Neurogranin enhances synaptic strength through its interaction with calmodulin
Open accessAbstract
Learning-correlated plasticity at CA1 hippocampal excitatory synapses is dependent on neuronal activity and NMDA receptor (NMDAR) activation. However, the molecular mechanisms that transduce plasticity stimuli to postsynaptic potentiation are poorly understood. Here, we report that neurogranin (Ng), a neuron-specific and postsynaptic protein, enhances postsynaptic sensitivity and increases synaptic strength in an activity- and NMDAR-dependent manner. In addition, Ng-mediated potentiation of synaptic transmission mimics and occludes long-term potentiation (LTP). Expression of Ng mutants that lack the ability to bind to, or dissociate from, calmodulin (CaM) fails to potentiate synaptic transmission, strongly suggesting that regulated Ng-CaM binding is necessary for Ng-mediated potentiation. Moreover, knocking-down Ng blocked LTP induction. Thus, Ng-CaM interaction can provide a mechanistic link between induction and expression of postsynaptic potentiation.
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A novel association for SCZ is in Ensembl gene RP11-490G2.1 which encodes the primary transcript for miR-137 (MIR137).
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- Authors
- Zhong, L., Cherry, T., Bies, C. E., Florence, M. A., & Gerges, N. Z.
- Affiliations
- Medical College of Wisconsin (US)
- Corresponding author
- Gerges, Nashaat Z
- ORCID
- Zhong, Ling
- Venue
- The EMBO Journal
- Published
- 2009-08-27
- Volume
- 28
- Issue
- 19
- Pages
- 3027-3039
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC2736013
- OpenAlex
- W2161262899
- Cited by
- 158
- References
- 84
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 11 · 2023: 6 · 2022: 17 · 2021: 5 · 2020: 17 · 2019: 12 · 2018: 9 · 2017: 11 · 2016: 5 · 2015: 9 · 2014: 6 · 2013: 5 · 2012: 8
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association
- Extendicare Foundation
- National Institute on Aging (AG032320, R01AG032320)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- neurogranin, calmodulin, synaptic plasticity, long-term potentiation, NMDA receptor, hippocampal CA1, postsynaptic potentiation, synaptic transmission
- MeSH terms
- Animals, Calcium, Calmodulin, Cells, Cultured, Hippocampus, Synaptic Transmission, Neuronal Plasticity, Neurons, Protein Binding, Spine, Gene Expression, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Receptors, AMPA, Rats, Neurogranin, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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