Cited by 428interferon and immune responsesImmune Response and InflammationCytokine Signaling Pathways and Interactions

The DOI matches its Crossref record; 168 of the 168 references it cites were found in a registry or an index.

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

Levy, D·2001·Cytokine & Growth Factor Reviews

Open this paper in CoChat — free account

Abstract

Response to IFN involves a rapid and direct signal transduction mechanism that quickly reports that presence of extracellular cytokine to the cell nucleus, preserving the specificity inherent in cytokine-receptor interactions to transcriptionally induce expression of a set of genes encoding important antiviral proteins. Establishment of the resulting antiviral state provides a crucial initial line of defense against viral infection. Studies of IFN-deficient cells and animals derived by gene targeting have demonstrated the essential nature of IFN-mediated innate immunity. The long co-evolutionary history of viruses with their hosts has seen the development of a variety of evasive adaptations that allow viruses to circumvent or inactivate host antiviral mechanisms. Further understanding of both host and viral components of this battle may provide important new strategies for vaccine development and creation of novel antiviral compounds.

Integrity signals

Registry

Crossref · 10.1016/s1359-6101(00)00027-7

Cites

168 of 168 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
Functional Role of Type I and Type II Interferons in Antiviral Defense
Müller, U., Steinhoff, U., Reis, L. F. L., Hemmi, S., Pavlovic, J., Zinkernagel, R. M., & Aguet, M. (1994) · Science · doi:10.1126/science.8009221 · Cited by 2,453
Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex
de Vos, A. M., Ultsch, M. H., & Kossiakoff, A. A. (1992) · Science · doi:10.1126/science.1549776 · Cited by 2,237
Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.
Dalton, D., Pitts-Meek, S., Keshav, S., Figari, I., Bradley, A., & Stewart, T. (1993) · Science · doi:10.1126/science.8456300 · Cited by 2,015
Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays
Der, S. D., Zhou, A., Williams, B. R. G., & Silverman, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15623 · Cited by 1,840
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656
Immune Response in Mice that Lack the Interferon-γ Receptor
Huang, S., Hendriks, W. J. A. J., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., Vilček, J., Zinkernagel, R. M., & Aguet, M. (1993) · Science · doi:10.1126/science.8456301 · Cited by 1,551
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,539
Self-citation

