Bone mineral density in a cohort of adolescent women using depot medroxyprogesterone acetate for one to two years
Abstract
The purpose of this study was to examine estradiol and bone mineral density (BMD) in a cohort of adolescents using depot medroxyprogesterone acetate (DMPA) for one to two years. BMD was significantly decreased in the femoral neck and lumbar spine at year one. Estradiol levels suggested hypoestrogenization among subjects
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Prolonged DMPA use is associated with decrease in BMD and increased risk of fracture due to estrogen deficiency.
“One of major sources of concerns regarding prolonged use of DMPA is the decrease of BMD and the increase risk of fracture, due to estrogen deficiency accompanying its use.”
From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [58]
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- Authors
- BUSEN, N., BRITT, R., & RIANON, N.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Texas Woman's University (US)
- Baylor College of Medicine (US)
- ORCID
- RIANON, N
- Venue
- Journal of Adolescent Health
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 32
- Issue
- 4
- Pages
- 257-259
- ISSN
- 1054-139X (ISSN-L)
- OpenAlex
- W2028590998
- Cited by
- 66
- References
- 11
- Citations by year
- 2024: 1 · 2021: 2 · 2020: 1 · 2017: 4 · 2016: 5 · 2014: 2
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Adolescent Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- bone mineral density, depot medroxyprogesterone acetate, adolescent women, estradiol, femoral neck, lumbar spine, long-term contraceptive use, bone loss
- MeSH terms
- Adolescent, Adult, Contraceptive Agents, Female, Drug Administration Schedule, Estradiol, Female, Humans, Prospective Studies, Reference Values, Cohort Studies, Absorptiometry, Photon, Bone Density, Body Mass Index, Medroxyprogesterone Acetate
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