Cited by 386Wound Healing and TreatmentsNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Nitric oxide and wound repair: role of cytokines?

Schwentker, Ann, Vodovotz, Yoram, Weller, Richard, Billiar, Timothy R·2002·Nitric Oxide

DOI 10.1016/s1089-8603(02)00002-2

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Abstract

Wound healing involves platelets, inflammatory cells, fibroblasts, and epithelial cells. All of these cell types are capable of producing nitric oxide (NO), either constitutively or in response to inflammatory cytokines, through the activity of nitric oxide synthases (NOSs): eNOS (NOS3; endothelial NOS) and iNOS (NOS2; inducible NOS), respectively. Indeed, pharmacological inhibition or gene deletion of these enzymes impairs wound healing. The wound healing mechanisms that are triggered by NO appear to be diverse, involving inflammation, angiogenesis, and cell proliferation. All of these processes are controlled by defined cytokine cascades; in many cases, NO appears to modulate these cytokines. In this review, we summarize the history and present state of research on the role of NO in wound healing within the framework of modulation of cytokines.

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Authors: Schwentker, A., Vodovotz, Y., Weller, R., & Billiar, T. R.
Affiliations: University of Pittsburgh (US)
Corresponding author: Billiar, Timothy R
ORCID: Schwentker, Ann
Weller, Richard
Billiar, Timothy R
Venue: Nitric Oxide
Publisher: Elsevier BV
Published: 2002-08
Volume: 7
Issue: 1
Pages: 1-10
ISSN: 1089-8603 (ISSN-L)
DOI: 10.1016/s1089-8603(02)00002-2
OpenAlex: W1970996854
Cited by: 386
References: 161
Citations by year: 2026: 5 · 2025: 11 · 2024: 15 · 2023: 13 · 2022: 21 · 2021: 20 · 2020: 22 · 2019: 22 · 2018: 20 · 2017: 16 · 2016: 19 · 2015: 11 · 2014: 20 · 2013: 22 · 2012: 18
FWCI: 11.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nitric Oxide (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: wound healing, cytokines, nitric oxide synthase, endothelial nitric oxide synthase, inducible nitric oxide synthase, inflammation, angiogenesis, cell proliferation, platelets, fibroblasts, epithelial cells
MeSH terms: Animals, Extracellular Matrix, Humans, Inflammation, Nitric Oxide, Wound Healing, Keratinocytes, Cytokines, Neovascularization, Physiologic

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Nitric oxide and wound repair: role of cytokines?

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