Show all 168 references

Sorted by citations

Items 201–300 of 427

Oligodendroglia are limited in type I interferon induction and responsiveness in vivo
Kapil, P., Butchi, N. B., Stohlman, S. A., & Bergmann, C. C. (2012) · Glia · doi:10.1002/glia.22375 · Cited by 41
Attenuating mutations in the P/C gene of human parainfluenza virus type 1 (HPIV1) vaccine candidates abrogate the inhibition of both induction and signaling of type I interferon (IFN) by wild-type HPIV1
Cleve, W. V., Amaro-Carambot, E., Surman, S. R., Bekisz, J., Collins, P. L., Zoon, K. C., Murphy, B. R., Skiadopoulos, M. H., & Bartlett, E. J. (2006) · Virology · doi:10.1016/j.virol.2006.04.011 · Cited by 40
Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection
Alagarasu, K., Honap, T. P., Damle, I. M., Mulay, A. P., Shah, P. S., & Cecilia, D. (2013) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2012.12.021 · Cited by 40
Activated Ras/MEK Inhibits the Antiviral Response of Alpha Interferon by Reducing STAT2 Levels
Christian, S. L., Collier, T. W., Zu, D., Licursi, M., Hough, C., & Hirasawa, K. (2009) · Journal of Virology · doi:10.1128/jvi.02213-08 · Cited by 40
Functional characterisation of the Japanese flounder, Paralichthys olivaceus, Mx promoter
Ooi, E. L., Hırono, I., & Aoki, T. (2006) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2005.12.004 · Cited by 39
Human Parainfluenza Virus Type 1 C Proteins Are Nonessential Proteins That Inhibit the Host Interferon and Apoptotic Responses and Are Required for Efficient Replication in Nonhuman Primates
Bartlett, E. J., Cruz, A.-M., Esker, J., Castaño, A., Schomacker, H., Surman, S. R., Scull, M. A., Boonyaratanakornkit, J. B., Pickles, R. J., Collins, P. L., et al. (2008) · Journal of Virology · doi:10.1128/jvi.00853-08 · Cited by 39
The Role of Interferon in Persistent Viral Infection: Insights from Murine Norovirus
Nice, T. J., Robinson, B. A., & Winkle, J. A. V. (2017) · Trends in Microbiology · doi:10.1016/j.tim.2017.10.010 · Cited by 39
PIASy Inhibits Virus-induced and Interferon-stimulated Transcription through Distinct Mechanisms
Kubota, T., Matsuoka, M., Xu, S., Otsuki, N., Takeda, M., Kato, A., & Ozato, K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.195255 · Cited by 38
Different responses of human pancreatic adenocarcinoma cell lines to oncolytic Newcastle disease virus infection
Buijs, P., van Eijck, C. H. J., Hofland, L. J., Fouchier, R. A. M., & van den Hoogen, B. G. (2014) · Cancer Gene Therapy · doi:10.1038/cgt.2013.78 · Cited by 38
The Critical Role of IFN-γ in Experimental Coronavirus Retinopathy
Hooks, J. J., Wang, Y., & Detrick, B. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1106 · Cited by 37
ZIKV infection regulates inflammasomes pathway for replication in monocytes
Khaiboullina, S. F., Uppal, T., Sarkar, R., Gorzalski, A. J., Jeor, S. S., & Verma, S. C. (2017) · Scientific Reports · doi:10.1038/s41598-017-16072-3 · Cited by 40
The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3
Zhou, Y., He, C., Yan, D., Liu, F., Liu, H., Chen, J., Cao, T., Zuo, M., Wang, P., Ge, Y., et al. (2016) · Nature Immunology · doi:10.1038/ni.3395 · Cited by 37
Hepatitis B Virus e Antigen Activates the Suppressor of Cytokine Signaling 2 to Repress Interferon Action
Yu, Y., Wan, P., Cao, Y., Zhang, W., Chen, J., Tan, L. H., Wang, Y., Sun, Z., Qi, Z., Wan, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01773-6 · Cited by 38
Interferon responses in HIV infection: from protection to disease.
Sivro, A., Su, R., Plummer, F. A., & Ball, T. B. (2014) · PubMed · Cited by 35
Characterization of the antiviral effects of interferon-α against a SARS-like coronoavirus infection in vitro
Zorzitto, J. R., Galligan, C. L., Ueng, J. J. M., & Fish, E. N. (2006) · Cell Research · doi:10.1038/sj.cr.7310030 · Cited by 35
Attenuation of the influenza virus sickness behavior in mice deficient in Toll-like receptor 3
Majde, J. A., Kapás, L., Bohnet, S. G., De, A., & Krueger, J. M. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.011 · Cited by 35
Intrinsic and extrinsic negative regulators of nuclear protein transport processes
