The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?
Abstract
A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.
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“There is a cysteine in an extension following the predicted prodomain barrel; taken together, these data are consistent with experimental data suggesting that the ADAM prodomain inhibits metalloprotease activity using a cysteine switch (26).”
From Accurate prediction of protein structures and interactions using a 3-track network (2021) · cites this paper as [26]
Citations
Cites
A comprehensive two-hybrid analysis to explore the yeast protein interactome
Ito, T., Chiba, T., Ozawa, R., Yoshida, M., Hattori, M., & Sakaki, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061034498 · Cited by 3,566
Schäffer, A. A. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.14.2994 · Cited by 1,375
Shimano, H. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00010-8 · Cited by 763
Rost, B., Fariselli, P., & Casadio, R. (1996) · Protein Science · doi:10.1002/pro.5560050824 · Cited by 608
TRAPP, a highly conserved novel complex on the cis‐Golgi that mediates vesicle docking and fusion
Sacher, M., Jiang, Y., Barrowman, J., Scarpa, A., Burston, J., Zhang, L., Schieltz, D., Yates, J. R., Abeliovich, H., & Ferro-Novick, S. (1998) · EMBO Journal · doi:10.1093/emboj/17.9.2494 · Cited by 326
Ranta, S., Zhang, Y., Ross, B., Lonka, L., Takkunen, E., Messer, A. C., Sharp, J. D., Wheeler, R. B., Kusumi, K., Mole, S., et al. (1999) · Nature Genetics · doi:10.1038/13868 · Cited by 319
The sterol-sensing domain: multiple families, a unique role?
Kuwabara, P. E., & Labouesse, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02640-9 · Cited by 285
Venkataraman, K., Riebeling, C., Bodennec, J., Riezman, H., Allegood, J. C., Sullards, M. C., Merrill, A. H., & Futerman, A. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205211200 · Cited by 282
C26‐CoA‐dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p
Guillas, I., Kirchman, P. A., Chuard, R., Pfefferli, M., Jiang, J. C., Jazwinski, S. M., & Conzelmann, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2655 · Cited by 277
Schorling, S., Vallée, B., Barz, W. P., Riezman, H., & Oesterhelt, D. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.11.3417 · Cited by 276
Cited by
Sorted by citations
Accurate prediction of protein structures and interactions using a 3-track network
Baek, M., DiMaio, F., Anishchenko, I., Dauparas, J., Ovchinnikov, S., Lee, G. R., Wang, J., Cong, Q., Kinch, L. N., Schaeffer, R. D., et al. (2021) · doi:10.1101/2021.06.14.448402 · Cited by 5,549
“The RoseTTAFold CERS1 model for residues 98 to 304 (Pfam TLC domain) (26) includes six TMH that traverse the membrane in an up and down arrangement (Fig.”
Levy, M., & Futerman, A. H. (2010) · IUBMB Life · doi:10.1002/iub.319 · Cited by 632
“Subsequent bioinformatics analyses (13, 17, 18) revealed additional mammalian Lag homologs, originally characterized as translocating chain-associating membrane protein homologs (TRH) (8, 10), with the ceramides synthesized”
BackgroundCeramide synthases at the centre of sphingolipid metabolism and biology
Mullen, T. D., Hannun, Y. A., & Obeid, L. M. (2012) · Biochemical Journal · doi:10.1042/bj20111626 · Cited by 541
“CLN proteins are involved in the human neurodegenerative syndromes called CLNs [14].”
When Do Lasses (Longevity Assurance Genes) Become CerS (Ceramide Synthases)?
Pewzner-Jung, Y., Ben-Dor, S., & Futerman, A. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600010200 · Cited by 435
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
Mizutani, Y., Kihara, A., & Igarashi, Y. (2005) · Biochemical Journal · doi:10.1042/bj20050291 · Cited by 376
Metadata
- Authors
- Winter, E., & Ponting, C. P.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Ponting, Chris P
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 27
- Issue
- 8
- Pages
- 381-383
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2016874659
- Cited by
- 181
- References
- 22
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 11 · 2015: 4 · 2014: 5 · 2013: 10 · 2012: 16
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Medicine › Genetics (clinical) › Lysosomal Storage Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- tram, CLN8, membrane-associated proteins, ceramide synthesis, lipid regulation, neuronal ceroid lipofuscinosis, protein families
- MeSH terms
- Amino Acid Sequence, Animals, Fungal Proteins, Humans, Membrane Glycoproteins, Membrane Proteins, Molecular Sequence Data, Mutation, Sequence Homology, Amino Acid, Protein Structure, Tertiary, Membrane Transport Proteins, Saccharomyces cerevisiae Proteins, Lipid Metabolism, Mice
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