The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Insulin and neurodegenerative disease: shared and specific mechanisms
Abstract
Insulin has functions in the brain and dysregulation of these functions may contribute to the expression of late-life neurodegenerative disease. We provide a brief summary of research on the influence of insulin on normal brain function. We then review evidence that perturbation of this role may contribute to the symptoms and pathogenesis of various neurodegenerative disorders, such as Alzheimer's disease, vascular dementia, Parkinson's disease, and Huntington's disease. We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms.
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“The localization of insulin receptors in the hippocampus and medial temporal cortex suggests that insulin and glucose homeostasis play a role in physiological memory functions through their effect on synaptic plasticity and cellular survival [110].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [110]
Citations
Cites
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
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Peila, R., Rodriguez, B. L., & Launer, L. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1256 · Cited by 1,207
Insulin receptors are widely distributed in the central nervous system of the rat
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Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes
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Research works printed but not linked: 1
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Cited by
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Risk of dementia in diabetes mellitus: a systematic review
Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C., & Scheltens, P. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70284-2 · Cited by 2,187
Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus
Whitmer, R. A. (2009) · JAMA · doi:10.1001/jama.2009.460 · Cited by 1,128
Intranasal insulin improves cognition and modulates β-amyloid in early AD
Reger, M. A., Watson, G. S., Green, P. S., Wilkinson, C. W., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Breitner, J. C. S., DeGroodt, W., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000265401.62434.36 · Cited by 830
Self-citationCognition and diabetes: a lifespan perspective
Biessels, G. J., Deary, I. J., & Ryan, C. M. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70021-8 · Cited by 662
Is Alzheimer’s disease a type 3 diabetes? A critical appraisal
Kandimalla, R., Thirumala, V., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.08.018 · Cited by 621
Metadata
- Authors
- Craft, S., & Stennis Watson, G.
- Affiliations
- University of Washington (US)
- Corresponding author
- Craft, Suzanne
- ORCID
- Craft, Suzanne
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 3
- Issue
- 3
- Pages
- 169-178
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2145451941
- Cited by
- 830
- References
- 145
- Citations by year
- 2026: 17 · 2025: 26 · 2024: 29 · 2023: 37 · 2022: 36 · 2021: 27 · 2020: 49 · 2019: 42 · 2018: 36 · 2017: 36 · 2016: 43 · 2015: 37 · 2014: 66 · 2013: 44 · 2012: 48
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01-AG-10880, R01AG010880)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061606, DK61606)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- insulin, neurodegenerative diseases, brain insulin signaling, Alzheimer's disease, vascular dementia, Parkinson's disease, Huntington's disease, insulin dysregulation, late-life cognitive decline
- MeSH terms
- Animals, Brain, Cognition Disorders, Diabetes Mellitus, Energy Metabolism, Humans, Insulin, Receptor, Insulin, Signal Transduction, Neurodegenerative Diseases, Diabetes Complications
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