A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

Hentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8175 · Cited by 1,292

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C. (1997) · Nature Genetics · doi:10.1038/ng0897-383 · Cited by 1,159

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

Vulpe, C. D., Kuo, Y.-M., Murphy, T. L., Cowley, L., Askwith, C., Libina, N., Gitschier, J., & Anderson, G. J. (1999) · Nature Genetics · doi:10.1038/5979 · Cited by 1,084

Nramp 2 is mutated in the anemic Belgrade ( b ) rat: Evidence of a role for Nramp2 in endosomal iron transport

Fleming, M. D., Romano, M. A., Su, M. A., Garrick, L. M., Garrick, M. D., & Andrews, N. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1148 · Cited by 936

The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.

Askwith, C., Eide, D., Van Ho, A., Bernard, P. S., Li, L., Davis-Kaplan, S., Sipe, D. M., & Kaplan, J. (1994) · Cell · doi:10.1016/0092-8674(94)90346-8 · Cited by 670

Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport

Dancis, A., Yuan, D. S., Haile, D., Askwith, C., Eide, D., Moehle, C., Kaplan, J., & Klausner, R. D. (1994) · Cell · doi:10.1016/0092-8674(94)90345-x · Cited by 659

The biochemical basis of the NADPH oxidase of phagocytes

Segal, A. W., & Abo, A. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90051-n · Cited by 622

Direct Comparison of GAPDH, β-Actin, Cyclophilin, and 28S rRNA as Internal Standards for Quantifying RNA Levels under Hypoxia

Zhong, H., & Simons, J. W. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0815 · Cited by 473

Nramp2 is mutated in the anemic Belgrade (b) rat : evidence of a role for Nramp2 in endosomal iron transport

Flemming (1998) · Medical Entomology and Zoology · Cited by 412

The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression

Lymboussaki, A., Pignatti, E., Montosi, G., Garuti, C., Haile, D. J., & Pietrangelo, A. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00408-2 · Cited by 182

A Systems Biology Approach to Iron Metabolism

Chifman, J., Laubenbacher, R., & Torti, S. V. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2095-2_10 · Cited by 189

Hepcidin inhibits apical iron uptake in intestinal cells

Mena, N. P., Esparza, A., Tapia, V., Valdés, P., & Núñez, M. T. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00122.2007 · Cited by 180

Iron homeostasis: new tales from the crypt

Roy, C. N., & Enns, C. A. (2000) · Blood · doi:10.1182/blood.v96.13.4020 · Cited by 177

A Comparative Inventory of Metal Transporters in the Green Alga Chlamydomonas reinhardtii and the Red Alga Cyanidioschizon merolae

Hanikenne, M., Krämer, U., Demoulin, V., & Baurain, D. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.054189 · Cited by 174

Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis

Wallace, D. F., Pedersen, P. L., Dixon, J. L., Stephenson, P. M., Searle, J. W., Powell, L. W., & Subramaniam, V. N. (2002) · Blood · doi:10.1182/blood.v100.2.692 · Cited by 174

Mechanisms of Iron Accumulation in Hereditary Hemochromatosis

Fleming, R. E., & Sly, W. S. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.155838 · Cited by 174

Iron export through the transporter ferroportin 1 is modulated by the iron chaperone PCBP2

Yanatori, I., Richardson, D. R., Imada, K., & Kishi, F. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.721936 · Cited by 170

A promising new approach to cancer therapy: Targeting iron metabolism in cancer stem cells

El-Hout, M., Santos, L. D., Hamaï, A., & Mehrpour, M. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.07.009 · Cited by 173

Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

Ding, H., Yan, C.-Z., Shi, H., Zhao, Y., Chang, S., Yu, P., Wu, W., Zhao, C., Chang, Y., & Duan, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025324 · Cited by 172

Mouse brains deficient in H‐ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress

Thompson, K., Menzies, S. L., Muckenthaler, M. U., Torti, F. M., Wood, T. L., Torti, S. V., Hentze, M. W., Beard, J., & Connor, J. R. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10463 · Cited by 171

The Regulation of Cellular Iron Metabolism

Chua, A. C. G., Graham, R. M., Trinder, D., & Olynyk, J. K. (2007) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360701428257 · Cited by 172

Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children

Prentice, A. M., Doherty, C. P., Abrams, S. A., Cox, S. E., Atkinson, S. H., Verhoef, H., Armitage, A. E., & Drakesmith, H. (2012) · Blood · doi:10.1182/blood-2011-11-391219 · Cited by 167

Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo

Soe-Lin, S., Apte, S. S., Andriopoulos, B., Andrews, M. C., Schranzhofer, M., Kahawita, T., Garcia-Santos, D., & Ponka, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900808106 · Cited by 167

