Intracellular pharmacodynamics of antibiotics

Goodman & Gilman's The Pharmacological Basis of Therapeutics

Brunton, L. L. (1985) · Cited by 7,321 · see citing works

Goodman and Gilman's the Pharmacological Basis of Therapeutics

Stigelman, W. H., & Pharm, D. (1986) · Military Medicine · doi:10.1093/milmed/151.1.386 · Cited by 6,796 · see citing works

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

Ohkuma, S., & Poole, B. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.7.3327 · Cited by 2,185 · see citing works

Lysosomotropic Agents

De Duve, C., De Barsy, T., Poole, B., Trouet, A., Tulkens, P., & Van Hoof, F. (1974) · Biochemical Pharmacology · doi:10.1016/0006-2952(74)90174-9 · Cited by 1,901 · see citing works

Role of nitric oxide synthesis in macrophage antimicrobial activity

Nathan, C. F., & Hibbs, J. B. (1991) · Current Opinion in Immunology · doi:10.1016/0952-7915(91)90079-g · Cited by 1,523 · see citing works

Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine.

Tipper, D. J., & Strominger, J. L. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.4.1133 · Cited by 1,008 · see citing works

Tularemia

Ellis, J., Oyston, P. C. F., Green, M., & Titball, R. W. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.4.631-646.2002 · Cited by 814 · see citing works

Mammalian defensins in immunity: more than just microbicidal

Yang, D., Biragyn, A., Kwak, L. W., & Oppenheim, J. J. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02246-9 · Cited by 696 · see citing works

Murine Salmonellosis Studied by Confocal Microscopy: <i>Salmonella typhimurium</i> Resides Intracellularly Inside Macrophages and Exerts a Cytotoxic Effect on Phagocytes In Vivo

Richter-Dahlfors, A., Buchan, A. M. J., & Finlay, B. B. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.4.569 · Cited by 502 · see citing works

The cell biology of Listeria monocytogenes infection

Portnoy, D. A., Auerbuch, V., & Glomski, I. J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205009 · Cited by 449 · see citing works

Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells

Byrne, G. I., LEHMANN, L. K., & Landry, G. (1986) · Infection and Immunity · doi:10.1128/iai.53.2.347-351.1986 · Cited by 392 · see citing works

Continuous infusion of beta-lactam antibiotics

Craig, W. A., & Ebert, S. C. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.12.2577 · Cited by 340 · see citing works

Comparative Pharmacokinetics and Pharmacodynamics of the Rifamycin Antibacterials

Burman, W. J., Gallicano, K., & Peloquin, C. A. (2001) · Clinical Pharmacokinetics · doi:10.2165/00003088-200140050-00002 · Cited by 338 · see citing works

Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.

Moestrup, S. K., Cui, S., Vorum, H., Bregengaard, C., Bjørn, S. E., Norris, K. E., Gliemann, J., & Christensen, E. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118176 · Cited by 337 · see citing works

Autoradiography of gentamicin uptake by the rat proximal tubule cell

Silverblatt, F. J., & Kuehn, C. (1979) · Kidney International · doi:10.1038/ki.1979.45 · Cited by 304 · see citing works

Antibiotic entry into human polymorphonuclear leukocytes

Prokesch, R. C., & Hand, W. L. (1982) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.21.3.373 · Cited by 293 · see citing works

Intracellular distribution and activity of antibiotics

Tulkens, P. M. (1991) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01964420 · Cited by 291 · see citing works

The road less traveled

Roy, C. R., & Tilney, L. G. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205011 · Cited by 284 · see citing works

Antibiotic uptake by alveolar macrophages.

Johnson, J. D., Hand, W. L., Francis, J., King-Thompson, N. L., & Corwin, R. W. (1980) · PubMed · Cited by 280 · see citing works

Multiple Drug–ResistantChlamydia trachomatisAssociated with Clinical Treatment Failure

Somani, J., Bhullar, V. B., Workowski, K., FARSHY, C. E., & Black, C. M. (2000) · The Journal of Infectious Diseases · doi:10.1086/315372 · Cited by 262 · see citing works

Identification of the aminoglycoside binding site in rat renal brush border membranes.

Sastrasinh, M., Knauss, T. C., Weinberg, J. M., & Humes, H. D. (1982) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33203-9 · Cited by 220 · see citing works

Megalin Deficiency Offers Protection from Renal Aminoglycoside Accumulation

Schmitz, C., Hilpert, J., Jacobsen, C. B., Boensch, C., Christensen, E., Luft, F. C., & Willnow, T. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109959200 · Cited by 215 · see citing works

THE SURVIVAL OF STAPHYLOCOCCI WITHIN HUMAN LEUKOCYTES

Rogers, D. E., & Tompsett, R. R. (1952) · The Journal of Experimental Medicine · doi:10.1084/jem.95.2.209 · Cited by 201 · see citing works

Proteins in the chlamydial inclusion membrane

Rockey, D. D., Scidmore, M. A., Bannantine, J. P., & Brown, W. J. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)01546-0 · Cited by 186 · see citing works

Antibiotic tissue penetration and its relevance: impact of tissue penetration on infection response

Nix, D. E., Goodwin, S., Peloquin, C. A., Rotella, D. L., & Schentag, J. J. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.10.1953 · Cited by 176 · see citing works

Antimicrobial Drugs, Microorganisms, and Phagocytes

van den Broek, P. J. (1989) · Clinical Infectious Diseases · doi:10.1093/clinids/11.2.213 · Cited by 175 · see citing works

The uptake and intracellular accumulation of aminoglycoside antibiotics in lysosomes of cultured rat fibroblasts

Tulkens, P., & Trouet, A. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90370-2 · Cited by 157 · see citing works

Coxiella burnetii Survival in THP-1 Monocytes Involves the Impairment of Phagosome Maturation: IFN-γ Mediates its Restoration and Bacterial Killing

Ghigo, É., Capo, C., Tung, C., Raoult, D., Gorvel, J., & Mège, J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4488 · Cited by 154 · see citing works

Quantitative Analysis of Gentamicin, Azithromycin, Telithromycin, Ciprofloxacin, Moxifloxacin, and Oritavancin (LY333328) Activities against Intracellular Staphylococcus aureus in Mouse J774 Macrophages

Seral, C., Bambeke, F. V., & Tulkens, P. M. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.7.2283-2292.2003 · Cited by 152 · see citing works

Entry and survival of pathogenic mycobacteriain macrophages

Pieters, J. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01376-4 · Cited by 147 · see citing works

Intracellular multiplication of Legionnaires' disease bacteria (Legionella pneumophila) in human monocytes is reversibly inhibited by erythromycin and rifampin.

