Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research

Angiogenesis in cancer, vascular, rheumatoid and other disease

Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627 · see citing works

Tumor Metastasis: Molecular Insights and Evolving Paradigms

Valastyan, S., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.024 · Cited by 4,011 · see citing works

Strategies in the design of nanoparticles for therapeutic applications

Petros, R. A., & DeSimone, J. M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2591 · Cited by 3,651 · see citing works

Drug penetration in solid tumours

Minchinton, A. I., & Tannock, I. F. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1893 · Cited by 2,805 · see citing works

Capturing complex 3D tissue physiology in vitro

Griffith, L. G., & Swartz, M. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1858 · Cited by 2,274 · see citing works

Distinct role of macrophages in different tumor microenvironments

Lewis, C. E., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4005 · Cited by 2,225 · see citing works

High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy

Heldin, C.-H., Rubin, K., Pietras, K., & Östman, A. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1456 · Cited by 2,222 · see citing works

Putting tumours in context

Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180 · see citing works

Cell and environment interactions in tumor microregions: the multicell spheroid model.

Sutherland, R. M. (1988) · Science · doi:10.1126/science.2451290 · Cited by 1,803 · see citing works

Multicellular tumor spheroids: An underestimated tool is catching up again

Hirschhaeuser, F., Menne, H., Dittfeld, C., West, J., Mueller-Klieser, W., & Kunz-Schughart, L. A. (2010) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2010.01.012 · Cited by 1,674 · see citing works

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

Bernardo, M. E., & Fibbe, W. E. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.09.006 · Cited by 1,389 · see citing works

Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress

Lammers, T., Kiessling, F., Hennink, W. E., & Storm, G. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.063 · Cited by 1,324 · see citing works

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

Danhier, F. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.11.015 · Cited by 1,288 · see citing works

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

Mehta, G., Hsiao, A. Y., Ingram, M., Luker, G. D., & Takayama, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.045 · Cited by 1,172 · see citing works

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

Zanoni, M., Piccinini, F., Arienti, C., Zamagni, A., Santi, S., Polico, R., Bevilacqua, A., & Tesei, A. (2016) · Scientific Reports · doi:10.1038/srep19103 · Cited by 1,144 · see citing works

Spheroid culture as a tool for creating 3D complex tissues

Fennema, E., Rivron, N., Rouwkema, J., van Blitterswijk, C., & de Boer, J. (2013) · Trends in Biotechnology · doi:10.1016/j.tibtech.2012.12.003 · Cited by 1,054 · see citing works

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

Vinci, M., Gowan, S., Boxall, F., Patterson, L., Zimmermann, M., Court, W., Lomas, C., Mendiola, M., Hardisson, D., & Eccles, S. A. (2012) · BMC Biology · doi:10.1186/1741-7007-10-29 · Cited by 1,024 · see citing works

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

Tung, Y.-C., Hsiao, A. Y., Allen, S. G., Torisawa, Y.-S., Ho, M., & Takayama, S. (2011) · The Analyst · doi:10.1039/c0an00609b · Cited by 969 · see citing works

Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

Kelm, J. M., Timmins, N. E., Brown, C. J., Fussenegger, M., & Nielsen, L. K. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10655 · Cited by 934 · see citing works

Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo

Huang, K., Ma, H., Liu, J., Huo, S., Kumar, A., Wei, T., Zhang, X., Jin, S., Gan, Y., Wang, P. C., et al. (2012) · ACS Nano · doi:10.1021/nn301282m · Cited by 843 · see citing works

EPR: Evidence and fallacy

Nichols, J. W., & Bae, Y. H. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.057 · Cited by 834 · see citing works

Cell-penetrating peptides: classes, origin, and current landscape

Milletti, F. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.03.002 · Cited by 811 · see citing works

In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform

Katt, M. E., Placone, A. L., Wong, A. D., Xu, Z. S., & Searson, P. C. (2016) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2016.00012 · Cited by 754 · see citing works

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression

Gottfried, E., Kunz-Schughart, L. A., Ebner, S., Mueller-Klieser, W., Hoves, S., Andreesen, R., Mackensen, A., & Kreutz, M. (2006) · Blood · doi:10.1182/blood-2005-05-1795 · Cited by 729 · see citing works

Investigating the optimal size of anticancer nanomedicine

Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411499111 · Cited by 658 · see citing works

Exosome-mediated delivery of siRNA in vitro and in vivo

Andaloussi, S. E., Lee, Y., Lakhal‐Littleton, S., Li, J., Seow, Y., Gardiner, C., Alvarez‐Erviti, L., Sargent, I. L., & Wood, M. J. A. (2012) · Nature Protocols · doi:10.1038/nprot.2012.131 · Cited by 602 · see citing works

Rapid Generation of Single-Tumor Spheroids for High-Throughput Cell Function and Toxicity Analysis

Ivascu, A., & Kubbies, M. (2006) · SLAS DISCOVERY · doi:10.1177/1087057106292763 · Cited by 598 · see citing works

Growth of Multicell Spheroids in Tissue Culture as a Model of Nodular Carcinomas 2

