Cited by 240Cancer survivorship and careCancer-related cognitive impairment studiesChildhood Cancer Survivors' Quality of Life

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Radiotherapy-related fatigue

Jereczek-Fossa, Barbara Alicja, Marsiglia, Hugo Raul, Orecchia, Roberto·2002·Critical Reviews in Oncology/Hematology

DOI 10.1016/s1040-8428(01)00143-3

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Abstract

Radiotherapy-induced fatigue is a common early and chronic side-effect of irradiation, reported in up to 80 and 30% of patients during radiation therapy and at follow-up visits, respectively. It is frequently underestimated by medical and nursing staff, only about 50% of patients discuss it with a physician and in one fourth of cases any intervention is proposed to the patient. The patients rarely expect fatigue to be a side-effect of treatment. The etiology of this common symptom, its correlates and prevalence are poorly understood. In numerous studies the level and time course of fatigue was demonstrated to depend on the site of tumor and treatment modalities. For example, psychological mechanisms have been proposed to explain fatigue in women receiving irradiation for early breast cancer, whereas decline in neuromuscular efficiency rather than psychological reasons can lead to the fatigue observed in patients undergoing radiotherapy for prostate cancer. Fatigue can affect global quality of life more than pain, sexual dysfunction and other cancer- or treatment-related symptoms. Several interventions have been tested in the management of radiotherapy-related fatigue and some randomized studies have been recently published. Although an optimal method has not yet been established, some promising results have been reported with relaxation therapy, group psychotherapy, physical exercise and sleep. Further methodologically correct studies are warranted to define better the causes, optimal prevention and management of this symptom.

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Result
Psychosocial interventions for reducing fatigue during cancer treatment in adults
Goedendorp, M. M., Gielissen, M., Verhagen, C. A., & Bleijenberg, G. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006953 · Cited by 34
Trait anxiety determines depressive symptoms and fatigue in women with an abnormality in the breast
Vries, J. D., van der Steeg, A. F. W., & Roukema, J. A. (2008) · British Journal of Health Psychology · doi:10.1348/135910708x310200 · Cited by 34
Fatigue and sleep during cancer and chemotherapy: translational rodent models.
Ray, M. A., Rogers, L. Q., Trammell, R. A., & Toth, L. A. (2008) · PubMed Central · Cited by 34
Fatigue in the radiation therapy patient: current management and investigations
Jacobsen, P. B., & Thors, C. L. (2003) · Seminars in Radiation Oncology · doi:10.1016/s1053-4296(03)00021-3 · Cited by 35
Differential Expression of Genes Related to Mitochondrial Biogenesis and Bioenergetics in Fatigued Prostate Cancer Men Receiving External Beam Radiation Therapy
Hsiao, C., Wang, D., Kaushal, A., Chen, M., & Saligan, L. N. (2014) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2014.03.010 · Cited by 33
Effect of Processed Honey and Royal Jelly on Cancer-Related Fatigue: A Double-Blind Randomized Clinical Trial
Mofid, B., Rezaeizadeh, H., Termos, A., Rakhsha, A., Mafi, A. R., & Taheripanah, T. (2016) · Electronic physician · doi:10.19082/2475 · Cited by 33
Prospective Evaluation of a 12-Week Walking Exercise Program and Its Effect on Fatigue in Prostate Cancer Patients Undergoing Radical External Beam Radiotherapy
Truong, P. T., Gaul, C. A., McDonald, R. E., Petersen, R. B., Jones, S. O., Alexander, A., Lim, J. T. W., & Ludgate, C. M. (2010) · American Journal of Clinical Oncology · doi:10.1097/coc.0b013e3181e841ec · Cited by 33
Time Course and Predictors for Cancer-Related Fatigue in a Series of Oropharyngeal Cancer Patients Treated with Chemoradiation Therapy
Spratt, D. E., Sakae, M., Riaz, N., Lok, B. H., Essandoh, S., Hsu, M., Zhang, Z., Schupak, K. D., Setton, J. S., & Lee, N. Y. (2012) · The Oncologist · doi:10.1634/theoncologist.2011-0437 · Cited by 34
Determinants of fatigue 6 and 12 months after surgery in women with early-stage breast cancer: a comparison with women with benign breast problems
De Vries, J., Van der Steeg, A. F., & Roukema, J. A. (2009) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.11.008 · Cited by 32
Acupuncture for nonpalliative radiation therapy-related fatigue: feasibility study.
Mao, J. J. J., Styles, T., Cheville, A. L., Wolf, J., Fernandes, S., & Farrar, J. T. (2009) · PubMed · Cited by 32
US Oncology-Wide Incidence, Duration, Costs and Deaths from Chemoradiation Mucositis and Antimucositis Therapy Benefits
McCullough, R. W. (2017) · Future Oncology · doi:10.2217/fon-2017-0418 · Cited by 35
Psychometric properties of the Fatigue Assessment Scale (FAS) in women with breast problems
Vries, J. D., van der Steeg, A. F. W., & Roukema, J. A. (2010) · Research portal (Tilburg University) · Cited by 31
Experiences of Fatigue and Self-management of Thai Buddhist Cancer Patients Undergoing Radiation Therapy
Lundberg, P. C., & Rattanasuwan, O. (2007) · Cancer Nursing · doi:10.1097/01.ncc.0000265005.02559.43 · Cited by 32
Quality-of-Life Outcomes in Oncology
Siddiqui, F., Kachnic, L. A., & Movsas, B. (2006) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2006.01.003 · Cited by 31
Evaluation of a Fatigue Initiative: Information on Exercise for Patients Receiving Cancer Treatment
Windsor, P. M., Potter, J., McAdam, K., & McCowan, C. (2009) · Clinical Oncology · doi:10.1016/j.clon.2009.01.009 · Cited by 30
Cytotoxic chemotherapy increases sleep and sleep fragmentation in non-tumor-bearing mice
Borniger, J. C., Gaudier‐Diaz, M. M., Zhang, N., Nelson, R. J., & DeVries, A. C. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.001 · Cited by 28
“Among breast cancer patients, cognitive impairments, fatigue, and sleep problems rank among the most commonly reported side effects influencing quality of life (Vardy, 2009; Azim et al., 2011; Cella et al., 2001; Wood et al., 2006; Jereczek-Fossa et al., 2002).”
Background
Association of Fatigue with Perceived Stress in Chinese Women with Early Stage Breast Cancer Awaiting Adjuvant Radiotherapy
Ho, R., Kwan, T., Cheung, I. K. M., Chan, C. K. P., Lo, P. H. Y., Yip, P. S. F., Luk, M., & Chan, C. (2013) · Stress and Health · doi:10.1002/smi.2548 · Cited by 31
The Extraction, Anticancer Effect, Bioavailability, and Nanotechnology of Baicalin
Moore, O. A. (2016) · Journal of Nutritional Medicine and Diet Care · doi:10.23937/2572-3278.1510011 · Cited by 27
“Fatigue, a common early and chronic side effect of irradiation, was reported in up to 80% of patients during radiation therapy and 30% of follow-up visits [2].”
Fatigue following radiation therapy in nasopharyngeal cancer survivors: A dosimetric analysis incorporating patient report and observer rating
Kamal, M. J., Rosenthal, D. I., Batra, A., Volpe, S., Elgohari, B., Goepfert, R. P., Garden, A. S., Phan, J., Eraj, S., Le, A., et al. (2019) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2018.12.023 · Cited by 26
Radiotherapy-Induced Fatigue in Breast Cancer Patients
Kowalczyk, L., Deutschmann, C., Crevenna, R., Konrad, S., Singer, C. F., & Farr, A. (2020) · Breast Care · doi:10.1159/000509410 · Cited by 26
Quantitative proteomic analysis of single or fractionated radiation-induced proteins in human breast cancer MDA-MB-231 cells
Kim, M., Jung, S.-Y., Ahn, J., Hwang, S., Woo, H., An, S., Nam, S. Y., Lim, D., & Song, J. (2015) · Cell & Bioscience · doi:10.1186/2045-3701-5-2 · Cited by 25
Symptom Management and Palliative Care in Pancreatic Cancer
Rabow, M. W., Petzel, M. Q. B., & Adkins, S. H. (2017) · The Cancer Journal · doi:10.1097/ppo.0000000000000293 · Cited by 25
Alleviation of Side Effects and Distress in Breast Cancer Patients by Cognitive-Behavioral Interventions: A Systematic Review and Meta-analysis
Cobeanu, O., & David, D. (2018) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-017-9526-7 · Cited by 27
Could Objective Tests Be Used to Measure Fatigue in Patients With Advanced Cancer?
Schvartsman, G., Park, M., Liu, D. D., Yennurajalingam, S., Bruera, E. D., & Hui, D. (2017) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2016.12.343 · Cited by 26
Exercise Programming and Counseling Preferences of Breast Cancer Survivors During or After Radiation Therapy
Karvinen, K. H., Raedeke, T. D., Arastu, H. H., & Allison, R. R. (2011) · Oncology nursing forum · doi:10.1188/11.onf.e326-e334 · Cited by 24
Art therapy using famous painting appreciation maintains fatigue levels during radiotherapy in cancer patients
Koom, W. S., Choi, M. Y., Lee, J., Park, E. J., Kim, J. H., Kim, S., & Kim, Y. B. (2016) · Radiation Oncology Journal · doi:10.3857/roj.2016.01760 · Cited by 24
“The fatigue starts increasing from the second week onwards and decreases subsequently at around 4 weeks after completion of radiation [9,12].”
Background
Symptoms Predictive of Overall Quality of Life Using the Edmonton Symptom Assessment Scale in Breast Cancer Patients Receiving Radiotherapy
Chow, S. L.-M., Wan, B. A., Pidduck, W., Zhang, L., DeAngelis, C., Chan, S., Yee, C., Drost, L., Leung, E., Sousa, P., et al. (2019) · Clinical Breast Cancer · doi:10.1016/j.clbc.2019.05.007 · Cited by 24
Comparison of hospital based and home based exercise on quality of life, and neck and shoulder function in patients with spinal accessary nerve injury after head and neck cancer surgery
Hwa, J., Yoon, I. J., Cho, Y. K., Ahn, J. S., Kim, J. K., & Jeon, J. Y. (2018) · Oral Oncology · doi:10.1016/j.oraloncology.2018.06.019 · Cited by 23
Effets non ciblés (bystander, abscopal) de la radiothérapie externe : potentielles implications pour le clinicien ?
Sun, R., Sbai, A., Ganem, G., Boudabous, M., Collin, F., Marcy, P. Y., Doglio, A., & Thariat, J. (2014) · Cancer/Radiothérapie · doi:10.1016/j.canrad.2014.08.004 · Cited by 20
Results From a Pilot Study of Handheld Vibration: Exercise Intervention Reduces Upper-Limb Dysfunction and Fatigue in Breast Cancer Patients Undergoing Radiotherapy: VibBRa Study
Kneis, S., Wehrle, A., Ilaender, A., Volegova-Neher, N., Gollhofer, A., & Bertz, H. (2018) · Integrative Cancer Therapies · doi:10.1177/1534735418766615 · Cited by 20
“724 Integrative Cancer Therapies 17(3)”
Influential
Managing radiation therapy side effects with complementary medicine.
Thomas, J., Beinhorn, C. M., Norton, D., Richardson, M., Sumler, S.-S., & Frenkel, M. A. (2010) · PubMed · Cited by 21
Cancer-related fatigue: a review
Campos, M. P. D. O., Hassan, B. J., Riechelmann, R. P., & del Giglio, A. (2011) · Revista da Associação Médica Brasileira · doi:10.1016/s0104-4230(11)70046-x · Cited by 20
Double E1B 19 kDa- and E1B 55 kDa-deleted oncolytic adenovirus in combination with radiotherapy elicits an enhanced anti-tumor effect
Kim, J., Kim, P.-H., Yoo, J. Y., Yoon, A.-R., Choi, H. J., Seong, J., Kim, I.-W., Kim, J.-H., & Yun, C.-O. (2009) · Gene Therapy · doi:10.1038/gt.2009.72 · Cited by 20
Cancer-Related Fatigue
Franklin, D. J., & Packel, L. B. (2006) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2005.12.015 · Cited by 19
Cancer-Related Fatigue: A Review and a Conceptual Framework to Guide Therapists' Understanding
Pigott, A. E., Fleming, J., Haines, T. P., & Bennett, S. H. (2009) · British Journal of Occupational Therapy · doi:10.1177/030802260907200205 · Cited by 20
“This conflicts with another literature review of the same year (Jereczek-Fossa et al 2002), which found that fatigue was dependent on the type of malignancy, with patients with lung, breast and prostate cancer having the highest levels of early and chronic fatigue.”
Result
Commonalities in the Features of Cancer and Chronic Fatigue Syndrome (CFS): Evidence for Stress-Induced Phenotype Instability?
Rusin, A., Seymour, C. B., Cocchetto, A. M., & Mothersill, C. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020691 · Cited by 18
Health-related Quality of Life, Fatigue, and Posttraumatic Growth of Cancer Patients Undergoing Radiation Therapy: A Longitudinal Study
Tanyi, Z., Szluha, K., Nemes, L., Kovács, S., & Bugán, A. (2013) · Applied Research in Quality of Life · doi:10.1007/s11482-013-9261-7 · Cited by 18
“Fatigue is a common, highly disruptive complaint of patients undergoing external RT (Ahsberg and Fürst 2001), and its prevalence rates among patients receiving RT can reach 70% or more (Danjoux et al. 2007; Janaki et al. 2010; Jereczek-Fossa et al. 2002).”
Background

Authors: Jereczek-Fossa, B. A., Marsiglia, H. R., & Orecchia, R.
Affiliations: European Institute of Oncology (IT)
University of Milan (IT)
ORCID: Orecchia, Roberto
Venue: Critical Reviews in Oncology/Hematology
Publisher: Elsevier BV
Published: 2002-03
Volume: 41
Issue: 3
Pages: 317-325
ISSN: 1040-8428 (ISSN-L)
DOI: 10.1016/s1040-8428(01)00143-3
OpenAlex: W1968760806
Cited by: 240
References: 64
Citations by year: 2026: 8 · 2025: 11 · 2024: 4 · 2023: 11 · 2022: 7 · 2021: 13 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 11 · 2016: 11 · 2015: 8 · 2014: 16 · 2013: 16 · 2012: 17
FWCI: 0.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Critical Reviews in Oncology/Hematology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer survivorship and care
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
Keywords: radiation side effects, chronic fatigue, breast cancer radiotherapy, prostate cancer radiotherapy, quality of life, fatigue management, relaxation training, group therapy, physical activity, sleep, neuromuscular efficiency, psychological mechanisms
MeSH terms: Fatigue, Humans, Neoplasms, Radiotherapy, Disease Management

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