The DOI matches its Crossref record; 158 of the 161 references it cites were found in a registry or an index.
Nitric oxide and wound repair: role of cytokines?
Abstract
Wound healing involves platelets, inflammatory cells, fibroblasts, and epithelial cells. All of these cell types are capable of producing nitric oxide (NO), either constitutively or in response to inflammatory cytokines, through the activity of nitric oxide synthases (NOSs): eNOS (NOS3; endothelial NOS) and iNOS (NOS2; inducible NOS), respectively. Indeed, pharmacological inhibition or gene deletion of these enzymes impairs wound healing. The wound healing mechanisms that are triggered by NO appear to be diverse, involving inflammation, angiogenesis, and cell proliferation. All of these processes are controlled by defined cytokine cascades; in many cases, NO appears to modulate these cytokines. In this review, we summarize the history and present state of research on the role of NO in wound healing within the framework of modulation of cytokines.
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“NO is also believed to control inflammatory cell recruitment in the early stages of the FBR.215”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [215]
Citations
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Cited by
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Biomaterials: Foreign Bodies or Tuners for the Immune Response?
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Metadata
- Authors
- Schwentker, A., Vodovotz, Y., Weller, R., & Billiar, T. R.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Billiar, Timothy R
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 7
- Issue
- 1
- Pages
- 1-10
- ISSN
- 1089-8603 (ISSN-L)
- OpenAlex
- W1970996854
- Cited by
- 386
- References
- 161
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 15 · 2023: 13 · 2022: 21 · 2021: 20 · 2020: 22 · 2019: 22 · 2018: 20 · 2017: 16 · 2016: 19 · 2015: 11 · 2014: 20 · 2013: 22 · 2012: 18
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- wound healing, cytokines, nitric oxide synthase, endothelial nitric oxide synthase, inducible nitric oxide synthase, inflammation, angiogenesis, cell proliferation, platelets, fibroblasts, epithelial cells
- MeSH terms
- Animals, Extracellular Matrix, Humans, Inflammation, Nitric Oxide, Wound Healing, Keratinocytes, Cytokines, Neovascularization, Physiologic
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