Effect of therapeutic macromolecules in spheroids.

Establishment in culture of pluripotential cells from mouse embryos

Evans, M. J., & Kaufman, M. H. (1981) · Nature · doi:10.1038/292154a0 · Cited by 8,623 · see citing works

Cell and environment interactions in tumor microregions: the multicell spheroid model.

Sutherland, R. M. (1988) · Science · doi:10.1126/science.2451290 · Cited by 1,803 · see citing works

Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis

Hakomori, S. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.003505 · Cited by 1,643 · see citing works

Colorectal carcinoma antigens detected by hybridoma antibodies

Koprowski, H., Steplewski, Z., Mitchell, K. F., Herlyn, M., Herlyn, D., & Fuhrer, P. (1979) · Somatic Cell and Molecular Genetics · doi:10.1007/bf01542654 · Cited by 1,360 · see citing works

The Gompertz Curve as a Growth Curve

Winsor, C. P. (1932) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.18.1.1 · Cited by 1,007 · see citing works

Dynamics of Tumor Growth

Laird, A. K. (1964) · British Journal of Cancer · doi:10.1038/bjc.1964.55 · Cited by 880 · see citing works

One molecule of diphtheria toxin fragment a introduced into a cell can kill the cell

Yamaizumi, M., Mekada, E., Uchida, T., & Okada, Y. (1978) · Cell · doi:10.1016/0092-8674(78)90099-5 · Cited by 745 · see citing works

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo

Sethi, T., Rintoul, R. C., Moore, S. M., MacKinnon, A. C., Salter, D. M., Choo, C., Chilvers, E. R., Dransfield, I., Donnelly, S. C., Strieter, R. M., et al. (1999) · Nature Medicine · doi:10.1038/9511 · Cited by 739 · see citing works

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor

Bremer, E. G., Schlessinger, J., & Hakomori, S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35954-9 · Cited by 706 · see citing works

Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies

Jain, R. K. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.8.570 · Cited by 564 · see citing works

A simplified method for production and growth of multicellular tumor spheroids.

Yuhas, J. M., Li, A. P., Martinez, A. O., & Ladman, A. J. (1977) · PubMed · Cited by 506 · see citing works

Liposomes Revisited

Lasic, D. D., & Papahadjopoulos, D. (1995) · Science · doi:10.1126/science.7871422 · Cited by 434 · see citing works

Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier.

Juweid, M. E., Neumann, R. D., Paik, C. H., Pérez-Bacete, M., Sato, J., van Osdol, W. W., & Weinstein, J. N. (1992) · PubMed · Cited by 406 · see citing works

SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells

Zeman, E. M., Brown, J. M., Lemmon, M. J., Hirst, V. K., & Lee, W. W. (1986) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(86)90267-1 · Cited by 402 · see citing works

Ribosome‐inactivating proteins up to date

Stirpe, F., & Barbieri, L. L. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80118-1 · Cited by 388 · see citing works

Dynamics of Tumour Growth: Comparison of Growth Rates and Extrapolation of Growth Curve to One Cell

Laird, A. K. (1965) · British Journal of Cancer · doi:10.1038/bjc.1965.32 · Cited by 308 · see citing works

Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells

Eiklid, K. L., Olsnes, S., & Pihl, A. (1980) · Experimental Cell Research · doi:10.1016/0014-4827(80)90270-0 · Cited by 303 · see citing works

Antibodies against metal chelates

Reardan, D. T., Meares, C. F., Goodwin, D. A., McTigue, M., David, G. S., Stone, M. R., Leung, J. P., Bartholomew, R. M., & Frincke, J. M. (1985) · Nature · doi:10.1038/316265a0 · Cited by 260 · see citing works

Apoptosis induced by inhibition of intercellular contact.

Bates, R. C., Buret, A. G., Helden, D. F. V., Horton, M. A., & Burns, G. F. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.2.403 · Cited by 244 · see citing works

Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.

Bacha, P., Williams, D. P., Waters, C. A., Williams, J. M., Murphy, J. R., & Strom, T. B. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.2.612 · Cited by 220 · see citing works

Dosimetric aspects of radiolabeled antibodies for tumor therapy.

Humm, J. L. (1986) · PubMed · Cited by 213 · see citing works

A Multi-component Radiation Survival Curve Using anin VitroTumour Model

Sutherland, R. M., Inch, W. R., McCredie, J. A., & Kruuv, J. (1970) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553007014551401 · Cited by 201 · see citing works

Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution.

Youle, R. J., & Neville, D. M. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68077-4 · Cited by 196 · see citing works

Kinetics of cytotoxicity induced by immunotoxins. Enhancement by lysosomotropic amines and carboxylic ionophores.

Casellas, P., Bourrié, B., Gros, P., & Jansen, F. K. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42707-4 · Cited by 194 · see citing works

A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis

Grimm, E. A. (1994) · Lung Cancer · doi:10.1016/0169-5002(94)92198-9 · Cited by 191 · see citing works

Mutations in Diphtheria Toxin Separate Binding from Entry and Amplify Immunotoxin Selectivity

Greenfield, L., Johnson, V. G., & Youle, R. J. (1987) · Science · doi:10.1126/science.3498987 · Cited by 175 · see citing works

Effects of EGF, BFGF, NGF and PDGF(bb) on cell proliferative, migratory and invasive capacities of human brain‐tumour biopsies In Vitro

Engebraaten, O., Bjerkvig, R., Pedersen, P., & Lærum, O. D. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910530206 · Cited by 159 · see citing works

Immunotoxins: An Update

Thrush, G. R., Lr, L., Clinchy, B., & Vitetta, E. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.49 · Cited by 159 · see citing works

Fluence rate effects in photodynamic therapy of multicell tumor spheroids.

Foster, T. H., Hartley, D. F., Nichols, M. G., & Hilf, R. (1993) · PubMed · Cited by 157 · see citing works

DTPA-coupled antibodies labeled with yttrium-90.

Hnatowich, D. J., Virzi, F., & Doherty, P. W. (1985) · PubMed · Cited by 155 · see citing works

Phase I trial of a mouse monoclonal antibody against GD3 ganglioside in patients with melanoma: induction of inflammatory responses at tumor sites.

