Lack of interferon-γ confers impaired neutrophil granulocyte function and imparts prolonged survival of adult filarial worms in murine filariasis
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We investigated the role of IFN-gamma in host defense during murine filariasis. Using the fully permissive infection of BALB/c mice with the rodent filaria Litomosoides sigmodontis, we show that interferon (IFN)-gamma is essential for encapsulation of adult filarial worms in inflammatory nodules and for normal worm clearance. IFN-gamma knockout (KO) mice had only one third of the nodules of wild-type mice but displayed a more than twofold increase in worm burden and increased microfilaremia. Neutrophil granulocytes, but not macrophages or eosinophils, appear to directly control worm load and nodule formation. Neutrophils, which we showed earlier to be essential for the encapsulation process in the thoracic cavity, where the worms reside, were diminished at this location in IFN-gamma KO compared to wild-type mice; they also displayed strongly reduced chemotactic and phagocytic activity compared to neutrophils of controls. This argues for a distinct defect in neutrophil activation accounting for the low formation of inflammatory nodules. Tumor necrosis factor-alpha, a major neutrophil-activating cytokine expressed by macrophages in the thoracic cavity around the worms, was highly induced in wild-type but absent in KO mice. Diminished activation of neutrophils seems to be a general hallmark of IFN-gamma KO mice, since neutrophils from uninfected KO mice also showed a reduction in chemotactic and phagocytic activity when induced by casein. In conclusion, these data are the first to define an IFN-gamma-dependent immune effector mechanism in murine filarial infection, i.e. neutrophil-mediated control of the adult worm load.
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Th1 cytokines (INF-gamma) can be involved in protection against helminths through proper neutrophil migration.
“In contrast, many studies have shown that Th 1 cytokines (INF-gamma) can be involved in the protection against helminths through proper neutrophil migration [52].”
From Emergent and Neglected Equine Filariosis in Egypt: Species Diversity and Host Immune Response (2022) · cites this paper as [52]
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Immune Effectors Important in Protective Resistance
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- Authors
- Saeftel, M., Volkmann, L., Korten, S., Brattig, N., Al-Qaoud, K., Fleischer, B., & Hoerauf, A.
- Affiliations
- Bernhard Nocht Institute for Tropical Medicine (DE)
- Corresponding author
- Hoerauf, Achim
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 3
- Issue
- 3
- Pages
- 203-213
- ISSN
- 1286-4579 (ISSN-L)
- OpenAlex
- W2001912237
- Cited by
- 62
- References
- 56
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Keywords
- interferon-gamma, neutrophils, filariasis, Litomosoides sigmodontis, inflammatory nodules, TNF-α, neutrophil chemotaxis, neutrophil phagocytosis, microfilaremia, host defense, IFN-gamma knockout mice
- MeSH terms
- Animals, Chemotaxis, Leukocyte, Filariasis, Filarioidea, Flow Cytometry, Interferon-gamma, Lung, Macrophages, Mice, Inbred BALB C, Neutrophils, Phagocytosis, RNA, Messenger, Thorax, Tumor Necrosis Factor-alpha, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Mice
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