Cited by 1,245DNA Repair MechanismsBRCA gene mutations in cancerPARP inhibition in cancer therapy

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Brca1 Controls Homology-Directed DNA Repair

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Moynahan, Mary Ellen, Chiu, Joanne W, Koller, Beverly H, Jasin, Maria·1999·Molecular Cell

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Abstract

Germline mutations in BRCA1 confer a high risk of breast and ovarian tumors. The role of BRCA1 in tumor suppression is not yet understood, but both transcription and repair functions have been ascribed. Evidence that BRCA1 is involved in DNA repair stems from its association with RAD51, a homolog of the yeast protein involved in the repair of DNA double-strand breaks (DSBs) by homologous recombination. We report here that Brca1-deficient mouse embryonic stem cells have impaired repair of chromosomal DSBs by homologous recombination. The relative frequencies of homologous and nonhomologous DNA integration and DSB repair were also altered. The results demonstrate a caretaker role for BRCA1 in preserving genomic integrity by promoting homologous recombination and limiting mutagenic nonhomologous repair processes.

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3 retracted

BRCA1 required for transcription-coupled repair of oxidative DNA damage
Gowen, L. C., Avrutskaya, A. V., Latour, A. M., Koller, B. H., & Leadon, S. A. (1998) · Science · doi:10.1126/science.281.5379.1009 · Cited by 496
Self-citation
Retracted
RETRACTED: Growth Retardation, DNA Repair Defects, and Lack of Spermatogenesis in BRCA1-Deficient Mice
Cressman, V. L., Backlund, D. C., Avrutskaya, A. V., Leadon, S. A., Godfrey, V., & Koller, B. H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7061 · Cited by 108
Self-citation
Retracted
Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.
Leadon, S. A., & Avrutskaya, A. V. (1997) · PubMed · Cited by 78
Retracted
The double-strand-break repair model for recombination
Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J., & Stahl, F. W. (1983) · Cell · doi:10.1016/0092-8674(83)90331-8 · Cited by 2,437
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459
XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint
Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,384
Self-citation
Gatekeepers and caretakers
Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386761a0 · Cited by 1,240
The Genetic Basis of Human Cancer
Vogelstein, B., & Kinzler, K. W. (1997) · Cited by 1,120
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,087
Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells
Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
de Wind, N., Dekker, M., Berns, A. J. M., Radman, M., & Riele, H. T. (1995) · Cell · doi:10.1016/0092-8674(95)90319-4 · Cited by 780
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
Hakem, R., de la Pompa, J. L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81302-1 · Cited by 680
Homology-directed repair is a major double-strand break repair pathway in mammalian cells
Liang, F., Han, M., Romanienko, P. J., & Jasin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5172 · Cited by 649
Self-citation
Involvement of Brca2 in DNA Repair
Patel, K. J., Yu, V. P. C. C., Lee, H., Corcoran, A. E., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A. J., & Venkitaraman, A. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80035-0 · Cited by 646
Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells
Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G. E., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80276-2 · Cited by 635
Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response
Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626
RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2
Wong, A. K. C., Pero, R. S., Ormonde, P. A., Tavtigian, S. V., & Bartel, P. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.31941 · Cited by 544
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.Preprint
Ludwig, T. E., Chapman, D. L., Papaioannou, V. E., & Efstratiadis, A. (1997) · Genes & Development · doi:10.1101/gad.11.10.1226 · Cited by 539
XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages
Liu, N., Lamerdin, J. E., Tebbs, R. S., Schild, D., Tucker, J. D., Shen, M. R., Brookman, K. W., Siciliano, M. J., Walter, C. A., Fan, W., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80078-7 · Cited by 534
The scid mutation in mice causes a general defect in DNA repair
Fulop, G. M., & Phillips, R. A. (1990) · Nature · doi:10.1038/347479a0 · Cited by 532
Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
Gowen, L. C., Johnson, B. L., Latour, A. M., Sulik, K. K., & Koller, B. H. (1996) · Nature Genetics · doi:10.1038/ng0296-191 · Cited by 489
Self-citation
Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants
Taccioli, G. E., Rathbun, G. A., Oltz, E. M., Stamato, T. D., Jeggo, P. A., & Alt, F. W. (1993) · Science · doi:10.1126/science.8469973 · Cited by 451
Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocationsPreprint
Richardson, C. A., Moynahan, M. E., & Jasin, M. (1998) · Genes & Development · doi:10.1101/gad.12.24.3831 · Cited by 442
Self-citation
Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.
Riele, H. T., Maandag, E. R., & Berns, A. J. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.5128 · Cited by 441
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