Sutherland, R. M., McCredie, J. A., & Inch, W. R. (1971) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/46.1.113 · Cited by 585 · see citing works

A Cellular Trojan Horse for Delivery of Therapeutic Nanoparticles into Tumors

Choi, M.-R., Stanton-Maxey, K. J., Stanley, J. K., Levin, C. S., Bardhan, R., Akin, D., Badve, S., Sturgis, J. E., Robinson, J. P., Bashir, R., et al. (2007) · Nano Letters · doi:10.1021/nl072209h · Cited by 584 · see citing works

Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications

Maeda, H., Fang, J. Q., Inutsuka, T., & Kitamoto, Y. (2003) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00271-0 · Cited by 537 · see citing works

A simplified method for production and growth of multicellular tumor spheroids.

Yuhas, J. M., Li, A. P., Martinez, A. O., & Ladman, A. J. (1977) · PubMed · Cited by 506 · see citing works

Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals

Ying, X., Wen, H., Lü, W.-L., Du, J., Guo, J., Tian, W. J., Men, Y., Zhang, Y., Li, R., Yang, T., et al. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.09.020 · Cited by 448 · see citing works

Experimental anti-tumor therapy in 3-D: Spheroids – old hat or new challenge?

Friedrich, J., Ebner, R., & Kunz‐Schughart, L. A. (2007) · International Journal of Radiation Biology · doi:10.1080/09553000701727531 · Cited by 445 · see citing works

3D tumour models: novel in vitro approaches to cancer studies

Nyga, A., Cheema, U., & Loizidou, M. (2011) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-011-0132-4 · Cited by 403 · see citing works

Superior Penetration and Retention Behavior of 50 nm Gold Nanoparticles in Tumors

Huo, S., Ma, H., Huang, K., Liu, J., Wei, T., Jin, S., Zhang, J., He, S., & Liang, X. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2071 · Cited by 337 · see citing works

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

Albanese, A., Lam, A. K., Sykes, E. A., Rocheleau, J. V., & Chan, W. C. W. (2013) · Nature Communications · doi:10.1038/ncomms3718 · Cited by 330 · see citing works

Exosomes as novel bio-carriers for gene and drug delivery

Jiang, X., & Gao, J. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.02.038 · Cited by 321 · see citing works

Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

Song, J. W., Cavnar, S. P., Walker, A. C., Luker, K. E., Gupta, M., Tung, Y.-C., Luker, G. D., & Takayama, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005756 · Cited by 317 · see citing works

Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles

Xin, H., Sha, X., Jiang, X., Zhang, W., Chen, L., & Fang, X. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.07.046 · Cited by 311 · see citing works

PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors

He, H., Li, Y., Jia, X., Du, J., Ying, X., Lü, W.-L., Lou, J., & Wei, Y. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.09.002 · Cited by 303 · see citing works

Increased nanoparticle penetration in collagenase-treated multicellular spheroids.

Goodman, T. T., Olive, P. L., & Pun, S. H. (2007) · PubMed Central · Cited by 302 · see citing works

Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release

Ruan, S., Cao, X., Cun, X., Hu, G., Zhou, Y., Zhang, Y., Lu, L., He, Q., & Gao, H. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.05.006 · Cited by 291 · see citing works

Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells

Rao, W., Wang, H., Han, J., Zhao, S., Dumbleton, J., Agarwal, P., Zhang, W., Zhao, G., Yu, J., Zynger, D. L., et al. (2015) · ACS Nano · doi:10.1021/nn506928p · Cited by 281 · see citing works

Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles

Gao, H., Qian, J., Cao, S., Yang, Z. H., Pang, Z., Pan, S., Fan, L., Xi, Z., Jiang, X., & Zhang, Q. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.058 · Cited by 280 · see citing works

Microfluidic self-assembly of tumor spheroids for anticancer drug discovery

Wu, L. Y., Carlo, D. D., & Lee, L. P. (2007) · Biomedical Microdevices · doi:10.1007/s10544-007-9125-8 · Cited by 268 · see citing works

Recent advances in cancer stem cells.

Cho, R. W., & Clarke, M. F. (2008) · Current Opinion in Genetics and Development · doi:10.1016/j.gde.2008.01.017 · Cited by 257 · see citing works

The multicellular tumor spheroid model for high-throughput cancer drug discovery

LaBarbera, D. V., Reid, B. G., & Yoo, B. H. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.708334 · Cited by 254 · see citing works

Methotrexate Loaded Polyether-Copolyester Dendrimers for the Treatment of Gliomas: Enhanced Efficacy and Intratumoral Transport Capability

Dhanikula, R. S., Argaw, A., Bouchard, J., & Hildgen, P. (2008) · Molecular Pharmaceutics · doi:10.1021/mp700086j · Cited by 246 · see citing works

Generation of Multicellular Tumor Spheroids by the Hanging-Drop Method

Timmins, N. E., & Nielsen, L. K. (2007) · Methods in Molecular Medicine™ · doi:10.1007/978-1-59745-443-8_8 · Cited by 241 · see citing works

