Enzyme therapy of xeroderma pigmentosum: safety and efficacy testing of T4N5 liposome lotion containing a prokaryotic DNA repair enzyme
Abstract
Xeroderma pigmentosum (XP) is a rare genetic disease in which patients are defective in DNA repair and are extremely sensitive to solar UV radiation exposure. A new treatment approach was tested in these patients, in which a prokaryotic DNA repair enzyme specific for UV‐induced DNA damage was delivered into the skin by means of topically applied liposomes to supplement the deficient activity. Acute and chronic safety testing in both mice and humans showed neither adverse reactions nor significant changes in serum chemistry or in skin histology. The skin of XP patients treated with the DNA repair liposomes had fewer cyclobutylpyrimidine dimers in DNA and showed less erythema than did control sites. The results encourage further clinical testing of this new enzyme therapy approach.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Delivery of T4-pdg in mouse models increased the rate of CPD removal, reduced the frequency of SCC, and minimized UVB-induced immune suppression.
“Delivery of T4-pdg in mouse models increased the rate of CPD removal, reduced the frequency of SCC, and minimized UVB-induced immune suppression.”
From Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways (2018) · cites this paper as [16]
Cites
Kraemer, K. H. (1987) · Archives of Dermatology · doi:10.1001/archderm.123.2.241 · Cited by 1,205 · see citing works
Nonmelanoma skin cancer in the United States: Incidence
Miller, D. L., & Weinstock, M. A. (1994) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(08)81509-5 · Cited by 1,118 · see citing works
Kraemer, K. H. (1987) · Archives of Dermatology · doi:10.1001/archderm.1987.01660260111026 · Cited by 800 · see citing works
Robbins, J. H., Kraemer, K. H., Lutzner, M. A., Festoff, B. W., & COON, H. G. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-2-221 · Cited by 751 · see citing works
Mechanisms of DNA Excision Repair
Sancar, A. (1994) · Science · doi:10.1126/science.7801120 · Cited by 555 · see citing works
Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice.
Kripke, M. L., Cox, P. A., Alas, L., & Yarosh, D. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7516 · Cited by 507 · see citing works
Self-citationXERODERMA PIGMENTOSUM: BIOCHEMICAL AND GENETIC CHARACTERISTICS
Cleaver, J. E., & Bootsma, D. (1975) · Annual Review of Genetics · doi:10.1146/annurev.ge.09.120175.000315 · Cited by 394 · see citing works
Slow Repair of Pyrimidine Dimers at <i>p53</i> Mutation Hotspots in Skin Cancer
Tornaletti, S., & Pfeifer, G. P. (1994) · Science · doi:10.1126/science.8128225 · Cited by 296 · see citing works
Unified catalytic mechanism for DNA glycosylases
Dodson, M. L., Michaels, M. L., & Lloyd, R. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)30047-8 · Cited by 268 · see citing works
Tanaka, K., Sekiguchi, M., & Okada, Y. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.10.4071 · Cited by 209 · see citing works
ULTRAVIOLET RADIATION ‐ INDUCED MALIGNANT MELANOMA IN Monodelphis domestica
Ley, R. D., Applegate, L. A., Padilla, R. S., & Stuart, T. D. (1989) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1989.tb04123.x · Cited by 162 · see citing works
Yarosh, D. B., Alas, L., Yee, V., Oberyszyn, T. M., Kibitel, J. T., Mitchell, D. L., Rosenstein, R. B., Spinowitz, A. L., & Citron, M. L. (1992) · PubMed · Cited by 152 · see citing works
Self-citationYoung, A. R., Chadwick, C. A., Harrison, G. I., Hawk, J. L. M., Nikaido, O., & Potten, C. S. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12349031 · Cited by 147 · see citing works
Self-citationLocalization of Liposomes Containing a DNA Repair Enzyme in Murine Skin
