Effect of xenogenic repair enzymes on photoimmunology and photocarcinogenesis
Abstract
Exposure to ultraviolet B (UVB) radiation leads to an increased generation of UVB-induced skin damage in humans. The most important UVB-induced side effects are UVB-induced immunosuppression and photocarcinogenesis and there is a large body of evidence that cyclobutane pyrimidine dimers (CPD) induced by UVB radiation play a pivotal role in both processes. The topical application of DNA repair enzymes is a new innovative strategy to reduce the amount of CPDs in human skin. Two different methods have recently been established. The use of T4 endonuclease V was of clinical efficacy in protecting patients with a nucleotide excision repair defect from premalignant and malignant skin lesions. Application of photolyase, a xenogenic enzyme which has been found in different organisms is also capable of removing UVB-induced CPD from normal human skin cells in vivo and appears to be more effective than T4 endonuclease V in damage removal. Photolyase encapsulated in liposomes may have in the near future a broad use as an active ingredient in modern skin care products.
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The same approach with photolyase enzyme suggested more effective removal of CPDs.
“Subsequently the same approach was undertaken with photolyase enzyme and suggested more effective removal of CPDs [183,184].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [184]
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Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies
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- Authors
- Stege, H.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Stege, Helger
- Venue
- Journal of Photochemistry and Photobiology B: Biology
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 65
- Issue
- 2-3
- Pages
- 105-108
- ISSN
- 1011-1344 (ISSN-L)
- OpenAlex
- W1995833707
- Cited by
- 38
- References
- 19
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 2
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Photochemistry and Photobiology B Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- photolyase, T4 endonuclease V, cyclobutane pyrimidine dimers, UV-B radiation, photocarcinogenesis, UVB-induced immunosuppression, skin care products, skin cancer prevention
- MeSH terms
- Animals, Deoxyribodipyrimidine Photo-Lyase, DNA Repair, Endodeoxyribonucleases, Humans, Immune Tolerance, Skin, Skin Neoplasms, Sunlight, Ultraviolet Rays, Viral Proteins, Deoxyribonuclease (Pyrimidine Dimer)
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