Chemotherapeutic drug delivery to cancer cells using a combination of folate targeting and tumor microenvironment-sensitive polypeptides

Gao, W., Xiang, B., Meng, T., Liu, F., & Qi, X. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.014 · Cited by 238 · see citing works

AlgiMatrix™ Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies

Godugu, C., Patel, A. R., Desai, U. S., Andey, T. A., Sams, A., & Singh, M. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053708 · Cited by 234 · see citing works

The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy

Burke, A. R., Singh, R. N., Carroll, D., Wood, J. C. S., D’Agostino, R. B., Ajayan, P. M., Torti, F. M., & Torti, S. V. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.052 · Cited by 227 · see citing works

Life in 3D is never flat: 3D models to optimise drug delivery

Fitzgerald, K. A., Malhotra, M., Curtin, C. M., O’Brien, F. J., & O’Driscoll, C. M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.020 · Cited by 226 · see citing works

Mind the gap: A survey of how cancer drug carriers are susceptible to the gap between research and practice

Stirland, D. L., Nichols, J. W., Miura, S., & Bae, Y. H. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.09.026 · Cited by 225 · see citing works

Three-dimensional growth patterns of various human tumor cell lines in simulated microgravity of a NASA bioreactor

Ingram, M., Techy, G. B., Saroufeem, R. M. G., Yazan, O., Narayan, K. S., Goodwin, T. J., & Spaulding, G. F. (1997) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-997-0064-8 · Cited by 225 · see citing works

Multicellular tumor spheroids: intermediates between monolayer culture and in vivo tumor

Kunz‐Schughart, L. A. (1999) · Cell Biology International · doi:10.1006/cbir.1999.0384 · Cited by 217 · see citing works

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

Vinci, M., Box, C., & Eccles, S. A. (2015) · Journal of Visualized Experiments · doi:10.3791/52686 · Cited by 214 · see citing works

Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways

Onodera, Y., Nam, J., & Bissell, M. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci63146 · Cited by 209 · see citing works

3-D Tissue Culture Systems for the Evaluation and Optimization of Nanoparticle-Based Drug Carriers

Goodman, T. T., Ng, C. P., & Pun, S. H. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800233a · Cited by 208 · see citing works

Hyaluronic Acid-Based Nanogel–Drug Conjugates with Enhanced Anticancer Activity Designed for the Targeting of CD44-Positive and Drug-Resistant Tumors

Wei, X., Senanayake, T. H., Warren, G., et al. (2013) · Bioconjugate Chemistry · doi:10.1021/bc300632w · Cited by 195 · see citing works

F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery

Hu, Q., Gu, G., Liu, Z., Jiang, M., Kang, T., Miao, D., Tu, Y., Pang, Z., Song, Q., Yao, L., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.10.048 · Cited by 194 · see citing works

Generation of Multicellular Breast Cancer Tumor Spheroids: Comparison of Different Protocols

Fröhlich, K., Häeger, J.-D., Héger, J., Pastuschek, J., Photini, S. M., Yan, Y., Lupp, A., Pfarrer, C. D., Mrowka, R., Schleußner, E., et al. (2016) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-016-9359-2 · Cited by 189 · see citing works

Intratumoral Drug Delivery with Nanoparticulate Carriers

Holback, H., & Yeo, Y. (2011) · Pharmaceutical Research · doi:10.1007/s11095-010-0360-y · Cited by 186 · see citing works

PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy

Gu, G., Xia, H., Hu, Q., Liu, Z., Jiang, M., Kang, T., Miao, D., Tu, Y., Pang, Z., Song, Q., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.044 · Cited by 184 · see citing works

Multicellular tumor spheroids as an in vivo-like tumor model for three-dimensional imaging of chemotherapeutic and nano material cellular penetration

Ma, H.-L., Jiang, Q., Han, S., Wu, Y., Tomshine, J. C., Wang, D., Gan, Y., Zou, G., & Liang, X.-J. (2012) · Molecular Imaging · doi:10.2310/7290.2012.00012 · Cited by 182 · see citing works

Glioma therapy using tumor homing and penetrating peptide-functionalized PEG–PLA nanoparticles loaded with paclitaxel

Hu, Q., Gao, X., Gu, G., Kang, T., Tu, Y., Liu, Z., Song, Q., Yao, L., Pang, Z., Jiang, X., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.04.025 · Cited by 174 · see citing works

Development of Multicellular Tumor Spheroid (MCTS) Culture from Breast Cancer Cell and a High Throughput Screening Method Using the MTT Assay

Ho, W. Y., Yeap, S. K., Ho, C. L., Rahim, R. A., & Alitheen, N. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044640 · Cited by 173 · see citing works

Using Fluorescence Lifetime Imaging Microscopy to Monitor Theranostic Nanoparticle Uptake and Intracellular Doxorubicin Release

Basuki, J. S., Duong, H. T. T., Macmillan, A., Erlich, R. B., Esser, L., Åkerfeldt, M. C., Whan, R. M., Kavallaris, M., Boyer, C. A., & Davis, T. P. (2013) · ACS Nano · doi:10.1021/nn404407g · Cited by 172 · see citing works

