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Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study
Open accessAbstract
BACKGROUND: Listeriosis is a severe foodborne infection and a notifiable disease in France. We did a nationwide prospective study to characterise its clinical features and prognostic factors. METHODS: MONALISA was a national prospective observational cohort study. We enrolled eligible cases declared to the National Reference Center for Listeria (all microbiologically proven) between Nov 3, 2009, and July 31, 2013, in the context of mandatory reporting. The outcomes were analysis of clinical features, characterisation of Listeria isolates, and determination of predictors of 3-month mortality or persisting impairment using logistic regression. A hierarchical clustering on principal components was also done for neurological and bacteraemic cases. The study is registered at ClinicalTrials.gov, number NCT01520597. FINDINGS: We enrolled 818 cases from 372 centres, including 107 maternal-neonatal infections, 427 cases of bacteraemia, and 252 cases of neurolisteriosis. Only five (5%) of 107 pregnant women had an uneventful outcome. 26 (24%) of 107 mothers experienced fetal loss, but never after 29 weeks of gestation or beyond 2 days of admission to hospital. Neurolisteriosis presented as meningoencephalitis in 212 (84%) of 252 patients; brainstem involvement was only reported in 42 (17%) of 252 patients. 3-month mortality was higher for bacteraemia than neurolisteriosis (hazard ratio [HR] 0·54 [95% CI 0·41-0·69], p<0·0001). For both bacteraemia and neurolisteriosis, the strongest mortality predictors were ongoing cancer (odds ratio [OR] 5·19 [95% CI 3·01-8·95], p<0·0001), multi-organ failure (OR 7·98 [4·32-14·72], p<0·0001), aggravation of any pre-existing organ dysfunction (OR 4·35 [2·79-6·81], p<0·0001), and monocytopenia (OR 3·70 [1·82-7·49], p=0·0003). Neurolisteriosis mortality was higher in blood-culture positive patients (OR 3·67 [1·60-8·40], p=0·002) or those receiving adjunctive dexamethasone (OR 4·58 [1·50-13·98], p=0·008). INTERPRETATION: The severity of listeriosis is higher than reported elsewhere. We found evidence of a significantly reduced survival in patients with neurolisteriosis treated with adjunctive dexamethasone, and also determined the time window for fetal losses. MONALISA provides important new data to improve management and predict outcome in listeriosis. FUNDING: Programme Hospitalier Recherche Clinique, Institut Pasteur, Inserm, French Public Health Agency.
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- Charlier, C., Perrodeau, É., Leclercq, A., Cazenave, B., Pilmis, B., Henry, B., Lopes, A., Maury, M. M., Moura, A., Goffinet, F., Dieye, H. B., Thouvenot, P., Ungeheuer, M.-N., Tourdjman, M., Goulet, V., de Valk, H., Lortholary, O., Ravaud, P., Lecuit, M., Hausfater, P., Pourriat, J.-L., Casalino, E., Riou, B., Pateron, D., Yéni, P., Bricaire, F., Ville, Y., Azria, E., Dommergues, M., Bergmann, J.-F., Wolff, M., Mira, J.-P., Guillevin, L., Zuber, M., Abasse, S., Aberrane, S., Abgueguen, P., Abokasem, A., Abraham, B., Ache-Papillon, C., Adam, P., Adam, M.