Yarosh, D., Bucana, C., Cox, P. A. T., Alas, L., Kibitel, J., & Kripke, M. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12395551 · Cited by 142 · see citing works
Self-citationX-Ray Structure of T4 Endonuclease V: an Excision Repair Enzyme Specific for a Pyrimidine Dimer
Morikawa, K., Matsumoto, O., Tsujimoto, M., Katayanagi, K., Ariyoshi, M., Doi, T., Ikehara, M., Inaoka, T., & Ohtsuka, E. (1992) · Science · doi:10.1126/science.1575827 · Cited by 140 · see citing works
Wolf, P., Cox, P., Yarosh, D. B., & Kripke, M. L. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12612828 · Cited by 127 · see citing works
Self-citationLey, R. D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.8.2409 · Cited by 112 · see citing works
Mitchell, D. L., Brash, D. E., & Nairn, R. S. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.4.963 · Cited by 92 · see citing works
Detergent, Liposome, and Micelle-Assisted Protein Refolding
Zardeneta, G., & Horowitz, P. M. (1994) · Analytical Biochemistry · doi:10.1006/abio.1994.1537 · Cited by 84 · see citing works
Cleaver, J. E., Charles, W. C., McDowell, M., Sadinski, W., & Mitchell, D. L. (1995) · PubMed · Cited by 62 · see citing works
Potten, C. S., Chadwick, C. A., Cohen, A. J., Nikaido, O., Matsunaga, T., Schipper, N. W., & Young, A. R. (1993) · International Journal of Radiation Biology · doi:10.1080/09553009314550421 · Cited by 53 · see citing works
Self-citationPhysical mapping and complete nucleotide sequence of the denV gene of bacteriophage T4
Radany, E. H., Naumovski, L., Love, J. D., Gutekunst, K. A., Hall, D. H., & Friedberg, E. C. (1984) · Journal of Virology · doi:10.1128/jvi.52.3.846-856.1984 · Cited by 45 · see citing works
Hori, N., Doi, T., Karaki, Y., Kituchi, M., Ikehara, M., & Ohtsuka, E. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.18.4761 · Cited by 44 · see citing works
Bito, T., Ueda, M., Nagano, T., Fujii, S., & Ichihashi, M. (1995) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.1995.tb00130.x · Cited by 36 · see citing works
Self-citationRole of DNA damage in local suppression of contact hypersensitivity in mice by UV radiation
Kripke, M. L., Cox, P. A., Bucana, C., Vink, A. A., Alas, L., & Yarosh, D. B. (1996) · Experimental Dermatology · doi:10.1111/j.1600-0625.1996.tb00113.x · Cited by 36 · see citing works
Self-citationEnhanced Unscheduled DNA Synthesis in UV-Irradiated Human Skin Explants Treated with T4N5 Liposomes
Yarosh, D. B., Kibitel, J. T., Green, L. A., & Spinowitz, A. L. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12479314 · Cited by 33 · see citing works
Self-citationInhibition of UV Radiation‐Induced DNA Damage by a 5‐Methoxypsoralen Tan in Human Skin
Young, A. R., Potten, C. S., Chadwick, C. A., MURPHY, G. M., & COHEN, A. J. (1988) · Pigment Cell Research · doi:10.1111/j.1600-0749.1988.tb00131.x · Cited by 32 · see citing works
Self-citationKibitel, J. T., Yee, V., & Yarosh, D. B. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02086.x · Cited by 29 · see citing works
Self-citationKusewitt, D. F., Ley, R. D., & Henderson, E. E. (1991) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(91)90012-e · Cited by 18 · see citing works
Kusewitt, D. F., Budge, C. L., Anderson, M. M., Ryan, S. L., & Ley, R. D. (1993) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1993.tb09589.x · Cited by 16 · see citing works
Kusewitt, D. F., Budge, C. L., & Ley, R. D. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12373084 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Enzymes inside lipid vesicles: preparation, reactivity and applications
Walde, P., & Ichikawa, S. (2001) · Biomolecular Engineering · doi:10.1016/s1389-0344(01)00088-0 · Cited by 635 · see citing works