Cancer cell spheroids as a model to evaluate chemotherapy protocols

Perche, F., & Torchilin, V. P. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.21353 · Cited by 163 · see citing works

Spatio‐temporal modeling of nanoparticle delivery to multicellular tumor spheroids

Goodman, T. T., Chen, J., Matveev, K. I., & Pun, S. H. (2008) · Biotechnology and Bioengineering · doi:10.1002/bit.21910 · Cited by 158 · see citing works

Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment

Reynolds, D. S., Tevis, K. M., Blessing, W. A., Colson, Y. L., Zaman, M. H., & Grinstaff, M. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-10863-4 · Cited by 156 · see citing works

Enhancing Accumulation and Penetration of HPMA Copolymer–Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer

Peng, Z., & Kopec̆ek, J. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b00922 · Cited by 151 · see citing works

Liposome-based engineering of cells to package hydrophobic compounds in membrane vesicles for tumor penetration.

Lee, J.-S., Kim, J., Jeong, M., Lee, H., Goh, U., Kim, H., Kim, B., & Park, J.-H. (2015) · Nano letters (Print) · doi:10.1021/nl5047494 · Cited by 151 · see citing works

Exploiting macrophages as targeted carrier to guide nanoparticles into glioma

Pang, L., Qin, J., Han, L., Zhao, W., Liang, J., Xie, Z., Yang, P., & Wang, J. (2016) · Oncotarget · doi:10.18632/oncotarget.9464 · Cited by 151 · see citing works

Review: <i>in vitro</i> microvessel models

Bogorad, M. I., DeStefano, J., Karlsson, J., Wong, A. D., Gerecht, S., & Searson, P. C. (2015) · Lab on a Chip · doi:10.1039/c5lc00832h · Cited by 145 · see citing works

Engineering liver tissue spheroids with inverted colloidal crystal scaffolds

Lee, J., Cuddihy, M. J., Cater, G. M., & Kotov, N. A. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.05.024 · Cited by 145 · see citing works

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

Young, E. W. K. (2013) · Integrative Biology · doi:10.1039/c3ib40076j · Cited by 144 · see citing works

The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells

Yao, H.-J., Zhang, Y., Sun, L., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.07.033 · Cited by 142 · see citing works

Tumor cells and their crosstalk with endothelial cells in 3D spheroids

Shoval, H., Karsch-Bluman, A., Brill-Karniely, Y., Stern, T., Zamir, G., Hubert, A., & Benny, O. (2017) · Scientific Reports · doi:10.1038/s41598-017-10699-y · Cited by 138 · see citing works

Translating tissue engineering technology platforms into cancer research

Hutmacher, D. W., Horch, R. E., Loessner, D., Rizzi, S. C., Sieh, S., Reichert, J. C., Clements, J. A., Beier, J. P., Arkudas, A., Bleiziffer, O., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00853.x · Cited by 136 · see citing works

Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG–PE micelles in ovarian cancer cell spheroid model

Perche, F., Patel, N. R., & Torchilin, V. P. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.09.003 · Cited by 136 · see citing works

Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies

Ong, S., Zhao, Z., Arooz, T., Zhao, D., Zhang, S., Du, T., Wasser, M., van Noort, D., & Yu, H. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.049 · Cited by 135 · see citing works

Development of an <i>in Vitro</i> 3D Tumor Model to Study Therapeutic Efficiency of an Anticancer Drug

Shin, C. S., Kwak, B., Han, B., & Park, K. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300595a · Cited by 135 · see citing works

Hybrid-Actuating Macrophage-Based Microrobots for Active Cancer Therapy

Han, J., Zhen, J., Nguyen, V. D., et al. (2016) · Scientific Reports · doi:10.1038/srep28717 · Cited by 135 · see citing works

The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells

Gu, G., Gao, X., Hu, Q., Kang, T., Liu, Z., Jiang, M., Miao, D., Song, Q., Yao, L., Tu, Y., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.036 · Cited by 133 · see citing works

Cell spheroids: the new frontiers in in vitro models for cancer drug validation

Chatzinikolaidou, Μ. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.06.024 · Cited by 131 · see citing works

Micro-ring structures stabilize microdroplets to enable long term spheroid culture in 384 hanging drop array plates

Hsiao, A. Y., Tung, Y.-C., Kuo, C.-H., Mosadegh, B., Bedenis, R., Pienta, K. J., & Takayama, S. (2012) · Biomedical Microdevices · doi:10.1007/s10544-011-9608-5 · Cited by 129 · see citing works

Cisplatin–alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells

Wang, Y., Zhou, J., Qiu, L., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.035 · Cited by 128 · see citing works

Binding and interstitial penetration of liposomes within avascular tumor spheroids

Kostarelos, K., Emfietzoglou, D., Papakostas, A., Yang, W., Ballangrud, Å., & Sgouros, G. (2004) · International Journal of Cancer · doi:10.1002/ijc.20457 · Cited by 127 · see citing works

