Modafinil in Obstructive Sleep Apnea-Hypopnea Syndrome: A Pilot Study in 6 Patients
Abstract
We studied the effects of modafinil, a vigilance-enhancing drug, on excessive daytime sleepiness, memory, night sleep and respiration in 6 patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) using a double-blind random cross-over design with 24-hour polysomnography, verbal memory test and a 5-week sleep-wake diary kept by the patients. There were two 2-week treatment periods in which either modafinil or placebo was used; they were separated by a 1-week wash-out period. Our results show that modafinil reduces daytime sleep duration, lengthens the duration of subjective daytime vigilance and improves long-term memory in patients with OSAHS without modifying night sleep and respiration events.
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Modafinil has no effect on the AHI but reduces objective sleepiness by approximately one minute.
“This drug has no effect on the AHI, 71,72 but has been shown to reduce objective sleepiness by approximately one minute.[70][71][72][73][74][75]”
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- Authors
- Arnulf, I., Homeyer, P., Garma, L., Whitelaw, W. A., & Derenne, J.-P.
- Affiliations
- Pitié-Salpêtrière Hospital (FR)
- ORCID
- Arnulf, Isabelle
- Venue
- Respiration
- Publisher
- S. Karger AG
- Published
- 2009-01-21
- Volume
- 64
- Issue
- 2
- Pages
- 159-161
- ISSN
- 0025-7931 (ISSN-L)
- 1423-0356
- OpenAlex
- W2059150023
- Cited by
- 64
- References
- 0
- Citations by year
- 2024: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2013: 1 · 2012: 2
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Respiration (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- modafinil, obstructive sleep apnea-hypopnea syndrome, excessive daytime sleepiness, long-term memory, nocturnal sleep
- MeSH terms
- Modafinil, Aged, Central Nervous System Stimulants, Benzhydryl Compounds, Double-Blind Method, Humans, Male, Memory, Middle Aged, Pilot Projects, Sleep Apnea Syndromes, Sleep Stages, Polysomnography, Cross-Over Studies
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