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Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
Abstract
Background Patients with non-small-cell lung cancer harbouring mutations in the epidermal growth factor receptor (EGFR) gene respond well to the EGFR-specific tyrosine kinase inhibitor gefitinib. However, whether gefitinib is better than standard platinum doublet chemotherapy in patients selected by EGFR mutation is uncertain.Methods We did an open label, phase 3 study (WJTOG3405) with recruitment between March 31, 2006, and June 22, 2009, at 36 centres in Japan. 177 chemotherapy-naive patients aged 75 years or younger and diagnosed with stage IIIB/IV non-small-cell lung cancer or postoperative recurrence harbouring EGFR mutations (either the exon 19 deletion or L858R point mutation) were randomly assigned, using a minimisation technique, to receive either gefitinib (250 mg/day orally; n=88) or cisplatin (80 mg/m(2), intravenously) plus docetaxel (60 mg/m(2), intravenously; n=89), administered every 21 days for three to six cycles. The primary endpoint was progression-free survival. Survival analysis was done with the modified intention-to-treat population. This study is registered with UMIN (University Hospital Medical Information Network in Japan), number 000000539.Findings Five patients were excluded (two patients were found to have thyroid and colon cancer after randomisation, one patient had an exon 18 mutation, one patient had insufficient consent, and one patient showed acute allergic reaction to docetaxel). Thus, 172 patients (86 in each group) were included in the survival analyses. The gefitinib group had significantly longer progression-free survival compared with the cisplatin plus docetaxel goup, with a median progression-free survival time of 9.2 months (95% CI 8.0-13.9) versus 6.3 months (5.8-7.8; HR 0.489, 95% CI 0.336-0.710, log-rank p<0.0001). Myelosuppression, alopecia, and fatigue were more frequent in the cisplatin plus docetaxel group, but skin toxicity, liver dysfunction, and diarrhoea were more frequent in the gefitinib group. Two patients in the gefitinib group developed interstitial lung disease (incidence 2.3%), one of whom died.Interpretation Patients with lung cancer who are selected by EGFR mutations have longer progression-free survival if they are treated with gefitinib than if they are treated with cisplatin plus docetaxel.Funding West Japan Oncology Group (WJOG): a non-profit organisation supported by unrestricted donations from several pharmaceutical companies.
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In the citing paper
“have shown improved efficacy and tolerability compared with chemotherapy in numerous phase III trials”
From Afatinib for the treatment of EGFR mutation-positive NSCLC: A review of clinical findings (2020) · cites this paper as [30]
In the citing paper
“In clinical trials, the incidence of all-grade liver injury due to different smallmolecule targeted drugs such as tyrosine kinase inhibitors is reportedly 5-55% [144-149].”
From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [145]
In the citing paper
“Eight randomised controlled phase III trials (table 1) have demonstrated that first-generation or second-generation EGFR-TKIs represent the best first-line treatment option in patients with advanced NSCLC whose tumours harbour EGFR mutations, when compared with chemotherapy, because they significantly improved the RR and progression-free survival (PFS).4–11”
From Mechanisms of resistance to EGFR-targeted drugs: lung cancer (2016) · cites this paper as [5]
In the citing paper
“Unfortunately, whilst patients with EGFRm+ tumors typically show good initial responses to first generation TKIs, most patients who respond to therapy ultimately develop disease progression after about 9-14 months of treatment (7-11).”
From AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer (2014) · cites this paper as [8]
In the citing paper
“Most patients whose tumors harbor exon 19 deletions or L858R EGFR activating mutations have radiographic responses to monotherapy with the reversible adenosine triphosphate (ATP)-competitive EGFR tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib 17–23 and the irreversible EGFR TKI afatinib 24.”
From Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer (2013) · cites this paper as [21]
In the citing paper
“Several randomized clinical trials have demonstrated that EGFR TKIs are more effective, as measured by response rate (RR) and progression free survival (PFS), than chemotherapy when used as initial systemic treatment for advanced EGFR mutant NSCLC (1, 4–9).”
From EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors (2015) · cites this paper as [9]
In the citing paper
“Several other trials conducted in Asia confirmed the superiority of Gefitinib over chemotherapy in EGFR-mutated patients [16, 44, 64].”
