Trans-mitochondrial coordination of cristae at regulated membrane junctions
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Reminiscent of bacterial quorum sensing, mammalian mitochondria participate in inter-organelle communication. However, physical structures that enhance or enable interactions between mitochondria have not been defined. Here we report that adjacent mitochondria exhibit coordination of inner mitochondrial membrane cristae at inter-mitochondrial junctions (IMJs). These electron-dense structures are conserved across species, resistant to genetic disruption of cristae organization, dynamically modulated by mitochondrial bioenergetics, independent of known inter-mitochondrial tethering proteins mitofusins and rapidly induced by the stable rapprochement of organelles via inducible synthetic linker technology. At the associated junctions, the cristae of adjacent mitochondria form parallel arrays perpendicular to the IMJ, consistent with a role in electrochemical coupling. These IMJs and associated cristae arrays may provide the structural basis to enhance the propagation of intracellular bioenergetic and apoptotic waves through mitochondrial networks within cells.
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IMJs allow coordination of cristae orientation and electrical coupling between adjacent mitochondria within the mitochondrial network.
“These structures allow the coordination of cristae orientation and electrical coupling between adjacent mitochondria within the mitochondrial network [27].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [27]
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- Authors
- Picard, M., McManus, M. J., Csordás, G., Várnai, P., Dorn II, G. W., Williams, D., Hajnóczky, G., & Wallace, D. C.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Thomas Jefferson University (US)
- Semmelweis University (HU)
- Corresponding author
- Wallace, Douglas C.
- ORCID
- Venue
- Nature Communications
- Published
- 2015-02-17
- Volume
- 6
- Issue
- 1
- Pages
- 6259-6259
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4332397
- OpenAlex
- W2133232243
- Cited by
- 166
- References
- 45
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 17 · 2023: 18 · 2022: 13 · 2021: 17 · 2020: 17 · 2019: 17 · 2018: 16 · 2017: 15 · 2016: 18 · 2015: 5
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Semmelweis University Repository (Semmelweis University) (submittedVersion)
- Funders
- Hungarian Scientific Research Fund (K105006)
- National Institutes of Health (DK051526)
- U.S. Public Health Service (R01-K105006)
- Canadian Institutes of Health Research
- National Heart, Lung, and Blood Institute (R01 HL 59888, R01HL059888)
- National Cancer Institute (R01-CA143351)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK73691, R01DK051526, R01DK073691)
- National Institute of Neurological Disorders and Stroke (R01 NS21328, R01NS021328)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- mitochondrial cristae, inner mitochondrial membrane, mitochondrial bioenergetics, electrochemical coupling, mitochondrial network, mitofusins
- MeSH terms
- Animals, Diptera, DNA, Mitochondrial, Electrons, Energy Metabolism, Female, Heart, Humans, Mice, Inbred C57BL, Mitochondria, Myocardium, Tissue Distribution, Apoptosis, Mice, Knockout, Muscle, Skeletal, Mitochondrial Proteins, Microscopy, Electron, Transmission, Pectinidae, Mitochondrial Membranes, Mice
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