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Telomerase Activity in Hematopoietic Cells Is Associated with Self-Renewal Potential
Open accessAbstract
It has been proposed that the biological clock underlying the limited division potential of eukaryotic cells is telomere length. We assayed telomerase activity in single cells of the hematopoietic and immune systems. We examined hematopoietic stem cells at four stages of differentiation, lineage-committed progenitors, and mature myeloid and lymphoid cells. The frequency of telomerase-expressing cells within each population was proportional to the frequency of cells thought to have self-renewal potential. Among bone marrow hematopoietic stem cells, 70% exhibited detectable telomerase activity. The telomerase-expressing somatic cells observed in this study are not thought to be immortal, and expression was not correlated with cell cycle distribution or differentiation state. This study demonstrates that the developmental characteristic most consistently associated with telomerase expression is self-renewal potential.
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“our data suggest that Terc is specific to cells of hematopoietic origin.”
From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [39]
In the citing paper
“In stem cell and progenitor cell compartments3–5, TERT serves an important role in keeping telomeres sufficiently long and stable to prevent the adverse consequences of dysfunctional telomeres on cell viability and chromosomal stability6–8.”
From Conditional telomerase induction causes proliferation of hair follicle stem cells (2005) · cites this paper as [3]
In the citing paper
“In normal tissues, TERT is expressed in stem cells and in progenitor cells3, but its role in these compartments is not fully understood.”
From Conditional telomerase induction causes proliferation of hair follicle stem cells (2005) · cites this paper as [3]
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Telomerase Activity in Female and Male Rat Germ Cells Undergoing Meiosis and in Early Embryos1
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Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance
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Metadata
- Authors
- Morrison, S. J., Prowse, K. R., Ho, P., & Weissman, I. L.
- Affiliations
- Stanford Medicine (US)
- Geron (United States) (US)
- Corresponding author
- Morrison, Sean J
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1996-09
- Volume
- 5
- Issue
- 3
- Pages
- 207-216
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1973577066
- Cited by
- 394
- References
- 73
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 11 · 2015: 22 · 2014: 15 · 2013: 14 · 2012: 14
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Immunity (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r35ca042551-13)
- National Cancer Institute (CA 42551)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- telomerase activity, hematopoietic stem cells, self-renewal, telomere length, hematopoietic differentiation, myeloid cells, lymphoid cells, bone marrow, somatic cells
- MeSH terms
- Animals, Cell Differentiation, Hematopoietic Stem Cells, Humans, Mice, Inbred C57BL, Telomerase, Mice
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