From A decade of EGFR inhibition in EGFR-mutated non small cell lung cancer (NSCLC): Old successes and future perspectives (2015) · cites this paper as [16]
In the citing paper
“Targeted therapies for these lung cancers were established based on 7 phase III randomized trials.5, 6, 7, 8, 9, 10, 11”
From Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy (2016) · cites this paper as [6]
In the citing paper
“Randomized phase III trials have demonstrated the superiority of these TKI, in terms of progression free survival (PFS), to conventional chemotherapy in patients with lung cancers harboring EGFR mutations.5, 6, 11”
From Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy (2016) · cites this paper as [6]
In the citing paper
“Evidence of these common mutations has been developed in prospective trials: gefitinib, erlotinib and afatinib showed ORR of approximately 60% and PFS of 9–13 months.5, 6, 7, 8, 9, 10, 11”
From Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy (2016) · cites this paper as [6]
In the citing paper
“Despite high tumor response rates with first-line EGFR-TKIs, disease progresses in a majority of patients after 9 to 13 months of treatment.5–12”
From Osimertinib or Platinum–Pemetrexed in EGFR T790M–Positive Lung Cancer (2017) · cites this paper as [6]
In the citing paper
“Several studies have consistently demonstrated that the EGFR TKIs (gefitinib, erlotinib and afatinib) produce higher RRs, longer PFS and improve QoL compared with standard platinum-based doublet chemotherapy in patients with good PS (PS 0-2), whose tumour harbours an activating (sensitising) EGFR mutation [105-112].”
From Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (2016) · cites this paper as [109]
Citations
Cites
Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368
Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma
Mok, T. S., Wu, Y.-L., Thongprasert, S., Yang, C.-H., Chu, D.-T., Saijo, N., Sunpaweravong, P., Han, B., Margono, B., Ichinose, Y., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810699 · Cited by 8,261
Self-citationComparison of Four Chemotherapy Regimens for Advanced Non–Small-Cell Lung Cancer
Schiller, J. H., Harrington, D., Belani, C. P., Langer, C., Sandler, A., Krook, J., Zhu, J., & Johnson, D. H. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011954 · Cited by 4,955
Fukuoka, M., Yano, S., Giaccone, G., Tamura, T., Nakagawa, K., Douillard, J., Nishiwaki, Y., Vansteenkiste, J., Kudoh, S., Rischin, D., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.10.038 · Cited by 2,871
Self-citationKris, M. G., Natale, R. B., Herbst, R. S., Lynch, Jr., Prager, D., Belani, C. P., Schiller, J. H., Kelly, K., Spiridonidis, H., Sandler, A., et al. (2003) · JAMA · doi:10.1001/jama.290.16.2149 · Cited by 2,517
Herbst, R. S., Heymach, J. V., & Lippman, S. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0802714 · Cited by 2,435
Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer
Rosell, R., Moran, T., Queralt, C., Porta, R., Cardenal, F., Camps, C., Majem, M., Lopez-Vivanco, G., Isla, D., Provencio, M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904554 · Cited by 2,373
Pocock, S. J., & Simon, R. (1975) · Biometrics · doi:10.2307/2529712 · Cited by 2,350
Research works printed but not linked: 2
- Cappuzzo, 2009, Efficacy and safety of erlotinib as first-line maintenance in NSCLC following non-progression with chemotherapy: results from the phase III SATURN study, J Thorac Oncol, 4