Thi, T. T. H., Suys, E. J. A., Lee, J. S., Nguyen, D. H., Park, K. D., & Truong, N. P. (2021) · Vaccines · doi:10.3390/vaccines9040359 · Cited by 538 · see citing works
Yarosh, D., Klein, J., O'Connor, A., Hawk, J., Rafal, E., & Wolf, P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04214-8 · Cited by 390 · see citing works
Self-citationWinsey, S., Haldar, N., Marsh, H. P., Bunce, M., Marshall, S. E., Harris, A. L., WOJNAROWSKA, F. T., & Welsh, K. I. (2000) · PubMed · Cited by 298 · see citing works
Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin
Stege, H., Roza, L., Vink, A. A., Grewe, M., Ruzicka, T., Grether-Beck, S., & Krutmann, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.030528897 · Cited by 292 · see citing works
Wolf, P., Müllegger, R., Soyer, H. P., Hofer, A., Smolle, J., Horn, M., Cerroni, L., Hofmann‐Wellenhof, R., Kerl, H., Maier, H., et al. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00839.x · Cited by 167 · see citing works
Self-citationNucleotide excision repair and cancer
Leibeling, D., Laspe, P., & Emmert, S. (2006) · Journal of Molecular Histology · doi:10.1007/s10735-006-9041-x · Cited by 164 · see citing works
Protein oxidation, UVA and human DNA repair
Karran, P., & Brem, R. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.024 · Cited by 163 · see citing works
Liposomes in dermatology today
de Leeuw, J., de Vijlder, H. C., Bjerring, P., & Neumann, H. A. M. (2009) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2009.03100.x · Cited by 162 · see citing works
Azathioprine treatment photosensitizes human skin to ultraviolet A radiation
Perrett, C. M., Walker, S. L., O’Donovan, P., Warwick, J., Harwood, C. A., Karran, P., & McGregor, J. M. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08610.x · Cited by 152 · see citing works
Xeroderma pigmentosum – bridging a gap between clinic and laboratory
Moriwaki, S., & Kraemer, K. H. (2001) · Photodermatology Photoimmunology & Photomedicine · doi:10.1034/j.1600-0781.2001.017002047.x · Cited by 136 · see citing works
John, R., monpara, J., Swaminathan, S., & Kalhapure, R. S. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16010131 · Cited by 96 · see citing works
Synthetic cells in biomedical applications
Sato, W., Zajkowski, T., Moser, F., & Adamala, K. P. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1761 · Cited by 75 · see citing works
Functional viral metagenomics and the next generation of molecular tools
Schoenfeld, T. W., Liles, M. R., Wommack, K. E., Polson, S. W., Godiska, R., & Mead, D. A. (2009) · Trends in Microbiology · doi:10.1016/j.tim.2009.10.001 · Cited by 73 · see citing works
Photoimmunology, DNA repair and photocarcinogenesis
Berneburg, M., & Krutmann, J. (2000) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(00)00024-5 · Cited by 68 · see citing works
Brown, D. A. (2001) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(01)00212-3 · Cited by 66 · see citing works
T4 endonuclease V: review and application to dermatology
Cafardi, J. A., & Elmets, C. A. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.6.829 · Cited by 65 · see citing works
Measurement of UVB-Induced DNA damage and its consequences in models of immunosuppression
Yarosh, D. B., Boumakis, S., Brown, A. B., Canning, M. T., Galvin, J. W., Both, D., Kraus, E., O’Connor, A., & Brown, D. A. (2002) · Methods · doi:10.1016/s1046-2023(02)00209-8 · Cited by 54 · see citing works
Self-citationNon‐Melanoma Skin Cancer and Other Epidermal Skin Tumours
Quinn, A., & Perkins, W. A. (2010) · Wiley eBooks · doi:10.1002/9781444317633.ch52 · Cited by 52 · see citing works
Actinic Keratosis: The Key Event in the Evolution from Photoaged Skin to Squamous Cell Carcinoma
Oppel, T., & Körting, H. C. (2004) · Skin Pharmacology and Physiology · doi:10.1159/000076016 · Cited by 51 · see citing works