Connor, F., Bertwistle, D., Mee, P. J., Ross, G. M., Swift, S., Grigorieva, E. F., Tybulewicz, V. L. J., & Ashworth, A. (1997) · Nature Genetics · doi:10.1038/ng1297-423 · Cited by 432
The Genetic Basis of Human Cancer
Rubin, C. M. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-9-199811010-00045 · Cited by 403
Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). I. Clinical description of resource
Lynch, H. T., Kimberling, W. J., Albano, W. A., Lynch, J. F., Biscone, K. A., Schuelke, G. S., Sandberg, A. A., Lipkin, M., Deschner, E. E., Mikol, Y. B., et al. (1985) · Cancer · doi:10.1002/1097-0142(19850815)56:4 · Cited by 400
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
Chen, P., Chen, C., Chen, Y., Xiao, J., Sharp, Z. D., & Lee, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5287 · Cited by 394
Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations.
Tirkkonen, M., Johannsson, O. T., Agnarsson, B. A., Olsson, H. L., Ingvarsson, S., Karhu, R., Tanner, M., Isola, J. J., Barkardottir, R. B., Borg, Å., et al. (1997) · PubMed · Cited by 354
A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability
Shen, S.-X., Ohler, Z. W., Xu, X., Li, C., Weinstein, M. B., Chen, L., Guan, X., Ried, T., & Deng, C. (1998) · Oncogene · doi:10.1038/sj.onc.1202243 · Cited by 329
Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.Preprint
Liu, C., Flesken‐Nikitin, A., Li, S., Zeng, Y., & Lee, W. (1996) · Genes & Development · doi:10.1101/gad.10.14.1835 · Cited by 323
Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
Johnson, R. D., Liu, N., & Jasin, M. (1999) · Nature · doi:10.1038/43932 · Cited by 323
Self-citation
Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.
Tomlinson, G. E., Chen, T. T., Stastny, V., Virmani, A. K., Spillman, M. A., Tonk, V. S., Blum, J. L., Schneider, N. R., Wistuba, I. I., Shay, J. W., et al. (1998) · PubMed · Cited by 292
Radiation Mutagenesis: The Initial DNA Lesions Responsible
Ward, J. F. (1995) · Radiation Research · doi:10.2307/3579145 · Cited by 271
BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.
Chen, Y., Farmer, A. A., Chen, C., Jones, D. C., Chen, P., & Lee, W. (1996) · PubMed · Cited by 267
Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.
Tebbs, R. S., Zhao, Y., Tucker, J. D., Scheerer, J. B., Siciliano, M., Hwang, M. S., Liu, N., Legerski, R. J., & Thompson, L. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.14.6354 · Cited by 257
Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells
Riele, H. T., Maandag, E. R., Clarke, A. R., Hooper, M., & Berns, A. J. M. (1990) · Nature · doi:10.1038/348649a0 · Cited by 239
RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with the RAD51 protein
Mizuta, R., LaSalle, J. M., Cheng, H.-L., Shinohara, A., Ogawa, H., Copeland, N. G., Jenkins, N. A., Lalande, M., & Alt, F. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6927 · Cited by 235
BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair
Abbott, D. W., Thompson, M. E., Robinson‐Benion, C., Tomlinson, G. E., Jensen, R. A., & Holt, J. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18808 · Cited by 228
Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome.
Leadon, S. A., & Cooper, P. K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.22.10499 · Cited by 215
Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells
Jones, N. J., Cox, R., & Thacker, J. (1987) · Mutation Research/DNA Repair Reports · doi:10.1016/0167-8817(87)90011-3 · Cited by 207
Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.Preprint
Lane, T. F., Deng, C., Elson, A., Lyu, M. S., Kozak, C. A., & Leder, P. (1995) · Genes & Development · doi:10.1101/gad.9.21.2712 · Cited by 198
Chromosomal double-strand break repair in Ku80-deficient cells.
Liang, F., Romanienko, P. J., Weaver, D. T., Jeggo, P. A., & Jasin, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.8929 · Cited by 190
Self-citation
Loss of heterozygosity induced by a chromosomal double-strand break
Moynahan, M. E., & Jasin, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.8988 · Cited by 186
Self-citation
The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family
Cartwright, R. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.13.3084 · Cited by 147
BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells.
Vaughn, J. P., Davis, P. L., Jarboe, M. D., Hüper, G., Evans, A. C., Wiseman, R. W., Berchuck, A., Iglehart, J. D., Futreal, P. A., & Marks, J. R. (1996) · PubMed · Cited by 145
Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line
Kemp, L. M., & Jeggo, P. A. (1986) · Mutation Research/DNA Repair Reports · doi:10.1016/0167-8817(86)90025-8 · Cited by 100
Mammary tumor formation in p53- and BRCA1-deficient mice.
Cressman, V. L., Backlund, D. C., Hicks, E., Gowen, L. C., Godfrey, V., & Koller, B. H. (1999) · PubMed · Cited by 82
Self-citation
Chromosome Instability Syndromes: Lessons for Carcinogenesis
Meyn, M. S. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60505-5_6 · Cited by 73
Hereditary Nonpolyposis Colorectal Cancer
Thorland, E. C., & Thibodeau, S. N. (2007) · Springer eBooks · doi:10.1007/978-0-387-33227-7_19 · Cited by 65
Isolation of the Mouse Homologue of BRCA1 and Genetic Mapping to Mouse Chromosome 11
BENNETT, M. L., Haugen, A. C., Cochran, C., Brownlee, H. A., Fiedorek, F. T., & Wiseman, R. W. (1995) · Genomics · doi:10.1006/geno.1995.9963 · Cited by 42
Chromosome instability syndromes
Howell, R. T., & Taylor, A. M. R. (1992) · doi:10.1093/oso/9780199632909.003.0008 · Cited by 12

