Levy, David E.

STATs: transcriptional control and biological impact

Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology

Cytokine Signaling Pathways and InteractionsGenomics and Chromatin Dynamics

Cited by 3,201

Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host

Huang, B., Pan, P.-Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., Divino, C. M., & Chen, S.-H. (2006) · Cancer Research

Immune cells in cancerImmunotherapy and Immune Responses

Cited by 1,435

What does Stat3 do?

Levy, D. E., & Lee, C.-K. (2002) · Journal of Clinical Investigation

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 734

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

Gough, D. J., Corlett, A., Schlessinger, K., Wegrzyn, J., Larner, A. C., & Levy, D. E. (2009) · Science

Cytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 716

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

Levy, D. (2001) · Cytokine & Growth Factor Reviews

interferon and immune responsesImmune Response and Inflammation

Cited by 428

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

Manel, N., Hogstad, B., Wang, Y., Levy, D. E., Unutmaz, D., & Littman, D. R. (2010) · Nature

HIV Research and Treatmentinterferon and immune responses

Cited by 427

STAT3 Plays a Critical Role in KRAS -Induced Pancreatic Tumorigenesis

Corcoran, R. B., Contino, G., Deshpande, V., Tzatsos, A., Conrad, C., Benes, C. H., Levy, D. E., Settleman, J., Engelman, J. A., & Bardeesy, N. (2011) · Cancer Research

Cytokine Signaling Pathways and InteractionsPancreatic and Hepatic Oncology Research

Cited by 413

Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation

Yang, J., Chatterjee-Kishore, M., Staugaitis, S. M., Nguyen, H., Schlessinger, K., Levy, D. E., & Stark, G. R. (2005) · Cancer Research

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 405

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

de la Iglesia, N., Konopka, G., Puram, S. V., Chan, J. A., Bachoo, R. M., You, M. J., Levy, D. E., DePinho, R. A., & Bonni, A. (2008) · Genes & Development

Cytokine Signaling Pathways and InteractionsGlioma Diagnosis and Treatment

Cited by 336

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

Kessler, D. S., Veals, S. A., Fu, X. Y., & Levy, D. E. (1990) · Genes & Development

interferon and immune responsesCytokine Signaling Pathways and Interactions

Cited by 312

STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation

Lee, C.-K., Raz, R., Gimeno, R., Gertner, R., Wistinghausen, B., Takeshita, K., DePinho, R. A., & Levy, D. E. (2002) · Immunity

Cytokine Signaling Pathways and InteractionsBlood disorders and treatments

Cited by 242

Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation

Shen, Y., Schlessinger, K., Zhu, X., Meffre, E., Quimby, F., Levy, D. E., & Darnell, J. E. (2004) · Molecular and Cellular Biology

Cytokine Signaling Pathways and InteractionsGrowth Hormone and Insulin-like Growth Factors

Cited by 200

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.

Bovolenta, C., Driggers, P. H., Marks, M. S., Medin, J. A., Politis, A. D., Vogel, S. N., Levy, D. E., Sakaguchi, K., Appella, E., & Coligan, J. E. (1994) · Proceedings of the National Academy of Sciences

interferon and immune responsesCytokine Signaling Pathways and Interactions

Cited by 167

Stat2 Is a Transcriptional Activator That Requires Sequence-specific Contacts Provided by Stat1 and p48 for Stable Interaction with DNA

Bluyssen, H. R., & Levy, D. E. (1997) · Journal of Biological Chemistry

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 150

Malignant Transformation but not Normal Cell Growth Depends on Signal Transducer and Activator of Transcription 3

Schlessinger, K., & Levy, D. E. (2005) · Cancer Research

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 112

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

Genini, D., Brambilla, L., Laurini, E., Merulla, J., Civenni, G., Pandit, S., D'Antuono, R., Perez, L., Levy, D. E., Pricl, S., et al. (2017) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsMitochondrial Function and Pathology

Cited by 106

STAT3 positively regulates an early step in B-cell development

Chou, W.-C., Levy, D. E., & Lee, C.-K. (2006) · Blood

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 94

IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain

Zhang, L., Badgwell, D. B., Bevers, J. J., Schlessinger, K., Murray, P. J., Levy, D. E., & Watowich, S. S. (2006) · Molecular and Cellular Biochemistry

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 89

The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses

MacDonald, M. R., Machlin, E. S., Albin, O. R., & Levy, D. E. (2007) · Journal of Virology

interferon and immune responsesVirology and Viral Diseases

Cited by 88

The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity

Xiao, Y., Zou, Q., Xie, X., Liu, T., Li, H. S., Jie, Z., Jin, J., Hu, H., Manyam, G., Zhang, L., et al. (2017) · Journal of Experimental Medicine

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 87

Regulation of Interferon-α Responsiveness by the Duration of Janus Kinase Activity

Lee, C.-K., Bluyssen, H. A. R., & Levy, D. E. (1997) · Journal of Biological Chemistry

interferon and immune responsesCytokine Signaling Pathways and Interactions

Cited by 87

STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis

Kaplan, M. H., Glosson, N. L., Stritesky, G. L., Yeh, N., Kinzfogl, J., Rohrabaugh, S. L., Goswami, R., Pham, D., Levy, D. E., Brutkiewicz, R. R., et al. (2011) · Blood

Hematopoietic Stem Cell TransplantationCytokine Signaling Pathways and Interactions

Cited by 41