-N., Adhoute, X., Adoue, D., Afi, M., Afroukh, N., Agha-Mir, I., Aissa, N., Aissaoui, L., Akerman, G., Akkari, A., Al Chaar, M., Al Freijat, F., Al-Jalaby, B., Albert, D., Albertini, M.-T., Albinet, H., Alfonsi, G., Ali, Y., Chaouche, Z.-E. A., Allart, A., Alric, L., Améri, A., Amoura, Z., Ampère, A., Amroun, H., Ananivi, A., Ancelin, P., André, T., Andremont, A., Andreotti, D., Andriamaneo, H., Andriau, C., Anglaret, H., Anguel, N., Annaix, V., Anteur, W., Anuset, D., Aoudia, O., Arabi, M., Archambaud, M., Archambaud, M., Ardiet, E., Argaud, L., Arista, S., Arlet, G., Armengaud, J., Arnal, J.-M., Arnault, I., Arsène, O., Assaf, Z., Assi, A., Assouline, D., Astruc, D., Aubard, Y., Aubert, C., Aubry, J.-P., Auburtin, M., Aucher, P., Audeguy, P., Audié, J.-P., Aumaitre, H., Aumersier, M., Auroux, J., Autret, F., Auvray, E., Ayach, B., Aye, P., Ayouz, K., Azria, E., Bachelier, M.-N., Badia, T. B. P., Badila, P., Bador, J., Badurescu, V., Baldesi, O., Bandaly, F., Bandin, O., Bani-Sadr, F., Bannier, S., Baranger, T., Barazer, I., Barbier, M.-C., Barbier, F., Barbier, C., Barbieux, M., Marie, Barboteau, A., Barbut, P., Baret, M., Barière, F., Baril, J.-Y., Barillot, I., Barjon, G., Barnaud, G., Barraduc, R., Barraud, F., Barraud, O., Barre, E., Barrelet, A., Barrier, J., Bart, F., Barthélémy, G., Baty, G., Baud, O., Baudel, J.-L., Bay, J.-O., Bay, J., Bazin, C., Beague, S., Beal Ardisson, D., Beaune, B., Beauplet-Lepage, A., Bébéar, C., Bechade, D., Becherrawy, C., Becker-Schneider, M., Bednarek, N., Bedock, B., Begon, E., Bekguesmia, Z., Belaisch-Amart, J., Belhadj, K., Belle, E., Belmonte, O., Belot, J.-P., Bemrah, A., Ben Soltana, M., Benbara, A., Benddif-Fin, F., Bénézit, F., Benifla, J.-L., Benjelloul, A., Benkaci, Y., Benkhelil, A., Benoit-Cattin, T., Benoit-Coustou, S., Bensadoun, R.-J., Bensaid, T., Jacques Bensaude, R., Bérard, H., Bercot, B., Berdin, B., Berger, M., Berger, P., Bergheul, S., Bergmann, J.-F., Bergues, B., Berland, Y., Bernard, C., Bernard, L., Bernardaud, B., Bernardi, F., Bernardin, G., Bernasconi, F., Bert-Marcaz, P., Berteaux, B., Berth-Farges, A., Berthelot, G., Berthet, J., Bertrand, K., Bertrou, A., Besnard, M., Bessede, E., Bethery, P., Beuscart, C., Beyne-Rauzy, O., Beytout, J., Bezian, M.-C., Bicais, B., Bidart, S., Bidault, C., Biessy, H., Bigot, P., Bildea, A., Bille, E., Billy, C., Biron, N., Bizet, J., Blaise, D., Blaise, A., Blaison, G., Blaka, M., Blanc, P., Blanc, S., Blanc-Amrane, V., Blanchard, P., Blanchard-Marche, G., Blancs, M., Blazejewski, C., Bléher, Y., Blewoussi, K., Blondet, R., Blot, F., Blum, G.-F., Bodson, L., Boidin, E., Boileau, J., Boileau, P., Boin-Gay, V., Boisseau, M., Boisselier, C., Bollaert, P.-E., Bolot, P., Bonacorsi, S., Bonfils, M., Bonitchi, P., Bonnan, M., Bonnefoy, P., Bonnet, D., Bonnet, R., Bonnin, E., Bor, J., Borie, M.-F., Borstein, B., Bossi, P., Botreau, Y., Bottero, J., Bouasria, A., Bouaziz, R., Bouchaud, O., Bouche, F., Bouchet, G., Bouden, V., Boudhane, A., Boudy, C.-A., Boue, F., Bouet, C., Claude Boufetteau, J., Bouffandeau, B., Bouhour, D., Bouiller, M., Bouillet, L., Bouissou, A., Boulain, L., Bourgeois, S., Bourgerette, E., Bourlet, A., Bourlière, M., Bourrée, T., Bourrouillou, A., Boussekey, N., Boussier, R., Boutoille, D., Bouyer, J.