Impact of the spheroid model complexity on drug response

Hoffmann, O. I., Ilmberger, C., Magosch, S., Joka, M., Jauch, K.-W., & Mayer, B. (2015) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2015.02.029 · Cited by 125 · see citing works

Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors

Iessi, E., Logozzi, M., Lugini, L., et al. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2017.1292263 · Cited by 122 · see citing works

Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas

Allard-Vannier, É., Passirani, C., Garcion, E., et al. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.027 · Cited by 121 · see citing works

A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics

Xu, X., Sabanayagam, C. R., Harrington, D. A., Farach‐Carson, M. C., & Jia, X. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.080 · Cited by 118 · see citing works

Appropriate Size of Magnetic Nanoparticles for Various Bioapplications in Cancer Diagnostics and Therapy

Guo, X., Wu, Z., Li, W., Wang, Z., Li, Q., Kong, F., Zhang, H., Zhu, X., Du, Y. P., Jin, Y., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b10352 · Cited by 117 · see citing works

Exosomes function in cell–cell communication during brain circuit development

Sharma, P., Schiapparelli, L., & Cline, H. T. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.08.005 · Cited by 110 · see citing works

Nanomedicine based curcumin and doxorubicin combination treatment of glioblastoma with scFv-targeted micelles: In vitro evaluation on 2D and 3D tumor models

Sarısözen, C., Dhokai, S., Tsikudo, E. G., Luther, E., Rachman, I. M., & Torchilin, V. P. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.08.013 · Cited by 108 · see citing works

Size and Surface Charge of Engineered Poly(amidoamine) Dendrimers Modulate Tumor Accumulation and Penetration: A Model Study Using Multicellular Tumor Spheroids

Bugno, J., Hsu, H.-J., Pearson, R. M., Noh, H., & Hong, S. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00946 · Cited by 107 · see citing works

Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine

Harink, B., Gac, S. L., Truckenmüller, R. K., van Blitterswijk, C., & Habibović, P. (2013) · Lab on a Chip · doi:10.1039/c3lc50293g · Cited by 105 · see citing works

The eradication of breast cancer cells and stem cells by 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticle-supported lipid bilayers containing docetaxel

Wang, D., Huang, J., Wang, X., Yu, Y., Zhang, H., Chen, Y., Liu, J., Sun, Z., Zou, H. L., Sun, D., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.06.042 · Cited by 103 · see citing works

Increased tumor targeted delivery using a multistage liposome system functionalized with RGD, TAT and cleavable PEG

Mei, L., Fu, L., Shi, K., Zhang, Q., Liu, Y., Tang, J., Gao, H., Zhang, Z., & He, Q. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.04.008 · Cited by 103 · see citing works

Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy

Sha, H., Zou, Z., Xin, K., Bian, X., Cai, X., Lu, W., Chen, J., Chen, G., Huang, L., Blair, A. M., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.039 · Cited by 103 · see citing works

Tumor-associated macrophages are predominant carriers of cyclodextrin-based nanoparticles into gliomas

Alizadeh, D., Zhang, L., Hwang, J., et al. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.10.001 · Cited by 103 · see citing works

A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems

Tang, Y., Soroush, F., Sheffield, J. B., Wang, B., Prabhakarpandian, B., & Kiani, M. F. (2017) · Scientific Reports · doi:10.1038/s41598-017-09815-9 · Cited by 102 · see citing works

Pulsed Ultrasound Enhances Nanoparticle Penetration into Breast Cancer Spheroids

Grainger, S. J., Serna, J. V., Sunny, S., Zhou, Y., Deng, C. X., & ElSayed, M. E. H. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100280b · Cited by 99 · see citing works

Tissue-engineered kidney disease models

DesRochers, T. M., Palma, E., & Kaplan, D. L. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.12.002 · Cited by 99 · see citing works

Tumor Engineering: The Other Face of Tissue Engineering

Ghajar, C. M., & Bissell, M. J. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0135 · Cited by 96 · see citing works

Predictive Models of Diffusive Nanoparticle Transport in 3-Dimensional Tumor Cell Spheroids

Gao, Y., Li, M., Chen, B., et al. (2013) · The AAPS Journal · doi:10.1208/s12248-013-9478-2 · Cited by 95 · see citing works

Exosomes: the ideal nanovectors for biodelivery

Fais, S., Logozzi, M., Lugini, L., Federici, C., Azzarito, T., Zarovni, N., & Chiesi, A. (2012) · Biological Chemistry · doi:10.1515/hsz-2012-0236 · Cited by 90 · see citing works

Formation and manipulation of cell spheroids using a density adjusted PEG/DEX aqueous two phase system

Han, C., Takayama, S., & Park, J. (2015) · Scientific Reports · doi:10.1038/srep11891 · Cited by 90 · see citing works

Liposome-Based Systemic Glioma-Targeted Drug Delivery Enabled by All- d Peptides

Man, Y. M., Zhan, C., Wang, S., Yao, B., Hu, X., Song, X., Zhang, M., Wei, X., Xiong, Y., & Lu, W. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b10146 · Cited by 90 · see citing works

