Cited by 394Telomeres, Telomerase, and SenescenceHematopoietic Stem Cell TransplantationGenetics, Aging, and Longevity in Model Organisms

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Telomerase Activity in Hematopoietic Cells Is Associated with Self-Renewal Potential

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Morrison, Sean J, Prowse, Karen R, Ho, Peter, Weissman, Irving L·1996·Immunity

DOI 10.1016/s1074-7613(00)80316-7

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Abstract

It has been proposed that the biological clock underlying the limited division potential of eukaryotic cells is telomere length. We assayed telomerase activity in single cells of the hematopoietic and immune systems. We examined hematopoietic stem cells at four stages of differentiation, lineage-committed progenitors, and mature myeloid and lymphoid cells. The frequency of telomerase-expressing cells within each population was proportional to the frequency of cells thought to have self-renewal potential. Among bone marrow hematopoietic stem cells, 70% exhibited detectable telomerase activity. The telomerase-expressing somatic cells observed in this study are not thought to be immortal, and expression was not correlated with cell cycle distribution or differentiation state. This study demonstrates that the developmental characteristic most consistently associated with telomerase expression is self-renewal potential.

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Authors: Morrison, S. J., Prowse, K. R., Ho, P., & Weissman, I. L.
Affiliations: Stanford Medicine (US)
Geron (United States) (US)
Corresponding author: Morrison, Sean J
ORCID: Morrison, Sean J
Weissman, Irving L
Venue: Immunity
Publisher: Elsevier BV
Published: 1996-09
Volume: 5
Issue: 3
Pages: 207-216
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/s1074-7613(00)80316-7
OpenAlex: W1973577066
Cited by: 394
References: 73
Citations by year: 2026: 4 · 2025: 10 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 11 · 2015: 22 · 2014: 15 · 2013: 14 · 2012: 14
FWCI: 9.91
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 2048 d)
Locations: Immunity (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r35ca042551-13)
National Cancer Institute (CA 42551)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: telomerase activity, hematopoietic stem cells, self-renewal, telomere length, hematopoietic differentiation, myeloid cells, lymphoid cells, bone marrow, somatic cells
MeSH terms: Animals, Cell Differentiation, Hematopoietic Stem Cells, Humans, Mice, Inbred C57BL, Telomerase, Mice

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Telomerase Activity in Hematopoietic Cells Is Associated with Self-Renewal Potential

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