Sekimoto, T., & Yoneda, Y. (2012) · Genes to Cells · doi:10.1111/j.1365-2443.2012.01609.x · Cited by 36
How Pathogen-Derived Cysteine Proteases Modulate Host Immune Responses
Donnelly, S., Dalton, J. P., & Robinson, M. W. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8414-2_12 · Cited by 35
Ambisense Sendai Viruses Are Inherently Unstable but Are Useful To Study Viral RNA Synthesis
Mercier, P. L., Garcin, D., Hausmann, S., & Kolakofsky, D. (2002) · Journal of Virology · doi:10.1128/jvi.76.11.5492-5502.2002 · Cited by 35
Interferons Mediate Terminal Differentiation of Human Cortical Thymic Epithelial Cells
Vidalain, P., Laine, D., Zaffran, Y., Azocar, O., Delprat, C., Wild, T., Rabourdin‐Combe, C., & Valentin, H. (2002) · Journal of Virology · doi:10.1128/jvi.76.13.6415-6424.2002 · Cited by 35
Human T-cell leukemia virus type 1 blunts signaling by interferon alpha
Feng, X., & Ratner, L. (2008) · Virology · doi:10.1016/j.virol.2007.12.036 · Cited by 37
Non-specific antiviral response detected in RNA-treated cultured cells of the sandfly, Lutzomyia longipalpis
Pitaluga, A. N., Mason, P. W., & Traub-Csekö, Y. M. (2007) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2007.06.008 · Cited by 34
Safety of DW-MSC infusion in patients with low clinical risk COVID-19 infection: a randomized, double-blind, placebo-controlled trial
Karyana, M., Djaharuddin, I., Rif’ati, L., Arif, M., Choi, M. K., Angginy, N., Yoon, A., Han, J., Josh, F., Arlinda, D., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02812-4 · Cited by 33
Role of Interferon in the Replication of Human Parainfluenza Virus Type 1 Wild Type and Mutant Viruses in Human Ciliated Airway Epithelium
Bartlett, E. J., Scull, M. A., Skiadopoulos, M. H., Schmidt, A. C., Collins, P. L., Murphy, B. R., & Pickles, R. J. (2008) · Journal of Virology · doi:10.1128/jvi.02263-07 · Cited by 33
A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation
Peng, D., Wang, Z., Huang, A., Zhao, Y. B., & Qin, F. X.-F. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601009 · Cited by 32
A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?
Toro, A. R., Ruiz, M. S., Lage-Vickers, S., Sanchis, P., Sabater, A. A., Pascual, G., Seniuk, R. A., Cascardo, F., Ledesma-Bazan, S., Vilicich, F., et al. (2022) · Antioxidants · doi:10.3390/antiox11020276 · Cited by 33
Exhaustion of Type I Interferon Response following an Acute Viral Infection
Alsharifi, M., Regner, M., Blanden, R. V., Lobigs, M., Lee, E., Koskinen, A. M. L., & Müllbacher, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.3235 · Cited by 32
How robust are estimates of key parameters in standard viral dynamic models?
Zitzmann, C., Ke, R., Ribeiro, R. M., & Perelson, A. S. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011437 · Cited by 30
Pyruvate Carboxylase Activates the RIG-I-like Receptor-Mediated Antiviral Immune Response by Targeting the MAVS signalosome
Cao, Z., Zhou, Y., Zhu, S., Feng, J. J., Chen, X., Liu, S., Peng, N., Yang, X., Xu, G., & Zhu, Y. (2016) · Scientific Reports · doi:10.1038/srep22002 · Cited by 31
Yin Yang 1 Dynamically Regulates Antiviral Innate Immune Responses During Viral Infection
Zan, J., Zhang, H., Gu, A.-P., Zhong, K.-L., Lu, M., Bai, X., Zhang, J., & Cai, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485116 · Cited by 30
Interferon-Induced Tetherin Restricts Vesicular Stomatitis Virus Release in Neurons
Sarojini, S., Theofanis, T. N., & Reiss, C. S. (2011) · DNA and Cell Biology · doi:10.1089/dna.2011.1384 · Cited by 32
Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner
Shakya, A. K., O’Callaghan, D. J., & Kim, S. K. (2019) · Journal of Virology · doi:10.1128/jvi.00257-19 · Cited by 29
Cytokine Patterns in COVID-19 Patients: Which Cytokines Predict Mortality and Which Protect Against?
Basheer, M., Saad, E., Kananeh, M., Asad, L., Khayat, O., Badarne, A., Abdo, Z., Arraf, N., Milhem, F., Bassal, T., et al. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44100323 · Cited by 29
Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex
Xia, Z., Xu, G., Yang, X., Peng, N., Zuo, Q., Zhu, S., Hao, H., Liu, S., & Zhu, Y. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601588 · Cited by 29