- Lee, 2009, A randomized phase III study of gefitinib versus standard chemotherapy (gemcitabine plus cisplatin) as a first-line treatment for never-smokers with advanced or metastatic adenocarcinoma of the lung, J Thorac Oncol, 4
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Ah, B., Imielinski, M. B., Duke, F. F., Wala, J. A., Kaplan, N. O., Gx, S., Andres, D., & Meyerson, M. M. (2014) · Oncogene · doi:10.1038/onc.2013.581 · Cited by 86
Haaland, B. A., Tan, P. S., de Castro, G., & Lopes, G. D. L., Jr. (2014) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000156 · Cited by 84
Tanaka, K., Nosaki, K., Otsubo, K., Azuma, K., Sakata, S., Ouchi, H., Morinaga, R., Wataya, H., Fujii, A., Nakagaki, N., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19243 · Cited by 84
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Nishino, M., Soejima, K., & Mitsudomi, T. (2019) · Translational Lung Cancer Research · doi:10.21037/tlcr.2019.05.15 · Cited by 84
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Donington, J. S., & Colson, Y. L. (2011) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2011.07.001 · Cited by 84
Wu, K., Tsai, M., Yang, C., Chang, W., Hung, J., Yen, C.-J., Shen, C.-H., Kuo, T.-Y., Lee, J., Chou, S., et al. (2015) · Lung Cancer · doi:10.1016/j.lungcan.2015.02.012 · Cited by 84
Handorf, E. A., McElligott, S. C., Vachani, A., Langer, C. J., Bristol, M. N., Armstrong, K., & Asch, D. A. (2012) · Journal of Oncology Practice · doi:10.1200/jop.2011.000502 · Cited by 85
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Jurado, J. E., Saqi, A., Maxfield, R. A., Newmark, A., Lavelle, M., Bacchetta, M. D., Gorenstein, L. A., D’Ovidio, F., Ginsburg, M. E., Sonett, J. R., et al. (2013) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2013.05.066 · Cited by 84
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Bylicki, O., Paleiron, N., Margery, J., Guisier, F., Vergnenégre, A., Robinet, G., Auliac, J. B., Gervais, R., & CHOUAID, C. (2017) · Targeted Oncology · doi:10.1007/s11523-017-0510-9 · Cited by 82
Wang, L., Syn, N. L. X., Subhash, V. V., Any, Y., Thuya, W. L., Cheow, E. S. H., Kong, L. R., Yu, F., Peethala, P. C., Wong, A. L., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2017.12.030 · Cited by 82
Petrek, H. E., & Yu, A. (2019) · Pharmacology Research & Perspectives · doi:10.1002/prp2.528 · Cited by 82
Bazhenova, L. A., Minchom, A. R., Viteri, S., Bauml, J. M., Ou, S. I., Gadgeel, S. M., Trigo, J. M., Backenroth, D., Li, T. M. W. Y., Londhe, A., et al. (2021) · Lung Cancer · doi:10.1016/j.lungcan.2021.10.020 · Cited by 82
The Tissue Is the Issue: Personalized Medicine for Non-Small Cell Lung Cancer
Hirsch, F. R., Wynes, M. W., Gandara, D. R., & Bunn, P. A. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2005 · Cited by 82
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Wang, R., Zhang, Y., Pan, Y., Li, Y., Hu, H., Cai, D., Li, H., Ye, T., Luo, X., Zhang, Y., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5549 · Cited by 82
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Torres-Roca, J. F. (2012) · Personalized Medicine · doi:10.2217/pme.12.55 · Cited by 81
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Dy, G. K., & Reungwetwattana, T. (2013) · Journal of Carcinogenesis · doi:10.4103/1477-3163.123972 · Cited by 80
Rolfo, C. D., Giovannetti, E., Hong, D. S., Bivona, T. G., Raez, L. E., Bronte, G., Buffoni, L., Reguart, N., Santos, E. S., Germonpré, P. R., et al. (2014) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2014.05.009 · Cited by 80