New Vision in Photoprotection and Photorepair
Leccia, M. ‐., Lebbé, C., Claudel, J., Narda, M., & Basset‐Séguin, N. (2019) · Dermatology and Therapy · doi:10.1007/s13555-019-0282-5 · Cited by 48 · see citing works
Photoprotection by Topical DMA Repair Enzymes: Molecular Correlates of Clinical Studies
Yarosh, D. B., O’Connor, A., Alas, L., Potten, C. S., & Wolf, P. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb03265.x · Cited by 48 · see citing works
Self-citationLiposomes in investigative dermatology
Yarosh, D. B. (2001) · Photodermatology Photoimmunology & Photomedicine · doi:10.1034/j.1600-0781.2001.170501.x · Cited by 47 · see citing works
Self-citationGenetic predisposition to skin cancer
Halpern, A. C., & Altman, J. F. (1999) · Current Opinion in Oncology · doi:10.1097/00001622-199903000-00010 · Cited by 44 · see citing works
Effect of xenogenic repair enzymes on photoimmunology and photocarcinogenesis
Stege, H. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00246-9 · Cited by 38 · see citing works
Investigations of pyrimidine dimer glycosylases—A paradigm for DNA base excision repair enzymology
Lloyd, R. S. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2005.04.003 · Cited by 37 · see citing works
Six critical questions for DNA repair enzymes in skincare products: a review in dialog
Yarosh, D. B., Rosenthal, A., & Moy, R. L. (2019) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s220741 · Cited by 34 · see citing works
Self-citationXeroderma Pigmentosum: Man Deprived of His Right to Light
Mareddy, S., Reddy, J., Babu, S., & Balan, P. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/534752 · Cited by 25 · see citing works
Non‐Melanoma Skin Cancer and Other Epidermal Skin Tumours
MacKie, R. M., & Quinn, A. (2004) · Wiley eBooks · doi:10.1002/9780470750520.ch36 · Cited by 25 · see citing works
A review of DNA repair and possible DNA-repair adjuvants and selected natural anti-oxidants
Emanuel, P. O., & Scheinfeld, N. S. (2007) · Dermatology Online Journal · doi:10.5070/d39ww9f65d · Cited by 24 · see citing works
Johnson, J. L., Lowell, B., Ryabinina, O. P., Lloyd, R. S., & McCullough, A. K. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.300 · Cited by 23 · see citing works
Pooja, D., Kadari, A., Kulhari, H., & Sistla, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813687-4.00013-x · Cited by 21 · see citing works
UV Protection in the Cornea: Failure and Rescue
Volatier, T. L. A., Schumacher, B., Cursiefen, C., & Notara, M. (2022) · Biology · doi:10.3390/biology11020278 · Cited by 22 · see citing works
Micro and Nanotechnologies for Biotechnology
Stanciu, S. G. (2016) · InTech eBooks · doi:10.5772/61530 · Cited by 20 · see citing works
UV-induced pigmentation in human skin
Young, A. R., & Sheehan, J. M. (2001) · Comprehensive series in photosciences · doi:10.1016/s1568-461x(01)80053-3 · Cited by 20 · see citing works
Self-citationBase excision repair of cyclobutane pyrimidine dimers
Lloyd, R. S. (1998) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(98)00032-9 · Cited by 20 · see citing works
Zghal, M., Fazaa, B., Abdelhak, S., & Mokni, M. (2018) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/j.annder.2018.09.004 · Cited by 18 · see citing works
Micro‐ and Nanocarriers for Immobilization of Enzymes
Leitgeb, M., Knez, Ž., & Vasić, K. (2016) · InTech eBooks · doi:10.5772/63129 · Cited by 17 · see citing works
Yarosh, D. B., Kibitel, J. T., Ullrich, S. E., Kim, I. H., Ananthaswamy, H. N., Krien, P. M., Fourtanier, A. M., & Kripke, M. L. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb03329.x · Cited by 15 · see citing works
Self-citationCurrent Therapeutic Strategies of Xeroderma Pigmentosum
