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The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges
Open accessAbstract
Cytotoxic T lymphocytes (CTL) rapidly destroy their targets. Here we show that although target cell death occurs within 5 min of CTL-target cell contact, an immunological synapse similar to that seen in CD4 cells rapidly forms in CTL, with a ring of adhesion proteins surrounding an inner signaling molecule domain. Lytic granule secretion occurs in a separate domain within the adhesion ring, maintaining signaling protein organization during exocytosis. Live and fixed cell studies show target cell plasma membrane markers are transferred to the CTL as the cells separate. Electron microscopy reveals continuities forming membrane bridges between the CTL and target cell membranes, suggesting a possible mechanism for this transfer.
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Cited by
Sowinski, S., Jolly, C., Berninghausen, O., Purbhoo, M. A., Chauveau, A., Köhler, K., Oddos, S., Eissmann, P., Brodsky, F. M., Hopkins, C., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1682 · Cited by 754
Centrosome polarization delivers secretory granules to the immunological synapse
Stinchcombe, J. C., Majorovits, E., Bossi, G., Fuller, S., & Griffiths, G. M. (2006) · Nature · doi:10.1038/nature05071 · Cited by 599
Self-citationWhat is trogocytosis and what is its purpose?
Joly, E., & Hudrisier, D. (2003) · Nature Immunology · doi:10.1038/ni0903-815 · Cited by 543
Dustin, M. L. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0161 · Cited by 502
Cham, C. M., Driessens, G., O'Keefe, J. P., & Gajewski, T. F. (2008) · European Journal of Immunology · doi:10.1002/eji.200838289 · Cited by 388
Metadata
- Authors
- Stinchcombe, J. C., Bossi, G., Booth, S., & Griffiths, G. M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2001-11
- Volume
- 15
- Issue
- 5
- Pages
- 751-761
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1987240796
- Cited by
- 814
- References
- 0
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stinchcombe, J. C., Bossi, G., Booth, S., & Griffiths, G. M. (2001). The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges. Immunity. https://doi.org/10.1016/s1074-7613(01)00234-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