Vadhan‐Raj, S., Cordon‐Cardo, C., Carswell, E. A., Mintzer, D. M., Dantis, L., Duteau, C., Templeton, M. A., Oettgen, H. F., Old, L. J., & Houghton, A. N. (1988) · Journal of Clinical Oncology · doi:10.1200/jco.1988.6.10.1636 · Cited by 155 · see citing works

Penetration and binding of radiolabeled anti-carcinoembryonic antigen monoclonal antibodies and their antigen binding fragments in human colon multicellular tumor spheroids.

Sutherland, R. M., Buchegger, F., Schreyer, M., Vacca, A., & Mach, J. (1987) · PubMed · Cited by 151 · see citing works

CELLULAR FLUORESCENCE OF THE ENDOGENOUS PHOTOSENSITIZER PROTOPORPHYRIN IX FOLLOWING EXPOSURE TO 5‐AMINOLEVULINIC ACID

Steinbach, P., Wedmgandt, H., Baumgartner, R., Kriegmair, M., Hofstädter, F., & Knüchel, R. (1995) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1995.tb09152.x · Cited by 141 · see citing works

Efficient assembly of rat hepatocyte spheroids for tissue engineering applications

Wu, F. J., Friend, J. R., Hsiao, C. C., Zilliox, M. J., Ko, W., Cerra, F. B., & Hu, W. (1996) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19960520)50:4 · Cited by 139 · see citing works

Tenascin mediates human glioma cell migration and modulates cell migration on fibronectin

Deryugina, E. I., & Bourdon, M. A. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.3.643 · Cited by 136 · see citing works

Growth of nodular carcinomas in rodents compared with multi-cell spheroids in tissue culture.

Inch, W. R., Ja, M., & Rm, S. (1970) · PubMed · Cited by 135 · see citing works

Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors.

Tunggal, J. K., Cowan, D., Shaikh, H., & Tannock, I. F. (1999) · PubMed · Cited by 133 · see citing works

The Pharmacology of Monoclonal Antibodiesa

Weinstein, J. N., Eger, R. R., Covell, D. G., BLACK, C. D. V., Mulshine, J. L., Carrasquillo, J. A., Larson, S. M., & Keenan, A. M. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb45802.x · Cited by 127 · see citing works

Body-size indicators and risk of breast cancer according to menopause and estrogen-receptor status

Männistö, S., Pietinen, P., Pyy, M., Palmgren, J., Eskelinen, M. J., & Uusitupa, M. I. J. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960927)68:1 · Cited by 126 · see citing works

Inhibition of Human Acute Lymphoblastic Leukemia Cells by Immunotoxins: Potentiation by Chloroquine

Ramakrishnan, S., & Houston, L. L. (1984) · Science · doi:10.1126/science.6318313 · Cited by 120 · see citing works

3-D Coculture of Hepatic Sinusoidal Cells with Primary Hepatocytes—Design of an Organotypical Model

Bader, A., Knop, E., Kern, A., Böker, K. H. W., Frühauf, N. R., Crome, O., Esselmann, H., Pape, C., Kempka, G., & Sewing, K. ‐. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0222 · Cited by 119 · see citing works

Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid

Moan, J. E., Streckytė, G., Bagdonas, S., Gadmar, Ø. B., & Berg, K. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970106)70:1 · Cited by 118 · see citing works

An immunotoxin prepared with blocked ricin: a natural plant toxin adapted for therapeutic use.

Lambert, J., Goldmacher, V. S., Collinson, A. R., Nadler, L. M., & Blättler, W. A. (1991) · PubMed · Cited by 116 · see citing works

Comparative serum stability of radiochelates for antibody radiopharmaceuticals.

Cole, W. C., DeNardo, S. J., Meares, C. F., McCall, M. J., DeNardo, G. L., Epstein, A. L., O'Brien, H. A., & Moi, M. K. (1987) · PubMed · Cited by 108 · see citing works

Spheroid Culture in Cancer Research (1991)

(2017) · CRC Press eBooks · doi:10.1201/9780203710241 · Cited by 106 · see citing works

A chloride current associated with swelling of cultured chick heart cells.

Zhang, J., Rasmusson, R. L., Hall, S., & Lieberman, M. A. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019974 · Cited by 97 · see citing works

Collagens, integrins and the mesenchymal drift in glioblastomas: A comparison of biopsy specimens, spheroid and early monolayer cultures

Paulus, W., Huettner, C. S., & Tonn, J. C. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910580616 · Cited by 97 · see citing works

Blockade of the galactose‐binding sites of ricin by its linkage to antibody

Thorpe, P. E., Ross, W. C. J., Brown, A. N. F., Myers, C. D., Cumber, A. J., Foxwell, B. M. J., & FORRESTER, J. T. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb08067.x · Cited by 94 · see citing works

Phase I–II study of radiolabeled antibody integrated in the treatment of primary hepatic malignancies

Order, S. E., Klein, J. L., Ettinger, D. S., Alderson, P. O., Siegelman, S. S., & Leichner, P. K. (1980) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(80)90226-6 · Cited by 89 · see citing works

Cell culture as spheroids: an approach to multicellular resistance.

Desoize, B., Gimonet, D., & Jardiller, J. C. (1999) · PubMed · Cited by 88 · see citing works

A flow injection flow cytometry system for on-line monitoring of bioreactors

Zhao, R., Natarajan, A., & Srienc, F. (1999) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19990305)62:5 · Cited by 85 · see citing works

Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours

Phillips, R. M., Loadman, P. M., & Cronin, B. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.355 · Cited by 81 · see citing works

Cloned fragment of diphtheria toxin linked to T cell-specific antibody identifies regions of B chain active in cell entry.

Colombatti, M., Greenfield, L., & Youle, R. J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35741-1 · Cited by 77 · see citing works

Characterization of Morphology and Cellular Metabolism during the Spheroid Formation by Fibroblasts

Takezawa, T., Mori, Y., Yonaha, T., & Yoshizato, K. (1993) · Experimental Cell Research · doi:10.1006/excr.1993.1265 · Cited by 77 · see citing works

Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain.