Gonococcal Lipooligosaccharide Suppresses HIV Infection in Human Primary Macrophages through Induction of Innate Immunity
Liu, X., Mosoian, A., Chang, T. L.-Y., Zerhouni‐Layachi, B., Snyder, A., Jarvis, G. A., & Klotman, M. E. (2006) · The Journal of Infectious Diseases · doi:10.1086/506360 · Cited by 29
Signaling through RIG-I and type I interferon receptor: Immune activation by Newcastle disease virus in man versus immune evasion by Ebola virus (Review)
Schirrmacher, V. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2213 · Cited by 28
Suppression of Herpes Simplex Virus 1 in MDBK Cells via the Interferon Pathway
Barreca, C., & O’Hare, P. (2004) · Journal of Virology · doi:10.1128/jvi.78.16.8641-8653.2004 · Cited by 28
Immune and Imaging Correlates of Mild Cognitive Impairment Conversion to Alzheimer’s Disease
Rosa, F. L., Saresella, M., Baglio, F., Piancone, F., Marventano, I., Calabrese, E., Nemni, R., Ripamonti, E., Cabinio, M., & Clerici, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-16754-y · Cited by 26
So similar, yet so different: Selective translation of capped and polyadenylated viral mRNAs in the influenza virus infected cell
Yángüez, E., & Nieto, A. (2011) · Virus Research · doi:10.1016/j.virusres.2010.12.016 · Cited by 26
IRF-1 acts as a positive regulator in the transcription of grass carp (Ctenopharyngodon idella) IFN gene
Lai, Q., Lin, G., Ma, M., Huang, S., Li, W., Li, D., Gu, M., Mao, H., & Hu, C. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.03.358 · Cited by 26
Interferon regulated gene (IRG) expression-signature in a mouse model of chikungunya virus neurovirulence
Nair, S. R., Abraham, R., Sundaram, S., & Sreekumar, E. (2017) · Journal of NeuroVirology · doi:10.1007/s13365-017-0583-3 · Cited by 26
Activation and Inhibition of Virus and Interferon: The Herpesvirus Story
Mossman, K. L. (2002) · Viral Immunology · doi:10.1089/088282402317340198 · Cited by 26
Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-κB signaling by targeting MAVS complex
Cao, Z., Xia, Z., Zhou, Y., Yang, X., Hao, H., Peng, N., Liu, S., & Zhu, Y. (2016) · Scientific Reports · doi:10.1038/srep33557 · Cited by 26
RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cβ to deactivate IRF3
Zan, J., Xu, R., Tang, X., Lu, M., Xie, S., Cai, J., Huang, Z., & Zhang, J. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112332 · Cited by 25
SUMOylation of p53 mediates interferon activities
Marcos-Villar, L., Pérez-Girón, J. V., Vilas, J. M., Soto, A., de la Cruz-Herrera, C. F., Lang, V., Collado, M., Vidal, A., Rodríguez, M. S., Muñoz‐Fontela, C., et al. (2013) · Cell Cycle · doi:10.4161/cc.25868 · Cited by 25
A Novel Viral SOCS from Infectious Spleen and Kidney Necrosis Virus: Interacts with Jak1 and Inhibits IFN-α Induced Stat1/3 Activation
Guo, C.-J., Yang, L., Zhang, Y.-F., Wu, Y., Weng, S., Yu, X., & He, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041092 · Cited by 24
Association of Oligoadenylate Synthetase Gene Cluster and DC-SIGN ( CD209 ) Gene Polymorphisms with Clinical Symptoms in Chikungunya Virus Infection
Chaaithanya, I. K., Muruganandam, N., Palani, S., Maile, A., Alagarasu, K., & Vijayachari, P. (2015) · DNA and Cell Biology · doi:10.1089/dna.2015.2819 · Cited by 24
Cloning, expression and functional analysis of PKR from grass carp (Ctenopharyngodon idellus)
Hu, Y., Li, W., Li, D., Liu, Y., Fan, L., Rao, Z., Lin, G., & Hu, C. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.09.024 · Cited by 23
Immunosuppression as a Hallmark of Critical COVID-19: Prospective Study
Kalicińska, E., Szymczak, D., Zińczuk, A., Adamik, B., Śmiechowicz, J., Skalec, T., Nowicka‐Suszko, D., Biernat, M., Bogucka‐Fedorczuk, A., Rybka, J., et al. (2021) · Cells · doi:10.3390/cells10061293 · Cited by 24
Herpes zoster and Janus kinase inhibition in rheumatology and gastroenterology patients: managing risk and vaccination
Galloway, J. B., Raine, T., Rivett, L., Roberts, J., Dews, S.-A., & Choy, E. (2021) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/0jdyse · Cited by 23
HSV-2 inhibits type-I interferon signaling via multiple complementary and compensatory STAT2-associated mechanisms
