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Rac2 Stimulates Akt Activation Affecting BAD/Bcl-XL Expression while Mediating Survival and Actin Function in Primary Mast Cells
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“deficiency of Rac2 function results in decreased migration and F-actin generation in multiple differentiated blood cell types (10–13, 18).”
From Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization (2001) · cites this paper as [11]
In the citing paper
“Mast cells and neutrophils from Rac2Ϫ/Ϫ mice have a distinct phenotype, characterized by abnormal actin-based functions, such as adhesion, migration, L-selectin function, phagocytosis and degranulation, and abnormal cell survival, with increased apoptosis after growth factor stimulation (22,25).”
From Biochemical and Biological Characterization of a Human Rac2 GTPase Mutant Associated with Phagocytic Immunodeficiency (2001) · cites this paper as [25]
In the citing paper
“However, a member of the Rac family, Rac2, has recently been implicated in the migration of other, more differentiated hematopoietic cells in mice (10, 11), and a mutant of Rac2 has been implicated in a human phagocyte immunodeficiency (12, 13).”
From Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization (2001) · cites this paper as [11]
In the citing paper
“Rac2-deficient mast cells display diminished cell migration in response to stem cell factor (25).”
From Biochemical and Biological Characterization of a Human Rac2 GTPase Mutant Associated with Phagocytic Immunodeficiency (2001) · cites this paper as [25]
In the citing paper
“Rac2 function is required for activation of Akt downstream of phosphatidylinositol 3-kinase (25).”
From Biochemical and Biological Characterization of a Human Rac2 GTPase Mutant Associated with Phagocytic Immunodeficiency (2001) · cites this paper as [25]
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Research works printed but not linked: 74
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Metadata
- Authors
- Yang, F.-C., Kapur, R., King, A. J., Tao, W., Kim, C., Borneo, J., Breese, R., Marshall, M., Dinauer, M. C., & Williams, D. A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 12
- Issue
- 5
- Pages
- 557-568
- ISSN
- 1074-7613
- Cited by
- 126
- References
- 0
- Language
- en
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