Raso, V., & Lawrence, J. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.160.4.1234 · Cited by 77 · see citing works

Interleukin 2-diphtheria toxin fusion protein can abolish cell-mediated immunity in vivo.

Kelley, V. E., Bacha, P., PANKEWYCZ, O. G., NICHOLS, J. C., Murphy, J. R., & Strom, T. B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.3980 · Cited by 76 · see citing works

Skin Fibroblasts Are the Only Source of Nidogen During Early Basal Lamina Formation In Vitro

Fleischmajer, R., Schechter, A. N., Bruns, M., Perlish, J. S., MacDonald, E. D., Pan, T., Timpl, R., & Chu, M.-L. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12323604 · Cited by 74 · see citing works

Membrane-mediated cytotoxicity

(1986) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240320603 · Cited by 73 · see citing works

Ionic basis of the chronotropic effect of acetylcholine on the rabbit sinoatrial node

Boyett, M. R., Kodama, I., Honjo, H., Arai, A., Suzuki, R., & Toyama, J. (1995) · Cardiovascular Research · doi:10.1016/s0008-6363(96)88625-1 · Cited by 68 · see citing works

Leptomeningeal Tissue: a Barrier Against Brain Tumor Cell Invasion

Pedersen, P., Rucklidge, G. J., Mørk, S. J., Terzis, A. J. A., Engebraaten, O., Lund‐Johansen, M., Backlund, E.-O., Lærum, O. D., & Bjerkvig, R. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.21.1593 · Cited by 63 · see citing works

Pharmacokinetics, biodistribution and biological effects of intravenously administered bispecific monoclonal antibody OC/TR F(ab′)2 in ovarian carcinoma patients

Tibben, J. G., Boerman, O. C., Massuger, L. F. A. G., Schijf, C. P. T., Claessens, R. A. M. J., & Corstens, F. H. M. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960516)66:4 · Cited by 60 · see citing works

Tumor Therapy by Immune Recruitment with Bispecific Antibodies

Renner, C., & Pfreundschuh, M. (1995) · Immunological Reviews · doi:10.1111/j.1600-065x.1995.tb00082.x · Cited by 58 · see citing works

A phase I study of a HER2/neu bispecific antibody with granulocyte-colony-stimulating factor in patients with metastatic breast cancer that overexpresses HER2/neu

Pullarkat, V., Deo, Y., Link, J., Spears, L., Marty, V., Curnow, R., Groshen, S., Gee, C., & Weber, J. S. (1999) · Cancer Immunology, Immunotherapy · doi:10.1007/s002620050543 · Cited by 55 · see citing works

Self-diffusion of water in multicellular spheroids measured by magnetic resonance microimaging.

Neeman, M., JARRETT, K. A., Sillerud, L. O., & Freyer, J. P. (1991) · PubMed · Cited by 53 · see citing works

Selective down-regulation of integrin receptors in spheroids of squamous cell carcinoma.

Waleh, N. S., Gallo, J., Grant, T. D., Murphy, B. J., Kramer, R. H., & Sutherland, R. M. (1994) · PubMed · Cited by 53 · see citing works

Effects of growth factors on a human glioma cell line during invasion into rat brain aggregates in culture

Lund‐Johansen, M., Forsberg, K., Bjerkvig, R., & Lærum, O. D. (1992) · Acta Neuropathologica · doi:10.1007/bf00311394 · Cited by 53 · see citing works

Cellular energetics measured by phosphorous nuclear magnetic resonance spectroscopy are not correlated with chronic nutrient deficiency in multicellular tumor spheroids.

Freyer, J. P., Schor, P. L., JARRETT, K. A., Neeman, M., & Sillerud, L. O. (1991) · PubMed · Cited by 51 · see citing works

The vacuolar-type ATPase from insect plasma membrane: immunocytochemical localization in insect sensilla

Klein, U., & Zimmermann, B. B. (1991) · Cell and Tissue Research · doi:10.1007/bf00318182 · Cited by 50 · see citing works

Photocytotoxic efficacy of sulphonated species of aluminium phthalocyanine against cell monolayers, multicellular spheroids and in vivo tumours

Chan, W., West, C., Moore, J., & Hart, I. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.408 · Cited by 49 · see citing works

Comparisons between two monoclonal antibodies that bind to the same antigen but have differing affinities: uptake kinetics and 125I-antibody therapy efficacy in multicell spheroids.

Langmuir, V. K., Mendonca, H. L., & Woo, D. V. (1992) · PubMed · Cited by 47 · see citing works

Integrin expression on colorectal tumor cells growing as monolayers, as multicellular tumor spheroids, or in nude mice

Hauptmann, S., Denkert, C., Löhrke, H., Tietze, L., Ott, S. J., Klosterhalfen, B., & Mittermayer, C. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910610613 · Cited by 46 · see citing works

Potentiation of cytotoxic activity of immunotoxins on cultured human cells.

Akiyama, S., Seth, P. K., Pirker, R., Fitzgerald, D., Gottesman, M. M., & Pastan, I. H. (1985) · PubMed · Cited by 45 · see citing works

Lipid metabolism in large T47D human breast cancer spheroids: 31P- and 13C-NMR studies of choline and ethanolamine uptake

Ronen, S. M., Rushkin, E., & Degani, H. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(92)90039-p · Cited by 43 · see citing works

Effect of LAK cells against three-dimensional tumor tissue. In vitro study using multi-cellular human glioma spheroids as targets.

Jääskeläinen, J. E., Kalliomäki, P., Paetau, A. E., & Timonen, T. T. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.3.1036 · Cited by 39 · see citing works

Interaction of liposome-associated all- trans- retinoic acid with squamous carcinoma cells

Parthasarathy, R. V., Sacks, P. G., Harris, D., Brock, H., & Mehta, K. (1994) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00685666 · Cited by 37 · see citing works

Brain‐derived neurotrophic factor induces functional expression and phenotypic differentiation of cultured fetal neuropeptide Y‐producing neurons

Barnea, A., Cho, G., Lü, G., & Mathis, J. M. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490420506 · Cited by 36 · see citing works

Carrier protein-monensin conjugates: enhancement of immunotoxin cytotoxicity and potential in tumor treatment.

