Extraintestinal Pathogenic Escherichia coli , a Common Human Pathogen: Challenges for Vaccine Development and Progress in the Field
Open accessAbstract
Extraintestinal pathogenic Escherichia coli (ExPEC) is the most common gram-negative bacterial pathogen in humans. ExPEC causes the vast majority of urinary tract infections (UTIs), is a leading cause of adult bacteremia, and is the second most common cause of neonatal meningitis. Increasing multidrug resistance among ExPEC strains constitutes a major obstacle to treatment and is implicated in increasing numbers of hospitalizations and deaths and increasing healthcare costs associated with ExPEC infections. An effective vaccine against ExPEC infection is urgently needed. The O antigen, a component of the surface lipopolysaccharide, has been identified as a promising vaccine target. With the availability of a novel bioconjugation technology it is expected that multivalent O antigen conjugate vaccines can be produced at industrial scale. Clinical proof of concept of a 4-valent O antigen conjugate vaccine is ongoing. An ExPEC vaccine effective against strains that are associated with major diseases and resistant to multiple drugs could be routinely delivered to individuals at risk of developing severe E. coli infection, such as elderly people, individuals undergoing abdominal surgery and prostatic biopsy procedures, and persons at risk of recurrent and/or complicated UTI.
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There are no licensed vaccines against E. coli or group B S. agalactiae.
“There are no licensed vaccines against E. coli or group B S. agalactiae, despite these two pathogens being the major causes of bacterial meningitis in neonates.”
From Global etiology of bacterial meningitis: A systematic review and meta-analysis. (2018) · cites this paper as [14]
The Abstract says that no prophylactic vaccine against extraintestinal pathogenic E. coli (ExPEC) exists, supporting the E. coli portion within that scope. The paper does not address whether a vaccine against group B S. agalactiae is licensed, so it does not support the full claim. (LLM, conf=0.88)
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- Authors
- Poolman, J. T., & Wacker, M.
- Affiliations
- Janssen (Netherlands) (NL)
- Corresponding author
- Poolman, Jan T.
- ORCID
- Poolman, Jan T.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-09-02
- Volume
- 213
- Issue
- 1
- Pages
- 6-13
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC4676548
- OpenAlex
- W2243816940
- Cited by
- 246
- References
- 48
- Citations by year
- 2026: 20 · 2025: 25 · 2024: 31 · 2023: 29 · 2022: 30 · 2021: 21 · 2020: 27 · 2019: 26 · 2018: 15 · 2017: 11 · 2016: 11
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- The Journal of Infectious Diseases (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- extraintestinal pathogenic Escherichia coli, vaccine development, lipopolysaccharide, urinary tract infection, bacteremia, neonatal meningitis, multidrug resistance, bioconjugation, multivalent vaccine, vaccine targets
- MeSH terms
- Escherichia coli, Escherichia coli Infections, Humans, Urinary Tract Infections, O Antigens, Escherichia coli Vaccines, Drug Resistance, Bacterial
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