Effects of modafinil on sustained attention performance and quality of life in OSA patients with residual sleepiness while being treated with nCPAP
Abstract
Background Some patients with obstructive sleep apnea/hypopnea syndrome (OSA/HS) who are regular users of nasal continuous positive airway pressure (nCPAP) therapy continue to experience daytime sleepiness that impairs performance and quality of life. A randomized, double-blind, placebo-controlled, parallel-group study was conducted to determine the effect of modafinil on sustained attention performance and functional quality of life in OSA/HS patients with residual daytime sleepiness, who were regular users of nCPAP therapy. Methods Seventy-seven patients received modafinil (200 mg/day, week 1; 400 mg/day, weeks 2-4) and 80 patients received matching placebo once daily for 4 weeks. Sustained attention performance on the psychomotor vigilance task (PVT) and functional status and quality of life using the Functional Outcomes of Sleep Questionnaire (FOSQ) were measured. Results The frequency of lapses of attention during PVT performance was significantly decreased, and both the median and slowest reaction times were significantly improved in patients receiving nCPAP plus modafinil compared with those receiving nCPAP plus placebo (P=0.010 for the number of lapses [transformed], P=0.023 for the median reaction time, and P=0.014 for the reciprocal of the 10% slowest reaction times). Treatment with nCPAP plus modafinil significantly improved the FOSQ total score (weeks 1 and 4), the vigilance subscale score (weeks 1 and 4), and the activity level subscale score (week 4) compared wi…
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Many individuals treated with PAP therapy experience residual sleepiness despite marked improvements in the apnea-hypopnea index.
“In addition, many individuals treated with PAP therapy experience residual sleepiness, despite marked improvements in the apnea-hypopnea index.12,13”
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“The improvements in sustained attention performance and quality of life demonstrated with nCPAP plus modafinil treatment in the present study also are generally consistent with the results of a crossover study of OSA/HS patients with nCPAP-resistant daytime sleepiness [66], and with results of three placebo-controlled…”
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- Authors
- Dinges, D.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Dinges, D
- ORCID
- Dinges, D
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 4
- Issue
- 5
- Pages
- 393-402
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W2161061887
- Cited by
- 132
- References
- 7
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 9 · 2012: 4
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- modafinil, obstructive sleep apnea, residual daytime sleepiness, nasal continuous positive airway pressure, sustained attention, psychomotor vigilance task, reaction time, quality of life, functional outcome, adjunctive therapy
- MeSH terms
- Modafinil, Adult, Aged, Arousal, Attention, Benzhydryl Compounds, Double-Blind Method, Female, Humans, Male, Middle Aged, Nasal Cavity, Psychomotor Performance, Quality of Life, Sleep, Sleep Stages, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
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