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Ziv, E., Durack, J. C., & Solomon, S. B. (2016) · The Cancer Journal · doi:10.1097/ppo.0000000000000228 · Cited by 80
Kobayashi, Y., Azuma, K., Nagai, H., Kim, Y. H., Togashi, Y., Sesumi, Y., Chiba, M., Shimoji, M., Sato, K., Tomizawa, K., et al. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0407 · Cited by 80
Self-citationEGFR mutations as a prognostic and predictive marker in non-small-cell lung cancer
Wang, Z., & Fang, S. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s69690 · Cited by 80
Gurtner, K., Deuse, Y., Bütof, R., Schaal, K., Eicheler, W., Oertel, R., Grenman, R. A., Thames, H. D., Yaromina, A., Baumann, M. A., et al. (2011) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2011.05.035 · Cited by 80
Travis, W. D. (2011) · Seminars in Roentgenology · doi:10.1053/j.ro.2011.02.003 · Cited by 80
Langer, C. J. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.49.8782 · Cited by 79
Hashida, S., Yamamoto, H., Shien, K., Miyoshi, Y., Ohtsuka, T., Suzawa, K., Watanabe, M., Maki, Y., Soh, J., Asano, H., et al. (2015) · Cancer Science · doi:10.1111/cas.12749 · Cited by 79
Self-citationHirsch, F. R., Kabbinavar, F. F., Eisen, T. G., Martins, R. G., Schnell, F. M., Dziadziuszko, R., Richardson, K., Richardson, F. C., Wacker, B., Sternberg, D., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.34.4929 · Cited by 79
Song, Z., Yu, X., Cheng, G., & Zhang, Y. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0943-4 · Cited by 79
Luo, P., Yan, H., Du, J., Chen, X., Shao, J., Zhang, Y., Xu, Z., Jin, Y. H., Lin, N., Yang, B., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1851492 · Cited by 79
Iwama, E., Zenke, Y., Sugawara, S., Daga, H., Morise, M., Yanagitani, N., Sakamoto, T., Murakami, H., Kishimoto, J., Matsumoto, S., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.11.021 · Cited by 81
Self-citationTamiya, M., Okamoto, N., Sasada, S., Shiroyama, T., Morishita, N., Suzuki, H., Yoshida, E., Hirashima, T., Kawahara, K., & Kawase, I. (2013) · Respirology · doi:10.1111/resp.12095 · Cited by 79
Self-citationMak, R. H., Hermann, G., Lewis, J. H., Aerts, H. J. W. L., Baldini, E. H., Chen, A. B., Colson, Y. L., Hacker, F., Kozono, D., Wee, J. O., et al. (2014) · Clinical Lung Cancer · doi:10.1016/j.cllc.2014.09.005 · Cited by 79
Kuo, Y.-W., Wu, S., Ho, C., & Shih, J. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181f43274 · Cited by 79
Choi, Y., Sun, J., Cho, J., Rampal, S., Han, J., Parasuraman, B. M., Güallar, E., Lee, G., Lee, J., & Shim, Y. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056011 · Cited by 79
Ishii, H., Azuma, K., Sakai, K., Kawahara, A., Yamada, K., Tokito, T., Okamoto, I., Nishio, K., & Hoshino, T. (2015) · Oncotarget · doi:10.18632/oncotarget.5068 · Cited by 78
Self-citationBronte, G., Rolfo, C. D., Giovannetti, E., Cicero, G., Pauwels, P., Passiglia, F., Castiglia, M., Rizzo, S., Vullo, F. L., Fiorentino, E., et al. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.08.003 · Cited by 78
Han, H., Lim, S.-N., An, J. Y., Lee, K. M., Choe, K. H., Lee, K. H., Kim, S. T., Son, S.-M., Choi, S., Lee, H.-C., et al. (2011) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31823c4c1b · Cited by 78
Shin, D. H., Lee, D., Hong, D. W., Hong, S. H., Hwang, J.-A., Lee, B. I., You, H. J., Lee, G. K., Kim, I.-H., Lee, Y.-S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11913 · Cited by 78