-L., Bouyssou-Destriau, D., Bouziges, N., Boyer, M., Braem, L., Branger, B., Branger, C., Brasme, L., Bray, P., Brazille, P., Bresson, V., Bret, L., Breton, A.-L., Breuil, J., Brevet, F., Briaud, M., Bridoux, D., Briend, D., Briere, A.-I., de la Hosseraye, C. B., Brieu, N., Brieux, J.-P., Brihier, H., Brisou, P., Brival, M.-L., Broche, D., Brochen, J., Bron, C., Bronet, N., Bronner, J., Bronowicki, J.-P., Brosset, F., Brottier-Mancini, E., Brovedani, S., Bruley des Varannes, S., Brunel, P., Brunet, P., Brunet, X., Brunet, S., Brung-Lefebvre, M., Brunot, V., Brusset, A., Burc-Struxiano, L., Burdin, M., Bureau, T., Buron, F., Burucoa, C., Cabalion, J., Cabasson, S., Cabié, A., Cacheux, V., Cadiergue, V., Cadiot, G., Caille, V., Cailleaux Pierre-Etienne Cailleux, V., Caillon, J., Caillot, D., Camara, M., Cambau, E., Cambonie, G., Camiade, S., Canis, F., Canitrot, M., Canu, N., Capellier, G., Carbillon, L., Carbonelle, B., Carbonelle, E., Carboni, M., Carbonne, B., Carcenac, F., Cardot, F., Carette, S., Cariou, S., Carli, P., Carmagnol, F., Caroli-Bosc, F.-X., Caron, F., Cartron, G., Casali, P., Casanovas, O., Cassignard, D., Castaing, D., Castel, B., Castelin, S., Castelnau, P., Cathebras, P., Catineau, J., Catteu, S., Cattier, B., Cattoen, 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Collard, O., Collet, M., Collignon, A., Collus, M.-J., Colombani, J.-C., Colombat, P., Combe, C., Condominas, P., Conroy, M.-C., Constans, T., Constantin, N., Contamin, C., Corberand, D., Cordier, A.-M., Cordonnier, C., Corneloup, H., Costa, Y., Costa, F., Coste, M., Costes, C., Cotes, F., Cotteret, R., Couderc, L.-J., Cougoul, P., Coulaud, J.-M., Coulhon, M.-P., Coulon, P., Courcol, R., Courillon, F., Courjon, J., Courouble, J., Courouge-Dorcier, D., Courtade, H., Courtois, S., Couturier, P., Créange, A., Cremet, L., Cremniter, J., Croize, J., Crombe, V., Croquet, I., Cua, E., Cufi, M.-N., Cuvillier, P., Dabysing, M.-F., Dadoun, K., Dagada, C., Dahan, S., Dahoumane, R., Daleas, J., Dallay, D., Dalle, B., Damage, A., Damaj, L., Damaj Gandhi, L., Danalaché, A., Danin, P.-E., Danjean, M.-P., Danquechin Dorval, E., Dao, A., Daoud, P., Darchen, O., Dargère, S., Darre, B., Dassant, D., Dassieu, G., Dattin-Dorrière, V., Daupin, C., Daurel, C., Dausset, J.-C., Daval Cote, M., David, G., 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Grandclerc, B., Grange, J.-D., Granger, T., Granier, F., Granier, M., Grasset, D., Gravet, A., Grawey, I., Greder Belan, A., Grelaud, J.-J., Grenet, K., Gressier, B., Grignon, B., Grimprel, E., Grise, G., Grobost, V., Gross Goupil, M., Grossi, O., Gruffat, B., Gruson, A., Guénard, Y., Guérard, A., Guérin, B., Guérin, M., Guérin, C., Guerquin, B., Guerrot, D., Guéry, B., Gueudet, P., Gueugniaud, P.-Y., Guichard, I., Guichart, F., Guiden, O., Guider, B., Guillarmé Grossmann, P., Guillemot, F., Guillet, P., Guillet-Caruba, C., Guillois, B., Guilloy, O., Guimard, T., Guimard, K., Guimier, P., Guinard, J., Guinet, F., Guisset, O., Guitteaud, K., Gutmann, L., Guyetand, S., Haccourt, F., Hacot, J.