The copper-iron chronicles: The story of an intimate relationship

Fox, P. L. (2003) · BioMetals · doi:10.1023/a:1020799512190 · Cited by 168

Iron Metabolism in Cardiovascular Disease: Physiology, Mechanisms, and Therapeutic Targets

Sawicki, K. T., Jesus, A. D., & Ardehali, H. (2023) · Circulation Research · doi:10.1161/circresaha.122.321667 · Cited by 168

Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice

Chen, H. (2004) · Blood · doi:10.1182/blood-2003-09-3139 · Cited by 165

Iron dysregulation in Alzheimer's disease: Multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents

Mandel, S., Amit, T., Bar-Am, O., & Youdim, M. B. H. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.06.001 · Cited by 164

Iron transport proteins: Gateways of cellular and systemic iron homeostasis

Knutson, M. D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.786632 · Cited by 177

Copper Availability Contributes to Iron Perturbations in Human Nonalcoholic Fatty Liver Disease

Aigner, E. S., Theurl, I., Haufe, H., Seifert, M., Hohla, F., Scharinger, L., Stickel, F., Mourlane, F., Weiß, G., & Datz, C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.007 · Cited by 165

Hepcidins in amphibians and fishes: Antimicrobial peptides or iron-regulatory hormones?

Shi, J. N., & Camus, A. C. (2005) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2005.10.009 · Cited by 167

Combinatorial mRNA Regulation: Iron Regulatory Proteins and Iso-iron-responsive Elements (Iso-IREs)

Theil, E. C., & Eisenstein, R. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000019200 · Cited by 162

Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1

Ludwiczek, S., Theurl, I., Muckenthaler, M. U., Jakab, M., Mair, S. M., Theurl, M., Kiss, J., Paulmichl, M., Hentze, M. W., Ritter, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1542 · Cited by 160

Ferroportin is a manganese‐responsive protein that decreases manganese cytotoxicity and accumulation

Yin, Z., Jiang, H., Lee, E.-S., Ni, M., Erikson, K. M., Milatović, D., Bowman, A. B., & Aschner, M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06534.x · Cited by 162

Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters ( Zip4 and Zip5 )

Weaver, B. P., Dufner‐Beattie, J., Kambe, T., & Andrews, G. K. (2007) · Biological Chemistry · doi:10.1515/bc.2007.149 · Cited by 160

Iron transport across the blood–brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy

McCarthy, R. C., & Kosman, D. J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1771-4 · Cited by 163

Unexpected role of ceruloplasmin in intestinal iron absorption

Cherukuri, S., Potla, R., Sarkar, J., Nurko, S., Harris, Z. L., & Fox, P. L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.003 · Cited by 163

The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia

Ng, S., Norwitz, S. G., & Norwitz, E. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133283 · Cited by 162

Metabolic regulation of citrate and iron by aconitases: role of iron–sulfur cluster biogenesis

Tong, W.-H., & Rouault, T. A. (2007) · BioMetals · doi:10.1007/s10534-006-9047-6 · Cited by 165

Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese

Shawki, A., Anthony, S., Nose, Y., Engevik, M. A., Niespodzany, E. J., Barrientos, T., Öhrvik, H., Worrell, R. T., Thiele, D. J., & Mackenzie, B. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00160.2015 · Cited by 156

Role of alcohol in the regulation of iron metabolism

Harrison-Findik, D. D. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i37.4925 · Cited by 156

Dietary inulin affects the expression of intestinal enterocyte iron transporters, receptors and storage protein and alters the microbiota in the pig intestine

Tako, E., Glahn, R. P., Welch, R. M., Lei, X. G., Yasuda, K., & Miller, D. D. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507825128 · Cited by 156

Genetics of haemochromatosis

Bomford, A. B. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11607-2 · Cited by 154

Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation

Lane, D. J. R., Bae, D.-H., Merlot, A. M., Sahni, S., & Richardson, D. R. (2015) · Nutrients · doi:10.3390/nu7042274 · Cited by 164

Interferon‐γ limits the availability of iron for intramacrophage Salmonella typhimurium

Nairz, M., Fritsche, G., Brunner, P., Talasz, H., Hantke, K., & Weiss, G. (2008) · European Journal of Immunology · doi:10.1002/eji.200738056 · Cited by 151

Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration

Andersen, H. H., Johnsen, K. B., & Moos, T. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1509-8 · Cited by 151

Ferroportin disease: pathogenesis, diagnosis and treatment

Pietrangelo, A. (2017) · Haematologica · doi:10.3324/haematol.2017.170720 · Cited by 151