Colombatti, M., Dell'Arciprete, L., Chignola, R., & Tridente, G. (1990) · PubMed · Cited by 36 · see citing works

Sensitivity of human glioma cells to cytotoxic heteroconjugates

Colombatti, M., Bisconti, M., Dell'Arciprete, L., Gerosa, M. A., & Tridente, G. (1988) · International Journal of Cancer · doi:10.1002/ijc.2910420322 · Cited by 36 · see citing works

Mathematical model of simultaneous diffusion and binding of antitumor antibodies in multicellular human tumor spheroids.

McFadden, R., & Kwok, C. S. (1988) · PubMed · Cited by 35 · see citing works

Kinetics of Cytotoxicity Induced by Immunotoxins

Casellas, P., Bourrié, B., Gros, P., & Jansen, F. K. (1984) · Cited by 35 · see citing works

Proton NMR Microscopy of Multicellular Tumor Spheroid Morphology

Sillerud, L. O., Freyer, J. P., Neeman, M., & Mattingly, M. A. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910160304 · Cited by 34 · see citing works

In vitro changes in plasma membrane heparan sulfate proteoglycans and in perlecan expression participate in the regulation of fibroblast growth factor 2 mitogenic activity

Guillonneau, X., Tassin, J., Berrou, E., Bryckaert, M., Courtois, Y., & Mascarelli, F. (1996) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199601)166:1 · Cited by 33 · see citing works

Radioimmunotherapy of prostatic adenocarcinomas: Effects of 131I‐labelled E4 antibodies on cells at different depth in DU 145 spheroids

Essand, M., Grönvik, C., Hartman, T., & Carlsson, J. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910630315 · Cited by 33 · see citing works

Heterogeneous response of individual multicellular tumour spheroids to immunotoxins and ricin toxin

Chignola, R., Foroni, R. I., Franceschi, A., Pasti, M., Candiani, C., Anselmi, C., Fracasso, G., Tridente, G., & Colombatti, M. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.381 · Cited by 32 · see citing works

Potentiation of tumor lysis by a bispecific antibody that binds to CA19-9 antigen and the Fc gamma receptor expressed by human large granular lymphocytes.

de Palazzo, I. G., Gerçel-Taylor, Ç., Kitson, J., & Weiner, L. M. (1990) · PubMed · Cited by 32 · see citing works

Use of multi‐cell spheroids of ovarian carcinoma as an intraperitoneal radio‐immunotherapy model: Uptake, retention kinetics and dosimetric evaluation

Bardiès, M., Thédrez, P., Gestin, J., Marcille, B., Guerreau, D., Faivre-Chauvet, A., Mahé, M. A., Maurel, C., & Chatal, J. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910500627 · Cited by 31 · see citing works

Role of chloride currents in repolarizing rabbit atrial myocytes

Wang, Z., Fermini, B., Feng, J., & Nattel, S. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.5.h1992 · Cited by 31 · see citing works

Effect of polarity and differentiation on antibody localization in multicellular tumour spheroid and xenograft models and its potential importance for in vivo IMMUNOTARGETING

Pervez, S., Kirkland, S. C., Epenetos, A. A., Mooi, W. J., Evans, D. J., & Krausz, T. N. (1989) · International Journal of Cancer · doi:10.1002/ijc.2910440532 · Cited by 30 · see citing works

Multicellular tumor spheroids in radiotherapy research (review).

Jh, S. (1990) · PubMed · Cited by 29 · see citing works

Automated selective dissociation of cells from different regions of multicellular spheroids

Freyer, J. P., & Schor, P. L. (1989) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02624405 · Cited by 28 · see citing works

A system for viably maintaining a stirred suspension of multicellular spheroids during NMR spectroscopy

Freyer, J. P., Fink, N. H., Schor, P. L., Coulter, J. R., Neeman, M., & Sillerud, L. O. (1990) · NMR in Biomedicine · doi:10.1002/nbm.1940030502 · Cited by 28 · see citing works

131I-anticarcinoembryonic antigen therapy of LS174T human colon adenocarcinoma spheroids.

Langmuir, V. K., McGann, J. K., Buchegger, F., & Sutherland, R. M. (1989) · PubMed · Cited by 28 · see citing works

A tumour spheroid model for antibody-targeted therapy of micrometastases

Walker, K. A., Murray, T. J., Hilditch, T., Wheldon, T. E., Gregor, A., & Hann, I. M. (1988) · British Journal of Cancer · doi:10.1038/bjc.1988.152 · Cited by 27 · see citing works

Targeting Radiation to Tumours

Wheldon, T. E. (1994) · International Journal of Radiation Biology · doi:10.1080/09553009414550151 · Cited by 26 · see citing works

Diffusion and Binding of Monoclonal Antibody TNT-1 in Multicellular Tumor Spheroids

Chen, F.-M., Hansen, E. B., Taylor, C. R., & Epstein, A. L. (1991) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/83.3.200 · Cited by 26 · see citing works

A Comparative Study of Effects of Isoproterenol and Dihydroouabain on Calcium transients and Contraction in Cultured Rat Ventricular Cells

Tatsukawa, Y., Arita, M., Kiyosue, T., Mikuriya, Y., & Nasu, M. (1993) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1993.1083 · Cited by 25 · see citing works

Homogeneous penetration but heterogeneous binding of antibodies to carcinoembryonic antigen in human colon carcinoma HT-29 spheroids

Carlsson, J., Daniel-Szolgay, E., Frykholm, G. J., Glimelius, B. L. G., Hedin, A., & Larsson, B. S. (1989) · Cancer Immunology Immunotherapy · doi:10.1007/bf01744893 · Cited by 24 · see citing works

Effects of cellular pharmacology on drug distribution in tissues

Rippley, R. K., & Stokes, C. L. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)79956-8 · Cited by 23 · see citing works

The distribution of alternative agents for targeted radiotherapy within human neuroblastoma spheroids

Mairs, R., Angerson, W. J., Gaze, M. N., Murray, T. J., Babich, J., Reid, R., & McSharry, C. P. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.93 · Cited by 23 · see citing works

Contribution of ATP‐sensitive potassium channels to the electrophysiological effects of adenosine in guinea‐pig atrial cells.