Clonality status of multifocal lung adenocarcinomas based on the mutation patterns of EGFR and K-ras
Takamochi, K., Oh, S., Matsuoka, J., & Suzuki, K. (2011) · Lung Cancer · doi:10.1016/j.lungcan.2011.08.007 · Cited by 78
Management of egfr tki—Induced Dermatologic Adverse Events
Melosky, B. L., Leighl, N. B., Rothenstein, J. M., Sangha, R. S., Stewart, D. J., & Papp, K. A. (2015) · Current Oncology · doi:10.3747/co.22.2430 · Cited by 78
Large-Cell Neuroendocrine Carcinoma of the Lung Harboring EGFR Mutation and Responding to Gefitinib
Pas, T. M. D., Giovannini, M., Manzotti, M., Trifirò, G., Toffalorio, F., Catania, C., Spaggiari, L., Labianca, R., & Barberis, M. C. P. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.36.2251 · Cited by 78
Milan, E., Lazzari, C., Anand, S. K., Floriani, I., Torri, V., Sorlini, C., Gregorc, V., & Bachi, A. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.06.022 · Cited by 78
Cheng, G., Song, Z., & Chen, D. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s108242 · Cited by 77
Drug development to overcome resistance to EGFR inhibitors in lung and colorectal cancer
Dienstmann, R., Dosso, S. D., Felip, E., & Tabernero, J. M. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.11.009 · Cited by 77
Drug Resistance Mechanisms in Non-Small Cell Lung Carcinoma
Wangari‐Talbot, J., & Hopper-Borge, E. A. (2013) · Journal of cancer research updates · doi:10.6000/1929-2279.2013.02.04.5 · Cited by 80
Okamoto, I., Morita, S., Tashiro, N., Imamura, F., Inoue, A., Seto, T., Yamamoto, N., Ohe, Y., Nakagawa, K., & Fukuoka, M. (2018) · Lung Cancer · doi:10.1016/j.lungcan.2018.01.005 · Cited by 77
Self-citationHayashi, H., Sugawara, S., Fukuda, Y., Fujimoto, D., Miura, S., Ota, K., Ozawa, Y., Hara, S., Tanizaki, J., Azuma, K., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-3194 · Cited by 77
Self-citationPredicting EGFR and PD-L1 Status in NSCLC Patients Using Multitask AI System Based on CT Images
Wang, C., Ma, J., Shao, J., Zhang, S., Liu, Z., Yu, Y., & Li, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.813072 · Cited by 80
Kasahara, K., Arao, T., Sakai, K., MATSUMOTO, K. Y., Sakai, A., Kimura, H., Sone, T., Horiike, A., Nishio, M., Ohira, T., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0383 · Cited by 77
The Value of Liquid Biopsies for Guiding Therapy Decisions in Non-small Cell Lung Cancer
Saarenheimo, J., Eigėlienė, N., Andersén, H., Tiirola, M., & Jekunen, A. P. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00129 · Cited by 76
Song, Z., Zhu, H., Guo, Z., Wu, W., Sun, W., & Zhang, Y. (2013) · Medical Oncology · doi:10.1007/s12032-013-0645-1 · Cited by 76
EGFR T790M resistance mutation in non small-cell lung carcinoma
Denis, M. G., Vallée, A., & Théoleyre, S. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.01.039 · Cited by 76
Qi, W., Sun, Y., Shen, Z., & Yao, Y. (2014) · Journal of Chemotherapy · doi:10.1179/1973947814y.0000000189 · Cited by 76
Guan, J., Chen, M., Xiao, N., Li, L., Zhang, Y., Li, Q., Yang, M. Y., Liu, L., & Chen, L. (2015) · Medical Oncology · doi:10.1007/s12032-015-0714-8 · Cited by 75
Nuclear mode of the EGFR signaling network: biology, prognostic value, and therapeutic implications.
Lo, H. (2010) · PubMed · Cited by 75
Robinson, K. W., & Sandler, A. B. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-0262 · Cited by 75
Won, Y., Han, J., Lee, G. K., Park, S.-Y., Lim, K. Y., Yoon, K., Yun, T., Kim, H. T., & Lee, J. S. (2011) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2011-200169 · Cited by 75
