The DOI matches its Crossref record; 168 of the 168 references it cites were found in a registry or an index.
The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
Abstract
Response to IFN involves a rapid and direct signal transduction mechanism that quickly reports that presence of extracellular cytokine to the cell nucleus, preserving the specificity inherent in cytokine-receptor interactions to transcriptionally induce expression of a set of genes encoding important antiviral proteins. Establishment of the resulting antiviral state provides a crucial initial line of defense against viral infection. Studies of IFN-deficient cells and animals derived by gene targeting have demonstrated the essential nature of IFN-mediated innate immunity. The long co-evolutionary history of viruses with their hosts has seen the development of a variety of evasive adaptations that allow viruses to circumvent or inactivate host antiviral mechanisms. Further understanding of both host and viral components of this battle may provide important new strategies for vaccine development and creation of novel antiviral compounds.
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“For instance, influenza virus (91) and RSV (161) bind RIG-I and rhinovirus binds MDA5 to inhibit their activity (304)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [161]
In the citing paper
“RSV targets the cytoplasmic RIG-I sensor through the NS2 protein (161).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [161]
Citations
Cites
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Metadata
- Authors
- Levy, D.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Levy, D
- ORCID
- Levy, D
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 12
- Issue
- 2-3
- Pages
- 143-156
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2043064608
- Cited by
- 428
- References
- 168
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 15 · 2022: 16 · 2021: 9 · 2020: 14 · 2019: 10 · 2018: 7 · 2017: 14 · 2016: 16 · 2015: 13 · 2014: 18 · 2013: 17 · 2012: 17
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ai046594-05)
- National Institute of Allergy and Infectious Diseases (AI48204, R01AI046503, AI 28900, AI46594, P01AI048204, AI46503, R01AI028900)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- interferon, antiviral state, viral evasion, innate immunity, interferon signaling, cytokine-cytokine receptor interaction, antiviral gene expression, host-virus coevolution, antiviral agents
- MeSH terms
- Animals, Antiviral Agents, DNA-Binding Proteins, Gene Expression Regulation, Humans, Interferons, Protein-Tyrosine Kinases, RNA, Double-Stranded, Viruses, Signal Transduction, Trans-Activators, Receptors, Interferon, eIF-2 Kinase, STAT1 Transcription Factor, Mice, Janus Kinase 1
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