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Authors: Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
University of North Carolina at Chapel Hill (US)
Corresponding author: Jasin, Maria
ORCID: Moynahan, Mary Ellen
Koller, Beverly H
Jasin, Maria
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 1999-10
Volume: 4
Issue: 4
Pages: 511-518
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/s1097-2765(00)80202-6
OpenAlex: W2059365987
Cited by: 1,245
References: 60
Citations by year: 2026: 27 · 2025: 18 · 2024: 22 · 2023: 35 · 2022: 21 · 2021: 42 · 2020: 47 · 2019: 48 · 2018: 53 · 2017: 47 · 2016: 47 · 2015: 45 · 2014: 55 · 2013: 58 · 2012: 47
FWCI: 22.97
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 923 d)
Locations: Molecular Cell (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: National Institutes of Health
National Cancer Institute (1P50CA68425, P50CA068425)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BRCA1, homologous recombination, homology-directed repair, DNA double-strand break repair, RAD51, non-homologous end joining, genome stability, tumor suppression, mouse embryonic stem cells, germline mutations, breast and ovarian cancer
MeSH terms: Animals, Arabinofuranosyluracil, Cell Line, Chromosomes, DNA Damage, DNA Repair, DNA-Binding Proteins, Mutation, Proto-Oncogene Proteins, Recombination, Genetic, Stem Cells, Thymidine Kinase, Transfection, Retinoblastoma Protein, Mice, Knockout, Gene Targeting, BRCA1 Protein, Rad51 Recombinase, Mice

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Brca1 Controls Homology-Directed DNA Repair

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