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Cited by 113Cholesterol and Lipid MetabolismAdvanced Glycation End Products researchAtherosclerosis and Cardiovascular Diseases

Scavenger Receptors that Recognize Advanced Glycation End Products

Miyazaki, A·2002·Trends in Cardiovascular Medicine
DOI 10.1016/s1050-1738(02)00171-8
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Abstract

Scavenger receptors recognize modified low-density lipoproteins (LDLs) such as acetylated LDL and oxidized LDL. Advanced glycation end products (AGE), which are generated through long-term exposure of proteins to glucose, also behave as active ligands for some scavenger receptors, including class A scavenger receptor (SR-A) and class B scavenger receptors such as CD36 and scavenger receptor, class B, type I (SR-BI). SR-BI, the first identified high-density lipoprotein (HDL) receptor, plays key roles in reverse cholesterol transport by promoting selective uptake of cholesteryl esters (CE) in HDL by hepatocytes, and cholesterol efflux of unesterified cholesterol from peripheral cells to HDL. Using Chinese hamster ovary cells overexpressing SR-BI (CHO-SR-BI cells), it was demonstrated that AGE-bovine serum albumin binds to SR-BI and inhibits selective uptake of HDL-CE by CHO-SR-BI cells as well as cholesterol efflux from CHO-SR-BI cells to HDL, suggesting potential roles of AGE in diabetic dyslipidemia and accelerated atherosclerosis in diabetes.

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  • AGEs can interact with other cell surface receptors, including AGE-R1, AGE-R2, AGE-R3, and scavenger receptors, that possess the opposite function of RAGEs.

    “These AGE cell surface receptors include AGE-R1, AGE-R2, AGE-R3, and scavenger receptors such as macrophage scavenger receptors, scavenger receptor class B type I and II (SR-BI, SR-BII), and cluster of differentiation 36 (CD36).”

    From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [45]

  • Interaction of AGEs with these receptors can enhance their catabolism and clearance by modulating endocytosis and degradation, suggesting a potentially adaptive defensive mechanism.

    “The interaction of AGEs with these receptors can enhance their catabolism and clearance by modulating endocytosis and degradation45,46, suggesting a potentially adaptive defensive mechanism in the body to reduce the detrimental effects of increased glycation products.”

    From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [45]

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Authors
Miyazaki, A.
Affiliations
Kumamoto University (JP)
Corresponding author
Miyazaki, A
ORCID
Miyazaki, A
Venue
Trends in Cardiovascular Medicine
Publisher
Elsevier BV
Published
2002-08
Volume
12
Issue
6
Pages
258-262
ISSN
1050-1738 (ISSN-L)
DOI
10.1016/s1050-1738(02)00171-8
OpenAlex
W2130961250
Cited by
113
References
37
Citations by year
2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 8 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 4
FWCI
7.96
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Cardiovascular Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
advanced glycation end products, scavenger receptors, scavenger receptor class B type I, scavenger receptor A, CD36, modified low-density lipoprotein, high-density lipoprotein, reverse cholesterol transport, cholesteryl ester uptake, cholesterol efflux, diabetic dyslipidemia, atherosclerosis
MeSH terms
Animals, Disease Models, Animal, Cricetinae, Humans, Hyperlipidemias, Membrane Proteins, Receptors, Immunologic, Glycation End Products, Advanced, Receptors, Lipoprotein, CD36 Antigens, Receptors, Scavenger, Scavenger Receptors, Class A, Scavenger Receptors, Class B, In Vitro Techniques

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