Horwitz, M. A., & Silverstein, S. C. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110744 · Cited by 147 · see citing works

Antibiotic tissue penetration and its relevance: models of tissue penetration and their meaning

Nix, D. E., Goodwin, S., Peloquin, C. A., Rotella, D. L., & Schentag, J. J. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.10.1947 · Cited by 143 · see citing works

The renal handling of polybasic drugs

Just, M., Erdmann, G., & Habermann, E. (1977) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00505080 · Cited by 140 · see citing works

Comparative Intracellular (THP-1 Macrophage) and Extracellular Activities of β-Lactams, Azithromycin, Gentamicin, and Fluoroquinolones against Listeria monocytogenes at Clinically Relevant Concentrations

Carryn, S., Françoise Van Bambeke, A., Mingeot‐Leclercq, M., & Tulkens, P. M. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.7.2095-2103.2002 · Cited by 132 · see citing works

Uptake of ciprofloxacin by human neutrophils

EASMON, C. S. F., & Crane, J. P. (1985) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/16.1.67 · Cited by 132 · see citing works

Role of megalin in renal handling of aminoglycosides

Nagai, J., Tanaka, H., Nakanishi, N., Murakami, T., & Takano, M. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.281.2.f337 · Cited by 126 · see citing works

Role of transferrin, transferrin receptors, and iron in macrophage listericidal activity.

Alford, C., King, T. E., & Campbell, P. A. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.2.459 · Cited by 118 · see citing works

Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus

Seral, C. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg223 · Cited by 115 · see citing works

Cellular uptake, localization and activity of fluoroquinolones in uninfected and infected macrophages

Carlier, M.-B., Scorneaux, B., Zenebergh, A., Desnottes, J. F., & Tulkens, P. M. (1990) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/26.suppl_b.27 · Cited by 112 · see citing works

Gentamicin-Induced Apoptosis in Renal Cell Lines and Embryonic Rat Fibroblasts

Mouedden, M. E. (2000) · Toxicological Sciences · doi:10.1093/toxsci/56.1.229 · Cited by 108 · see citing works

Ultrastructure of Rickettsia rickettsii Actin Tails and Localization of Cytoskeletal Proteins

Kirk, L. S. V., Hayes, S. F., & Heinzen, R. A. (2000) · Infection and Immunity · doi:10.1128/iai.68.8.4706-4713.2000 · Cited by 105 · see citing works

Uptake of ciprofloxacin by macrophages.

EASMON, C. S. F., & Crane, J. P. (1985) · Journal of Clinical Pathology · doi:10.1136/jcp.38.4.442 · Cited by 103 · see citing works

Antibiotic efflux pumps in eukaryotic cells: occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics

Françoise Van Bambeke, A. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg225 · Cited by 101 · see citing works

THE PHAGOCYTOSIS AND INACTIVATION OF STAPHYLOCOCCI BY MACROPHAGES OF NORMAL RABBITS

Mackaness, G. B. (1960) · The Journal of Experimental Medicine · doi:10.1084/jem.112.1.35 · Cited by 100 · see citing works

Uptake of antibiotics by human alveolar macrophages.

Hand, W. L., Corwin, R. W., Steinberg, T. H., & Grossman, G. (1984) · PubMed · doi:10.1164/arrd.1984.129.6.933 · Cited by 93 · see citing works

A Microbial Strategy to Multiply in Macrophages: The Pregnant Pause

Swanson, M. S., & Fernández-Moreira, E. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.030302.x · Cited by 90 · see citing works

Interactions of Macrolide Antibiotics (Erythromycin A, Roxithromycin, Erythromycylamine [Dirithromycin], and Azithromycin) with Phospholipids: Computer-Aided Conformational Analysis and Studies on Acellular and Cell Culture Models

Montenez, J. P., Françoise Van Bambeke, A., Piret, J., Brasseur, R., Tulkens, P. M., & Mingeot-Leclercq, M. P. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8632 · Cited by 86 · see citing works

Uptake, Transport, and Delivery of Antimicrobial Agents by Human Polymorphonuclear Neutrophils

Mandell, G. L., & Coleman, E. J. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.6.1794-1798.2001 · Cited by 85 · see citing works

Influence of conversion of penicillin G into a basic derivative on its accumulation and subcellular localization in cultured macrophages

Renard, C., Vanderhaeghe, H., Claes, P. J., Zenebergh, A., & Tulkens, P. M. (1987) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.31.3.410 · Cited by 80 · see citing works

Membrane transport of clindamycin in alveolar macrophages

Hand, W. L., & King-Thompson, N. L. (1982) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.21.2.241 · Cited by 75 · see citing works

Azithromycin, a Lysosomotropic Antibiotic, Has Distinct Effects on Fluid-Phase and Receptor-Mediated Endocytosis, but Does Not Impair Phagocytosis in J774 Macrophages

Tyteca, D. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5613 · Cited by 75 · see citing works

Accumulation, release and subcellular localization of azithromycin in phagocytic and non-phagocytic cells in culture.

Carlier, M.-B., Garcı́a, I., Montenez, J. P., Tulkens, P. M., & Piret, J. (1994) · PubMed · Cited by 74 · see citing works

Molecular Basis of the Intracellular Spreading of Shigella

Suzuki, T., & Sasakawa, C. (2001) · Infection and Immunity · doi:10.1128/iai.69.10.5959-5966.2001 · Cited by 73 · see citing works

In Vitro Activities of Azithromycin and Ofloxacin againstChlamydia pneumoniaein a Continuous-Infection Model

Kutlin, A., Roblin, P. M., & Hammerschlag, M. R. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.9.2268 · Cited by 71 · see citing works

Fluorometric measurement of ofloxacin uptake by human polymorphonuclear leukocytes

Pascual, Á., Garcı́a, I., & Perea, E. J. (1989) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.33.5.653 · Cited by 70 · see citing works

Prediction of Efficacy of Antimicrobial Agents in Treatment of Infections Due to Chlamydia trachomatis

Bowie, W., Lee, C. K., & Alexander, E. R. (1978) · The Journal of Infectious Diseases · doi:10.1093/infdis/138.5.655 · Cited by 67 · see citing works

Influence of P-Glycoprotein Inhibitors on Accumulationof Macrolides in J774 MurineMacrophages

Seral, C., Michot, J.-M., Chanteux, H., Mingeot‐Leclercq, M., Tulkens, P. M., & Françoise Van Bambeke, A. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.3.1047-1051.2003 · Cited by 67 · see citing works

Uptake of 3 H-Dihydrostreptomycin by Macrophages in Culture

Bonventre, P. F., & Imhoff, J. G. (1970) · Infection and Immunity · doi:10.1128/iai.2.1.89-95.1970 · Cited by 63 · see citing works

Mechanism of the Intracellular Killing and Modulation of Antibiotic Susceptibility of Listeria monocytogenes in THP-1 Macrophages Activated by Gamma Interferon

Ouadrhiri, Y., Scorneaux, B., Sibille, Y., & Tulkens, P. M. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.5.1242 · Cited by 63 · see citing works

Erythromycin Uptake and Accumulation by Human Polymorphonuclear Leukocytes and Efficacy of Erythromycin in Killing Ingested Legionella pneumophila

MILLER, M. F., Martin, J. R., Johnson, P. M., Ulrich, J. T., Rdzok, E. J., & Billing, P. (1984) · The Journal of Infectious Diseases · doi:10.1093/infdis/149.5.714 · Cited by 62 · see citing works

