The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Polygenic Autoimmune Traits: Lyn, CD22, and SHP-1 Are Limiting Elements of a Biochemical Pathway Regulating BCR Signaling and Selection
Open accessAbstract
A B lymphocyte hyperactivity syndrome resembling systemic lupus erythematosus characterizes mice lacking the src-family kinase Lyn. Lyn is not required to initiate B cell antigen receptor (BCR) signaling but is an essential inhibitory component. lyn-/- B cells have a delayed but increased calcium flux and exaggerated negative selection responses in the presence of antigen and spontaneous hyperactivity in the absence of antigen. As in invertebrates, genetic effects of loci with only one functional allele can be used to analyze signaling networks in mice, demonstrating that negative regulation of the BCR is a complex quantitative trait in which Lyn, the coreceptor CD22, and the tyrosine phosphatase SHP-1 are each limiting elements. The biochemical basis of this complex trait involves a pathway requiring Lyn to phosphorylate CD22 and recruit SHP-1 to the CD22/BCR complex.
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Goodnow, C. C., Crosbie, J., Adelstein, S., Lavoie, T. B., Smith-Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., Raphael, K., et al. (1988) · Nature · doi:10.1038/334676a0 · Cited by 1,565
Self-citationSimon, M. A., Bowtell, D. D. L., Dodson, G. S., Laverty, T. R., & Rubin, G. M. (1991) · Cell · doi:10.1016/0092-8674(91)90065-7 · Cited by 859
Genetic Analysis of Autoimmune Disease
Vyse, T. J., & Todd, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81110-1 · Cited by 717
Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
Hibbs, M. L., Tarlinton, D. M., Armes, J., Grail, D., Hodgson, G., Maglitto, R., Stacker, S. A., & Dunn, A. R. (1995) · Cell · doi:10.1016/0092-8674(95)90171-x · Cited by 700
Self-citationHartley, S. B., Crosbie, J., Brink, R., Kantor, A. B., Basten, A., & Goodnow, C. C. (1991) · Nature · doi:10.1038/353765a0 · Cited by 695
Self-citationTakata, M., Sabe, H., Hata, A., Inazu, T., Homma, Y., Nukada, T., Yamamura, H., & Kurosaki, T. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06387.x · Cited by 650
A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP
Doody, G. M., Justement, L. B., Delibrias, C. C., Matthews, R. J., Lin, J., Thomas, M. L., & Fearon, D. T. (1995) · Science · doi:10.1126/science.7618087 · Cited by 538
Induction of self-tolerance in mature peripheral B lymphocytes
Goodnow, C. C., Crosbie, J., Jorgensen, H., Brink, R. A., & Basten, A. (1989) · Nature · doi:10.1038/342385a0 · Cited by 535
Self-citationHyperresponsive B Cells in CD22-Deficient Mice
O'Keefe, T. L., Williams, G. T., Davies, S. L., & Neuberger, M. S. (1996) · Science · doi:10.1126/science.274.5288.798 · Cited by 532
Hartley, S. B., Cooke, M. P., Fulcher, D. A., Harris, A. W., Cory, S., Basten, A., & Goodnow, C. C. (1993) · Cell · doi:10.1016/0092-8674(93)90111-3 · Cited by 509
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Cited by
Genetics and pathogenesis of diffuse large B-cell lymphoma
Schmitz, R., Wright, G. W., Huang, D. W., Johnson, C. A., Phelan, J. D., Wang, J. Q., Roulland, S., Kasbekar, M., Young, R. M., Shaffer, A. L., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1801445 · Cited by 2,241
Davidson, A., & Diamond, B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200108023450506 · Cited by 1,042
REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS
Long, E. O. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.875 · Cited by 939
Origins and Functions of B-1 Cells with Notes on the Role of CD5
Berland, R., & Wortis, H. H. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064833 · Cited by 745
Autoimmune disease: why and where it occurs
Marrack, P., Kappler, J., & Kotzin, B. L. (2001) · Nature Medicine · doi:10.1038/90935 · Cited by 609
Metadata
- Authors
- Cornall, R. J., Cyster, J. G., Hibbs, M. L., Dunn, A. R., Otipoby, K. L., Clark, E. A., & Goodnow, C. C.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1998-04
- Volume
- 8
- Issue
- 4
- Pages
- 497-508
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2088551118
- Cited by
- 428
- References
- 49
- FWCI
- 12.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Polygenic Autoimmune Traits: Lyn, CD22, and SHP-1 Are Limiting Elements of a Biochemical Pathway Regulating BCR Signaling and Selection. https://app.cochat.ai/papers/10.1016/s1074-7613(00)80554-3
- The paper
- Cornall, R. J., Cyster, J. G., Hibbs, M. L., Dunn, A. R., Otipoby, K. L., Clark, E. A., & Goodnow, C. C. (1998). Polygenic Autoimmune Traits: Lyn, CD22, and SHP-1 Are Limiting Elements of a Biochemical Pathway Regulating BCR Signaling and Selection. Immunity. https://doi.org/10.1016/s1074-7613(00)80554-3
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