Kadeppagari, R., Sanchez, R. L., & Foster, T. P. (2012) · Virus Research · doi:10.1016/j.virusres.2012.05.010 · Cited by 23
Enabled interferon signaling evasion in an immune-competent transgenic mouse model of parainfluenza virus 5 infection
Kraus, T. A., Garza, L., & Horvath, C. M. (2007) · Virology · doi:10.1016/j.virol.2007.10.001 · Cited by 22
The crude latex of Euphorbia tirucalli modulates the cytokine response of leukocytes, especially CD4+ T lymphocytes
de Avelar, B. A., Lelis, F., Sathler-Avelar, R., Weber, M., de Souza-Fagundes, E. M., Lopes, M. T. P., Martins‐Filho, O. A., & de Melo, G. E. B. A. (2011) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2011005000096 · Cited by 22
Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models
Paragas, J., Blatt, L. M., Hartmann, C. J., Huggins, J. W., & Endy, T. P. (2005) · Antiviral Research · doi:10.1016/j.antiviral.2005.01.002 · Cited by 22
2‐5A induces a conformational change in the ankyrin‐repeat domain of RNase L
Nakanishi, M., Goto, Y., & Kitade, Y. (2005) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.20474 · Cited by 22
Quantification of Different Human Alpha Interferon Subtypes and Pegylated Interferon Activities by Measuring MxA Promoter Activation
François, C., Bernard, I., Castelain, S., Charleston, B., Fray, M., Capiod, J., & Duverlie, G. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.9.3770-3775.2005 · Cited by 22
Fucoidan from Fucus vesiculosus can inhibit human norovirus replication by enhancing the host innate immune response
Tan, M. T. H., Gorji, M. E., Toh, J. Y. L., Park, A. Y., Li, Y., Gong, Z., & Li, D. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105149 · Cited by 22
Immune modulation through RNA interference-mediated silencing of CD40 in dendritic cells
Karimi, M. H., Ebadi, P., Pourfathollah, A. A., Soheili, Z., Samiee, S., Ataee, Z., Tabei, S. Z., & Moazzeni, S. M. (2009) · Cellular Immunology · doi:10.1016/j.cellimm.2009.05.016 · Cited by 21
On the Role of Interferon Regulatory Factors in HIV‐1 Replication
Marsili, G., Borsetti, A., Sgarbanti, M., Remoli, A. L., Ridolfi, B., Stellacci, E., Ensoli, B., & Battistini, A. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1299.005 · Cited by 21
Immune and ionic mechanisms mediating the effect of dexamethasone in severe COVID-19
Chimote, A. A., Alshwimi, A. O., Chirra, M., Gawali, V. S., Powers‐Fletcher, M. V., Hudock, K. M., & Conforti, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1143350 · Cited by 20
Association between SNPs in interferon regulatory factor 2 (IRF-2) gene and resistance to Aeromonas hydrophila in freshwater mussel Hyriopsis cumingii
Wang, G., Li, X., & Li, J. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.02.006 · Cited by 20
Attenuated Influenza Virus Construct with Enhanced Hemagglutinin Protein Expression
Maamary, J., Pica, N., Belicha‐Villanueva, A., Chou, Y., Krammer, F., Gao, Q., García‐Sastre, A., & Palese, P. (2012) · Journal of Virology · doi:10.1128/jvi.00190-12 · Cited by 20
Allo-priming as a universal anti-viral vaccine: protecting elderly from current COVID-19 and any future unknown viral outbreak
Har-Noy, M., & Or, R. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02363-3 · Cited by 20
Viral Pathogenesis, Modulation of Immune Receptor Signaling and Treatment
Kim, W. M., & Sigalov, A. B. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09789-3_22 · Cited by 20
Immune response profiling of HERV-W envelope proteins in multiple sclerosis: potential biomarkers for disease progression
Ruberto, S., Domínguez‐Mozo, M. I., García‐Martínez, M. Á., Cossu, D., Sechi, L. A., & Álvarez‐Lafuente, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1505239 · Cited by 19
Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family
Torices, S., Téglás, T., Naranjo, O., Fattakhov, N. S., Frydlova, K., Cabrera, R., Osborne, O., Sun, E., Kluttz, A., & Toborek, M. J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03381-0 · Cited by 19
Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivo
Moreau, J. M., Dyer, K. D., Bonville, C. A., Nitto, T., Vasquez, N. L., Easton, A. J., Domachowske, J. B., & Rosenberg, H. F. (2003) · Antiviral Research · doi:10.1016/s0166-3542(03)00111-6 · Cited by 19
The virus-induced signaling adaptor molecule enhances DNA-raised immune protection against H5N1 influenza virus infection in mice
Luo, M., Qu, X., Pan, R., Zhu, D., Zhang, Y., Wu, J., & Pan, Z. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.01.060 · Cited by 19
Correlation of OAS1 Gene Polymorphism at Exon 7 Splice Accepter Site with Interferon-Based Therapy of HCV Infection in Pakistan
Imran, M. S., Manzoor, S., Khattak, N. M., Tariq, M., Khalid, M., Javed, F., & Bhatti, S. (2014) · Viral Immunology · doi:10.1089/vim.2013.0107 · Cited by 19
Marek's Disease Virus and Reticuloendotheliosis Virus Coinfection Enhances Viral Replication and Alters Cellular Protein Profiles
Du, X., Zhou, D., Zhou, J., Xue, J., & Cheng, Z. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.854007 · Cited by 18
Active and inactive influenza virus induction of tumor necrosis factor-α and nitric oxide in J774.1 murine macrophages: modulation by interferon-γ and failure to induce apoptosis
McKinney, L. C., Galliger, S. J., & Lowy, R. J. (2003) · Virus Research · doi:10.1016/j.virusres.2003.08.007 · Cited by 18
Classical swine fever virus Ernsglycoprotein antagonizes induction of interferon-β by double-stranded RNA
Luo, X., Ling, D., Li, T., Wan, C., Zhang, C., & Pan, Z. (2009) · Canadian Journal of Microbiology · doi:10.1139/w09-013 · Cited by 18
Review on the Antiviral Organic Agents against Fish Rhabdoviruses
Sun, S., Shiwei, M., Li, J., Zhang, Q., & Zhou, G. (2023) · Fishes · doi:10.3390/fishes8010057 · Cited by 17
Frequency of T-cell FoxP3+ Treg and CD4+/CD8+ PD-1 expression is related to HBeAg seroconversion in hepatitis B patients on pegylated interferon
Ma, H., Zhang, H., & Wei, L. (2013) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20120535 · Cited by 17
The Us2 Gene Product of Herpes Simplex Virus 2 modulates NF-κB activation by targeting TAK1
Lu, X., Huang, C., Zhang, Y., Lin, Y., Wang, X., Li, Q., Liu, S., Tang, J., & Zhou, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-08856-4 · Cited by 17
Induction of Interferon Synthesis by the PKR-Inhibitory VA RNAs of Adenoviruses
Weber, F., Wagner, V., Kessler, N., & Haller, O. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.1 · Cited by 17
A class C CpG toll‐like receptor 9 agonist successfully induces robust interferon‐alpha production by plasmacytoid dendritic cells from patients chronically infected with hepatitis C
Libri, N. A., Barker, S. J., Rosenberg, W. M., & Semper, A. E. (2009) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2008.01011.x · Cited by 17
Host Response to Chikungunya Virus and Perspectives for Immune-Based Therapies
Teng, T., Kam, Y., Tan, J. J. L., & Ng, L. F. P. (2011) · Future Virology · doi:10.2217/fvl.11.67 · Cited by 17
The nucleolar protein GLTSCR2 is required for efficient viral replication
Wang, P., Meng, W., Han, S.-C., Li, C.-C., Wang, X., & Wang, X.-J. (2016) · Scientific Reports · doi:10.1038/srep36226 · Cited by 16
Differential Modulation of Innate Antiviral Profiles in the Intestinal Lamina Propria Cells of Chickens Infected with Infectious Bursal Disease Viruses of Different Virulence
Chen, R., Chen, J., Xiang, Y., Chen, Y., Shen, W., Wang, W., Li, Y., Wei, P., & He, X. (2022) · Viruses · doi:10.3390/v14020393 · Cited by 16
In vitro Screening of Herbal Medicinal Products for Their Supportive Curing Potential in the Context of SARS-CoV-2
Tran, H. T. T., Peterburs, P., Seibel, J., Abramov-Sommariva, D., & Lamy, E. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/8038195 · Cited by 16
Expression of IFN-Gamma is significantly reduced during severity of covid-19 infection in hospitalized patients
Mansoor, S., Butt, A. R., Bibi, A., Mushtaq, S., Ullah, I., Alshahrani, F., Khan, A., & Mansoor, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0291332 · Cited by 16
Type I Interferon-Mediated Induction of Antiviral Genes and Proteins Fails to Protect Cells from the Cytopathic Effects of Sendai Virus Infection