-P., Hadou, T., Haiat, S., Haioun, C., Hajjar, M., Hamitou, Z., Hammami, S., Hamon-Charles, S., Hamou-Plotkine, L., Hanouz, J.-L., Harbi, S., Harlé, J.-R., Haro, S., Harou, C., Harvey, T., Hatem, G., Hausermann, M.-H., Hauss, P.-A., Hayoun, F., Hecham, M., Heches, X., Hedjem, N., Heidt, A., Heisel, 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Malderet, C., Malfuson, J.-V., Malherbe, P., Malherbe, P., Malhiere, S., Mandelbrot, L., Mandin, L., Mandjee, A., Manéglier, B., Mansouria, M., Marcu, E., Mariette, J.-B., Mariette, S., Markarian, J., Marmouset, C., Marpeau, O., Marret, O., Marsepoil, T., Marterl-Lafay, I., Martha, B., Marthelet, P., Martin, X., Martin, F., Martin, P., Martin, R., Martin, C., Martin Lefèvre, L., Martineau, O., Martinet, O., Martinez, V., Martinot, M., Martres, P., Marty, S., Marty-Ane, C., Marzouk, P., Mascade, G., Masia, F., Masseron, T., Masson, L., Masson, P., Matheron, I., Matica, S., Matray, O., Mattei, M.-F., Maubert, B., Maugein, J., Maureira, J.-P., May, T., May, A., Maze, V., Meaudre Desgouttes, E., Mebazaa, A., Mechai, F., Medeau, V., Megbemado, R., Mehri, M., Mein-Bottini, M., Melis, A., Mellier, J., Ménager, P., Ménard, C., Mendes-Martin, L., Menguy, A.-C., Menouar, M., Merabet, T., Mercury, P., Meregnani, C., Mérigot, P., Mermont, S., Merrouche, Y., Merville, P.-G., Mesnage, R., Mesnard, L., Messager, A., Messiaen, T., Messika, J., Messner Pellenc, P., Métenier, H., Metton, P., Meyer, C., Mialon, M., Miatello, J., Michaud-herbst, A., Michault, A., Micheli, S., Michon, J., Baptiste Michot, J., Mielczarek, S., Mignart, S., Mignaut, V., Migraine Bouvagnet, A., Mihout, F., Mille, C., Millet, O., Milpied, N., Mimoz, O., Minet, J., Minguet, B., Mohty, M., Moiton, M.-P., Monarchi, R., Monceau, Y., Monchi, M., Monlun, E., Monsegu, J., Montagne, N., Montcriol, A., Montmasson, B., Mootien, P., Moquet, O., Morando, V., Moreau, A.-S., Morel, Y., Morelon, E., Morin-Fatome, A., Morincomme, M., Morlat, P., Mosser, L., Motard-Picheloup, A., Mottaz, P., Moulinoux, C., Mouly, L., Mourad, G., Mouries, J.-C., Moussa, H., Moustache, A., Muir, J.-F., Murbach, V., N'guyen, Y., N'guyen, J.-C., N'guyen-Khac, F., Nabholtz, J.-M., Naceur, T., Nakhleh, J., Nare, A., Nassif, X., Nathan-Bonnet, F., Negrery, H., Negrier, C., Neri, D., Nesrine, H., Neuwirth, C., Ngami, E., Carole Ngo Bell, E., Nicobaharaye, D., Nicolet, L., Nicolet, L., Nicolino, M., Niel, P., Nikodijevic, K., Nkunzimana, J.-M., Noel, C., Noirot, A., Noto, P., Noulard, M.-N., Ntalu Nkato, C., Nyunga, M., Obiols, J., Ochocki, P., Odent, S., Olivier, B., Oliviero, G., Ondze, B., Orléva, O., Orode, P., Osman, H., Oswald, E., Otean, P., Ouazir, A., Ozanon, C., Paccalin, M., Pages, M.-C., Paindaveine, B., Pangon, B., Pannecouck, J.-M., Paquet, J.-C., Parent, S., Parisi-Duchene, E., Pasche, J., Pasdeloup, T., Patin, D., Patrigeon, R.-G., Patry, I., Paul, J.-G., Pavel, S., Pavic, M., Pawlotsky, J.-M., Payan, C., Payen, C., Péan, Y., Péchinot, F., Péchinot, A., Pecquet, M., Pélaquier, A., Peltier, H., Penn, P., Pennaforte, J.