Mesenchymal Stem Cells as a Novel Carrier for Targeted Delivery of Gene in Cancer Therapy Based on Nonviral Transfection

Hu, Y., Huang, B., Zhang, T., Miao, P., Tang, G., Tabata, Y., & Gao, J. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300254s · Cited by 87 · see citing works

Design of Y-shaped targeting material for liposome-based multifunctional glioblastoma-targeted drug delivery

Belhadj, Z., Man, Y. M., Cao, X., Hu, X., Zhan, C., Wei, X., Gao, J., Wang, X., Yan, Z., & Lu, W. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.006 · Cited by 86 · see citing works

Detection of Hypoxic cells in a Murine Tumour With the Use of the Comet Assay

Olive, P. L., & Durand, R. E. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.9.707 · Cited by 83 · see citing works

Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice.

Zhang, T.-Y., Huang, B., Wu, H.-B., Wu, J.-H., Li, L.-M., Li, Y., Hu, Y.-L., Han, M., Shen, Y.-Q., Tabata, Y., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.05.007 · Cited by 80 · see citing works

CGKRK-modified nanoparticles for dual-targeting drug delivery to tumor cells and angiogenic blood vessels

Hu, Q., Gao, X., Kang, T., Feng, X., Jiang, D., Tu, Y., Song, Q., Yao, L., Jiang, X., Chen, H., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.001 · Cited by 80 · see citing works

Toward the broad adoption of 3D tumor models in the cancer drug pipeline

Cox, M. C., Reese, L. M., Bickford, L. R., & Verbridge, S. S. (2015) · ACS Biomaterials Science &amp; Engineering · doi:10.1021/acsbiomaterials.5b00172 · Cited by 80 · see citing works

Solid lipid nanoparticles co-loaded with doxorubicin and α-tocopherol succinate are effective against drug-resistant cancer cells in monolayer and 3-D spheroid cancer cell models

Oliveira, M. S., Aryasomayajula, B., Pattni, B. S., et al. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.08.049 · Cited by 79 · see citing works

Nanotechnology-Based Cancer Therapeutics—Promise and Challenge—Lessons Learned Through the NCI Alliance for Nanotechnology in Cancer

Farrell, D. F., Ptak, K., Panaro, N. J., & Grodzinski, P. A. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0214-7 · Cited by 76 · see citing works

Nanoparticles Penetrate into the Multicellular Spheroid-on-Chip: Effect of Surface Charge, Protein Corona, and Exterior Flow

Huang, K., Boerhan, R., Liu, C., & Jiang, G. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00726 · Cited by 74 · see citing works

Recapitulating epithelial tumor microenvironment in vitro using three dimensional tri-culture of human epithelial, endothelial, and mesenchymal cells

Lamichhane, S. P., Arya, N., Kohler, E., Xiang, S., Christensen, J., & Shastri, V. P. (2016) · BMC Cancer · doi:10.1186/s12885-016-2634-1 · Cited by 74 · see citing works

Alginate-based microfluidic system for tumor spheroid formation and anticancer agent screening

Chen, M. C. W., Gupta, M., & Cheung, K. C. (2010) · Biomedical Microdevices · doi:10.1007/s10544-010-9417-2 · Cited by 70 · see citing works

BBB-Genomics: creating new openings for brain-drug targeting

Pardridge, W. M. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(01)01721-4 · Cited by 70 · see citing works

Mechanisms of Drug Resistance Related to the Microenvironment of Solid Tumors and Possible Strategies to Inhibit Them

Tan, Q., Saggar, J. K., Yu, M., Wang, M., & Tannock, I. F. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000131 · Cited by 68 · see citing works

Drug delivery: Beyond active tumour targeting

Sagnella, S. M., McCarroll, J. A., & Kavallaris, M. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.04.012 · Cited by 68 · see citing works

Therapeutic implications of tumor interstitial fluid pressure in subcutaneous RG-2 tumors

Navalitloha, Y. (2006) · Neuro-Oncology · doi:10.1215/15228517-2006-007 · Cited by 64 · see citing works

A Hollow Sphere Soft Lithography Approach for Long-Term Hanging Drop Methods

Lee, W. G., Ortmann, D., Hancock, M. J., Bae, H., & Khademhosseini, A. (2010) · Tissue Engineering Part C: Methods · doi:10.1089/ten.tec.2009.0248 · Cited by 62 · see citing works

Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides

Ming, X., Carver, K. A., & Wu, L. H. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.06.066 · Cited by 59 · see citing works

Image-based analysis of the size- and time-dependent penetration of polymeric micelles in multicellular tumor spheroids and tumor xenografts

Mikhail, A. S., Eetezadi, S., Ekdawi, S. N., Stewart, J., & Allen, C. J. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.01.010 · Cited by 57 · see citing works

Sustained Expression of the RON Receptor Tyrosine Kinase by Pancreatic Cancer Stem Cells as a Potential Targeting Moiety for Antibody-Directed Chemotherapeutics

Padhye, S., Guin, S., Yao, H., Zhou, Y.-Q., Zhang, R., & Wang, M. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200193u · Cited by 56 · see citing works

pH-responsive endosomolytic pseudo-peptides for drug delivery to multicellular spheroids tumour models