A guided tour of the living cell

de Duve, C., & Hardy, N. O. (1984) · Medical Entomology and Zoology · Cited by 61 · see citing works

Lack of effective bactericidal activity of new quinolones against Brucella spp

García-Rodríguez, J. Á., Sánchez, J. E. G., & Trujillano, I. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.4.756 · Cited by 61 · see citing works

Uptake and Intracellular Activity of Moxifloxacin in Human Neutrophils and Tissue-Cultured Epithelial Cells

Pascual, Á., Garcı́a, I., Ballesta, S., & Perea, E. J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.1.12 · Cited by 60 · see citing works

The intramacrophagic environment of Brucella suis and bacterial response

Köhler, S., Porte, F., Jubier-Maurin, V., Ouahrani‐Bettache, S., Teyssier, J., & Liautard, J. (2002) · Veterinary Microbiology · doi:10.1016/s0378-1135(02)00215-8 · Cited by 60 · see citing works

Activity of antibiotics againstStaphylococcus aureus within polymorphonuclear neutrophils

Yancey, R. J., Sanchez, M. S., & Ford, C. W. (1991) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01964421 · Cited by 57 · see citing works

Uptake, accumulation, and egress of erythromycin by tissue culture cells of human origin

Martin, J. R., Johnson, P. M., & MILLER, M. F. (1985) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.27.3.314 · Cited by 56 · see citing works

Antibiotic uptake by alveolar macrophages of smokers

Hand, W. L., Boozer, R. M., & King-Thompson, N. L. (1985) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.27.1.42 · Cited by 55 · see citing works

Uptake and activity of rifapentine in human peritoneal macrophages and polymorphonuclear leukocytes

Pascual, Á., Tsukayama, D. T., Kovarik, J. M., Gekker, G., & Peterson, P. K. (1987) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf02018197 · Cited by 52 · see citing works

NADPH oxidase, Nramp1 and nitric oxide synthase 2 in the host antimicrobial response.

Karupiah, G., Hunt, N. H., King, N. J. C., & Chaudhri, G. (2000) · PubMed · Cited by 52 · see citing works

J774 Macrophages Secrete Antibiotics via Organic Anion Transporters

Cao, C. X., Silverstein, S. C., Neu, H. C., & Steinberg, T. H. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/165.2.322 · Cited by 50 · see citing works

Optimum Treatment of Intracellular Infection

Maurin, M., & Raoult, D. (1996) · Drugs · doi:10.2165/00003495-199652010-00004 · Cited by 49 · see citing works

Mechanisms of Fluoroquinolone Transport by Human Neutrophils

Walters, J. D., Zhang, F., & Nakkula, R. J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.11.2710 · Cited by 48 · see citing works

Uptake, intracellular activity, and influence of rifampin on normal function of polymorphonuclear leukocytes

Hoeger, P. H., Vosbeck, K., Seger, R. A., & Hitzig, W. H. (1985) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.28.5.667 · Cited by 47 · see citing works

Phagolysosomal Alkalinization and Intracellular Killing of Staphylococcus aureus by Amikacin

Maurin, M., & Raoult, D. (1994) · The Journal of Infectious Diseases · doi:10.1093/infdis/169.2.330 · Cited by 46 · see citing works

A guided tour of the living cell

(1985) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(85)90515-8 · Cited by 46 · see citing works

Lysosomal alterations induced in cultured rat fibroblasts by long-term exposure to low concentrations of azithromycin

Françoise Van Bambeke, A., Gerbaux, C., Michot, J.-M., d'Yvoire, M. B., Montenez, J. P., & Tulkens, P. M. (1998) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/42.6.761 · Cited by 43 · see citing works

Inhibition of intracellular growth of Listeria monocytogenes by antibiotics

Michelet, C., Avril, J., Cartier, F., & Berche, P. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.3.438 · Cited by 42 · see citing works

Tissue-Directed Antibiotics and Intracellular Parasites: Complex Interaction of Phagocytes, Pathogens, and Drugs

Donowitz, G. R. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/19.5.926 · Cited by 41 · see citing works

Subcellular localization of tobramycin and vancomycin given alone and in combination in proximal tubular cells, determined by immunogold labeling

Beauchamp, D., Gourde, P., Simard, M., & Bergeron, M. G. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.10.2204 · Cited by 41 · see citing works

Comparative activities of new fluoroquinolones, alone or in combination with amoxicillin, trimethoprim-sulfamethoxazole, or rifampin, against intracellular Listeria monocytogenes

Michelet, C., Avril, J., Arvieux, C., Jacquelinet, C., Vu, N., & Cartier, F. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.1.60 · Cited by 40 · see citing works

Clinical relevance of intracellular and extracellular concentrations of macrolides

Carbon, C. (1995) · Infection · doi:10.1007/bf02464953 · Cited by 40 · see citing works

Effect of recombinant human gamma interferon on intracellular activities of antibiotics against Listeria monocytogenes in the human macrophage cell line THP-1

Scorneaux, B., Ouadrhiri, Y., Anzalone, G., & Tulkens, P. M. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.5.1225 · Cited by 40 · see citing works

Intracellular Concentrations of Antibacterial Agents and Related Clinical Implications

Butts, J. D. (1994) · Clinical Pharmacokinetics · doi:10.2165/00003088-199427010-00006 · Cited by 39 · see citing works

An in-vitro comparison of the intraphagocytic bioactivity of erythromycin and roxithromycin

Anderson, R., van Rensburg, C. E. J., Joone, G., & Lukey, P. T. (1987) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/20.suppl_b.57 · Cited by 39 · see citing works

Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts

Tyteca, D., Smissen, P. V. D., Françoise Van Bambeke, A., Leys, K., Tulkens, P. M., Courtoy, P. J., & Mingeot‐Leclercq, M. (2001) · European Journal of Cell Biology · doi:10.1078/0171-9335-00180 · Cited by 37 · see citing works

Uptake and Intracellular Activity of Linezolid in Human Phagocytes and Nonphagocytic Cells

Pascual, Á., Ballesta, S., Garcı́a, I., & Perea, E. J. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.12.4013-4015.2002 · Cited by 37 · see citing works

The Importance of Penetration of Antimicrobial Agents into Cells

Schwab, J. C., & Mandell, G. L. (1989) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(20)30282-8 · Cited by 37 · see citing works

Antibiotic accumulation in human polymorphonuclear leucocytes and lymphocytes.