Li, G., Feng, J., Shrier, A., & Nattel, S. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020692 · Cited by 23 · see citing works

Formation of hair follicles from a single-cell suspension of embryonic rat skin by a two-step procedure in vitro

Ihara, S., Watanabe, M., Nagao, E., & Shioya, N. (1991) · Cell and Tissue Research · doi:10.1007/bf00678712 · Cited by 23 · see citing works

Effects of the inhibitors of energy metabolism, lonidamine and levamisole, on 5-aminolevulinic-acid-induced photochemotherapy

Shevchuk, I. N., Chekulayev, V. A., Moan, J. E., & Berg, K. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960917)67:6 · Cited by 22 · see citing works

The effect of antigen concentration, antibody valency and size, and tumor architecture on antibody binding in multicell spheroids

Langmuir, V. K., McGann, J. K., Buchegger, F., & Sutherland, R. M. (1991) · International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology · doi:10.1016/0883-2897(91)90014-c · Cited by 22 · see citing works

Resistance of ovarian teratocarcinoma cell spheroids to complement-mediated lysis

Bjørge, L., Junnikkala, S., Kristoffersen, E., Hakulinen, J., Matre, R., & Meri, S. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.213 · Cited by 22 · see citing works

Anti-GM2 monoclonal antibodies induce necrosis in GM2-rich cultures of a human glioma cell line.

Bjerkvig, R., Engebraaten, O., Lærum, O. D., Fredman, P., Svennerholm, L. T., Vrionis, F. D., Wikstrand, C. J., & Bigner, D. D. (1991) · PubMed · Cited by 21 · see citing works

Antitumor effects of a bispecific antibody targeting CA19-9 antigen and CD16.

de Palazzo, I. G., Holmes, M., Gerçel-Taylor, Ç., & Weiner, L. M. (1992) · PubMed · Cited by 21 · see citing works

Dynorphins Modulate DNA Synthesis in Fetal Brain Cell Aggregates

Gorodinsky, A., Barg, J., Belcheva, M. M., Levy, R., McHale, R. J., Vogel, Z., & Coscia, C. J. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041481.x · Cited by 21 · see citing works

MECHANISMS BEHIND THE RESISTANCE OF SPHEROIDS TO PHOTODYNAMIC TREATMENT: A FLOW CYTOMETRY STUDY

West, C., & Moore, J. V. (1992) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1992.tb04257.x · Cited by 21 · see citing works

Infiltrative and cytolytic activities of lymphokine-activated killer cells against a human glioma spheroid model.

Iwasaki, K., Kikuchi, H., Miyatake, S.-I., Aoki, T., Yamasaki, T., & Oda, Y. (1990) · PubMed · Cited by 21 · see citing works

Optimization of radioimmunotherapy using human malignant melanoma multicell spheroids as a model.

Kwok, C. S., Crivici, A., MacGregor, W. D., & UNGER, M. W. (1989) · PubMed · Cited by 21 · see citing works

T-lymphocyte killing by T101-ricin A-chain immunotoxin: pH-dependent potentiation with lysosomotropic amines

Casellas, P., Ravel, S. J., Bourrié, B., Derocq, J., Jansen, F. K., Laurent, G., & Gros, P. (1988) · Blood · doi:10.1182/blood.v72.4.1197.1197 · Cited by 21 · see citing works

The Combined Use of 131 I-Labeled Antibody and the Hypoxic Cytotoxin SR 4233 in Vitro and in Vivo

Langmuir, V. K., & Mendonca, H. L. (1992) · Radiation Research · doi:10.2307/3578244 · Cited by 20 · see citing works

Amantadine potentiates T lymphocyte killing by an anti-pan-T cell (CD5) ricin A-chain immunotoxin

Siena, S., Villa, S., Bregni, M., Bonadonna, G., & Am, G. (1987) · Blood · doi:10.1182/blood.v69.1.345.345 · Cited by 20 · see citing works

Laminin: a potential inhibitor of rat glioma cell invasion in vitro.

Reith, A., Bjerkvig, R., & Gj, R. (1994) · PubMed · Cited by 20 · see citing works

Blocking effect of human serum but not of cerebrospinal fluid on ricin A chain immunotoxin potentiation by monensin or carrier protein-monensin conjugates.

Candiani, C., Franceschi, A., Chignola, R., Pasti, M., Anselmi, C., Benoni, G., Tridente, G., & Colombatti, M. (1992) · PubMed · Cited by 18 · see citing works

Penetration and Binding of Monoclonal Antibody in Human Osteosarcoma Multicell Spheroids: Comparison of confocal laser scanning microscopy and autoradiography

Hjelstuen, M. H. B., Rasch-Halvorsen, K., Brekken, C., Bruland, Ø. S., & Davies, C. D. L. (1996) · Acta Oncologica · doi:10.3109/02841869609101641 · Cited by 17 · see citing works

Editorial: Your paper has been accepted

Murray, A. (1999) · Medical & Biological Engineering & Computing · doi:10.1007/bf02513257 · Cited by 14 · see citing works

Comparisons of the efficacy of 186Re- and 131I-labeled antibody in multicell spheroids

Langmuir, V. K., Mendonca, H. L., Vanderheyden, J., & Su, F. (1992) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(92)91031-h · Cited by 14 · see citing works

Cytoreductive effects of anti‐transferrin receptor immunotoxins in a multicellular tumor spheroid model

Chignola, R., Foroni, R. I., Candiani, C., Franceschi, A., Pasti, M., Stevanoni, G., Anselmi, C., Tridente, G., & Colombatti, M. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910570223 · Cited by 14 · see citing works

Enhancement of the Cytotoxic Effect of Anti-Carcinoembryonic Antigen Immunotoxins by Adenovirus and Carboxylic lonophores 2

Griffin, T. W., Childs, L. R., FitzGerald, D. J., & Levin, L. V. (1987) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/79.4.679 · Cited by 14 · see citing works