Ho, V. H. B., Slater, N. K. H., & Chen, R. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.010 · Cited by 55 · see citing works

Penetration of Endothelial Cell Coated Multicellular Tumor Spheroids by Iron Oxide Nanoparticles

Ho, D. N., Kohler, N., Sigdel, A., Kalluri, R., Morgan, J. R., Xu, C., & Sun, S. (2012) · Theranostics · doi:10.7150/thno.3568 · Cited by 53 · see citing works

Improved Tat-mediated plasmid DNA transfer by fusion to LK15 peptide

Saleh, A. F. A., Aojula, H. S., Arthanari, Y., Offerman, S. C., Alkotaji, M. M., & Pluen, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.12.025 · Cited by 51 · see citing works

Production of Cisplatin-Incorporating Hyaluronan Nanogels via Chelating Ligand–Metal Coordination

Ohta, S., Hiramoto, S., Amano, Y., Sato, M., Suzuki, Y., Shinohara, M., Emoto, S., Yamaguchi, H., Ishigami, H., Sakai, Y., et al. (2016) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00674 · Cited by 51 · see citing works

Mimicking Tumors: Toward More Predictive In Vitro Models for Peptide- and Protein-Conjugated Drugs

van den Brand, D., Massuger, L. F. A. G., Brock, R. E., & Verdurmen, W. P. R. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00699 · Cited by 48 · see citing works

Mesothelial cells interact with tumor cells for the formation of ovarian cancer multicellular spheroids in peritoneal effusions

Matte, I., Legault, C. M., Garde‐Granger, P., Laplante, C., Bessette, P., Rancourt, C., & Piché, A. (2016) · Clinical & Experimental Metastasis · doi:10.1007/s10585-016-9821-y · Cited by 44 · see citing works

Engineering Lipid Vesicles of Enhanced Intratumoral Transport Capabilities: Correlating Liposome Characteristics with Penetration into Human Prostate Tumor Spheroids

Kostarelos, K., Emfietzoglou, D., Papakostas, A., et al. (2005) · Journal of Liposome Research · doi:10.1081/lpr-64953 · Cited by 43 · see citing works

Paclitaxel Tumor-Priming Enhances siRNA Delivery and Transfection in 3-Dimensional Tumor Cultures

Wong, H. L., Shen, Z., Lu, Z., et al. (2011) · Molecular Pharmaceutics · doi:10.1021/mp1004383 · Cited by 42 · see citing works

Morphological and Immunohistochemical Characterization of Canine Osteosarcoma Spheroid Cell Cultures

Gebhard, C., Gabriel, C., & Walter, I. (2015) · Anatomia Histologia Embryologia · doi:10.1111/ahe.12190 · Cited by 39 · see citing works

Manipulating Magnetic 3D Spheroids in Hanging Drops for Applications in Tissue Engineering and Drug Screening

Ho, V. H. B., Guo, W. M., Huang, C. L., Ho, S. F., Chaw, S. Y., Tan, E. Y., Ng, K. W., & Loo, S. C. J. (2013) · Advanced Healthcare Materials · doi:10.1002/adhm.201200408 · Cited by 37 · see citing works

Interaction of liposome-associated all- trans- retinoic acid with squamous carcinoma cells

Parthasarathy, R. V., Sacks, P. G., Harris, D., Brock, H., & Mehta, K. (1994) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00685666 · Cited by 37 · see citing works

Interactions of Pluronic nanocarriers with 2D and 3D cell cultures: Effects of PEO block length and aggregation state

Arranja, A., Denkova, A. G., Morawska, K., Waton, G., Vlierberghe, S. V., Dubruel, P., Schosseler, F., & Mendes, E. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.014 · Cited by 37 · see citing works

Delivery of improved oncolytic adenoviruses by mesenchymal stromal cells for elimination of tumorigenic pancreatic cancer cells

Kaczorowski, A., Hammer, K., Liu, L., Villhauer, S., Nwaeburu, C. C., Fan, P., Zhao, Z., Gladkich, J., Groß, W., Nettelbeck, D. M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7031 · Cited by 35 · see citing works

Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis

Mitchell, M. J., Webster, J., Chung, A., Guimarães, P. P. G., Khan, O. F., & Langer, R. (2017) · Nature Communications · doi:10.1038/ncomms14179 · Cited by 34 · see citing works

Multicellular spheroids as anin vitromodel in experimental oncology: applications in translational medicine

Khaitan, D., & Dwarakanath, B. S. R. (2006) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.1.7.663 · Cited by 33 · see citing works

Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles

Lv, L., Jiang, Y., Liu, X., et al. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00523 · Cited by 33 · see citing works

3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation

Sethi, P., Jyoti, A., Swindell, E. P., Chan, R., Langner, U. W., Feddock, J., Nagarajan, R., O’Halloran, T. V., & Upreti, M. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.07.013 · Cited by 32 · see citing works