Bedsaul-Fryer, J. R., Zaritsky, L. A., & Zoon, K. C. (2016) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2016.0051 · Cited by 16
La Crosse Virus Infection of Human Keratinocytes Leads to Interferon-Dependent Apoptosis of Bystander Non-Infected Cells In Vitro
Cruz, M., & Parks, G. D. (2020) · Viruses · doi:10.3390/v12030253 · Cited by 16
Viral Evasion of the Interferon System: Old Viruses, New Tricks
Weber, F., Kochs, G., Haller, O., & Staeheli, P. (2003) · Journal of Interferon & Cytokine Research · doi:10.1089/107999003765027410 · Cited by 16
Understanding inhibition of viral proteins on type I IFN signaling pathways with modeling and optimization
Zou, X., Xiang, X., Chen, Y., Peng, T., Luo, X., & Pan, Z. (2010) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2010.05.001 · Cited by 15
An Integrated Ontology Resource to Explore and Study Host-Virus Relationships
Masson, P., Hulo, C., de Castro, E., Foulger, R. E., Poux, S., Bridge, A. J., Lomax, J., Bougueleret, L., Xénarios, I., & Mercier, P. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108075 · Cited by 15
Functions of IFNλs in Anti-Bacterial Immunity at Mucosal Barriers
Alphonse, N., Dickenson, R. E., Alrehaili, A., & Odendall, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.857639 · Cited by 16
Acute necrotizing encephalopathy in children with COVID-19: a retrospective study of 12 cases
Lin, X., Wang, Y., Li, X., Abdalla, M., Zhang, F., Dong, C., Lü, W., Liu, X., Zhang, J., Ma, K., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1184864 · Cited by 15
On the role of four small hairpins in the HIV-1 RNA genome
Knoepfel, S. A., & Berkhout, B. (2013) · RNA Biology · doi:10.4161/rna.24133 · Cited by 15
Demographic, clinical and genetic factors associated with COVID-19 disease susceptibility and mortality in a Kurdish population
Smail, S. W., Babaei, E., & Amin, K. (2023) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2023.125 · Cited by 14
Inhibition of murine herpesvirus-68 replication by IFN-gamma in macrophages is counteracted by the induction of SOCS1 expression
Shen, Y., Wang, S., Sun, F., Zheng, G., Wu, T.-T., Du, Y., Zhang, S., Qian, J., & Sun, R. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007202 · Cited by 14
Myxoma virus selectively disrupts type I interferon signaling in primary human fibroblasts by blocking the activation of the Janus kinase Tyk2
Wang, F., Barrett, J. W., Shao, Q., Gao, X., Dekaban, G. A., & McFadden, G. (2009) · Virology · doi:10.1016/j.virol.2009.02.013 · Cited by 14
Identification of Secreted Proteins Involved in Nonspecific dsRNA-Mediated Lutzomyia longipalpis LL5 Cell Antiviral Response
Martins-da-Silva, A., Telleria, E. L., Batista, M., Marchini, F. K., Traub-Csekö, Y. M., & Tempone, A. J. (2018) · Viruses · doi:10.3390/v10010043 · Cited by 13
Efficacy of Interferon-β in Moderate-to-Severe Hospitalised Cases of COVID-19: A Systematic Review and Meta-analysis
Kumar, S., Saurabh, M. K., Narasimha, V. L., & Maharshi, V. (2021) · Clinical Drug Investigation · doi:10.1007/s40261-021-01092-9 · Cited by 11
Revealing Mammalian Evolutionary Relationships by Comparative Analysis of Gene Clusters
Song, G., Riemer, C., Dickins, B., Kim, H. L., Zhang, L., Zhang, Y., Hsu, C.-H., Hardison, R. C., Program, N. C. S., Green, E. D., et al. (2012) · Genome Biology and Evolution · doi:10.1093/gbe/evs032 · Cited by 11
The kinetics and protection of the antiviral state induced by recombinant iIFN1a in rainbow trout against infectious hematopoietic necrosis virus
Cao, Y., Xu, L., LaPatra, S. E., Zhao, J., Liu, M., Liu, H., Lu, T., & Zhang, Q.-Y. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.06.002 · Cited by 11
Regulation of Early Host Immune Responses Shapes the Pathogenicity of Avian Influenza A Virus
Sun, J., Wang, J., Yuan, X., Wu, X., Sui, T., Wu, A., Cheng, G., & Jiang, T. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02007 · Cited by 11
The makings of a killer
Palese, P., Basler, C. F., & García‐Sastre, A. (2002) · Nature Medicine · doi:10.1038/nm0902-927 · Cited by 11
The Anti-Interferon Mechanisms of Paramyxoviruses
Stock, N., Goodbourn, S., & Randall, R. E. (2006) · Springer eBooks · doi:10.1007/1-4020-3242-0_6 · Cited by 11

