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WASH Knockout T Cells Demonstrate Defective Receptor Trafficking, Proliferation, and Effector Function
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WASH is recruited to endosomes where it is necessary for branched F-actin deposition, a process essential to maintain endolysosomal network structure, promote fission of membrane tubules, and traffic cargo proteins.
“WASH is recruited to endosomes where it is necessary for branched F-actin deposition, a process that is essential to maintain the structure of the endolysosomal network, to promote effective fission of membrane tubules and trafficking of cargo proteins37,39,41,43,44.”
From Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling (2019) · cites this paper as [43]
The Introduction says WASH localizes to endomembranes and participates in trafficking through localized Arp2/3-dependent F-actin nucleation. The Results show collapsed endosomal and lysosomal compartments and defective cargo trafficking in WASH-deficient T cells. Our copy does not establish that this actin process promotes fission of membrane tubules; the References list an earlier study on endosome fission, but that title alone does not support the more specific claim. (LLM, conf=0.85)
Experimental — accuracy not yet measuredRegulation of branched F-actin formation by WASH is needed for proper morphology of the endolysosomal system and endosomal trafficking of a broad range of cargoes.
“Regulation of branched F-actin formation by WASH is needed for proper morphology of the endolysosomal system and endosomal trafficking of a broad range of cargoes37,39,41–44”
From Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling (2019) · cites this paper as [43]
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Citations
Cites
The CD28 Signaling Pathway Regulates Glucose Metabolism
Frauwirth, K. A., Riley, J. L., Harris, M. H., Parry, R. V., Rathmell, J. C., Plas, D. R., Elstrom, R. L., June, C. H., & Thompson, C. B. (2002) · Immunity · doi:10.1016/s1074-7613(02)00323-0 · Cited by 1,475 · cited 1×
“This is important for proper T cell metabolic function since it is known that both TCR signaling (58) and CD28 costimulation (45, 61) are required for proper GLUT1 upregulation and cell surface localization.”
BackgroundJäger, A., Dardalhon, V., Sobel, R. A., Bettelli, E., & Kuchroo, V. K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901906 · Cited by 783
Glucose Availability Regulates IFN-γ Production and p70S6 Kinase Activation in CD8+ Effector T Cells
Cham, C. M., & Gajewski, T. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4670 · Cited by 359
The metabolic life and times of a T‐cell
Michalek, R. D., & Rathmell, J. C. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00911.x · Cited by 186 · cited 2×
“Finally, we investigated whether decreased GLUT1 on activated WASHout T cells affected glucose uptake since the primary form of metabolism in activated T cells is aerobic glycolysis (42), which is important for efficient T cell survival and proliferation (43, 44).”
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Research works printed but not linked: 67