-L., Perez, D., Périsson, C., Perotin, D., Perouse de Montclos, M., Perreve, S., Perronne, C., Perrotin, D., Pesque, V., Pestel-Caron, M., Pestre, V., Petassou, F., Petit, M.-C., Petit Hoang, C., Petitjean, P., Pettinelli, F., Peultier, A.-S., Piala, J.-M., Pialoux, G., Piau, C., Picard, A., Picaud, J.-C., Pichard, E., Pierre, M., Pierre, F., Pierrot, P., Piet, E., Piffaut, M.-C., Pigeon, B., Pignon, C., Pinon, G., Piquet, J., Piriou, V., Placidi, E., Plainfosse, G., Plane, C., Plantier, I., Claudiu-Plesa, N., Plésiat, P., Plessis, P., Plouzeau-Jayle, C., Ploy, M.-C., Pochmalicki, G., Pofelski, J., Poinsignon, Y., Poirier, A.-S., Poitevin, F., Pommier, C., Ponceau, B., Poncelet, C., Pop, D., Porcheron, M., Pordes, R., Porthault, E., Portneuf, M., Pottier, A., Pouedras, P., Poulain, J., Poulain, G., Poupet, H., Pouyanne, J., Pouzoullic, M., Poyart, C., Pozzetto, B., Prazuck, T., Pressac, D., Prévost, F., Prince, S., Priollet, P., Proost, O., Protar, D., Pujade Lauraine, E., Pujol, A., Puybasset, L., Puyhardy, J., Quentin, V., Quinsat, D., Rabier, V., Radaoui, F., Radenac, F., Radenne, S., Raffenot, D., Raffi, F., Rahmani, H., Ramanantsoa, C., Ranchon, G., Ranta, D., Raoult, D., Rasigade, J.-P., Rassiat, E., Raulin, O., Ravaud, A., Ravet, N., Razafimahefa, H., Razafimahery, M., Re, D., Real, P., Rebattu, P., Rebeyrotte, C., Reboul, P., Reboux, A.-H., Recule, C., Redonnet, J.-P., Redor, A., Regouby, Y., Rémy, C., Renard, G., Renard, B., Renou, F., Repellin, P., Reveil, J.-C., Revel, V., Reverseau, A., Revest, M., Rey, P., Rey, H., Rey Zermati, J., Reyes Ortega, G., Reynaud, A., Reynes, J., Rezgui, N., Riahi, J., Ribes, D., Ribier, A., Richard, C., Richardin, F., Riche, A., Richette, P., Ridah, K., Riegel, P., Riehl, F., Rigaux, F., Rioux, C., Rival, G., Rivière, B., Robert, H., Robert, R., Robillard, P.-Y., Roblin, M., Roblot, P., Roblot, F., Rogeaux, O., Roger, P.-M., Rohmer-Heitz, D., Rolland, C., Roncato-Saberane, M., Ronda, I., Rondepierre, P., Roque-Afonso, A.-M., Rosay, D., Rose, C., Roseau, J.-B., Rosello, S., Rosselli, S., Rossignol, S., Rostaing, L., Roth, C., Rothe, M.-R., Roubert, X., Rouget, S., Rouidi, A., Roulier, P., Rouquet, Y., Rouquette-Vincent, I., Roure Sobas, C., Rousseau, S., Rousseau, F., Roussel, E., Roussel, J.-C., Roussel, C., 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- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 17
- Issue
- 5
- Pages
- 510-519
- ISSN
- 1473-3099 (ISSN-L)
- OpenAlex
- W2581686152
- Cited by
- 581
- References
- 5
- FWCI
- 29.99
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-09-01)
- Open access
- hybrid
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study. https://app.cochat.ai/papers/10.1016/s1473-3099(16)30521-7
- The paper
- Charlier, C., Perrodeau, É., Leclercq, A., Cazenave, B., Pilmis, B., Henry, B., Lopes, A., Maury, M. M., Moura, A., Goffinet, F., Dieye, H. B., Thouvenot, P., Ungeheuer, M.-N., Tourdjman, M., Goulet, V., de Valk, H., Lortholary, O., Ravaud, P., Lecuit, M., . . . Zumbo, C. (2017). Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study. The Lancet Infectious Diseases. https://doi.org/10.1016/s1473-3099(16)30521-7
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.