · see citing works

New Insights into the Heparan Sulfate Proteoglycan-binding Activity of Apolipoprotein E

Libeu, C. P., Lund-Katz, S., Phillips, M. C., Wehrli, S., Hernáiz, M. J., Capila, I., Linhardt, R. J., Raffaı̈, R. L., Newhouse, Y. M., Zhou, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104746200 · Cited by 113 · see citing works

Past exposure to vaccines and subsequent risk of Alzheimer's disease.

Verreault, R., Laurin, D., Lindsay, J., & Serres, G. D. (2001) · Europe PMC (PubMed Central) · Cited by 111 · see citing works

Herpesvirus Infection Accelerates Atherosclerosis in the Apolipoprotein E–Deficient Mouse

Alber, D., Powell, K. L., Vallance, P. J., Goodwin, D. A., & Grahame-Clarke, C. N. (2000) · Circulation · doi:10.1161/01.cir.102.7.779 · Cited by 106 · see citing works

β-Amyloid Precursor Protein and β-Amyloid Peptide Immunoreactivity in the Rat Brain After Middle Cerebral Artery Occlusion

Popa‐Wagner, A., Schröder, E., Walker, L. C., & Kessler, C. (1998) · Stroke · doi:10.1161/01.str.29.10.2196 · Cited by 99 · see citing works

Stress‐induced hyperphosphorylation of tau in the mouse brain

Okawa, Y., Ishiguro, K., & Fujita, S. C. (2003) · FEBS Letters · doi:10.1016/s0014-5793(02)03883-8 · Cited by 98 · see citing works

Relapsing herpes simplex encephalitis: pathological confirmation of viral reactivation

Yamada, S. M., Kameyama, T., Nagaya, S., Hashizume, Y., & Yoshida, M. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.2.262 · Cited by 93 · see citing works

Fibril Formation and Neurotoxicity by a Herpes Simplex Virus Glycoprotein B Fragment with Homology to the Alzheimer's Aβ Peptide

Cribbs, D. H., Azizeh, B. Y., Cotman, C. W., & LaFerla, F. M. (2000) · Biochemistry · doi:10.1021/bi000029f · Cited by 93 · see citing works

Mild forms of herpes encephalitis.

Klapper, P. E., Cleator, G. M., & Longson, M. (1984) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.47.11.1247 · Cited by 90 · see citing works

Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to Alzheimer’ β amyloid peptide

Azizeh, B. Y., Cribbs, D. H., Cotman, C. W., & LaFerla, F. M. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46881-6_287 · Cited by 88 · see citing works

Herpes Simplex Virus Type 1 Latency in the Murine Nervous System Is Associated with Oxidative Damage to Neurons

Vályi-Nagy, T., Olson, S. J., Valyi‐Nagy, K., et al. (2000) · Virology · doi:10.1006/viro.2000.0678 · Cited by 87 · see citing works

Failure To Detect Chlamydia pneumoniae in Brain Sections of Alzheimer's Disease Patients

Gieffers, J., Reusche, E., Solbach, W., & Maass, M. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.2.881-882.2000 · Cited by 87 · see citing works

Failure To Detect <i>Chlamydia pneumoniae</i> in the Late-Onset Alzheimer's Brain

Ring, R. H., & Lyons, J. M. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.7.2591-2594.2000 · Cited by 81 · see citing works

HSV-1 in brain and risk of Alzheimer's disease.

Beffert, U., Bertrand, P., Champagne, D. L., Gauthier, S., & Poirier, J. (1998) · The Lancet · doi:10.1016/s0140-6736(05)79057-7 · Cited by 80 · see citing works

Apolipoprotein (apo) E genotype and apoE concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors.

Bohnet, K., Pillot, T., Visvikis‐Siest, S., Sabolovic, N., & Siest, G. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39161-6 · Cited by 78 · see citing works

Alzheimer's disease, herpes virus in brain, apolipoprotein E4 and herpes labialis

Lin, W., Graham, J. B., MacGowan, S., et al. (1998) · Alzheimers Reports · Cited by 74 · see citing works

Cytomegalovirus Is Present in a Very High Proportion of Brains from Vascular Dementia Patients

Lin, W., Wozniak, M. A., Wilcock, G. K., & Itzhaki, R. F. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0465 · Cited by 72 · see citing works

Viral infections of the nervous system

Sharief, M. K., & Swash, M. (1998) · Cambridge University Press eBooks · doi:10.1017/cbo9780511526947.022 · Cited by 70 · see citing works

