The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation
Abstract
The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in evolution, is a topic of extensive debate. We postulate a surveillance model: these receptors "keep watch" for both endogenous and exogenous molecules that indicate tissue inquiry, infection and remodeling. Furthermore, we suggest that the first Toll-like family receptors that arose in evolution might have acted in both development and immunity by recognizing the degradation of endogenous macromolecules.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“IL-6 is a chemotactic and prosurvival factor for monocytes and neutrophils.83”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [83]
Citations
Cites
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 7,009
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166
Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X.-F., & Achong, M. K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1368 · Cited by 1,578
Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396
Atreya, R., Mudter, J., Finotto, S., Müllberg, J., Jostock, T., Wirtz, S., Schütz, M., Bartsch, B., Holtmann, M., Becker, C., et al. (2000) · Nature Medicine · doi:10.1038/75068 · Cited by 1,293
Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment
Romano, M., Sironi, M., Toniatti, C., Polentarutti, N., Fruscella, P., Ghezzi, P., Faggioni, R., Luini, W., van Hinsbergh, V. W. M., Sozzani, S., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80334-9 · Cited by 1,124
Hurst, S. M., Wilkinson, T. S., McLoughlin, R. M., Jones, S., Horiuchi, S., Yamamoto, N., Rose-John, S., Fuller, G. M., Topley, N., & Jones, S. A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00151-0 · Cited by 811
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
Randolph, G. J., Beaulieu, S., Lebecque, S., Steinman, R. M., & Müller, W. A. (1998) · Science · doi:10.1126/science.282.5388.480 · Cited by 809
Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation
Buckley, C. D., Pilling, D., Lord, J. M., Akbar, A. N., Scheel-Toellner, D., & Salmon, M. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)01863-4 · Cited by 796
Cited by
Sorted by citations
Items 801–811 of 811
3D-QSAR Modeling of the Anti-Inflammatory Activity of 28 Rare Biflavones
Zheng, H., Cao, Y., Chin, F. W. L., Zhang, Q. F., Zhan, N., Zhang, M., Yang, X., Toy, J. Y. H., & Huang, D. (2026) · ACS Omega · doi:10.1021/acsomega.5c13338
Context-dependent regulation of IL-6 in exercise and colorectal cancer cachexia
Xiong, J., Liu, S., Xu, J., Zhang, J., Peng, Y., Xia, Y., & Qian, J. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1792184
Tizard, I. R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44863-8.00012-0
Ithurbide, M., Rupp, R., Fassier, T., Friggens, N. C., & Foucras, G. (2026) · PLoS ONE · doi:10.1371/journal.pone.0356779
Wu, T., Zhou, Y., Yao, G., Ding, Y., Hu, S., & Ding, Z. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188246
Avery, J. T., Zabroski, S. M., Hensley, H. E., Harmon, K. A., Kimmerling, K. A., & Mowry, K. C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1917691
Development of Paquinimod‐Loaded Implants to Modulate the Foreign Body Response
Weber, C., Vanderzee, I., Danon, S., Lin, M., Kodikalla, S., & Morris, A. H. (2026) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.70168
Dib, H. H. (2026) · International Reviews of Immunology · doi:10.1080/08830185.2026.2736207
Zhu, M., Lee, S.-H., Oh, G.-S., Kim, J.-S., Seo, J. H., & So, H.-S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1973758
BindingDB (2026) · UC San Diego · doi:10.7270/q2np29bc
BindingDB (2021) · UC San Diego · doi:10.7270/q2rr22tc
Metadata
- Authors
- Kaplanski, G.
- Affiliations
- Inserm (FR)
- Corresponding author
- Kaplanski, G
- ORCID
- Kaplanski, G
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 24
- Issue
- 1
- Pages
- 25-29
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2091169302
- Cited by
- 811
- References
- 39
- Citations by year
- 2026: 24 · 2025: 29 · 2024: 27 · 2023: 29 · 2022: 39 · 2021: 56 · 2020: 62 · 2019: 33 · 2018: 37 · 2017: 49 · 2016: 53 · 2015: 29 · 2014: 31 · 2013: 39 · 2012: 36
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- interleukin-6, neutrophil recruitment, monocyte recruitment, inflammation, Toll-like receptors, immune system evolution, innate immunity
- MeSH terms
- Animals, Cell Movement, Humans, Inflammation, Lymph Nodes, Models, Biological, Monocytes, Neutrophils, Signal Transduction, Interleukin-6, Apoptosis, Receptors, Interleukin-6, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
