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Cited by 68Diabetes Treatment and ManagementDementia and Cognitive Impairment ResearchPharmaceutical Practices and Patient Outcomes

Impact of Antidiabetic Medications on Physical and Cognitive Functioning of Older Mexican Americans with Diabetes Mellitus

Wu, Jasmanda H, Haan, Mary N, Liang, Jersey, Ghosh, Debashis, Gonzalez, Hector M, Herman, William H·2003·Annals of Epidemiology
DOI 10.1016/s1047-2797(02)00464-7
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Abstract

Purpose The current study was designed to evaluate the utility of antidiabetic medications in affecting changes in physical and cognitive functioning among older Mexican Americans with diabetes over a 2-year period.Methods A longitudinal analysis with repeated measurements between 1999 and 2001 was performed in a cohort of Mexican Americans, 60 or older, in the SALSA Project. Statistical analysis was conducted using a generalized estimating equation.Results For subjects with diagnosed diabetes </= 5 years (N = 381), there was less decline in physical and cognitive functioning over 2 years among subjects on treatment, compared to those without treatment. For subjects with diagnosed diabetes of 5+ years (N = 337), the effect of antidiabetic medications was more significant in preventing the decline in physical and cognitive functioning (ADL: mean in log scale = -0.10, 95% CI = -0.16, -0.04, 3MS: mean = 6.35, 95% CI = 3.23, 9.48). Combination therapy of antidiabetic agents appeared to be more effective than monotherapy in preventing the decline in physical and cognitive functioning for subjects.Conclusions Antidiabetic drugs appear to be useful in alleviating the decline in physical and cognitive functioning among older Mexican Americans with diabetes, especially for those with a longer duration of the disease.

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  • Six studies reported time-related changes as a continuous variable using either the MMSE or 3MS score in individuals with and without a history of diabetes.

    “Table 2 lists the six studies that reported time-related changes as a continuous variable using either the MMSE or 3MS score in individuals with and without a history of diabetes [49, 51, 52, 54, 65, 69].”

    From Cognitive decline and dementia in diabetes—systematic overview of prospective observational studies (2005) · cites this paper as [49]

  • Prospective epidemiological studies show a relationship between cognitive decline and clinical markers associated with hyperglycaemia (e.g., use of glucose-lowering medication, diabetes duration, diabetes complications).

    “Finally, prospective epidemiological studies also show a relationship between cognitive decline and clinical markers associated with hyperglycaemia, e.g. use of glucose-lowering medication, diabetes duration and diabetes complications [46, 48, 49, 54, 56, 64].”

    From Cognitive decline and dementia in diabetes—systematic overview of prospective observational studies (2005) · cites this paper as [49]

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Authors
Wu, J. H., Haan, M. N., Liang, J., Ghosh, D., Gonzalez, H. M., & Herman, W. H.
Affiliations
University of Michigan (US)
Corresponding author
Haan, Mary N
ORCID
Venue
Annals of Epidemiology
Publisher
Elsevier BV
Published
2003-05
Volume
13
Issue
5
Pages
369-376
ISSN
1047-2797 (ISSN-L)
DOI
10.1016/s1047-2797(02)00464-7
OpenAlex
W2580810426
Cited by
68
References
58
Citations by year
2023: 2 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 2 · 2014: 3 · 2013: 2 · 2012: 3
FWCI
1.63
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Annals of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (NIA 12975)
  • National Institute on Aging (R01AG012975, R03AG033751)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK060753)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords
antidiabetic drugs, diabetes mellitus, older Mexican Americans, physical function, cognitive function, functional decline, activities of daily living, Montreal Cognitive Assessment, combination therapy, monotherapy, disease duration
MeSH terms
Activities of Daily Living, Aged, Aged, 80 and over, Aging, Cognition, Humans, Hypoglycemic Agents, Longitudinal Studies, Middle Aged, Quality of Life, Cohort Studies, Mexican Americans

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