Hossain, M., Hasan, M. A., Shawan, M. M. A. K., Banik, S., & Jahan, I. (2021) · Indian Journal of Dermatology · doi:10.4103/ijd.ijd_329_21 · Cited by 14 · see citing works
Enzymes for dermatological use
Nascimento, N. S., Torres‐Obreque, K. M., de Oliveira, C. A., Rabelo, J., Baby, A. R., Long, P. F., Young, A. R., & Rangel‐Yagui, C. D. O. (2024) · Experimental Dermatology · doi:10.1111/exd.15008 · Cited by 14 · see citing works
Self-citationApproaches to the Development of Cosmetic Products to Counter the Effects of Skin Aging
Menon, G. K., Dryer, L., & Kalafsky, R. (2009) · Elsevier eBooks · doi:10.1016/b978-0-8155-1584-5.50015-6 · Cited by 14 · see citing works
Volatier, T. L. A., Schumacher, B., Meshko, B., Hadrian, K., Cursiefen, C., & Notara, M. (2023) · Biology · doi:10.3390/biology12020265 · Cited by 13 · see citing works
Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways
Sha, Y., Vartanian, V., Owen, N., Mengden Koon, S. J., Calkins, M. J., Thompson, C. S., Mirafzali, Z., Mir, S., Goldsmith, L. E., He, H., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-17940-8 · Cited by 12 · see citing works
Recent progress in macromolecules: From current therapeutic strategies to theranostic applications
Kumar, S., Garg, N. K., Jain, A., Pandey, P., Khopade, A. J., & Sawant, K. K. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105664 · Cited by 10 · see citing works
PEDIATRIC PHOTOSENSITIVITY DISORDERS
Hensley, D. R., & Hebert, A. A. (1998) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70253-9 · Cited by 10 · see citing works
Zghal, M., Fazaa, B., & Kamoun, M.-R. (2006) · EMC - Dermatologie · doi:10.1016/s0246-0319(06)41213-9 · Cited by 10 · see citing works
Nouvelles stratégies de photoprotection
Meunier, L. (2006) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/s0151-9638(06)70924-3 · Cited by 8 · see citing works
Pediatric Photosensitivity Disorders
Pacha, O., & Hebert, A. A. (2013) · Dermatologic Clinics · doi:10.1016/j.det.2012.12.008 · Cited by 8 · see citing works
Brown, D. A. (2001) · Comprehensive series in photosciences · doi:10.1016/s1568-461x(01)80068-5 · Cited by 7 · see citing works
Phage therapy and its role in cancer treatment and control
El‐Moaty, H. I. A., Doghish, A. S., Moustafa, H. A. M., Elkalla, W. S., Sayed, G. A., Elshami, N. H., Mageed, S. S. A., Mohammed, O. A., Elrebehy, M. A., AlFarsi, K., et al. (2025) · Folia Microbiologica · doi:10.1007/s12223-025-01342-9 · Cited by 6 · see citing works
Bernstein, C., & Bernstein, H. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-095-7_1 · Cited by 5 · see citing works
Nanomaterial Synthesis and Mechanism for Enzyme Immobilization: Part II
Singh, A. K., & Tiwari, I. (2020) · Clean Energy Production Technologies · doi:10.1007/978-981-13-9333-4_8 · Cited by 4 · see citing works
Enhancement of repair of UV damage in humans
Yarosh, D. B. (2001) · Comprehensive series in photosciences · doi:10.1016/s1568-461x(01)80066-1 · Cited by 3 · see citing works
Self-citationDNA Repair and Photoprotection
Yarosh, D. B., & Smiles, K. A. (2008) · CRC Press eBooks · doi:10.3109/9781420080858-15 · Cited by 3 · see citing works
Self-citationPfützner, W., Heinrich, P., & Zippel, S. A. (2005) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-005-1232-0 · Cited by 2 · see citing works
Zghal, M., Fazaa, B., Abdelhak, S., & Mokni, M. (2014) · EMC - Dermatología · doi:10.1016/s1761-2896(14)69294-3 · Cited by 2 · see citing works
Role of Radiation in DNA Damage and Radiation Induced Cancer
Chandel, V., Seth, G., Shukla, P., & Kumar, D. (2019) · Environmental science and engineering · doi:10.1007/978-3-319-96511-6_1 · Cited by 2 · see citing works
Guillén, P. S., & MARTÍNEZ‐LIARTE, J. H. (2004) · Piel · doi:10.1016/s0213-9251(04)72871-3 · Cited by 2 · see citing works
Chemoprevention in Skin Cancer: What Advice?