The selection of antibodies for targeted therapy of small-cell lung cancer (SCLC) using a human tumour spheroid model to compare the uptake of cluster 1 and cluster w4 antibodies

Olabiran, Y., Ledermann, J. A., Marston, N., Boxer, G., Hicks, R. J., Souhami, R. L., Spiro, S. G., & Stahel, R. A. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.47 · Cited by 13 · see citing works

A review of the effects of three cardioactive agents on the electrical activity from embryonic chick heart cell aggregates: TTX, ACh, and E-4031

Clay, J. R., Kristof, A. S., Shenasa, J., Brochu, R. M., & Shrier, A. (1994) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(94)90011-6 · Cited by 12 · see citing works

Efficacy and selectivity of monoclonal‐antibody‐targeted drugs and free methotrexate in fluorescence‐labelled mixed tumour‐cell monolayer cultures and multicellular spheroids

Embleton, M. J., Charleston, A., & Affleck, K. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910490416 · Cited by 10 · see citing works

A Novel Monoclonal Antibody, L1A3, Is Directed to the Functional Site of the α v Integrin Subunit

Deryugina, E. I., Strongin, A. Y., YU, C., & Bourdon, M. A. (1996) · Hybridoma · doi:10.1089/hyb.1996.15.279 · Cited by 10 · see citing works

Comparisons of sectioned micro‐TLD dose measurements with predicted dose from 131I‐labeled antibody

Langmuir, V. K., Wessels, B. W., Mendonca, H. L., Yorke, E. D., & Montilla, L. (1992) · Medical Physics · doi:10.1118/1.596753 · Cited by 10 · see citing works

Damage to Multicellular Human H-2 Glioma Spheroids Incubated With LAK Cells: An Ultrastructural Study

Jääskeläinen, J. E., Lehtonen, E., Heikkilä, P., Kalliomäki, P. ‐., & Timonen, T. T. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.6.497 · Cited by 10 · see citing works

Enhancement of the specific cytotoxicity of a breast cancer-associated antigen immunotoxin by the carboxylic ionophore monensin.

Tw, G., Pagnini, P., & Houston, L. L. (1987) · PubMed · Cited by 10 · see citing works

Penetration of anti-melanoma immunotoxin into multicellular tumor spheroids and cell kill effects

Kikuchi, T., Ohnuma, T., Holland, J. F., & S̄pitler, L. E. (1992) · Cancer Immunology Immunotherapy · doi:10.1007/bf01741142 · Cited by 8 · see citing works

Effects of131I-labeled TNT-1 radioimmunotherapy on HT-29 human colon adenocarcinoma spheroids

Chen, F., Liu, C.-Z., & Epstein, A. L. (1991) · Cancer Immunology Immunotherapy · doi:10.1007/bf01756136 · Cited by 7 · see citing works

Response of multicellular tumor spheroids to liposomes containing TNF-?

Weber, F., Kremer, C., Klinkhammer, M., Rasier, B., & Brock, M. (1994) · Journal of Neuro-Oncology · doi:10.1007/bf01328956 · Cited by 7 · see citing works

Comparison of indapamide and hydrochlorothiazide on spontaneous contraction of cardiomyocytes in culture: The effect on alterations of extracellular calcium or potassium

Rabkin, S. W. (1993) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(93)90234-o · Cited by 7 · see citing works

Uptake, penetration, and binding of monoclonal antibodies with increasing affinity in human osteosarcoma multicell spheroids.

Hjelstuen, M., Rasch-Halvorsen, K., Bruland, Ø. S., & Davies, C. D. L. (1998) · PubMed · Cited by 7 · see citing works

Cell death induced by a 131I-labeled monoclonal antibody in ovarian cancer multicell spheroids

Filippovich, I. V., Sorokina, N., Robillard, N., Faivre-Chauvet, A., Bardiès, M., & Chatal, J. (1996) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(96)00059-5 · Cited by 6 · see citing works

A non-parametric method for the analysis of experimental tumour growth data

Chignola, R., Liberati, D., Chiesa, E., Anselmi, C., Foroni, R. I., Sartoris, S., Brendolan, A., Tridente, G., & Andrighetto, G. (1999) · Medical & Biological Engineering & Computing · doi:10.1007/bf02513343 · Cited by 5 · see citing works

Distribution of disialoganglioside GD2-antigen and binding of anti-GD2 antibodies on spheroids of neuroblastoma cell line.

Heiss, P., Bermatz, S., Wehnes, H., Heinzmann, U., & Senekowitsch–Schmidtke, R. (1997) · PubMed · Cited by 5 · see citing works

Uptake and release of radiolabelled monoclonal antibody Po66 by multicellular aggregates obtained from a lung squamous carcinoma cell line.

Dazord, L., Cavallier, A., Thomas, D., Guiraud, J.-M., Lannic, J. L., Robin, V., Collet, B., Desrues, B., Ramée, M. P., & Toujas, L. (1993) · PubMed · Cited by 4 · see citing works

Effects of interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) association in intraperitoneal radioimmunotherapy: studies on an in vitro micrometastasis model.

Imbert‐Marcille, B., Berreur, M., Thédrez, P., Riet, A. V., Devys, A., Chatal, J., & Pradal, G. (1995) · PubMed · Cited by 4 · see citing works

Effects of epidermal growth factor receptor blocking in cultured glioma spheroids.

Capala, J., Acker, H., Lindström, A., & Carlsson, J. (1994) · PubMed · Cited by 2 · see citing works

Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

Kelm, J. M., Timmins, N. E., Brown, C. J., Fussenegger, M., & Nielsen, L. K. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10655 · Cited by 934 · see citing works

The use of 3-d cultures for high-throughput screening: the multicellular spheroid model.

