Cited by 811Immune Response and InflammationCytokine Signaling Pathways and InteractionsInflammation biomarkers and pathways

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IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation

Kaplanski, G·2003·Trends in Immunology

DOI 10.1016/s1471-4906(02)00013-3

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Abstract

The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in evolution, is a topic of extensive debate. We postulate a surveillance model: these receptors "keep watch" for both endogenous and exogenous molecules that indicate tissue inquiry, infection and remodeling. Furthermore, we suggest that the first Toll-like family receptors that arose in evolution might have acted in both development and immunity by recognizing the degradation of endogenous macromolecules.

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Authors: Kaplanski, G.
Affiliations: Inserm (FR)
Corresponding author: Kaplanski, G
ORCID: Kaplanski, G
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2003-01
Volume: 24
Issue: 1
Pages: 25-29
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/s1471-4906(02)00013-3
OpenAlex: W2091169302
Cited by: 811
References: 39
Citations by year: 2026: 24 · 2025: 29 · 2024: 27 · 2023: 29 · 2022: 39 · 2021: 56 · 2020: 62 · 2019: 33 · 2018: 37 · 2017: 49 · 2016: 53 · 2015: 29 · 2014: 31 · 2013: 39 · 2012: 36
FWCI: 7.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: interleukin-6, neutrophil recruitment, monocyte recruitment, inflammation, Toll-like receptors, immune system evolution, innate immunity
MeSH terms: Animals, Cell Movement, Humans, Inflammation, Lymph Nodes, Models, Biological, Monocytes, Neutrophils, Signal Transduction, Interleukin-6, Apoptosis, Receptors, Interleukin-6, Mice

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IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation

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