Iron levels in polarized macrophages: regulation of immunity and autoimmunity

Recalcati, S., Locati, M., Gammella, E., Invernizzi, P., & Cairo, G. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.03.003 · Cited by 150

The dentate nucleus in Friedreich’s ataxia: the role of iron-responsive proteins

Koeppen, A. H., Michael, S. C., Knutson, M. D., Haile, D. J., Qian, J., Levi, S., Santambrogio, P., Garrick, M. D., & Lamarche, J. B. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0220-y · Cited by 149

Influence of iron metabolism on manganese transport and toxicity

Ye, Q., Park, J. E., Gugnani, K. S., Betharia, S., Pino‐Figueroa, A. J., & Kim, J. (2017) · Metallomics · doi:10.1039/c7mt00079k · Cited by 155

Iron status influences trace element levels in human blood and serum

Bárány, E., Bergdahl, I. A., Bratteby, L. ‐., Lundh, T., Samuelson, G., Skerfving, S., & Oskarsson, A. (2004) · Environmental Research · doi:10.1016/j.envres.2004.09.010 · Cited by 148

Ceruloplasmin in neurodegenerative diseases

Vassiliev, V. B., Harris, Z. L., & Zatta, P. F. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.03.003 · Cited by 151

Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies

Ma, L., Azad, M. G., Dharmasivam, M., Richardson, V., Quinn, R. J., Feng, Y., Pountney, D. L., Tonissen, K. F., Mellick, G. D., Yanatori, I., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101896 · Cited by 151

Mammalian iron transporters: Families SLC11 and SLC40

Montalbetti, N., Simonin, A., Kovács, G., & Hediger, M. A. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.01.002 · Cited by 151

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

Grillo, A. S., SantaMaria, A. M., Kafina, M. D., Cioffi, A. G., Huston, N. C., Han, M., Seo, Y. A., Yien, Y. Y., Nardone, C., Menon, A. V., et al. (2017) · Science · doi:10.1126/science.aah3862 · Cited by 149

Hepcidin—A Peptide Hormone at the Interface of Innate Immunity and Iron Metabolism

Ganz, T. (2006) · Springer eBooks · doi:10.1007/3-540-29916-5_7 · Cited by 147

Dietary iron regulates intestinal cadmium absorption through iron transporters in rats

Ryu, D., Lee, S.-J., Park, D. W., Choi, B., Klaassen, C. D., & Park, J. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2004.03.015 · Cited by 146

Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells

Chaston, T., Chung, B., Mascarenhas, M., Marks, J., Patel, B., Srai, S. K., & Sharp, P. (2008) · Gut · doi:10.1136/gut.2007.131722 · Cited by 145

Iron acquisition by teleost fish

Bury, N. R. (2003) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(03)00021-8 · Cited by 145

Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression

Delaby, C., Pilard, N., Puy, H., & Canonne-Hergaux, F. (2008) · Biochemical Journal · doi:10.1042/bj20071474 · Cited by 144

Hepcidin expression and iron transport in alveolar macrophages

Nguyen, N.-B., Callaghan, K. D., Ghio, A. J., Haile, D. J., & Yang, F. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00484.2005 · Cited by 143

HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell Surface

Giannetti, A. M., & Björkman, P. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401467200 · Cited by 143

Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle

Robach, P., Cairo, G., Gelfi, C., Bernuzzi, F., Pilegaard, H., Viganò, A., Santambrogio, P., Cerretelli, P., Calbet, J. A. L., Moutereau, S., et al. (2007) · Blood · doi:10.1182/blood-2006-08-040006 · Cited by 141

Iron, lipocalin, and kidney epithelia

Yang, J., Mori, K., Li, J. Y., & Barasch, J. M. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00008.2003 · Cited by 139

Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum

Collins, J. F., Franck, C. A., Kowdley, K. V., & Ghishan, F. K. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00489.2004 · Cited by 140

Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption

Vanoaica, L., Darshan, D., Richman, L., Schümann, K., & Kühn, L. C. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.08.003 · Cited by 137

IRP2 Regulates Breast Tumor Growth

Wang, W., Deng, Z., Hatcher, H., Miller, L. D., Di, X., Tesfay, L., Sui, G., D'Agostino, R. B., Torti, F. M., & Torti, S. V. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1224 · Cited by 139

Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins

Frazer, D. M., Vulpe, C. D., McKie, A. T., Wilkins, S. J., Trinder, D., Cleghorn, G. J., & Anderson, G. J. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.4.g931 · Cited by 137

Nramp1 and Other Transporters Involved in Metal Withholding during Infection

Wessling-Resnick, M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.643973 · Cited by 136