Relapse of Herpes Simplex Encephalitis

Barthez‐Carpentier, M., Rozenberg, F., Dussaix, É., et al. (1995) · Journal of Child Neurology · doi:10.1177/088307389501000504 · Cited by 66 · see citing works

Detection of herpes simplex virus (types 1 and 2) and human herpesvirus 6 DNA in human brain tissue by polymerase chain reaction

Gordon, L., McQuaid, S., & Cosby, S. L. (1996) · Clinical and Diagnostic Virology · doi:10.1016/0928-0197(95)00203-0 · Cited by 66 · see citing works

Comparison of the LDL-receptor binding of VLDL and LDL from apoE4 and apoE3 homozygotes

Mamotte, C. D. S., Sturm, M., Foo, J. I., BOCKXMEER, F. M. V., & Taylor, R. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.3.e553 · Cited by 65 · see citing works

Herpes simplex encephalitis: involvement of apolipoprotein E genotype

Lin, W.-R. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.1.117 · Cited by 61 · see citing works

Herpes simplex virus encodes a virion‐associated protein which promotes long cellular processes in over‐expressing cells

Takakuwa, H., Goshima, F., Koshizuka, T., et al. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00475.x · Cited by 59 · see citing works

Failure to detect Chlamydia pneumoniae in brain tissues of Alzheimer’s disease

Nochlin, D., Shaw, C. M., Campbell, L. A., et al. (1999) · Neurology · doi:10.1212/wnl.53.8.1888-a · Cited by 57 · see citing works

Human neuroblastoma cells treated with aluminium express an epitope associated with Alzheimer's disease neurofibrillary tangles

Guy, S. P., Jones, D., Mann, D., et al. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90676-k · Cited by 57 · see citing works

Relapsing herpes simplex encephalitis following antiviral therapy

Davis, L. E., & McLaren, L. C. (1983) · Annals of Neurology · doi:10.1002/ana.410130215 · Cited by 56 · see citing works

Does apolipoprotein E polymorphism influence susceptibility to malaria?

Wozniak, M. A., Faragher, E. B., Todd, J. A., Koram, K. A., Riley, E. M., & Itzhaki, R. F. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.5.348 · Cited by 54 · see citing works

Neurotropic viruses and Alzheimer's disease: a search for varicella zoster virus DNA by the polymerase chain reaction.

Lin, W., Casas, I., Wilcock, G. K., et al. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.6.586 · Cited by 53 · see citing works

Incidence of axonal injury in human brain tissue

Niess, C., Grauel, U., Toennes, S. W., et al. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0525-9 · Cited by 51 · see citing works

Arguments against the involvement of Borrelia burgdorferi sensu lato in Alzheimer's disease

Gutacker, M. M., Valsangiacomo, C., Balmelli, T., Bernasconi, M. V., Bouras, C., & Piffaretti, J. C. (1998) · Research in Microbiology · doi:10.1016/s0923-2508(97)83621-2 · Cited by 51 · see citing works

Recurrent brainstem encephalitis associated with herpes simplex virus type 1 DNA in cerebrospinal fluid

Tyler, K. L., Tedder, D. G., Yamamoto, L. J., et al. (1995) · Neurology · doi:10.1212/wnl.45.12.2246 · Cited by 48 · see citing works

Further ultrastructural evidence that spirochaetes may play a role in the aetiology of Alzheimerʼs disease

Judith Miklossy, A., Kasas, S., Janzer, R. C., Ardizzoni, F., & der Loos, H. V. (1994) · Neuroreport · doi:10.1097/00001756-199406020-00010 · Cited by 43 · see citing works

Intractable seizure disorder associated with chronic herpes infection

Jay, V., Hwang, P., Hoffman, H. J., et al. (1998) · Child s Nervous System · doi:10.1007/s003810050167 · Cited by 36 · see citing works

Vaccination prevents latent HSV1 infection of mouse brain

Lin, W., Jennings, R., Smith, T. L., et al. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00239-1 · Cited by 36 · see citing works

Herpes simplex virus and risk of Alzheimer's disease.