- Lasserre R, 2010, FEBS Lett., 584, 4845, 10.1016/j.febslet.2010.09.001 · DOI
- Kurisu S, 2009, Genome Biol., 10, 226, 10.1186/gb-2009-10-6-226 · DOI
- Rottner K, 2010, Trends Cell Biol., 20, 650, 10.1016/j.tcb.2010.08.014 · DOI
- Badour K, 2003, Immunity, 18, 141, 10.1016/S1074-7613(02)00516-2 · DOI
- Nolz JC, 2007, Mol. Cell. Biol., 27, 5986, 10.1128/MCB.00136-07 · DOI
- Burkhardt JK, 2008, Annu. Rev. Immunol., 26, 233, 10.1146/annurev.immunol.26.021607.090347 · DOI
- Cannon JL, 2004, J. Immunol., 173, 1658, 10.4049/jimmunol.173.3.1658 · DOI
- Zhang J, 2009, Immunol. Rev., 232, 175, 10.1111/j.1600-065X.2009.00846.x · DOI
- Zipfel PA, 2006, Curr. Biol., 16, 35, 10.1016/j.cub.2005.12.024 · DOI
- Campellone KG, 2008, Cell, 134, 148, 10.1016/j.cell.2008.05.032 · DOI
- Campellone KG, 2010, Nat. Rev. Mol. Cell. Biol., 11, 237, 10.1038/nrm2867 · DOI
- Zuchero JB, 2009, Nat. Cell Biol., 11, 451, 10.1038/ncb1852 · DOI
- 10.1371/journal.pgen.0030237 · DOI
- Derivery E, 2009, Dev. Cell, 17, 712, 10.1016/j.devcel.2009.09.010 · DOI · Paper page
- Gomez TS, 2009, Dev. Cell, 17, 699, 10.1016/j.devcel.2009.09.009 · DOI · Paper page
- Jia D, 2010, Proc. Natl. Acad. Sci. U. S. A., 107, 10442, 10.1073/pnas.0913293107 · DOI · Paper page
- Harbour ME, 2012, Biochem. J., 442, 209, 10.1042/BJ20111761 · DOI · Paper page
- Jia D, 2012, Mol. Biol. Cell, 23, 2352, 10.1091/mbc.e11-12-1059 · DOI · Paper page
- Zech T, 2011, J. Cell Sci., 124, 3753, 10.1242/jcs.080986 · DOI · Paper page
- Temkin P, 2011, Nat. Cell Biol., 13, 717, 10.1038/ncb2252 · DOI · Paper page
- Gomez TS, 2008, Adv. Immunol., 97, 1, 10.1016/S0065-2776(08)00001-1 · DOI
- Dawlaty MM, 2006, Methods, 39, 370, 10.1016/j.ymeth.2006.06.009 · DOI
- Gomez TS, 2012, Mol. Biol. Cell, 23, 3215, 10.1091/mbc.e12-02-0101 · DOI · Paper page
- Perchonock CE, 2007, J. Immunol., 179, 1768, 10.4049/jimmunol.179.3.1768 · DOI
- Billadeau DD, 2000, J. Exp. Med., 192, 381, 10.1084/jem.192.3.381 · DOI
- Kortum RL, 2011, Proc. Natl. Acad. Sci. U. S. A., 108, 12407, 10.1073/pnas.1104295108 · DOI
- Mangalam AK, 2004, Eur. J. Immunol., 34, 280, 10.1002/eji.200324597 · DOI
- Ting AT, 1992, J. Exp. Med., 176, 1751, 10.1084/jem.176.6.1751 · DOI
- Gomez TS, 2005, Nat. Immunol., 6, 261, 10.1038/ni1168 · DOI
- Livak KJ, 2001, Methods, 25, 402, 10.1006/meth.2001.1262 · DOI · Paper page
- Rodriguez-Mesa E, 2012, Dev. Dyn., 241, 608
- Lee PP, 2001, Immunity, 15, 763, 10.1016/S1074-7613(01)00227-8 · DOI
- Liao W, 2011, Curr. Opin. Immunol., 23, 598, 10.1016/j.coi.2011.08.003 · DOI
- Hayashi S, 2002, Dev. Biol., 244, 305, 10.1006/dbio.2002.0597 · DOI
- Rudensky AY, 2011, Immunol. Rev., 241, 260, 10.1111/j.1600-065X.2011.01018.x · DOI
- Krammer PH, 2007, Nat. Rev. Immunol., 7, 532, 10.1038/nri2115 · DOI
- Balagopalan L, 2009, Immunol. Rev., 232, 84, 10.1111/j.1600-065X.2009.00840.x · DOI
- Das V, 2004, Immunity, 20, 577, 10.1016/S1074-7613(04)00106-2 · DOI
- Finetti F, 2009, Nat. Cell Biol., 11, 1332, 10.1038/ncb1977 · DOI
- Badour K, 2007, Proc. Natl. Acad. Sci. U. S. A., 104, 1593, 10.1073/pnas.0610543104 · DOI
- Fox CJ, 2005, Nat. Rev. Immunol., 5, 844, 10.1038/nri1710 · DOI
