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The origin of DNA genomes and DNA replication proteins
Abstract
In recent years, it has became clear that most proteins involved in cellular DNA precursor synthesis or DNA replication have been 'invented' more than once, indicating that the transition from RNA to DNA genomes was more complex than previously thought. Several authors have suggested that DNA viruses, which often encode their own version of these proteins, played an important role in this process. The nature of the genome of the last universal cellular ancestor (LUCA) -- that is, RNA or DNA, prokaryotic-like or eukaryotic-like -- remains in dispute. A hyperthermophilic LUCA would have suggested a circular, double-stranded DNA genome; however, recent data favor a mesophilic or moderately thermophilic LUCA.
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“Specifically, the last common ancestor may have had a cell membrane (Jékely 2006;Koga 2011;Lombard et al. 2012;Sojo et al. 2014;Coleman et al. 2019), RNA and phosphodiester-based energy coupling (e.g.Werner and Grohmann 2011), as well as thioester-based intermediary metabolism (Goldford et al. 2017;Weiss et al. 2018), but may not have used a strictly DNA genome (Mushegian and Koonin 1996;Leipe et”
From The Emergence of Life (2019) · cites this paper as Forterre 2002
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Metadata
- Authors
- Forterre, P.
- Affiliations
- Université Paris-Sud (FR)
- Corresponding author
- Forterre, P
- ORCID
- Forterre, P
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2002-10-01
- Volume
- 5
- Issue
- 5
- Pages
- 525-532
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W1998172162
- Cited by
- 190
- References
- 46
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 9 · 2017: 4 · 2016: 5 · 2015: 10 · 2014: 13 · 2013: 11 · 2012: 11
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- DNA replication proteins, RNA to DNA transition, DNA viruses, last universal common ancestor
- MeSH terms
- DNA, DNA Replication, Biological Evolution, Models, Genetic, Proteins, RNA, Selection, Genetic
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