The DOI matches its Crossref record; 88 of the 90 references it cites were found in a registry or an index.
Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training
Abstract
Nicotine has been demonstrated to enhance learning processes. The present experiments extend these results to examine the effects of nicotine on acquisition and consolidation of contextual and cued fear conditioning, and the duration of nicotine's enhancement of conditioned fear. C57BL/6 mice were trained with two pairings of an auditory CS and a foot shock US. Multiple doses of nicotine were given before or immediately after training and on testing day (0.0, 0.050, 0.125, 0.250, and 0.375 mg/kg, i.p). Freezing to both the context and auditory CS was measured 24h after training and again 1 week after training. Mice did not receive nicotine for the 1-week retest. Nicotine (0.125 and 0.250 mg/kg) given on both training and testing days enhanced freezing to the context at 24h. In addition, elevated freezing to the context was seen 1 week post-training in mice previously treated with 0.125 and 0.250 mg/kg nicotine. Thus, nicotine-treated mice did show elevated levels of freezing when retested 1 week later, even though no nicotine was administered at the 1-week retest. Mice that received nicotine on training day or testing day only and mice that received nicotine with mecamylamine, a nicotinic receptor antagonist, were not different from saline-treated mice. In addition, post-training administration of nicotine did not enhance fear conditioning. The present results indicate that nicotine enhancement of contextual fear conditioning depends on administration of nicotine on training and test days but results in a long-lasting enhancement of memories of contextual fear conditioning that remains in the absence of nicotine.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For example, acute nicotine exposure enhances fear conditioning in mice (Gould and Higgins 2003).”
From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Gould and Higgins 2003
Citations
Cites
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
The hippocampus as a cognitive map
Passingham, R. E. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90015-0 · Cited by 5,128
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Hippocampal synaptic transmission enhanced by low concentrations of nicotine
Gray, R. G. F., Rajan, A. S., Radcliffe, K. A., Yakehiro, M., & Dani, J. A. (1996) · Nature · doi:10.1038/383713a0 · Cited by 947
Phillips, R. G., & LeDoux, J. E. (1994) · Learning & Memory · doi:10.1101/lm.1.1.34 · Cited by 528
Nicotinic systems and cognitive function
Levin, E. D. (1992) · Psychopharmacology · doi:10.1007/bf02247415 · Cited by 511
Sahakian, B. J., Jones, G., Levy, R., Gray, J. A., & Warburton, D. M. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.6.797 · Cited by 494
Jones, G., Sahakian, B. J., Levy, R., Warburton, D. M., & Gray, J. A. (1992) · Psychopharmacology · doi:10.1007/bf02247426 · Cited by 476
Passive and active reactions to fear-eliciting stimuli.
Blanchard, R. J., & Blanchard, D. C. (1969) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0027676 · Cited by 415
Perry, E. K., Morris, C. M., COURT, J. A., Cheng, A. V., FAIRBAIRN, A. F., McKeith, I. G., Irving, D., Brown, A. J., & Perry, R. H. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00410-7 · Cited by 386
Cited by
Sorted by citations
Items 101–123 of 123
Leach, P. T., Kenney, J. W., & Gould, T. J. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.12.008 · Cited by 8
Self-citationKutlu, M. G., Marin, M., Tumolo, J. M., Kaur, N., VanElzakker, M. B., Shin, L. M., & Gould, T. J. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.03.002 · Cited by 8
Self-citationRodrigues, J. V. F., Vidigal, A. P. P., Minassa, V. S., Batista, T. J., de Lima, R. M. S., Funck, V. R., Antero, L. S., Resstel, L. B. M., Coitinho, J. B., Bertoglio, L. J., et al. (2020) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2020.106929 · Cited by 8
Kutlu, M. G., Braak, D. C., Tumolo, J. M., & Gould, T. J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.023 · Cited by 7
Self-citationRosa, J., Myskiw, J. D. C., Fiorenza, N. G., Furini, C. R. G., Sapiras, G. G., & Izquierdo, I. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114129 · Cited by 7
Nicotine- and cocaine-triggered methamphetamine reinstatement in female and male Sprague-Dawley rats
Pittenger, S. T., Chou, S., Barrett, S. T., Catalano, I., Lydiatt, M. F., & Bevins, R. A. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.07.003 · Cited by 7
Nicotine effects on associative learning in human non-smokers
Hahn, B., Wells, A. K., Lenartowicz, A., & Yuille, M. B. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0183-9 · Cited by 6
Translational Research in Nicotine AddictionPreprint
Fisher, M. L., Pauly, J. R., Froeliger, B., & Turner, J. R. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039776 · Cited by 7
The Effects of Nicotine on Learning and Memory
Gould, T. J. (2014) · The Receptors · doi:10.1007/978-1-4939-1167-7_11 · Cited by 5
Self-citationKutlu, M. G., Tumolo, J. M., Cann, C., & Gould, T. J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4837-4 · Cited by 6
Self-citationKutlu, M. G., Cole, R. D., Connor, D. A., Natwora, B. R., & Gould, T. J. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118758305 · Cited by 4
Self-citationTumolo, J. M., Kutlu, M. G., & Gould, T. J. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.01.002 · Cited by 4
Self-citationWells, A. C., Mojica, C., & Lotfipour, S. (2024) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2024.107959 · Cited by 3
Yadegary, A., Nazari-Serenjeh, F., & Darbandi, N. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102025 · Cited by 3
Pittenger, S. T. (2016) · Lincoln (University of Nebraska) · Cited by 1
Potential Mechanisms Underlying the Facilitation of Fear Memory Extinction by Cotinine
Echeverrı́a, V., & Iarkov, A. (2013) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2014/5219 · Cited by 1
Pharmakologische und nicht-pharmakologische Effekte auf die Kognition
Both, C. (2013) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver
Nicotine and Posttraumatic Stress Disorder
Acheson, D. T., & Glenn, D. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802574-1.00016-8
Kutlu, M. G., Holliday, E. L., & Gould, T. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802574-1.00004-1
Self-citationUliana, D. L. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-24072018-152954
Palmisano, A. N. (2019) · OpenCommons at University of Connecticut (University of Connecticut)
Nicotine Pretreatment Increases Sensitivity to Reward Devaluation in Extinction
Kirshenbaum, A. P., Kristofik, A., Geick, H., Schoenberg, H. L., & Toufexis, D. J. (2020) · The Psychological Record · doi:10.1007/s40732-020-00422-1
Kim, B. S., & Im, H.-I. (2024) · Figshare · doi:10.6084/m9.figshare.24995471
Metadata
- Authors
- Gould, T. J., & Stephen Higgins, J.
- Affiliations
- Temple University (US)
- Corresponding author
- Gould, Thomas J.
- ORCID
- Gould, Thomas J.
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 80
- Issue
- 2
- Pages
- 147-157
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2074624311
- Cited by
- 123
- References
- 90
- Citations by year
- 2024: 4 · 2023: 1 · 2022: 3 · 2020: 6 · 2019: 2 · 2018: 10 · 2017: 4 · 2016: 13 · 2015: 8 · 2014: 8 · 2013: 5 · 2012: 7
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- nicotine, contextual fear conditioning, cued fear conditioning, memory consolidation, long-term memory, mecamylamine, nicotinic acetylcholine receptors, freezing behavior, C57BL/6 mice
- MeSH terms
- Age Factors, Animals, Conditioning, Psychological, Fear, Ganglionic Stimulants, Male, Mice, Inbred C57BL, Nicotine, Teaching, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