Kunz-Schughart, L. A., Freyer, J. P., Hofstaedter, F., & Ebner, R. (2004) · SLAS DISCOVERY · doi:10.1177/1087057104265040 · Cited by 797 · see citing works

Three-dimensional in vitro tumor models for cancer research and drug evaluation

Xu, X., Farach‐Carson, M. C., & Jia, X. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.07.009 · Cited by 462 · see citing works

Superior Penetration and Retention Behavior of 50 nm Gold Nanoparticles in Tumors

Huo, S., Ma, H., Huang, K., Liu, J., Wei, T., Jin, S., Zhang, J., He, S., & Liang, X. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2071 · Cited by 337 · see citing works

Molecular description of a 3D in vitro model for the study of epithelial ovarian cancer (EOC)

Zietarska, M., Maugard, C. M., Filali‐Mouhim, A., Alam‐Fahmy, M., Tonin, P. N., Provencher, D. M., & Mes‐Masson, A. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20315 · Cited by 209 · see citing works

Salmonella typhimurium specifically chemotax and proliferate in heterogeneous tumor tissue in vitro

Kasinskas, R. W., & Forbes, N. S. (2006) · Biotechnology and Bioengineering · doi:10.1002/bit.20883 · Cited by 210 · see citing works

Theoretical analysis of antibody targeting of tumor spheroids: importance of dosage for penetration, and affinity for retention.

Graff, C. P., & Wittrup, K. D. (2003) · PubMed · Cited by 207 · see citing works

Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid Tumors

Xiang, D., Zheng, C., Zhou, S., Qiao, S., Tran, P. H. L., Pu, C., Li, Y., Kong, L., Kouzani, A. Z., Lin, J., et al. (2015) · Theranostics · doi:10.7150/thno.11711 · Cited by 205 · see citing works

Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery

MacEwan, S. R., Callahan, D. J., & Chilkoti, A. (2010) · Nanomedicine · doi:10.2217/nnm.10.50 · Cited by 205 · see citing works

Development of Multicellular Tumor Spheroid (MCTS) Culture from Breast Cancer Cell and a High Throughput Screening Method Using the MTT Assay

Ho, W. Y., Yeap, S. K., Ho, C. L., Rahim, R. A., & Alitheen, N. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044640 · Cited by 173 · see citing works

Generation of Homogenous Three-Dimensional Pancreatic Cancer Cell Spheroids Using an Improved Hanging Drop Technique

Ware, M. J., Colbert, K. L., Keshishian, V., Ho, J., Corr, S. J., Curley, S. A., & Godin, B. (2016) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2015.0280 · Cited by 171 · see citing works

The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles

Kim, T.-H., Mount, C., Gombotz, W. R., & Pun, S. H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.004 · Cited by 165 · see citing works

Spatio‐temporal modeling of nanoparticle delivery to multicellular tumor spheroids

Goodman, T. T., Chen, J., Matveev, K. I., & Pun, S. H. (2008) · Biotechnology and Bioengineering · doi:10.1002/bit.21910 · Cited by 158 · see citing works

Nanoscale Drug Delivery Systems for Enhanced Drug Penetration into Solid Tumors: Current Progress and Opportunities

Waite, C. L., & Roth, C. M. (2012) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.v40.i1.20 · Cited by 156 · see citing works

Mammalian Target of Rapamycin Contributes to the Acquired Apoptotic Resistance of Human Mesothelioma Multicellular Spheroids

Barbone, D., Yang, T., Morgan, J. R., Gaudino, G., & Broaddus, V. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709698200 · Cited by 148 · see citing works

Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery

Dolor, A., & Szoka, F. C. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00319 · Cited by 141 · see citing works

cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors

Quader, S., Liu, X., Chen, Y., Mi, P., Chida, T., Ishii, T., Miura, Y., Nishiyama, N., Cabral, H., & Kataoka, K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.033 · Cited by 137 · see citing works

Predictive oncology: A review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth

Sanga, S., Frieboes, H. B., Zheng, X., Gatenby, R. A., Bearer, E. L., & Vittorio Cristini, C. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.05.043 · Cited by 130 · see citing works

Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells

Davies, C. D. L., Berk, D. A., Pluen, A., & Jain, R. K. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600270 · Cited by 121 · see citing works

Issues related to targeted delivery of proteins and peptides

Lu, Y. J., Yang, J. J. J., & Sega, E. I. (2006) · The AAPS Journal · doi:10.1208/aapsj080355 · Cited by 99 · see citing works

Anti‐tumor effects of toxins targeted to the prostate specific membrane antigen

Fracasso, G., Bellisola, G., Cingarlini, S., Castelletti, D., Prayer‐Galetti, T., Pagano, F. C., Tridente, G., & Colombatti, M. (2002) · The Prostate · doi:10.1002/pros.10117 · Cited by 92 · see citing works

Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions

Carver, K. A., Ming, X., & Juliano, R. L. (2014) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2014.5 · Cited by 75 · see citing works

A Novel In Vitro Model of Human Mesothelioma for Studying Tumor Biology and Apoptotic Resistance

Kim, K., Wilson, S. M., Abayasiriwardana, K. S., Collins, R., Fjellbirkeland, L., Xu, Z., Jablons, D. M., Nishimura, S. L., & Broaddus, V. C. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0355oc · Cited by 73 · see citing works

Pharmacokinetic strategies to improve drug penetration and entrapment within solid tumors

Al-Abd, A. M., Aljehani, Z. K., Gazzaz, R. W., Fakhri, S. H., Jabbad, A. H., Alahdal, A. M., & Torchilin, V. P. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.055 · Cited by 66 · see citing works

A synergic approach to enhance long-term culture and manipulation of MiaPaCa-2 pancreatic cancer spheroids

Cavo, M., Cave, D. D., D’Amone, E., Gigli, G., Lonardo, E., & del Mercato, L. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-66908-8 · Cited by 58 · see citing works

When the Optimal Is Not the Best: Parameter Estimation in Complex Biological Models

Fernández Slezak, D., Suárez, C., Cecchi, G. A., Marshall, G., & Stolovitzky, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013283 · Cited by 57 · see citing works

Application of PBPK modeling to predict monoclonal antibody disposition in plasma and tissues in mouse models of human colorectal cancer

Abuqayyas, L., & Balthasar, J. P. (2012) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-012-9279-8 · Cited by 51 · see citing works

Development of radiotracers for oncology – the interface with pharmacology

Sharma, R., & Aboagye, E. O. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01160.x · Cited by 50 · see citing works

