Cited by 384Glaucoma and retinal disordersVisual perception and processing mechanismsDrug-Induced Ocular Toxicity

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Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma

Yücel, Y·2003·Progress in Retinal and Eye Research

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Abstract

Glaucoma is a leading cause of world blindness, and retinal ganglion cell death is its pathological hallmark. There is accumulating evidence that glaucomatous damage extends from retinal ganglion cells to vision centers in the brain. In an experimental primate model of unilateral glaucoma, degenerative changes are observed in magnocellular, parvocellular, and koniocellular pathways in the lateral geniculate nucleus, and these changes are presented in relation to intraocular pressure and the severity of optic nerve damage. Neuropathological findings are also present in lateral geniculate nucleus layers driven by the unaffected fellow eye. Finally, there is information on changes in the visual cortex in relation to varying degrees of retinal ganglion cell loss. The implications of these findings for refining concepts regarding the pathobiology of progression, and the detection and treatment of glaucoma, are discussed.

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Authors: Yücel, Y.
Affiliations: St. Michael's Hospital (CA)
Corresponding author: Yücel, Y
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2003-07
Volume: 22
Issue: 4
Pages: 465-481
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/s1350-9462(03)00026-0
OpenAlex: W1964207930
Cited by: 384
References: 90
Citations by year: 2026: 3 · 2025: 21 · 2024: 13 · 2023: 9 · 2022: 12 · 2021: 19 · 2020: 17 · 2019: 18 · 2018: 17 · 2017: 17 · 2016: 20 · 2015: 33 · 2014: 14 · 2013: 20 · 2012: 25
FWCI: 12.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Retinal and Eye Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute (R01EY002698, EY02698)
Topics: Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
Keywords: glaucoma, retinal ganglion cell death, lateral geniculate nucleus, visual cortex, magnocellular pathway, parvocellular pathway, koniocellular pathway, intraocular pressure, optic nerve injury
MeSH terms: Animals, Geniculate Bodies, Glaucoma, Humans, Nerve Degeneration, Optic Nerve, Retinal Ganglion Cells, Visual Cortex, Visual Pathways, Cell Death

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Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma

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