Suppression for lung metastasis by depletion of collagen I and lysyl oxidase via losartan assisted with paclitaxel-loaded pH-sensitive liposomes in breast cancer

Zhang, L., Wang, Y., Xia, T., Yu, Q., Zhang, Q., Yang, Y., Cun, X., Lu, L., Gao, H., Zhang, Z., et al. (2016) · Drug Delivery · doi:10.3109/10717544.2015.1132798 · Cited by 32 · see citing works

Three‐dimensional microtissues essentially contribute to preclinical validations of therapeutic targets in breast cancer

Falkenberg, N., Höfig, I., Rosemann, M., et al. (2016) · Cancer Medicine · doi:10.1002/cam4.630 · Cited by 30 · see citing works

A Novel Computer-Assisted Approach to evaluate Multicellular Tumor Spheroid Invasion Assay

Castillo, L. R. C., Oancea, A., Stüllein, C., et al. (2016) · Scientific Reports · doi:10.1038/srep35099 · Cited by 24 · see citing works

Glycogen synthase kinase-3β inhibition induces nuclear factor-κB-mediated apoptosis in pediatric acute lymphocyte leukemia cells

Hu, Y., Gu, X., Li, R., Luo, Q., & Xu, Y. (2010) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-29-154 · Cited by 19 · see citing works

An in vitro assessment of liposomal topotecan simulating metronomic chemotherapy in combination with radiation in tumor-endothelial spheroids

Jyoti, A., Fugit, K. D., Sethi, P., McGarry, R. C., Anderson, B. D., & Upreti, M. (2015) · Scientific Reports · doi:10.1038/srep15236 · Cited by 17 · see citing works

Evaluation of β-cyclodextrin-modified gemini surfactant-based delivery systems in melanoma models

Michel, D. L., Mohammed‐Saeid, W., Getson, H. M., et al. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s121156 · Cited by 15 · see citing works

Use of Three‐Dimensional Arterial Models To Predict the In Vivo Behavior of Nanoparticles for Drug Delivery

Chetprayoon, P., Matsusaki, M., Yokoyama, U., et al. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201509752 · Cited by 13 · see citing works

Impact of wall shear stress and ligand avidity on binding of anti-CD146-coated nanoparticles to murine tumor endothelium under flow

Thomann, S., Baek, S., & Ryschich, E. (2015) · Oncotarget · doi:10.18632/oncotarget.5662 · Cited by 11 · see citing works

Unique Boron Carbide Nanoparticle Nanobio Interface: Effects on Protein-RNA Interactions and 3-D Spheroid Metastatic Phenotype.

DeLong, R. K., Hurst, M. N., Aryal, S., et al. (2016) · PubMed · Cited by 11 · see citing works

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Nunes, A. S., Barros, A. S., Costa, E. C., Moreira, A. F., & Correia, I. J. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26845 · Cited by 721 · see citing works

Challenges of applying multicellular tumor spheroids in preclinical phase

Han, S. J., Kwon, S., & Kim, K. S. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01853-8 · Cited by 428 · see citing works

Colorectal cancer triple co-culture spheroid model to assess the biocompatibility and anticancer properties of polymeric nanoparticles

Bauleth-Ramos, T., Feijão, T., Gonçalves, A., Shahbazi, M.-A., Liu, Z., Barrias, C., Oliveira, M. J., Granja, P., Santos, H. A., & Sarmento, B. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.025 · Cited by 79 · see citing works

Nucleolin-Targeting AS1411 Aptamer-Modified Micelle for the Co-Delivery of Doxorubicin and miR-519c to Improve the Therapeutic Efficacy in Hepatocellular Carcinoma Treatment

Liang, X., Wang, Y., Shi, H., Dong, M., Han, H., & Li, Q. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s304526 · Cited by 41 · see citing works

3D Tumor Spheroid Models for In Vitro Therapeutic Screening of Nanoparticles

Daunys, S., Janonienė, A., Januškevičienė, I., Paškevičiūtė, M., & Petrikaitė, V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-58174-9_11 · Cited by 32 · see citing works

Recent advances in three‐dimensional multicellular spheroid culture for biomedical research

Lin, R., & Chang, H. (2008) · Biotechnology Journal · doi:10.1002/biot.200700228 · Cited by 1,264 · see citing works

Multicellular Spheroid

Khanna, S., Bhatt, A. N., & Dwarakanath, B. S. R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-416002-6.00011-0 · Cited by 8 · see citing works

Comparative Analysis of Dasatinib Effect between 2D and 3D Tumor Cell Cultures

Sabetta, S., Vecchiotti, D., Clementi, L., Nolfi, M. D. V., Zazzeroni, F., & Angelucci, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020372 · Cited by 18 · see citing works

Rapid spheroid assays in a 3-dimensional cell culture chip

Teh, J. L., Rahman, S. F. A., Domnic, G., et al. (2021) · BMC Research Notes · doi:10.1186/s13104-021-05727-0 · Cited by 3 · see citing works

Rapid Spheroid Assays in a 3-Dimensional Cell Culture ChipPreprint

Teh, J. L., Rahman, S. F. A., Domnic, G., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-132004/v1