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Pietrangelo, A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.06.045 · Cited by 136

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Madejczyk, M. S., & Ballatori, N. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.12.002 · Cited by 136

Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux

Troadec, M., Ward, D. M., Lo, E., Kaplan, J., & Domenico, I. D. (2010) · Blood · doi:10.1182/blood-2010-04-278614 · Cited by 136

Cellular localization of divalent metal transporter DMT-1 in rat kidney

Ferguson, C. J., Wareing, M., Ward, D. T., Green, R., Smith, C. P., & Riccardi, D. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.5.f803 · Cited by 135

Chaperone protein involved in transmembrane transport of iron

Yanatori, I., Yasui, Y., Tabuchi, M., & Kishi, F. (2014) · Biochemical Journal · doi:10.1042/bj20140225 · Cited by 139

FEA1 , FEA2 , and FRE1 , Encoding Two Homologous Secreted Proteins and a Candidate Ferrireductase, Are Expressed Coordinately with FOX1 and FTR1 in Iron-Deficient Chlamydomonas reinhardtii

Allen, M. D., del Campo, J. A., Kropat, J., & Merchant, S. (2007) · Eukaryotic Cell · doi:10.1128/ec.00205-07 · Cited by 137

Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene

Girelli, D., Bozzini, C., Roetto, A., Alberti, F., Daraio, F., Colombari, R., Olivieri, O., Corrocher, R., & Camaschella, C. (2002) · Gastroenterology · doi:10.1053/gast.2002.32984 · Cited by 134

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Hetet, G., Devaux, I., Soufir, N., Grandchamp, B., & Beaumont, C. (2003) · Blood · doi:10.1182/blood-2003-02-0439 · Cited by 135

Physiology of iron transport and the hemochromatosis gene

Pietrangelo, A. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00404.2001 · Cited by 135

Ferroportin disease: a systematic meta-analysis of clinical and molecular findings

Mayr, R., Janecke, A. R., Schranz, M., Griffiths, W. J. H., Vogel, W., Pietrangelo, A., & Zoller, H. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.05.016 · Cited by 133

Mechanisms and Regulation of Intestinal Iron Absorption

Morgan, E. H., & Oates, P. S. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0578 · Cited by 133

Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc

Mitchell, C. J., Shawki, A., Ganz, T., Nemeth, E., & Mackenzie, B. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00348.2013 · Cited by 132

Intestinal Iron Absorption

McKie, A. T., & Simpson, R. J. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_6 · Cited by 133

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David, S., Jhelum, P., Ryan, F., Jeong, S. Y., & Kroner, A. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0218 · Cited by 134

Functional consequences of ferroportin 1 mutations

Liu, X.-B., Yang, F., & Haile, D. J. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.04.005 · Cited by 136

Zinc regulates the function and expression of the iron transporters DMT1 and IREG1 in human intestinal Caco‐2 cells

Yamaji, S., Tennant, J. P., Tandy, S., Williams, M. R., Srai, S. K., & Sharp, P. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02953-2 · Cited by 132

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Boult, J. K. R., Roberts, K., Brookes, M., Hughes, S., Bury, J. P., Cross, S. S., Anderson, G. J., Spychal, R., Iqbal, T. H., & Tselepis, C. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1054 · Cited by 132

Untitled work

(2022) · doi:10.3390/metabo12070609

The Regulation of Hepcidin and Its Effects on Systemic and Cellular Iron Metabolism

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Localisation of proteins of iron metabolism in the human placenta and liver

Bastin, J. M., Drakesmith, H., REES, M. C. P., Sargent, I. L., & Townsend, A. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06216.x · Cited by 134

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Kalinowski, D. S., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G. J., Subramaniam, V. N., Trinder, D., Olynyk, J. K., Chua, A. C. G., Jansson, P. J., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.01.026 · Cited by 131

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Drakesmith, H., Sweetland, E., Schimanski, L., Edwards, J., Cowley, D., Ashraf, M., Bastin, J., & Townsend, A. R. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242614699 · Cited by 128

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Spottiswoode, N., Duffy, P. E., & Drakesmith, H. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00125 · Cited by 127

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Wang, S.-M., Fu, L.-L., Duan, X.-L., Crooks, D., Yu, P., Qian, Z., Di, X.-J., Li, J., Rouault, T. A., & Chang, Y. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0167-3 · Cited by 130

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Pietrangelo, A. (2004) · Hepatology · doi:10.1002/hep.20007 · Cited by 128

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Brissot, P., & Loréal, O. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.009 · Cited by 131

Dcytb (Cybrd1) functions as both a ferric and a cupric reductase in vitro

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