Sugano, T., Seike, M., Noro, R., Soeno, C., Chiba, M., Zou, F., Nakamichi, S., Nishijima, N., Matsumoto, M., Miyanaga, A., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0050 · Cited by 75
Sutiman, N., Tan, S. W., Tan, E. H., Lim, W. T., Kanesvaran, R., Ng, Q. S., Jain, A., Ang, M., Tan, W. L., Toh, C., et al. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.11.2225 · Cited by 75
The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib
Vishwanathan, K., Dickinson, P. A., So, K., Thomas, K., Chen, Y., de Castro, J., Dingemans, A. C., Kim, H. R., Kim, J.-H., Krebs, M., et al. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13534 · Cited by 75
Wang, W., Xu, C., Chen, H., Jia, J., Wang, L., Feng, H., Wang, H., Song, Z., Yang, N., & Zhang, Y. (2021) · Lung Cancer · doi:10.1016/j.lungcan.2021.03.006 · Cited by 75
Hata, A. N., Yeo, A., Faber, A. C., Lifshits, E., Chen, Z., Cheng, K. A., Walton, Z., Sarosiek, K. A., Letai, A., Heist, R. S., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3728 · Cited by 74
Nakamura, T., Sueoka‐Aragane, N., Iwanaga, K., Sato, A., Komiya, K., Abe, T., Ureshino, N., Hayashi, S., Hosomi, T., Hirai, M., et al. (2011) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31822956e8 · Cited by 74
Guo, L., Song, P., Xue, X., Guo, C., Han, L., Fang, Q., Ying, J., Gao, S., & Li, W. (2019) · Journal of Immunotherapy · doi:10.1097/cji.0000000000000275 · Cited by 74
Nakamura, T., Sueoka‐Aragane, N., Iwanaga, K., Sato, A., Komiya, K., Kobayashi, N., Hayashi, S., Hosomi, T., Hirai, M., Sueoka, E., et al. (2012) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31825f2821 · Cited by 74
Lozano, M. D., Zulueta, J. J., Echeveste, J. I., Gúrpide, A., Seijo, L. M., Martín‐Algarra, S., del Barrio, A., Pı́o, R., Idoate, M. A., Labiano, T., et al. (2011) · The Oncologist · doi:10.1634/theoncologist.2010-0155 · Cited by 74
Bria, E., Pilotto, S., Amato, E., Fassan, M., Novello, S., Peretti, U., Vavalà, T., Kinspergher, S., Righi, L., Santo, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3727 · Cited by 74
Kuiper, J. L., Hashemi, S. M. S., Thunnissen, E., Snijders, P. J. F., Grünberg, K., Bloemena, E., Sie, D., Postmus, P. E., Heideman, D. A. M., & Smit, E. F. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.372 · Cited by 73
Bulman, W. A., Saqi, A., & Powell, C. A. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201107-1199ci · Cited by 73
Takahama, T., Sakai, K., Takeda, M., Azuma, K., Hida, T., Hirabayashi, M., Oguri, T., Tanaka, H., Ebi, N., Sawa, T., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11303 · Cited by 73
Self-citationKenmotsu, H., Yoh, K., Mori, K., Ono, A., Baba, T., Fujiwara, Y., Yamaguchi, O., Ko, R., Okamoto, H., Yamamoto, N., et al. (2019) · Cancer Science · doi:10.1111/cas.14217 · Cited by 73
Greenhalgh, J., Boland, A., Bates, V., Vecchio, F., Dundar, Y., Chaplin, M., & Green, J. A. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010383.pub3 · Cited by 73
Berger, L. A., Riesenberg, H., Bokemeyer, C., & Atanackovic, D. (2013) · Lung Cancer · doi:10.1016/j.lungcan.2013.02.004 · Cited by 73
Landi, L. M., & Cappuzzo, F. (2013) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2013.846830 · Cited by 73
Cadranel, J. L., Mauguen, A., Beau‐Faller, M., Zalcman, G., Buisine, M., Westeel, V., Longchampt, É., Wislez, M., Coudert, B. P., Daniel, C., et al. (2012) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e318265b2b5 · Cited by 73
Advances on EGFR mutation for lung cancer.
