Cited by 428interferon and immune responsesImmune Response and InflammationCytokine Signaling Pathways and Interactions

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The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

Levy, D·2001·Cytokine & Growth Factor Reviews

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Abstract

Response to IFN involves a rapid and direct signal transduction mechanism that quickly reports that presence of extracellular cytokine to the cell nucleus, preserving the specificity inherent in cytokine-receptor interactions to transcriptionally induce expression of a set of genes encoding important antiviral proteins. Establishment of the resulting antiviral state provides a crucial initial line of defense against viral infection. Studies of IFN-deficient cells and animals derived by gene targeting have demonstrated the essential nature of IFN-mediated innate immunity. The long co-evolutionary history of viruses with their hosts has seen the development of a variety of evasive adaptations that allow viruses to circumvent or inactivate host antiviral mechanisms. Further understanding of both host and viral components of this battle may provide important new strategies for vaccine development and creation of novel antiviral compounds.

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Authors: Levy, D.
Affiliations: NYU Langone Health (US)
Corresponding author: Levy, D
ORCID: Levy, D
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2001-06
Volume: 12
Issue: 2-3
Pages: 143-156
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/s1359-6101(00)00027-7
OpenAlex: W2043064608
Cited by: 428
References: 168
Citations by year: 2026: 5 · 2025: 10 · 2024: 9 · 2023: 15 · 2022: 16 · 2021: 9 · 2020: 14 · 2019: 10 · 2018: 7 · 2017: 14 · 2016: 16 · 2015: 13 · 2014: 18 · 2013: 17 · 2012: 17
FWCI: 10.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ai046594-05)
National Institute of Allergy and Infectious Diseases (AI48204, R01AI046503, AI 28900, AI46594, P01AI048204, AI46503, R01AI028900)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: interferon, antiviral state, viral evasion, innate immunity, interferon signaling, cytokine-cytokine receptor interaction, antiviral gene expression, host-virus coevolution, antiviral agents
MeSH terms: Animals, Antiviral Agents, DNA-Binding Proteins, Gene Expression Regulation, Humans, Interferons, Protein-Tyrosine Kinases, RNA, Double-Stranded, Viruses, Signal Transduction, Trans-Activators, Receptors, Interferon, eIF-2 Kinase, STAT1 Transcription Factor, Mice, Janus Kinase 1

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The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

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