Caffeine intake is independently associated with neuropsychological performance in patients with obstructive sleep apnea
Open accessAbstract
In healthy individuals, caffeine intake may improve performance on cognitive tests. Obstructive sleep apnea (OSA) is a disorder that has been associated with impaired cognitive function. In this study, we investigated whether increased caffeine intake in untreated patients with OSA is linked to better cognitive performance. Forty-five untreated OSA patients underwent baseline polysomnography after completing a survey of 24-h caffeine intake. Participants completed a battery of neuropsychological tests, then demographically corrected T scores and a global deficit score (GDS) were calculated on these tests. Partial correlation analysis was performed to compare daily caffeine intake with GDS, after controlling for body mass index (BMI) and sleep apnea severity. Analysis of covariance was done to examine differences in daily caffeine intake between cognitively impaired (GDS ≥ 0.5) and non-impaired (GDS < 0.5) individuals. Seven out of the 45 subjects met the criteria (GDS ≥ 0.5) for cognitive impairment. There was a significant inverse association between caffeine intake and the GDS, both when controlling for BMI (r = −0.331, p = 0.04) and when controlling for BMI and apnea severity (r = −0.500, p = 0.002); those with less impairment consumed more caffeine. Analysis of covariance demonstrated that cognitively impaired individuals consumed one-sixth as much caffeine as non-impaired individuals (p < 0.05). In patients with moderately severe OSA, higher average daily caffeine intake was associated with less cognitive impairment.
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Caffeine may have a potential therapeutic effect and may serve as evidence for self-treatment of OSA.
“Studies on patients with untreated OSA have demonstrated that increased caffeine intake is associated with less cognitive impairment523 thereby indicating a potential therapeutic effect of caffeine and evidence for self-treatment of OSA.”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [523]
The Results report that higher caffeine intake was associated with less cognitive impairment in untreated OSA patients, and the Discussion proposes further research into caffeine’s potential to improve neuropsychological function. The Introduction speculates that greater caffeine use among OSA patients may be an attempt to stay alert, but the study does not establish that patients were self-treating OSA or that caffeine had a therapeutic effect. (LLM, conf=0.82)
Experimental — accuracy not yet measuredIncreased caffeine intake is associated with less cognitive impairment in patients with untreated OSA.
“Studies on patients with untreated OSA have demonstrated that increased caffeine intake is associated with less cognitive impairment523 thereby indicating a potential therapeutic effect of caffeine and evidence for self-treatment of OSA.”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [523]
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International Consensus Statement on Obstructive Sleep Apnea
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- Authors
- Norman, D., Bardwell, W. A., Loredo, J. S., Ancoli-Israel, S., Heaton, R. K., & Dimsdale, J. E.
- Affiliations
- Saint John's Health Center (US)
- University of California San Diego (US)
- Corresponding author
- Norman, Daniel
- Venue
- Sleep and Breathing
- Published
- 2007-11-09
- Volume
- 12
- Issue
- 3
- Pages
- 199-205
- ISSN
- 1520-9512 (ISSN-L)
- 1522-1709
- PMC
- PMC2633294
- OpenAlex
- W2046890952
- Semantic Scholar
- 6b637afb0cad879073d8951d32af55fe18e9885e
- Cited by
- 15
- References
- 46
- Citations by year
- 2024: 2 · 2022: 3 · 2016: 2 · 2015: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Sleep And Breathing (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Johns Hopkins University
- National Institute on Aging (R01AG008415, AG 08415)
- National Heart, Lung, and Blood Institute (HL44915, R01HL036005, R01HL044915)
- National Center for Research Resources (RR0827, M01RR000827)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- caffeine consumption, obstructive sleep apnea, cognitive impairment, neuropsychological performance, global deficit score, body mass index, apnea severity, cognitive function
- MeSH terms
- Adult, Aged, Central Nervous System Stimulants, Caffeine, Cognition Disorders, Female, Humans, Male, Middle Aged, Wechsler Scales, Body Mass Index, Polysomnography, Sleep Apnea, Obstructive
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