Metro, G., & Crinò, L. (2012) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2218-6751.2011.12.01 · Cited by 73
Cho, J., Pastorino, S., Zeng, Q., Xu, X., Johnson, W. E., VandenBerg, S. R., Verhaak, R. G. W., Cherniack, A. D., Watanabe, H., Dutt, A., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0821 · Cited by 73
MEK inhibitors under development for treatment of non-small-cell lung cancer
Kim, C. G., & Giaccone, G. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1415324 · Cited by 73
Gu, X., Zhang, Q., Chu, Y.-B., Zhao, Y., Zhang, Y., Kuo, D. C., Su, B., & Wu, B. Y. (2018) · Lung Cancer · doi:10.1016/j.lungcan.2018.11.029 · Cited by 73
Clinical Outcomes in Non–Small Cell Lung Cancers Harboring Different Exon 19 Deletions in EGFR
Chung, K.-P., Wu, S.-G., Wu, J.-Y., Yang, J. C.-H., Yu, C.-J., Wei, P.-F., Shih, J.-Y., & Yang, P.-C. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2353 · Cited by 72
Ku, G. Y., Haaland, B. A., & Lopes, G. D. L., Jr. (2011) · Lung Cancer · doi:10.1016/j.lungcan.2011.04.008 · Cited by 72
Shi, H. R., Pu, J., Zhou, X., Ning, Y., & Bai, C. (2017) · Tumor Biology · doi:10.1177/1010428317697568 · Cited by 72
Oh, I., Ban, H., Kim, K., & Kim, Y. (2012) · Lung Cancer · doi:10.1016/j.lungcan.2012.01.012 · Cited by 72
Shimada, Y., Saji, H., Yoshida, K., Kakihana, M., Honda, H., Nomura, M., Usuda, J., Kajiwara, N., Ohira, T., & Ikeda, N. (2013) · CHEST Journal · doi:10.1378/chest.12-1717 · Cited by 72
Next-Generation Covalent Irreversible Kinase Inhibitors in NSCLC: Focus on Afatinib
Hirsh, V. (2015) · BioDrugs · doi:10.1007/s40259-015-0130-9 · Cited by 72
Gao, X. Y., Le, X., & Costa, D. B. (2016) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2016.1162103 · Cited by 72
Ellis, P. M., Coakley, N., Feld, R. D., Kuruvilla, S., & Ung, Y. (2015) · Current Oncology · doi:10.3747/co.22.2566 · Cited by 71
Gefitinib for advanced non-small cell lung cancer
Sim, E., Yang, I. A., Wood-Baker, R. R., Bowman, R., & Fong, K. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006847.pub2 · Cited by 71
Bialk, P. A., Wang, Y., Banas, K. H., & Kmiec, E. B. (2018) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2018.10.002 · Cited by 71
Role of inflammation and oxidative stress in chemotherapy-induced neurotoxicity
Gupta, P., Makkar, T. K., Goel, L., & Pahuja, M. (2022) · Immunologic Research · doi:10.1007/s12026-022-09307-7 · Cited by 71
Personalized Targeted Therapy for Lung Cancer
Wu, K., House, L. K., Liu, W., & Cho, W. C. S. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130911471 · Cited by 71
Metadata
- Authors
- Mitsudomi, T., Morita, S., Yatabe, Y., Negoro, S., Okamoto, I., Tsurutani, J., Seto, T., Satouchi, M., Tada, H., Hirashima, T., Asami, K., Katakami, N., Takada, M., Yoshioka, H., Shibata, K., Kudoh, S., Shimizu, E., Saito, H., Toyooka, S., Nakagawa, K., & Fukuoka, M.
- Affiliations
- Aichi Cancer Center (JP)
- Yokohama City University Medical Center (JP)
- Hyogo Prefectural Cancer Center (JP)
- Kindai University (JP)
- National Hospital Organization Kyushu Cancer Center (JP)
- Osaka City General Hospital (JP)
- Osaka Habikino Medical Center (JP)
- NHO Kinki Chuo Chest Medical Center (JP)
- Kobe City Medical Center General Hospital (JP)
- Kurashiki Central Hospital (JP)
- Kouseiren Takaoka Hospital (JP)
- Osaka City University (JP)
- Tottori University (JP)
- Okayama University (JP)
- Corresponding author
- Mitsudomi, Tetsuya
- ORCID
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 11
- Issue
- 2
- Pages
- 121-128
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2129360604
- Cited by
- 4,090
- References
- 34
- Citations by year
- 2026: 31 · 2025: 110 · 2024: 130 · 2023: 140 · 2022: 211 · 2021: 228 · 2020: 236 · 2019: 264 · 2018: 318 · 2017: 329 · 2016: 312 · 2015: 382 · 2014: 372 · 2013: 352 · 2012: 300
- FWCI
- 187.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- AstraZeneca
- Sanofi
- European Society for Medical Oncology
- Chugai Pharmaceutical
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Keywords
- gefitinib, non-small cell lung cancer, EGFR mutation, EGFR tyrosine kinase inhibitors, exon 19 deletion, L858R mutation, progression-free survival, platinum-based chemotherapy, first-line therapy, myelosuppression, postoperative recurrence
- MeSH terms
- Docetaxel, Gefitinib, Aged, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Cisplatin, Female, Humans, Lung Neoplasms, Male, Middle Aged, Mutation, Quinazolines, Taxoids, ErbB Receptors
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