Itabashi, S., Arai, H., Matsui, T., Higuchi, S., & Sasaki, H. (1997) · The Lancet · doi:10.1016/s0140-6736(05)62325-2 · Cited by 35 · see citing works

Failure to correlate C. pneumoniae with late onset Alzheimer’s disease

Taylor, G. S., Vipond, I. B., Paul, I. D., Matthews, S. M., Wilcock, G. K., & Caul, E. O. (2002) · Neurology · doi:10.1212/wnl.59.1.142 · Cited by 35 · see citing works

The Relationship between Interleukin-6 and Herpes Simplex Virus Type 1: Implications for Behavior and Immunopathology

Baker, M. L., Noisakran, S., Gebhardt, B. M., Kriesel, J. D., & Carr, D. J. J. (1999) · Brain Behavior and Immunity · doi:10.1006/brbi.1999.0572 · Cited by 30 · see citing works

Alzheimerʼs disease may not be a spirochetosis

McLaughlin, R. W., Kin, N. M. K. N. Y., Chen, M. F., Nair, N. P. V., & Chan, E. C. S. (1999) · Neuroreport · doi:10.1097/00001756-199905140-00018 · Cited by 29 · see citing works

Chronic Active Destructive Herpes Simplex Encephalitis with Recovery of Viral DNA 12 Years After Disease Onset

Asenbauer, B., McEntagart, M., King, M., et al. (1998) · Neuropediatrics · doi:10.1055/s-2007-973546 · Cited by 28 · see citing works

Association of HSV1 and apolipoprotein E-ϵ4 in Alzheimer's disease

Dobson, C. B. (2001) · Journal of NeuroVirology · doi:10.1080/135502801753248169 · Cited by 25 · see citing works

Absence of Chlamydia pneumoniae in brain of vascular dementia patients

Wozniak, M. J. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00236-1 · Cited by 22 · see citing works

Apolipoprotein E and herpes simplex virus 1 in Alzheimer's disease

Corder, E. H., Lannfelt, L., & Mulder, M. (1998) · The Lancet · doi:10.1016/s0140-6736(05)70525-0 · Cited by 19 · see citing works

Apolipoprotein E and herpes virus diseases: herpes simplex keratitis

Lin, W., Tullo, A. B., & Itzhaki, R. F. (1999) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200313 · Cited by 17 · see citing works

Detection of herpes simplex virus DNA by polymerase chain reaction in the cerebrospinal fluid of patients with viral meningoencephalitis using primers for the glycoprotein D gene.

Kúdelová, M., Murányiová, M., Kúdela, O., et al. (1995) · PubMed · Cited by 9 · see citing works

A host defense role for a natural antiviral substance in the nervous system

Baron, S., Chopra, A. K., Coppenhaver, D. H., et al. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00015-0 · Cited by 8 · see citing works

Untitled work

(1999) · doi:10.1002/1531-8249(199904)45:4

HSV-1 and Alzheimer’s disease: more than a hypothesis

Piacentini, R., De Chiara, G., Li Puma, D. D., Ripoli, C., Marcocci, M. E., Garaci, E., Palamara, A. T., & Grassi, C. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00097 · Cited by 130 · see citing works

Infectious agents and Alzheimer's disease

Piekut, T., Hurła, M., Banaszek, N., Szejn, P., Dorszewska, J., Kozubski, W., & Prendecki, M. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2102073 · Cited by 123 · see citing works

Cognitive decline following acute viral infections: literature review and projections for post-COVID-19

Damiano, R. F., Guedes, B. F., de Rocca, C. C., de Pádua Serafim, A., Castro, L. H. M., Munhoz, C. D., Nitrini, R., Filho, G. B., Miguel, E. C., Lucchetti, G., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01286-4 · Cited by 98 · see citing works

VIRAL INFECTION AND COGNITIVE DECLINE

Itzhaki, R. F., & Wozniak, M. A. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.01001.x · Cited by 17 · see citing works

Cloning and Characterization of Rat BAT3 cDNA

Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works

Anthoxanthum Mosaic Virus

Catherall, P. L. (1970) · Plant Pathology · doi:10.1111/j.1365-3059.1970.tb00999.x · Cited by 6 · see citing works

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Preprint

Sasaki, T., Gan, E. C., Wakeham, A. C., Kornbluth, S. A., Mak, T. W., & Okada, H. (2007) · Genes & Development · doi:10.1101/gad.1534107 · Cited by 127 · see citing works

Ecological and evolutionary importance of neighbors in the grass Anthoxanthum odoratum

Platenkamp, G. A. J., & Foin, T. C. (1990) · Oecologia · doi:10.1007/bf00317753 · Cited by 21 · see citing works

Viral pathogens and the advantage of sex in the perennial grass Anthoxanthum odoratum

Kelley, S. E. (1997) · Springer eBooks · doi:10.1007/978-94-009-0077-6_3 · Cited by 39 · see citing works