Penetration and efficacy of VEGF siRNA using polyelectrolyte complex micelles in a human solid tumor model in-vitro

Al-Abd, A. M., Hyeon, L. S., Kim, S. H., Cha, J., Park, T. G., Lee, S. J., & Kuh, H. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.03.009 · Cited by 48 · see citing works

Emerging Technologies for Cancer Research: Towards Personalized Medicine with Microfluidic Platforms and 3D Tumor Models

Turetta, M., Ben, F. D., Brisotto, G., Biscontin, E., Bulfoni, M., Cesselli, D., Colombatti, A., Scoles, G., Gigli, G., & del Mercato, L. L. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180605122633 · Cited by 45 · see citing works

Application of the multicellular tumour spheroid model to screen PET tracers for analysis of early response of chemotherapy in breast cancer

Monazzam, A., Josephsson, R., BLOMQVIST, C. P., Carlsson, J., Långström, B., & Bergström, M. (2007) · Breast Cancer Research · doi:10.1186/bcr1747 · Cited by 33 · see citing works

γH2AX and cleaved PARP-1 as apoptotic markers in irradiated breast cancer BT474 cellular spheroids

Qvarnström (2009) · International Journal of Oncology · doi:10.3892/ijo_00000311 · Cited by 30 · see citing works

Cytoskeletal reorganization and repolarization of hepatocarcinoma cells in APA microcapsule to mimic native tumor characteristics

WANG, Q., Li, S., Xie, Y., Yu, W., Xiong, Y., MA, X., & YUAN, Q. (2006) · Hepatology Research · doi:10.1016/j.hepres.2006.03.003 · Cited by 27 · see citing works

Optical and magnetic resonance imaging approaches for investigating the tumour microenvironment: state-of-the-art review and future trends

Prasad, S., Chandra, A., Cavo, M., Parasido, E., Fricke, S., Lee, Y., D’Amone, E., Gigli, G., Albanese, C., Rodriguez, O., et al. (2020) · Nanotechnology · doi:10.1088/1361-6528/abc208 · Cited by 23 · see citing works

Cox-Inhibitors Relieve the Immunosuppressive Effect of Tumor Cells and Improve Functions of Immune Effectors

Lang, S., Picu, A., Hofmann, T., Andratschke, M., Mack, B., Moosmann, A., Gires, O., Tiwari, S., & Zeidler, R. (2006) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200601900217 · Cited by 24 · see citing works

Heat-induced transcription of diphtheria toxin A or its variants, CRM176 and CRM197: implications for pancreatic cancer gene therapy

Fogar, P., Navaglia, F., Basso, D., Zambon, C., Moserle, L., Indraccolo, S., Stranges, A., Greco, E., Fadi, E., Padoan, A., et al. (2009) · Cancer Gene Therapy · doi:10.1038/cgt.2009.48 · Cited by 23 · see citing works

Ex vivo cancer chemoprevention research possibilities

Hudson, E. A., Fox, L. H., Luckett, J., & Manson, M. M. (2005) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2005.07.011 · Cited by 22 · see citing works

Evaluation of the Hsp90 inhibitor NVP-AUY922 in multicellular tumour spheroids with respect to effects on growth and PET tracer uptake

Monazzam, A., Razifar, P., Ide, S. E., Jensen, M. R., Josephsson, R., BLOMQVIST, C. P., Långström, B., & Bergström, M. (2009) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2008.12.009 · Cited by 22 · see citing works

What Do, Can and Should We Learn From Models To Evaluate Potential Anticancer Agents?

Burchill, S. A. (2006) · Future Oncology · doi:10.2217/14796694.2.2.201 · Cited by 20 · see citing works

Identification of three gene candidates for multicellular resistance in colon carcinoma

Timmins, N. E., Maguire, T. L., Grimmond, S. M., & Nielsen, L. K. (2004) · Cytotechnology · doi:10.1007/s10616-005-1476-5 · Cited by 18 · see citing works

Photochemically enhanced adenoviral transduction in a multicellular environment

Bonsted, A., Engesæter, B. Ø., Høgset, A., & Berg, K. (2006) · Photochemical & Photobiological Sciences · doi:10.1039/b515066c · Cited by 6 · see citing works

Effects of affinity on binding of HER2-targeting Affibody molecules: Model experiments in breast cancer spheroids

Tran, T. A. (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.1045 · Cited by 5 · see citing works

Numerical simulation of avascular tumor growth

Slezak, D. F., Suárez, C. A., Soba, A., Risk, M. R., & Marshall, G. (2007) · Journal of Physics Conference Series · doi:10.1088/1742-6596/90/1/012049 · Cited by 5 · see citing works

Multicellular Tumour Spheroids in a Translational PET Imaging Strategy

Monazzam, A. (2007) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Photochemical delivery of bleomycin in malignant glioma cells

Blickenstaff, J. W. (2020) · Digital Scholarship - UNLV (University of Nevada Reno) · doi:10.34917/2508291

Engineering tumor-targeted poly(amidoamine) (PAMAM) dendrimers for improved penetration and cellular delivery of short-interfering RNA (siRNA) through solid tumors

Waite, C. L. (2011) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t36m35xg

Rapid Generation of In Vitro Multicellular Spheroids for the Study of Monoclonal Antibody Therapy

Phung, Y., Barbone, D., Broaddus, V. C., & Ho, M. (2011) · Journal of Cancer · doi:10.7150/jca.2.507 · Cited by 99 · see citing works

Test System for Trifunctional Antibodies in 3D MCTS Culture

Hirschhaeuser, F., Leidig, T., Rodday, B., Lindemann, C., & Mueller‐Klieser, W. (2009) · SLAS DISCOVERY · doi:10.1177/1087057109341766 · Cited by 46 · see citing works

Tumor spheroids: opportunities for in vitro validation of anticancer drugs in imaging and targeted drug delivery

Maity, A. R., Chandran, T., & Ghosh, S. K. (2026) · Therapeutic Delivery · doi:10.1080/20415990.2026.2699022

Drug delivery into multicellular tumor spheroids (MCTS) by polymeric micelles

Lu, H., & Martina, S. (2016) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/conf.fbioe.2016.01.01787

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