Elevated IL‐10 mRNA expression and downregulation of Th1‐type cytokines in microfilaraemic individuals with Wuchereria bancrofti infection
Open accessAbstract
To understand the molecular basis of parasite‐specific anergy in human lymphatic filariasis caused by the nematode Wuchereria bancrofti, parasite antigen‐dependent cellular proliferation and cytokine gene expression were investigated. By reverse transcriptase polymerase chain reaction (RT‐PCR), the levels of cytokine mRNA were determined in the peripheral blood mononuclear cells (PBMCs) of different clinical groups of filariasis patients. This includes individuals with circulating microfilariae (MF), patients with chronic lymphatic obstruction (CP), and exposed but uninfected individuals (EN). Those with CP exhibited both a Th2 and a Th1 parasite antigen‐driven response. In PBMCs from those with MF, there was a marked downregulation of cellular response to parasite antigens, with lowered expression of Th1‐specific cytokines (IFN‐γ and IL‐2) and this was paralleled by increased IL‐10 expression. The EN individuals had a purely Th1‐type pattern with absence of IL‐4 and IL‐5 expression. Further, the mRNA expression of the costimulatory surface marker, CD80 (B7‐1), was not associated with either disease status or IL‐10 expression. There was a significant negative correlation between IL‐10 mRNA expression and PBMC proliferation in the MF individuals, thus indicating the possible role of IL‐10 in antigen‐specific hyporesponsiveness.
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IL-10 expression is related to hyporesponsiveness in lymphatic filariasis.
“IL-10 expression is related to hyporesponsiveness in lymphatic filariasis (248,316,350)”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [350]
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- Authors
- RAVICHANDRAN, M., MAHANTY, S., KUMARASWAMI, V., NUTMAN, T. B., & JAYARAMAN, K.
- Affiliations
- Anna University, Chennai (IN)
- National Institutes of Health (US)
- National Institute of Research in Tuberculosis (IN)
- Corresponding author
- JAYARAMAN, KUNTHALA
- Venue
- Parasite Immunology
- Publisher
- Wiley
- Published
- 1997-02
- Volume
- 19
- Issue
- 2
- Pages
- 69-77
- ISSN
- 0141-9838 (ISSN-L)
- 1365-3024
- OpenAlex
- W2006843277
- Cited by
- 64
- References
- 0
- Citations by year
- 2018: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Parasite Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Keywords
- lymphatic filariasis, Wuchereria bancrofti, IL-10, Th1 cytokines, Th2 cytokines, peripheral blood mononuclear cells, microfilaremia, interferon-gamma, interleukin-2, IL-4, IL-5, CD80, costimulation
- MeSH terms
- Animals, Antigens, Helminth, Cell Division, Cells, Cultured, Elephantiasis, Filarial, Humans, RNA, Messenger, Wuchereria bancrofti, Down-Regulation, Gene Expression, Interleukin-10, B7-1 Antigen, Th1 Cells
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