Ortiz-Brugues, A., Cano, C. O., Corbella‐Bagot, L., Alamón‐Reig, F., Martí‐Martí, I., Ayguasanosa, M., Hernández-Santacana, M., Giavedoni, P., Aguilera, P., & Carrera, C. (2026) · Cancers · doi:10.3390/cancers18030436 · Cited by 1 · see citing works
Colon Cancer and the Western Diet
Hamill, F. A. (2002) · Integrative Cancer Therapies · doi:10.1177/153473540200100417 · Cited by 1 · see citing works
Quayle, C., Menck, C. F. M., & Moreno, K. (2011) · InTech eBooks · doi:10.5772/22946 · Cited by 1 · see citing works
How Much Photoprotection Does a Tan Afford?
Young, A. R. (2002) · Springer eBooks · doi:10.1007/978-1-4615-0937-0_9 · Cited by 1 · see citing works
Self-citationOpportunities and Challenges for Skin Cancer Chemoprevention
Viner, J. L., Hawk, E. T., Richmond, E. S., Higley, H. R., & Umar, A. (2008) · Humana Press eBooks · doi:10.1007/978-1-59259-768-0_31 · Cited by 1 · see citing works
Quayle, C. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2013.tde-07102013-104010
Guéranger, Q., Li, F., Peacock, M., Larnicol, A., Brem, R., Macpherson, P., Egly, J., & Karran, P. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.67
Der Weg ist das Ziel: Dermatologisches Drug Targeting
Körting, H. C. (2003) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-642-55661-6_24
Wolf, P. (2007) · Royal Society of Chemistry eBooks · doi:10.1039/9781847557957-00321
Wongpraparut, C., & Lim, H. W. (2013) · CRC Press eBooks · doi:10.1201/b15582-18
Zghal, M., Messaoud, O., & Mokni, M. (2021) · EMC - Dermatología · doi:10.1016/s1761-2896(21)45140-x
(1997) · Journal of Microencapsulation · doi:10.3109/02652049709006819
(1997) · Journal of Microencapsulation · doi:10.3109/02652049709033838
DNA Repair and Photoprotection
Yarosh, D. B., & Smiles, K. A. (2008) · Basic and clinical dermatology · doi:10.3109/9781420080858.012
Self-citationZghal, M., Fazaa, B., & Kamoun, M. R. (2006) · EMC - Dermatología · doi:10.1016/s1761-2896(06)47748-7
Wolf, P. (1997) · Springer eBooks · doi:10.1007/978-3-642-60425-6_16
De Sanctis-Cacchione Syndrome with Subdural Effusion
Kapat, A., Roy, G., Bhattacharjee, A., Mandal, A. K., Bala, A. K., & Podder, I. (2023) · Indian Journal of Dermatology · doi:10.4103/ijd.ijd_792_22
Coelho, A. A., Dias, E. P. S., & Kipnis, A. (2026) · Frontiers in Systems Biology · doi:10.3389/fsysb.2026.1686085
- Authors
- Yarosh, D., Klein, J., Kibitel, J., Alas, L., O'Connor, A., Cummings, B., Grab, D., Gerstein, D., Gilchrest, B. A., Ichihashi, M., Ogoshi, M., Ueda, M., Fernandez, V., Chadwick, C., Potten, C. S., Proby, C. M., Young, A. R., & Hawk, J. L. M.
- Affiliations
- Boston University (US)
- Kobe University Hospital (JP)
- Cancer Research UK Manchester Institute (GB)
- Corresponding author
- Yarosh, D.
- Venue
- Photodermatology, Photoimmunology & Photomedicine
- Publisher
- Wiley
- Published
- 1996-06
- Volume
- 12
- Issue
- 3
- Pages
- 122-130
- ISSN
- 0905-4383 (ISSN-L)
- 1600-0781
- OpenAlex
- W2005403770
- Cited by
- 81
- References
- 31
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 3 · 2016: 3 · 2014: 2 · 2013: 4
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photodermatology Photoimmunology & Photomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- xeroderma pigmentosum, enzyme therapy, DNA repair enzymes, topical drug delivery, UV-induced DNA damage, cyclobutane pyrimidine dimers, erythema, safety testing, efficacy evaluation
- MeSH terms
- Adolescent, Adult, Animals, Child, DNA Repair, Drug Carriers, Endodeoxyribonucleases, Female, Humans, Liposomes, Male, Ointments, Xeroderma Pigmentosum, Deoxyribonuclease (Pyrimidine Dimer), Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