Forsgren, A., & Bellahsène, A. (1985) · PubMed · Cited by 35 · see citing works

Apically and basolaterally internalized aminoglycosides colocalize in LLC-PK1 lysosomes and alter cell function

Ford, D. M., Dahl, R., Lamp, C. A., & Molitoris, B. A. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.1.c52 · Cited by 34 · see citing works

Autoradiographic Evidence for the Impermeability of Mouse Peritoneal Macrophages to Tritiated Streptomycin

Bonventre, P. F., Hayes, R. L., & Imhoff, J. G. (1967) · Journal of Bacteriology · doi:10.1128/jb.93.1.445-450.1967 · Cited by 32 · see citing works

The Value of In Vitro Drug Activity and Pharmacokinetics in Predicting the Effectiveness of Anti mycobacterial Therapy: A Critical Review

Burman, W. J. (1997) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)40137-5 · Cited by 28 · see citing works

Uptake and intracellular activity of ofloxacin isomers in human phagocytic and non-phagocytic cells

Garcı́a, I. (2000) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(00)00161-8 · Cited by 25 · see citing works

Discrepancy between Uptake and Intracellular Activity of Moxifloxacin in a Staphylococcus aureus -Human THP-1 Monocytic Cell Model

Paillard, D., Grellet, J., Dubois, V., Saux, M., & Quentin, C. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.2.288-293.2002 · Cited by 25 · see citing works

Cellular uptake of clindamycin and lincomycin.

EASMON, C. S. F., & Crane, J. P. (1984) · PubMed · Cited by 24 · see citing works

Activity of antibiotics against microorganisms ingested by mononuclear phagocytes

van den Broek, P. J. (1991) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01964422 · Cited by 24 · see citing works

β-Lactam antibiotics : mode of action, new developments, and future prospects

Salton, M. R. J., & Shockman, G. D. (1981) · Academic Press eBooks · Cited by 22 · see citing works

Intracellular Penetration and Activity of Gemifloxacin in Human Polymorphonuclear Leukocytes

Garcı́a, I., Pascual, Á., Ballesta, S., Joyanes, P., & Perea, E. J. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.11.3193-3195.2000 · Cited by 22 · see citing works

Rifampicin against Experimental Listeriosis in the Mouse

Vischer, W. A., & Rominger, C. (2009) · Chemotherapy · doi:10.1159/000237768 · Cited by 19 · see citing works

The Value of In Vitro Drug Activity and Pharmacokinetics in Predicting the Effectiveness of Antimycobacterial Therapy: A Critical Review

Burman, W. J. (1997) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199706000-00008 · Cited by 19 · see citing works

High Teicoplanin Uptake by Human Neutrophils

Maderazo, E. G., Breaux, S. P., Woronick, C. L., Quintiliani, R., & Nightingale, C. H. (2009) · Chemotherapy · doi:10.1159/000238576 · Cited by 18 · see citing works

Uptake of antimicrobial agents by human polymorphonuclear leucocytes.

Laufen, H., Wildfeuer, A., & Räder, K. (1985) · PubMed · Cited by 17 · see citing works

Quinolones in Intracellular Infections

Péchère, J.-C. (1993) · Drugs · doi:10.2165/00003495-199300453-00007 · Cited by 15 · see citing works

Effects of tetracyclines on experimental Legionella pneumophila infection in guinea-pigs

Yoshida, S., Mizuguchi, Y., Ohta, H., & Ogawa, M. (1985) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/16.2.199 · Cited by 15 · see citing works

Staphylococcal Infection and Leukocyte Bactericidal Defect in a 22-Year-Old Woman

Mandell, G. L. (1972) · Archives of Internal Medicine · doi:10.1001/archinte.1972.03650050074014 · Cited by 13 · see citing works

Review of azithromycin activity against Legionella spp.

Edelstein, P. H. (1995) · PubMed · Cited by 12 · see citing works

Penetration, retention, intracellular localization, and antimicrobial activity of antibiotics within phagocytes.

Silverstein, S. C., & Kabbash, C. A. (1994) · PubMed · Cited by 11 · see citing works

Is the uptake of pefloxacin in human blood monocytes a simple diffusion process?

Mémin, E., Panteix, G., & Revol, A. (1996) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/38.5.787 · Cited by 10 · see citing works

Effects of antimicrobial drugs on human neutrophil-microbe interactions.

Cj, P., & Rj, L. (2000) · PubMed · Cited by 10 · see citing works

Cellular Uptake and Cell-Associated Activity of Third Generation Cephalosporins

Jacobs, R. F., Thompson, J. W., Kiel, D. P., & Johnson, D. (1986) · Pediatric Research · doi:10.1203/00006450-198609000-00021 · Cited by 9 · see citing works

Probenecid-resistant J774 cell expression of enhanced organic anion transport by a mechanism distinct from multidrug resistance.

Cao, C., Steinberg, T. H., Hc, N., Cohen, D., Sb, H., Hickman, S., & Silverstein, S. C. (1993) · PubMed · Cited by 9 · see citing works

Regulation of fluoroquinolone uptake by human neutrophils: involvement of mitogen-activated protein kinase

Hotta, K. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf042 · Cited by 8 · see citing works

Localization of chlorotetracycline fluorescence in human polymorphonuclear neutrophils

Coates, T. D., Torrès, M., Harman, J., & Williams, V. (1987) · Blood · doi:10.1182/blood.v69.4.1146.1146 · Cited by 8 · see citing works

Kinetics of the uptake of rifampicin and tetracycline into mouse macrophages. In vitro study of the early stages.

Najar, I., Oberti, J., Teyssier, J., & Caravano, R. (1984) · PubMed · Cited by 6 · see citing works

Staphylococcal infection and leukocyte bactericidal defects in a 22-year-old woman

Mandell, G. L. (1972) · Archives of Internal Medicine · doi:10.1001/archinte.130.5.754 · Cited by 5 · see citing works

The d-alanyl-d-Ala peptidases. Mechanism of action of penicillins and delta-3-cephalosporins

Ghuysen, J., Frère, J., Leyh‐Bouille, M., & Dideberg, O. (1981) · Open Repository and Bibliography (University of Liège) · Cited by 3 · see citing works

Pharmacokinetics and Pharmacodynamics of Antibacterial Agents

Levison, M. E., & Levison, J. H. (2009) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2009.06.008 · Cited by 564 · see citing works

Nanotechnology approaches for global infectious diseases

Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520 · see citing works

The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions

Gan, B., Gaynord, J. S., Rowe, S. M., Deingruber, T., & Spring, D. R. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00729c · Cited by 516 · see citing works

Quinolones in 2005: an update

Françoise Van Bambeke, A., Michot, J.-M., Eldere, J. V., & Tulkens, P. M. (2005) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2005.01131.x · Cited by 342 · see citing works

Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?

Thwaites, G. E., & Gant, V. A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2508 · Cited by 319 · see citing works

Delivery of antibiotics with polymeric particles

Xiong, M., Bao, Y., Yang, X., Zhu, Y., & Wang, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.02.002 · Cited by 304 · see citing works

The Concept of an Ideal Antibiotic: Implications for Drug Design

Gajdács, M. (2019) · Molecules · doi:10.3390/molecules24050892 · Cited by 275 · see citing works

Pharmacodynamic Evaluation of the Intracellular Activities of Antibiotics against Staphylococcus aureus in a Model of THP-1 Macrophages

Barcia-Macay, M., Seral, C., Mingeot‐Leclercq, M., Tulkens, P. M., & Françoise Van Bambeke, A. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.3.841-851.2006 · Cited by 266 · see citing works

Reducing Bacterial Infections and Biofilm Formation Using Nanoparticles and Nanostructured Antibacterial Surfaces

Mi, G., Shi, D., Wang, M., & Webster, T. J. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800103 · Cited by 245 · see citing works

Delivery systems to increase the selectivity of antibiotics in phagocytic cells

Briones, E., Colino, C. I., & Lanao, J. M. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.10.027 · Cited by 226 · see citing works

Bacteria-Targeting Nanoparticles with Microenvironment-Responsive Antibiotic Release To Eliminate Intracellular Staphylococcus aureus and Associated Infection

Yang, S., Han, X., Yang, Y., Qiao, H., Yu, Z., Liu, Y., Wang, J., & Tang, T. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b15678 · Cited by 214 · see citing works

Correcting a Fundamental Flaw in the Paradigm for Antimicrobial Susceptibility Testing

Ersoy, S. C., Heithoff, D. M., Barnes, L., V, Tripp, G. K., House, J. K., Marth, J. D., Smith, J. W., & Mahan, M. J. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.05.026 · Cited by 213 · see citing works

Effective Antibiotics against ‘Candidatus Liberibacter asiaticus’ in HLB-Affected Citrus Plants Identified via the Graft-Based Evaluation

Zhang, M., Guo, Y., Powell, C. A., Doud, M. S., Yang, C., & Duan, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111032 · Cited by 165 · see citing works

Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide

Brezden, A., Mohamed, M. F., Nepal, M., Harwood, J. S., Kuriakose, J., Seleem, M. N., & Chmielewski, J. A. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b04831 · Cited by 160 · see citing works

Importance of Relating Efficacy Measures to Unbound Drug Concentrations for Anti-Infective Agents

González, D., Schmidt, S., & Derendorf, H. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00092-12 · Cited by 151 · see citing works

Molecular Vehicles for Mitochondrial Chemical Biology and Drug Delivery

Jean, S. R., Tulumello, D. V., Wisnovsky, S., Lei, E. K., Pereira, M. P., & Kelley, S. O. (2014) · ACS Chemical Biology · doi:10.1021/cb400821p · Cited by 144 · see citing works

Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and perspectives.

Françoise Van Bambeke, A., Barcia-Macay, M., Lemaire, S., & Tulkens, P. M. (2006) · PubMed · Cited by 138 · see citing works

Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels

Itzkan, I., Qiu, L., Fang, H., Zaman, M. M., Vitkin, E. I., Ghiran, I. C., Salahuddin, S., Modell, M. D., Andersson, C., Kimerer, L. M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708669104 · Cited by 131 · see citing works

Exosome-encapsulated antibiotic against intracellular infections of methicillin-resistant Staphylococcus aureus

Yang, X., Shi, G., Guo, J. J., Wang, C., & He, Y. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s179380 · Cited by 128 · see citing works

Staphylococcus aureus develops increased resistance to antibiotics by forming dynamic small colony variants during chronic osteomyelitis

Tuchscherr, L. P. N., Kreis, C., Hoerr, V., Flint, L., Hachmeister, M., Geraci, J., Bremer-Streck, S., Kiehntopf, M., Medina, E., Kribus, M., et al. (2015) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv371 · Cited by 124 · see citing works

Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics? A systematic review and narrative synthesis

Zelmer, A. R., Nelson, R., Richter, K., & Atkins, G. J. (2022) · Bone Research · doi:10.1038/s41413-022-00227-8 · Cited by 117 · see citing works

Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections

Baudoux, P., Bles, N., Lemaire, S., Mingeot-Leclercq, M. P., Tulkens, P. M., & Françoise Van Bambeke, A. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl489 · Cited by 108 · see citing works

Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes

Yang, X., Xie, B., Peng, H., Shi, G., Banne, S., Guo, J. J., Wang, C., & He, Y. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.11.045 · Cited by 107 · see citing works

Combination Antibiotic Treatment of Serious Methicillin-Resistant Staphylococcus aureus Infections

van Hal, S. J., Tong, S. Y. C., & Davis, J. S. (2015) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0034-1396906 · Cited by 106 · see citing works

Antimicrobial Activity against Intraosteoblastic Staphylococcus aureus

Valour, F., Trouillet‐Assant, S., Riffard, N., Tasse, J., Flammier, S., Rasigade, J., Chidiac, C., Vandenesch, F., Ferry, T., & Laurent, F. J. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.04359-14 · Cited by 101 · see citing works

Influence of Efflux Transporters on the Accumulation and Efflux of Four Quinolones (Ciprofloxacin, Levofloxacin, Garenoxacin, and Moxifloxacin) in J774 Macrophages

Michot, J.-M., Seral, C., Françoise Van Bambeke, A., Mingeot‐Leclercq, M., & Tulkens, P. M. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.6.2429-2437.2005 · Cited by 97 · see citing works

Drug delivery approaches to overcome bacterial resistance to β-lactam antibiotics

Abeylath, S. C., & Turos, E. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.9.931 · Cited by 93 · see citing works

Repurposing clinically approved cephalosporins for tuberculosis therapy

Ramón‐García, S., del Río, R. G., Santos-Villarejo, Á., Sweet, G., Cunningham, F., Barros, D., Ballell, L., Mendoza-Losana, A., Ferrer, S. B., & Thompson, C. J. (2016) · Scientific Reports · doi:10.1038/srep34293 · Cited by 86 · see citing works

An efficient system for intracellular delivery of beta-lactam antibiotics to overcome bacterial resistance

Abed, N., Hassane, F. S., Zouhiri, F., Mougin, J., Nicolas, V., Desmaële, D., Gref, R., & Couvreur, P. (2015) · Scientific Reports · doi:10.1038/srep13500 · Cited by 87 · see citing works

Riboflavin along with antibiotics balances reactive oxygen species and inflammatory cytokines and controls Staphylococcus aureus infection by boosting murine macrophage function and regulates inflammation

Dey, S., & Bishayi, B. (2016) · Journal of Inflammation · doi:10.1186/s12950-016-0145-0 · Cited by 84 · see citing works

Intracellular Activity of Antibiotics against Staphylococcus aureus in a Mouse Peritonitis Model

Sandberg, A., Hessler, J. H. R., Skov, R. L., Blom, J., & Møller, J. K. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01605-07 · Cited by 82 · see citing works

Intracellular proliferation of S. aureus in osteoblasts and effects of rifampicin and gentamicin on S. aureus intracellular proliferation and survival

Mohamed, W. A., Sommer, U., Sethi, S., Domann, E., Thormann, U., Schutz, I., Lips, K., Chakraborty, T., Schnettler, R., & Alt, V. (2014) · European Cells and Materials · doi:10.22203/ecm.v028a18 · Cited by 82 · see citing works

Liposomal antibiotics for the treatment of infectious diseases

Alhariri, M., Azghani, A. O., & Omri, A. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.822860 · Cited by 81 · see citing works

Nanoparticle based Drug Delivery Systems for Treatment of Infectious Diseases

Salouti, M., & Ahangari, A. (2014) · InTech eBooks · doi:10.5772/58423 · Cited by 78 · see citing works

Smart Drug Delivery System

Sezer, A. D. (2016) · InTech eBooks · doi:10.5772/60475 · Cited by 77 · see citing works

Bacterium-Derived Cell-Penetrating Peptides Deliver Gentamicin To Kill Intracellular Pathogens

Gomarasca, M., Martins, T. F. C., Greune, L., Hardwidge, P. R., Schmidt, M. A., & Rüter, C. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02545-16 · Cited by 76 · see citing works

Novel bioactive hydrophobic gentamicin carriers for the treatment of intracellular bacterial infections

Imbuluzqueta, E., Elizondo, E., Gamazo, C., Moreno‐Calvo, E., Veciana, J., Ventosa, N., & Blanco‐Prieto, M. J. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.11.031 · Cited by 75 · see citing works

Targeting Intracellular Pathogenic Bacteria with Unnatural Proline‐Rich Peptides: Coupling Antibacterial Activity with Macrophage Penetration

Kuriakose, J., Hernandez‐Gordillo, V., Nepal, M., Brezden, A., Pozzi, V., Seleem, M. N., & Chmielewski, J. A. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201302693 · Cited by 75 · see citing works

Macrophage-targeted drugamers with enzyme-cleavable linkers deliver high intracellular drug dosing and sustained drug pharmacokinetics against alveolar pulmonary infections

Su, F., Srinivasan, S., Lee, B., Chen, J., Convertine, A. J., West, T. E., Ratner, D. M., Skerrett, S. J., & Stayton, P. S. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.08.014 · Cited by 69 · see citing works

Host-dependent Induction of Transient Antibiotic Resistance: A Prelude to Treatment Failure

Kubicek-Sutherland, J. Z., Heithoff, D. M., Ersoy, S. C., Shimp, W. R., House, J. K., Marth, J. D., Smith, J. W., & Mahan, M. J. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.08.012 · Cited by 68 · see citing works

Polymer-augmented liposomes enhancing antibiotic delivery against intracellular infections

Su, F., Chen, J., Son, H., Kelly, A. M., Convertine, A. J., West, T. E., Skerrett, S. J., Ratner, D. M., & Stayton, P. S. (2018) · Biomaterials Science · doi:10.1039/c8bm00282g · Cited by 65 · see citing works

Chasing bacteria within the cells using levofloxacin-loaded hyaluronic acid nanohydrogels

Montanari, E., D’Arrigo, G., Meo, C. D., Virga, A., Coviello, T., Passariello, C., & Matricardi, P. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.03.003 · Cited by 60 · see citing works

Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines

Lemaire, S., Françoise Van Bambeke, A., Appelbaum, P. C., & Tulkens, P. M. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp267 · Cited by 60 · see citing works

Activity of three β-lactams (ertapenem, meropenem and ampicillin) against intraphagocytic Listeria monocytogenes and Staphylococcus aureus

Lemaire, S., Françoise Van Bambeke, A., Mingeot‐Leclercq, M., & Tulkens, P. M. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki094 · Cited by 59 · see citing works

Hydrophobic modification improves the delivery of cell-penetrating peptides to eliminate intracellular pathogens in animals

Tang, Q., Tan, P., Dai, Z., Wang, T., Xu, S., Ding, Y., Jin, J., Zhang, X., Zhang, Y., Zhou, C., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.11.055 · Cited by 58 · see citing works

Poly(lactic-co-glycolic) Acid–Lipid Hybrid Microparticles Enhance the Intracellular Uptake and Antibacterial Activity of Rifampicin

Maghrebi, S., Joyce, P., Jambhrunkar, M., Thomas, N., & Prestidge, C. A. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b22991 · Cited by 56 · see citing works

A Phage Lysin Fused to a Cell-Penetrating Peptide Kills Intracellular Methicillin-Resistant Staphylococcus aureus in Keratinocytes and Has Potential as a Treatment for Skin Infections in Mice

Wang, Z., Kong, L., Liu, Y., Fu, Q., Cui, Z., Wang, J., Ma, J., Wang, H., Yan, Y., & Sun, J. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.00380-18 · Cited by 56 · see citing works

Cellular Accumulation and Pharmacodynamic Evaluation of the Intracellular Activity of CEM-101, a Novel Fluoroketolide, againstStaphylococcus aureus,Listeria monocytogenes, andLegionella pneumophilain Human THP-1 Macrophages

Lemaire, S., Françoise Van Bambeke, A., & Tulkens, P. M. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00203-09 · Cited by 55 · see citing works

Toward an Optimized Treatment of Intracellular Bacterial Infections: Input of Nanoparticulate Drug Delivery Systems

Ladavière, C., & Gref, R. (2015) · Nanomedicine · doi:10.2217/nnm.15.128 · Cited by 52 · see citing works

Pharmacodynamic Evaluation of the Intracellular Activity of Antibiotics towards Pseudomonas aeruginosa PAO1 in a Model of THP-1 Human Monocytes

Buyck, J. M., Tulkens, P. M., & Françoise Van Bambeke, A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02609-12 · Cited by 52 · see citing works

Cellular Pharmacodynamics of the Novel Biaryloxazolidinone Radezolid: Studies with Infected Phagocytic and Nonphagocytic cells, UsingStaphylococcus aureus,Staphylococcus epidermidis,Listeria monocytogenes, andLegionella pneumophila

Lemaire, S., Kosowska-Shick, K., Appelbaum, P. C., Verween, G., Tulkens, P. M., & Françoise Van Bambeke, A. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01724-09 · Cited by 51 · see citing works

A “Double-Edged” Scaffold: Antitumor Power within the Antibacterial Quinolone

Bisacchi, G. S., & Hale, M. R. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666151223095839 · Cited by 51 · see citing works

Antibacterial Activity of Ciprofloxacin-Encapsulated Cockle Shells Calcium Carbonate (Aragonite) Nanoparticles and Its Biocompatability in Macrophage J774A.1

Isa, T., Zakaria, Z., Rukayadi, Y., Noor, M. H. M., Jaji, A. Z., Imam, M. U., Hammadi, N. I., & Mahmood, S. K. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050713 · Cited by 50 · see citing works

Increased intracellular activity of MP1102 and NZ2114 against Staphylococcus aureus in vitro and in vivo

Wang, X., Wang, X., Teng, D., Mao, R., Hao, Y., Wang, J., Li, Z., & Wang, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-22245-5 · Cited by 49 · see citing works

The bactericidal effects of anti-MRSA agents with rifampicin and sulfamethoxazole-trimethoprim against intracellular phagocytized MRSA

Yamaoka, T. (2007) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-007-0521-z · Cited by 48 · see citing works

Bacteria in the respiratory tract—how to treat? Or do not treat?

Prat, C., & Lacoma, A. (2016) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2016.09.005 · Cited by 51 · see citing works

In vitro antimicrobial activity against 10 North American and European Lawsonia intracellularis isolates

Wattanaphansak, S., Singer, R. S., & Gebhart, C. J. (2008) · Veterinary Microbiology · doi:10.1016/j.vetmic.2008.08.007 · Cited by 47 · see citing works

Antimicrobial Activities of Daptomycin, Vancomycin, and Oxacillin in Human Monocytes and of Daptomycin in Combination with Gentamicin and/or Rifampin in Human Monocytes and in Broth against Staphylococcus aureus

Baltch, A. L., Ritz, W. J., Bopp, L. H., Michelsen, P. B., & Smith, R. P. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00973-06 · Cited by 46 · see citing works

Chemical Biology Approach to Reveal the Importance of Precise Subcellular Targeting for Intracellular Staphylococcus aureus Eradication

Bai, S., Song, J., Pu, H., Yu, Y., Song, W.-W., Chen, Z., Wang, M., Campbell‐Valois, F., Wong, W., Cai, Q., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c09587 · Cited by 44 · see citing works

Comparison of the In Vitro Efficacies of Moxifloxacin and Amoxicillin against Listeria monocytogenes

Grayo, S., Join‐Lambert, O., Desroches, M.-C., & Monnier, A. L. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01211-07 · Cited by 42 · see citing works

Beyond oncology — Application of HPMA copolymers in non-cancerous diseases☆

Liu, X.-M., Miller, S. C., & Wang, D. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.10.006 · Cited by 41 · see citing works

Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections

Françoise Van Bambeke, A., Harms, J. M., Laethem, Y. V., & Tulkens, P. M. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.2.267 · Cited by 41 · see citing works

Cell-Penetrating Antimicrobial Peptides – Prospectives for Targeting Intracellular Infections

Bahnsen, J. S., Franzyk, H., Sayers, E. J., Jones, A. T., & Nielsen, H. M. (2015) · Pharmaceutical Research · doi:10.1007/s11095-014-1550-9 · Cited by 40 · see citing works

Nanomaterials for Delivering Antibiotics in the Therapy of Pneumonia

Tang, J., Ouyang, Q., Li, Y., Zhang, P., Jin, W., Qu, S., Yang, F., He, Z., & Qin, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415738 · Cited by 39 · see citing works

Killing of Staphylococcus aureus in murine macrophages by chloroquine used alone and in combination with ciprofloxacin or azithromycin

Bishayi, B., & Dey, S. (2015) · Journal of Inflammation Research · doi:10.2147/jir.s76045 · Cited by 39 · see citing works

Intracellular Pharmacokinetics of Antibacterials and Their Clinical Implications

Pea, F. (2017) · Clinical Pharmacokinetics · doi:10.1007/s40262-017-0572-y · Cited by 40 · see citing works

Garlic-Derived Exosome-like Nanovesicles-Based Wound Dressing for Staphylococcus aureus Infection Visualization and Treatment

Zhou, S., Huang, P., Cao, Y., Hua, X., Yao, Y., & Liu, S. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c01256 · Cited by 36 · see citing works

A bioinspired hierarchical nanoplatform targeting and responding to intracellular pathogens to eradicate parasitic infections

Yu, Y., Li, J., Zhang, Y., Ma, Z., Sun, H., Wei, X., Bai, Y., Wu, Z., & Zhang, X. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121309 · Cited by 36 · see citing works

Interaction of amoxicillin with DNA in human lymphocytes and H. pylori-infected and non-infected gastric mucosa cells

Arabski, M., Kaźmierczak, P., Wiśniewska‐Jarosińska, M., Popławski, T., Klupińska, G., Chojnacki, J., Drzewoski, J., & Błasiak, J. (2005) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.01.004 · Cited by 36 · see citing works

Cellular pharmacokinetics and intracellular activity against Listeria monocytogenes and Staphylococcus aureus of chemically modified and nanoencapsulated gentamicin

Imbuluzqueta, E., Lemaire, S., Gamazo, C., Elizondo, E., Ventosa, N., Veciana, J., Françoise Van Bambeke, A., & Blanco‐Prieto, M. J. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks172 · Cited by 36 · see citing works

Hyaluronan‐Based Nanohydrogels for Targeting Intracellular S. Aureus in Human Keratinocytes

Montanari, E., Oates, A., Meo, C. D., Meade, J. L., Cerrone, R., Francioso, A., DeVine, D., Coviello, T., Mancini, P., Mosca, L., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701483 · Cited by 36 · see citing works

The Interplay between Daptomycin and the Immune System

Kelesidis, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00052 · Cited by 35 · see citing works

Targeted Drug Delivery Systems for Eliminating Intracellular Bacteria

Feng, W., Chittò, M., Moriarty, T. F., Li, G., & Wang, X. (2022) · Macromolecular Bioscience · doi:10.1002/mabi.202200311 · Cited by 35 · see citing works

Factors influencing the intracellular activity of fluoroquinolones: a study using levofloxacin in a Staphylococcus aureus THP-1 monocyte model

Nguyen, H. A., Grellet, J., Paillard, D., Dubois, V., Quentin, C., & Saux, M. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl079 · Cited by 33 · see citing works

Genome of Ca. Pandoraea novymonadis, an Endosymbiotic Bacterium of the Trypanosomatid Novymonas esmeraldas

Kostygov, A. Y., Butenko, A., Nenarokova, A., Tashyreva, D., Flegontov, P., Lukeš, J., & Yurchenko, V. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01940 · Cited by 32 · see citing works

Antibiotic persistence of intracellular Brucella abortus

Mode, S., Ketterer, M., Québatte, M., & Dehio, C. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010635 · Cited by 32 · see citing works

Liposome Encapsulation of Ciprofloxacin Improves Protection against Highly Virulent Francisella tularensis Strain Schu S4

Hamblin, K. A., Armstrong, S. J., Barnes, K. B., Davies, C. H., Wong, J. P., Blanchard, J. D., Harding, S. V., Simpson, A. J. H., & Atkins, H. S. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02555-13 · Cited by 32 · see citing works

Efficacy of Liposome-Encapsulated Ciprofloxacin in a Murine Model of Q Fever

Norville, I. H., Hatch, G. J., Bewley, K. R., Atkinson, D., Hamblin, K. A., Blanchard, J. D., Armstrong, S. J., Pitman, J. K., Rayner, E. L., Hall, G. A., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03443-14 · Cited by 31 · see citing works

Mathematical model and tool to explore shorter multi-drug therapy options for active pulmonary tuberculosis

Fors, J., Strydom, N., Fox, W. S., Keizer, R. J., & Savić, R. M. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008107 · Cited by 30 · see citing works

Delayed parasite elimination in human infections treated with clindamycin parallels ‘delayed death’ of Plasmodium falciparum in vitro

Burkhardt, D., Wiesner, J., Stoesser, N. E., Ramharter, M., Uhlemann, A., Issifou, S., Jomaa, H., Krishna, S., Kremsner, P. G., & Borrmann, S. (2006) · International Journal for Parasitology · doi:10.1016/j.ijpara.2006.12.010 · Cited by 29 · see citing works

Macromolecular Nanotherapeutics and Antibiotic Adjuvants to Tackle Bacterial and Fungal Infections

Dey, R. K., Mukherjee, S., Barman, S., & Haldar, J. (2021) · Macromolecular Bioscience · doi:10.1002/mabi.202100182 · Cited by 28 · see citing works

Microfluidic arenas for war games between neutrophils and microbes

Ellett, F. E., Jalali, F., Marand, A. L., Jorgensen, J. A., Mutlu, B. R., Lee, J., Raff, A. B., & Irimia, D. (2019) · Lab on a Chip · doi:10.1039/c8lc01263f · Cited by 27 · see citing works

Antibiotic Drug Delivery Systems for the Intracellular Targeting of Bacterial Pathogens

Chifiriuc, M. C., Holban, A. M., Curuțiu, C., Diţu, L.-M., Mihăescu, G., Oprea, A. E., Grumezescu, A. M., & Lazăr, V. (2016) · InTech eBooks · doi:10.5772/61327 · Cited by 26 · see citing works

Susceptibilities of MDR Mycobacterium tuberculosis isolates to unconventional drugs compared with their reported pharmacokinetic/pharmacodynamic parameters

Cavanaugh, J. S., Jou, R., Wu, M.-H., Dalton, T. L., Kurbatova, E. V., Ershova, J. V., Cegielski, J. P., & for the Global PETTS Investigators (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx022 · Cited by 27 · see citing works

Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST): study protocol for a randomised controlled trial

Thwaites, G. E., Auckland, C., Barlow, G. D., Cunningham, R., Davies, G., Edgeworth, J. D., Greig, J. M., Hopkins, S., Jeyaratnam, D., Jenkins, N., et al. (2012) · Trials · doi:10.1186/1745-6215-13-241 · Cited by 26 · see citing works

Principles of use of antibacterial agents

Hessen, M. T., & Kaye, D. (2004) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2004.04.002 · Cited by 26 · see citing works

The immune response and antibacterial therapy

Anuforom, O., Wallace, G. R., & Piddock, L. J. V. (2014) · Medical Microbiology and Immunology · doi:10.1007/s00430-014-0355-0 · Cited by 24 · see citing works

Targeting intracellular bacteria with an extended cationic amphiphilic polyproline helix

Nepal, M., Thangamani, S., Seleem, M. N., & Chmielewski, J. A. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob00227c · Cited by 25 · see citing works

Predicting in vivo phospholipidosis-inducing potential of drugs by a combined high content screening and in silico modelling approach

Bauch, C., Bevan, S. J., Woodhouse, H. J., Dilworth, C., & Walker, P. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.01.014 · Cited by 24 · see citing works

High-Throughput Intracellular Antimicrobial Susceptibility Testing of Legionella pneumophila

Chiaraviglio, L., & Kirby, J. E. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01248-15 · Cited by 24 · see citing works

Novel Intracellular Antibiotic Delivery System Against Staphylococcus Aureus : Cloxacillin-Loaded Poly( D , L -Lactide-Co-Glycolide) Acid Nanoparticles

Lacoma, A., Usón, L., Mendoza, G., Sebastián, V., García-García, E., Muriel-Moreno, B., Domínguez, J., Arruebo, M., & Prat, C. (2020) · Nanomedicine · doi:10.2217/nnm-2019-0371 · Cited by 24 · see citing works

Ginsenoside 20(S)-Rh2 promotes cellular pharmacokinetics and intracellular antibacterial activity of levofloxacin against Staphylococcus aureus through drug efflux inhibition and subcellular stabilization

Chen, X., Qian, F., Wang, Y., Liu, Y., Sun, Y., Zha, W., Hao, K., Zhou, F., Wang, G., & Zhang, J. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00751-z · Cited by 24 · see citing works

Treatment of Citrobacter kosen Infection with Ciprofloxacin and Cefotaxime in a Preterm Infant

McPherson, C. C., Gal, P., & Ransom, J. L. (2008) · Annals of Pharmacotherapy · doi:10.1345/aph.1l008 · Cited by 24 · see citing works

Dual-targeted poly(amino acid) nanoparticles deliver drug combinations on-site: an intracellular synergistic strategy to eliminate intracellular bacteria

Zhao, D., Feng, W., Kang, X., Li, H., Liu, F., Zheng, W., Li, G., & Wang, X. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb00125c · Cited by 23 · see citing works

Macrophages Targeted Drug Delivery as a Key Therapy in Infectious Disease

Cătoi, C. (2014) · Cited by 23 · see citing works

Matryoshka-Type Gastro-Resistant Microparticles for The Oral Treatment of Mycobacterium Tuberculosis

Andreu, V., Larrea, A., Rodríguez-Fernández, P., Alfaro, S., Gracia, B., Lucía, A., Usón, L., Gómez, A.-C., Mendoza, G., Lacoma, A., et al. (2019) · Nanomedicine · doi:10.2217/nnm-2018-0258 · Cited by 23 · see citing works

In vitroantibiotic activity against intraosteoblasticStaphylococcus aureus: a narrative review of the literature

Marro, F. C., Abad, L., Blocker, A., Laurent, F. J., Josse, J., & Valour, F. (2021) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkab301 · Cited by 23 · see citing works

Susceptibility to Alternative Oral Antimicrobial Agents in Relation to Sequence Type ST131 Status and Coresistance Phenotype among Recent Escherichia coli Isolates from U.S. Veterans

Johnson, J. R., Drawz, S. M., Porter, S. B., & Kuskowski, M. A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00650-13 · Cited by 22 · see citing works

Delivery of host cell-directed therapeutics for intracellular pathogen clearance

Collier, M. A., Gallovic, M. D., Peine, K. J., Duong, A. D., Bachelder, E. M., Gunn, J. S., Schlesinger, L. S., & Ainslie, K. M. (2013) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2013.845524 · Cited by 22 · see citing works

Pharmacokinetic/pharmacodynamic considerations for new and current therapeutic drugs for uncomplicated gonorrhoea—challenges and opportunities

Theuretzbacher, U., Barbee, L. A., Connolly, K. L., Drusano, G. L., Fernandes, P., Hook, E. W., Jerse, A. E., O’Donnell, J. P., Unemo, M., Françoise Van Bambeke, A., et al. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.08.006 · Cited by 21 · see citing works

Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and perspectives.

Françoise Van Bambeke, A., Barcia-Macay, M., Lemaire, S., & Tulkens, P. M. (2006) · PubMed · Cited by 138 · see citing works

Research progress of intracellular activity of antibiotics and its celluar pharmacokinetics evaluation

Wang, G. (2012) · Zhongguo linchuang yaolixue yu zhiliaoxue

[Intracellular pharmacokinetics and pharmacodynamics of antibiotics].

Tulkens, P. M. (1996) · PubMed · Cited by 2 · see citing works

Challenges to Antibiotic Activity in Tissue

Barza, M. J. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/19.5.910 · Cited by 45 · see citing works

AUC Area under the concentration-time curve

Françoise Van Bambeke, A., Barcia-Macay, M., Lemaire, R., Paul, M., Pharmacologie, U., Moléculaire, C., & Concentration, P. P. (2014)