Authors: Levy, D.
Affiliations: NYU Langone Health (US)
Corresponding author: Levy, D
ORCID: Levy, D
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2001-06
Volume: 12
Issue: 2-3
Pages: 143-156
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/s1359-6101(00)00027-7
OpenAlex: W2043064608
Cited by: 428
References: 168
Citations by year: 2026: 5 · 2025: 10 · 2024: 9 · 2023: 15 · 2022: 16 · 2021: 9 · 2020: 14 · 2019: 10 · 2018: 7 · 2017: 14 · 2016: 16 · 2015: 13 · 2014: 18 · 2013: 17 · 2012: 17
FWCI: 10.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ai046594-05)
National Institute of Allergy and Infectious Diseases (AI48204, R01AI046503, AI 28900, AI46594, P01AI048204, AI46503, R01AI028900)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: interferon, antiviral state, viral evasion, innate immunity, interferon signaling, cytokine-cytokine receptor interaction, antiviral gene expression, host-virus coevolution, antiviral agents
MeSH terms: Animals, Antiviral Agents, DNA-Binding Proteins, Gene Expression Regulation, Humans, Interferons, Protein-Tyrosine Kinases, RNA, Double-Stranded, Viruses, Signal Transduction, Trans-Activators, Receptors, Interferon, eIF-2 Kinase, STAT1 Transcription Factor, Mice, Janus Kinase 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks