Determinants of fatigue 6 and 12 months after surgery in women with early-stage breast cancer: a comparison with women with benign breast problems
Abstract
Objective The objective of this study was to examine the predictors of fatigue 6 and 12 months after surgical treatment in women with early-stage breast cancer (BC group) and in women with benign breast problems (BBP group) in a prospective follow-up study.Methods Women entered the study prior to diagnosis and completed questionnaires on personality factors, psychological factors, and social support. Fatigue was assessed 6 and 12 months after diagnosis (BBP group) or surgical treatment (BC group). Clinical data were taken from medical records.Results In the BC group (n=117), fatigue at 6 months was predicted by trait anxiety (P<.001) and extraversion (P<.05). Trait anxiety (P<.05), extraversion (P<.05), and depressive symptoms (P<.05) predicted fatigue at 12 months. In the BBP group (n=190), the predictors were trait anxiety (P<.001) for fatigue at 6 months, and trait anxiety (P<.001) and neuroticism (P<.01) for fatigue at 12 months.Conclusion Many patients who are already fatigued before diagnosis remain tired regardless of diagnosis. Trait anxiety is strongly related to fatigue in both groups.
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The most frequent psychological risk factors for CPSP and fatigue include anxiety, such as hypervigilance and pain catastrophizing.
“The most frequent tap into anxiety, such as hypervigilance and pain catastrophizing [24–28].”
Psychological factors are modifiable, robust, and potent predictors of CPSP and fatigue.
“However, a preventive intervention could target psychological factors, which are both modifiable, robust, and potent predictors of CPSP and fatigue [20,24].”
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Prevalence of Fatigue in Patients With Cancer: A Systematic Review and Meta-Analysis
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“However, a preventive intervention could target psychological factors, which are both modifiable, robust, and potent predictors of CPSP and fatigue [20,24].”
- Authors
- De Vries, J., Van der Steeg, A. F., & Roukema, J. A.
- Affiliations
- Tilburg University (NL)
- Venue
- Journal of Psychosomatic Research
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 66
- Issue
- 6
- Pages
- 495-502
- ISSN
- 0022-3999 (ISSN-L)
- OpenAlex
- W2075621200
- Cited by
- 32
- References
- 62
- Citations by year
- 2026: 1 · 2025: 2 · 2022: 2 · 2020: 2 · 2019: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychosomatic Research (publishedVersion)
- Research portal (Tilburg University) (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- postoperative fatigue, early breast cancer, trait anxiety, extraversion, neuroticism, depressive symptoms, personality traits, social support, predictors of fatigue
- MeSH terms
- Adult, Aged, Anxiety Disorders, Breast Diseases, Breast Neoplasms, Cognition, Demography, Fatigue, Female, Humans, Middle Aged, Neoplasm Staging, Personality Disorders, Postoperative Period, Predictive Value of Tests, Prospective Studies, Surveys and Questionnaires, Severity of Illness Index, Social Support, Time Factors
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