Cited by 164HIV Research and TreatmentT-cell and B-cell ImmunologyCell death mechanisms and regulation

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Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells

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Mueller, Yvonne M, De Rosa, Stephen C, Hutton, Justin A, Witek, James, Roederer, Mario, Altman, John D, Katsikis, Peter D·2001·Immunity

DOI 10.1016/s1074-7613(01)00246-1

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Abstract

Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) T cells express the CD45RA(-)CD62L(-) but lack the CD45RA(+)CD62L(-) T cell effector memory (T(EM)) phenotype. This skewing is not found in CMV- and EBV-specific CD8(+) T cells in HIV-infected individuals. CD95/Fas-induced apoptosis is much higher in the CD45RA(-)CD62L(-) T(EM) cells. However, cytotoxicity and IFNgamma production by HIV-specific CD8(+) T cells is not impaired. Our data suggest that the survival and differentiation of HIV-specific CD8(+) T cells may be compromised by CD95/Fas apoptosis induced by FasL-expressing HIV-infected cells.

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Authors: Mueller, Y. M., De Rosa, S. C., Hutton, J. A., Witek, J., Roederer, M., Altman, J. D., & Katsikis, P. D.
Affiliations: Hahnemann University Hospital (US)
National Institutes of Health (US)
Emory University (US)
Corresponding author: Katsikis, Peter D
ORCID: Mueller, Yvonne M
Witek, James
Roederer, Mario
Altman, John D
Katsikis, Peter D
Venue: Immunity
Publisher: Elsevier BV
Published: 2001-12
Volume: 15
Issue: 6
Pages: 871-882
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/s1074-7613(01)00246-1
OpenAlex: W2044870374
Cited by: 164
References: 48
Citations by year: 2026: 3 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 9 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 7 · 2013: 7 · 2012: 4
FWCI: 5.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4246 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01 AI46719, R01AI046719)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: HIV-specific CD8+ T cells, Fas ligand, T cell survival, T cell differentiation, effector memory T cells, CD45RA, L-selectin, cytotoxicity, IFN-gamma production, HIV infection, cytotoxic T lymphocytes
MeSH terms: Adult, Cell Differentiation, Cytomegalovirus, Cytotoxicity, Immunologic, Herpesvirus 4, Human, HIV, Humans, Immunologic Memory, Interferon-gamma, Macrophages, T-Lymphocytes, Cytotoxic, HIV Infections, Immunophenotyping, T-Lymphocyte Subsets, Apoptosis, Leukocyte Common Antigens, Coculture Techniques, fas Receptor, L-Selectin, Viral Load

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Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells

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