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Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species
Abstract
The control of signal transduction involves post-translational modification of proteins at key amino acids. Cysteine residues are important in the control of 'redox' cell-signaling pathways, as thiol chemistry offers the possibility of modification by structurally diverse species, including those derived from oxidized lipids, peroxides or nitric oxide. An important and provocative study of the modification of thiols in the transcription factor OxyR recently extended this hypothesis. The findings offer the enticing possibility that the cell can distinguish between different degrees of oxidant and nitrosative exposure by modification at a single site on a signaling molecule.
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“Mitochondrial proteins are also subject to attack by ROS (88, 121, 157, 257, 318).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [88]
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Metadata
- Authors
- Cooper, C. E., Patel, R. P., Brookes, P. S., & Darley-Usmar, V. M.
- Affiliations
- University of Essex (GB)
- University of Alabama at Birmingham (US)
- Corresponding author
- Darley-Usmar, Victor M.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 27
- Issue
- 10
- Pages
- 489-492
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W1999952146
- Cited by
- 180
- References
- 22
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 11
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- redox signaling, nanotransducers, thiol modification, cysteine residues, reactive oxygen species, reactive nitrogen species, nitrosative stress, OxyR, post-translational modification, protein oxidation, nitrosylation, oxidized lipids, peroxides, nitric oxide
- MeSH terms
- Animals, Cysteine, Escherichia coli, Oxidation-Reduction, Protein Processing, Post-Translational, Proteins, Sulfhydryl Compounds, Signal Transduction, Reactive Oxygen Species, Reactive Nitrogen Species
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