- Frauwirth KA, 2004, J. Immunol., 172, 4661, 10.4049/jimmunol.172.8.4661 · DOI
- Jacobs SR, 2008, J. Immunol., 180, 4476, 10.4049/jimmunol.180.7.4476 · DOI
- MacIver NJ, 2008, J. Leukoc. Biol., 84, 949, 10.1189/jlb.0108024 · DOI
- DeNucci CC, 2009, Crit. Rev. Immunol., 29, 87, 10.1615/CritRevImmunol.v29.i2.10 · DOI
- Alcover A, 2000, Crit. Rev. Immunol., 20, 325, 10.1615/CritRevImmunol.v20.i4.20 · DOI
- Wieman HL, 2007, Mol. Biol. Cell, 18, 1437, 10.1091/mbc.e06-07-0593 · DOI · Paper page
- Duleh SN, 2010, Cytoskeleton, 67, 193, 10.1002/cm.20437 · DOI · Paper page
- Carnell M, 2011, J. Cell Biol., 193, 831, 10.1083/jcb.201009119 · DOI · Paper page
- Ciofani M, 2005, Nat. Immunol., 6, 881, 10.1038/ni1234 · DOI
- Wofford JA, 2008, Blood, 111, 2101, 10.1182/blood-2007-06-096297 · DOI
- Hayday AC, 2007, Nat. Immunol., 8, 137, 10.1038/ni1436 · DOI
- Paessens LC, 2008, Mol. Immunol., 45, 42, 10.1016/j.molimm.2007.05.016 · DOI
- Michalek RD, 2011, Proc. Natl. Acad. Sci. U. S. A., 108, 18348, 10.1073/pnas.1108856108 · DOI · Paper page
- Zhang J, 1998, Nature, 392, 296, 10.1038/32681 · DOI
- Rathmell JC, 2000, Mol. Cell, 6, 683, 10.1016/S1097-2765(00)00066-6 · DOI · Paper page
- Cullen PJ, 2008, Nat. Rev. Mol. Cell. Biol., 9, 574, 10.1038/nrm2427 · DOI · Paper page
- Hsu VW, 2010, Curr. Opin. Cell Biol., 22, 528, 10.1016/j.ceb.2010.05.008 · DOI
- Gamper CJ, 2010, Immunol. Res., 47, 162, 10.1007/s12026-009-8147-0 · DOI
- Riley JL, 2002, Proc. Natl. Acad. Sci. U. S. A., 99, 11790, 10.1073/pnas.162359999 · DOI
- Cemerski S, 2008, Immunity, 29, 414, 10.1016/j.immuni.2008.06.014 · DOI
- Tohyama Y, 2003, Mol. Biol. Cell, 14, 2570, 10.1091/mbc.e02-09-0615 · DOI
- Fabbri M, 2005, Mol. Biol. Cell, 16, 5793, 10.1091/mbc.e05-05-0413 · DOI
- Ouchida R, 2008, Immunity, 29, 33, 10.1016/j.immuni.2008.04.024 · DOI
- Swamy M, 2010, Cell Commun. Signal, 8, 5, 10.1186/1478-811X-8-5 · DOI
- Eyster CA, 2009, Traffic, 10, 590, 10.1111/j.1600-0854.2009.00894.x · DOI
- Cullen PJ, 2012, Nat. Cell Biol., 14, 29, 10.1038/ncb2374 · DOI · Paper page
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Sorted by citations
Zavodszky, E., Seaman, M. N. J., Moreau, K., Jimenez-Sanchez, M., Breusegem, S. Y., Harbour, M. E., & Rubinsztein, D. C. (2014) · Nature Communications · doi:10.1038/ncomms4828 · Cited by 466
Retromer: A Master Conductor of Endosome Sorting
Burd, C., & Cullen, P. J. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016774 · Cited by 435
Endosomal retrieval of cargo: Retromer is not alone
McNally, K. E., & Cullen, P. J. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.06.005 · Cited by 169
Singla, A., Fedoseienko, A., Giridharan, S. S. P., Overlee, B. L., Lopez, A., Jia, D., Song, J., Huff-Hardy, K., Weisman, L., Burstein, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12221-6 · Cited by 113
Self-citation
Metadata
- Authors
- Piotrowski, J. T., Gomez, T. S., Schoon, R. A., Mangalam, A. K., & Billadeau, D. D.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2013-03-01
- Volume
- 33
- Issue
- 5
- Pages
- 958-973
- ISSN
- 1098-5549
- Cited by
- 101
- References
- 4
- Language
- en
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